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Sphingosine 1-phosphate receptor Edg-8 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Sphingosine 1-phosphateIC500.55 [1], 1.1 [2], 2.0 [3], 3.1 [4]
\n\n - Open Babel Depiction\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nN\nO\nS\nF\nF\nF\nO\nHO\n\n\n\n\n1-(4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acidIC5023.0 [1]
Merck SIP AgonistIC501.0 [1]
3-(Tetradecylamino)propylphosphonic acidIC5013.0 [1]
5-(2,5-Dichlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamideIC5014000.0 [1]
1-(4-Nonylbenzyl)pyrrolidin-3-ylphosphonic acidIC502.2 [1], 6.3 [2]
(S)-2-Amino-3-(4-(2-(biphenyl-4-yl)ethoxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphateIC5043.6 [1], 122.0 [2]
(R)-2-Amino-2-(4-(4-(biphenyl-4-ylmethoxy)phenyl)-1H-imidazol-2-yl)propyl dihydrogen phosphateIC509.6 [1]
FingolimodIC502100.0 [1]
5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazoleIC504600.0 [1]
FTY720 phosphateIC500.77 [1]
CeralifimodKi0.57 [1]
N-(4-(Aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamideIC505500.0 [1]
CID 59393720IC5010000.0 [1]
CID 90309142IC5010000.0 [1]
1-[[4-[5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC5016.0 [1]
[3-(4-Nonyl-benzylamino)-propyl]-phosphonic acidIC508.2 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC506.0 [1]
3-(3-Bromo-5-methoxy-4-(octyloxy)benzylamino)propylphosphonic acidIC5010.0 [1]
1-{4-[5-(4-Tert-butylphenyl)-1,3,4-oxadiazol-2-yl]benzyl}azetidine-3-carboxylic acidIC501000.0 [1]
1-{4-[3-(4-Tert-butylphenyl)-1,2,4-oxadiazol-5-yl]benzyl}azetidine-3-carboxylic acidIC5020.0 [1]
[(2R)-2-Amino-2-[5-[4-[(4-phenylphenyl)methoxy]-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]propyl] dihydrogen phosphateIC509.6 [1]
1-(4-(3,4-Dichlorobenzyloxy)-2-methylbenzyl)azetidine-3-carboxylic acidIC501.0 [1]
1-[(2-Chloro-4-phenylmethoxyphenyl)methyl]azetidine-3-carboxylic acidIC506.0 [1]
1-[[2-Methyl-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC501.0 [1]
1-[[2-Fluoro-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC502.0 [1]
1-[[2-Chloro-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC502.0 [1]
1-[[4-[[3-(Trifluoromethyl)phenyl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC504.0 [1]
1-[[4-[(2,4-Dichlorophenyl)methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC504.0 [1]
1-(4-(3-(Trifluoromethyl)phenethyl)benzyl)azetidine-3-carboxylic acidIC501.0 [1]
CID 54580603IC5020000.0 [1]
4-[3-(4-Fluorophenoxy)-5-[[4-(4-fluorophenyl)-4-hydroxypiperidine-1-carbonyl]amino]phenoxy]benzoic acidIC5010000.0 [1]
1-({4-[5-(4-Butylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC501.0 [1]
1-(4-Nonylbenzyl)azetidine-3-carboxylic acidIC5011.0 [1]
1-(4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)pyrrolidine-3-carboxylic acidIC50120.0 [1]
1-(4-Nonylbenzyl)pyrrolidine-3-carboxylic acidIC5029.0 [1]
1-(3-Chloro-4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acidIC5018.0