Sphingosine 1-phosphate receptor Edg-6 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Sphingosine 1-phosphate	IC50	23.0 [1]
	3-(Tetradecylamino)propylphosphonic acid	IC50	140.0 [1]
	FTY720 phosphate	IC50	15.0 [1]
\n\n	1-(4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acid	IC50	1600.0 [1]
	Merck SIP Agonist	IC50	70.0 [1]
	5-(2,5-Dichlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamide	IC50	78.0 [1]
	[(1R,3R)-3-Amino-1-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid	IC50	16.0 [1], 280.0 [2]
	[3-(4-Nonyl-benzylamino)-propyl]-phosphonic acid	IC50	26.0 [1], 260.0 [2]
	Phosphonic acid, [3-amino-5-(4-octylphenyl)pentyl]-	IC50	240.0 [1]
	1-(4-Nonylbenzyl)pyrrolidin-3-ylphosphonic acid	IC50	45.0 [1], 86.0 [2]
	(S)-2-Amino-3-(4-(2-(biphenyl-4-yl)ethoxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate	IC50	4.17 [1], 10.3 [2]
	(R)-2-Amino-2-(4-(4-(biphenyl-4-ylmethoxy)phenyl)-1H-imidazol-2-yl)propyl dihydrogen phosphate	IC50	4.87 [1], 4.9 [2]
	CID 54580603	IC50	64.0 [1]
	Fingolimod	IC50	10000.0 [1]
	5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole	IC50	10000.0 [1]
	Fingolimod phosphate ester, S-	IC50	2.2 [1]
	Ceralifimod	Ki	28.8 [1]
	5-(2,4-Dichlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamide	IC50	2000.0 [1]
	N-(4-(Aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide	IC50	25.0 [1]
	CID 59393720	IC50	10000.0 [1]
	5-(2,5-Difluorophenyl)-N-(2,6-dimethylphenyl)-2-furancarboxamide	IC50	308.0 [1]
	5-(2,5-Dichlorophenyl)-N-(2,6-dimethoxyphenyl)-2-furancarboxamide	IC50	417.0 [1]
	5-(2,5-Dichlorophenyl)-N-[2,6-di(propan-2-yl)phenyl]-2-furancarboxamide	IC50	105.0 [1]
	5-(2,5-Dichlorophenyl)-N-(2,6-diethylphenyl)-2-furancarboxamide	IC50	89.0 [1]
	N-(2,6-Dimethylphenyl)-5-(4-methyl-3-thiophenyl)-2-furancarboxamide	IC50	286.0 [1]
	CID 90309142	IC50	10000.0 [1]
	1-[[4-[5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid	IC50	10000.0 [1]
	3-(4-(5-(3-Cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoic acid	IC50	10000.0 [1]
	4-Amino-6-(4-octylphenyl)hexanoic Acid	IC50	10000.0 [1]
	3-(3-Bromo-5-methoxy-4-(octyloxy)benzylamino)propylphosphonic acid	IC50	80.0 [1]
	3-Amino-5-(4-octylphenyl)pentanoic Acid	IC50	10000.0 [1]
	[2-Amino-4-(4-octylphenyl)butyl] dihydrogen phosphate	IC50	1.7 [1]
	[3-Amino-3-hydroxymethyl-5-(4-octyl-phenyl)-pentyl]-phosphonic acid	IC50	210.0 [1]
	1-{4-[5-(4-Tert-butylphenyl)-1,3,4-oxadiazol-2-yl]benzyl}azetidine-3-carboxylic acid	IC50	4300.0 [1]
	1-{4-[3-(4-Tert-butylphenyl)-1,2,4-oxadiazol-5-yl]benzyl}azetidine-3-carboxylic acid	IC50	640.0 [1]
	3-[3-Methyl-4-[5-[4-propan-2-yloxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]propanoic acid	IC50	10000.0 [1]
	[(2R)-2-Amino-2-[5-[4-[(4-phenylphenyl)methoxy]-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]propyl] dihydrogen phosphate	IC50	4.4 [1]
	4-[3-(4-Fluorophenoxy)-5-[[4-(4-fluorophenyl)-4-hydroxypiperidine-1-carbonyl]amino]phenoxy]benzoic acid	IC50	10000.0 [1]
	1-({4-[5-(4-Butylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	70.0 [1]
	(3-Amino-heptadecyl)-phosphonic acid	IC50	76.0 [1]
	2-Hydroxy-4-(4-nonyl-benzylamino)-butyric acid	IC50	1200.0 [1]
	3-Fluoro-4-(4-nonyl-benzylamino)-butyric acid	IC50	600.0 [1]
	1-(4-Nonylbenzyl)azetidine-3-carboxylic acid	IC50	5400.0 [1]
	[3-Amino-2-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid	IC50	140.0 [1]
	[3-(3-Bromo-5-methoxy-4-nonyloxy-benzylamino)-propyl]-phosphonic acid	IC50	33.0 [1]
	2,2-Difluoro-4-(4-nonyl-benzylamino)-butyric acid	IC50	4000.0 [1]
	1-(4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)pyrrolidine-3-carboxylic acid	IC50	790.0 [1]
	(3-Amino-hexadecyl)-phosphonic acid	IC50	140.0 [1]
	1-(4-Nonylbenzyl)pyrrolidine-3-carboxylic acid	IC50	2500.0 [1]
	(3-Amino-henicosyl)-phosphonic acid	IC50	10000.0 [1]
	1-(3-Chloro-4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acid	IC50	1300.0 [1]
	4-(4-Nonyl-benzylamino)-butyric acid	IC50	10000.0 [1]
	1-({4-[5-(4-Tert-butylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	370.0 [1]
	1-[(4-{5-[4-(Propan-2-yloxy)phenyl]-1,2,4-oxadiazol-3-yl}phenyl)methyl]azetidine-3-carboxylic acid	IC50	370.0 [1]
	1-({4-[5-(4-Phenylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	240.0 [1]
	Methyl-[3-(4-nonyl-benzylamino)-propyl]-phosphinic acid	IC50	590.0 [1]
	1-(3-Methyl-4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acid	IC50	1500.0 [1]
	3-Hydroxy-4-(4-nonyl-benzylamino)-butyric acid	IC50	1400.0 [1]
	3-Amino-5-(4-octyl-phenyl)-pentane-1-sulfonic acid	IC50	10000.0 [1]
	1-[[3-Methoxy-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	2800.0 [1]
	1-({4-[5-(4-Propylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	150.0 [1]
	1-[[4-[5-[4-(2-Methylbutan-2-yl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid	IC50	75.0 [1]
	1-({4-[5-(4-Cyclopentylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	49.0 [1]
	1-({4-[5-(4-Hexylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	1-[[4-[5-[4-(2,2-Dimethylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid	IC50	90.0 [1]
	5-(2,5-Dichlorophenyl)-N-(2,5-dimethylphenyl)furan-2-carboxamide	IC50	165.0 [1]
	1-[[4-[[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]-3-(trifluoromethyl)phenyl]methyl]azetidine-3-carboxylic acid	IC50	340.0 [1]
	(5Z)-5-[[3-Chloro-4-[(2S)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-one	IC50	1956.0 [1]
	1-[[3-Fluoro-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	2700.0 [1]
	1-[[3-Ethyl-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	10000.0 [1]
	1-[[3,5-Dimethyl-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	120.0 [1]
	1-[[3-Bromo-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	2400.0 [1]
	2-(trans-5-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)phenyl)pyrrolidin-3-yl)acetic acid	IC50	150.0 [1]
	3-[3-Methyl-4-[5-[4-propan-2-yloxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]butanoic acid	IC50	10000.0 [1]
	1-({4-[5-(4-Ethoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	1000.0 [1]
	(S)-2-Amino-3-(4-(3-(biphenyl-4-yl)propanoyl)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate	IC50	13.1 [1]
	1-[[4-[5-[4-[(1R)-3,3-Difluorocyclopentyl]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid	IC50	89.0 [1]
	1-({4-[5-(4-Cyclopropylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	1000.0 [1]
	1-[[4-[5-[4-[(1S)-3,3-Difluorocyclopentyl]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid	IC50	68.0 [1]
	1-({4-[5-(4-Cyclobutylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acid	IC50	520.0 [1]
	2-Methyl-3-[3-methyl-4-[5-[4-propan-2-yloxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]propanoic acid	IC50	10000.0 [1]
	(S)-2-Amino-3-(4-(biphenyl-4-ylmethoxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate	IC50	6.15 [1]
	(S)-2-Amino-3-(4-(biphenyl-4-yloxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate	IC50	123.0 [1]
	1-[[4-[5-[4-(3,3,3-Trifluoropropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid	IC50	430.0 [1]
	1-[[3,5-Dichloro-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acid	IC50	640.0 [1]
	4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)-5-pyridin-4-yloxyphenyl]-4-hydroxypiperidine-1-carboxamide	IC50	10000.0 [1]
	(3-Hexadecylamino-propyl)-phosphonic acid	IC50	800.0 [1]
	[2-Amino-1-hydroxy-4-(4-octylphenyl)butan-2-yl] dihydrogen phosphate	IC50	15.0 [1]
	3-(5-{5-[3-Cyano-4-(propan-2-yloxy)phenyl]-1,2,4-oxadiazol-3-yl}-6-methylpyridin-2-yl)propanoic acid	IC50	10000.0 [1]
	3-Phenyl-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole	IC50	10000.0 [1]
	3-(2,4-Dichlorophenyl)-5-[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]-1,2,4-oxadiazole	IC50	10000.0 [1]
	[(1S,3R)-3-Amino-1-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid	IC50	16.0 [1]
	[(1R,3S)-3-Amino-1-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid	IC50	880.0 [1]
	[3-Amino-2-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid;[(E)-3-amino-5-(4-octylphenyl)pent-1-enyl]phosphonic acid	IC50	140.0 [1]
	[(1S,3S)-3-Amino-1-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid	IC50	500.0 [1]
	(3-Tridecylamino-propyl)-phosphonic acid	IC50	200.0 [1]
	(3-Dodecylamino-propyl)-phosphonic acid	IC50	650.0 [1]
	{3-[4-(4-Heptyl-phenyl)-butylamino]-propyl}-phosphonic acid	IC50	10000.0 [1]
	3-[(4-Nonylphenyl)methylamino]propylphosphonous acid	IC50	900.0 [1]
	[3-(10-Phenyl-decylamino)-propyl]-phosphonic acid	IC50	140.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Sphingosine 1-phosphate receptor Edg-6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/sphingosine-1-phosphate-receptor-edg-6-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Sphingosine 1-phosphate receptor Edg-6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sphingosine-1-phosphate-receptor-edg-6-inhibitors-ic50-ki.
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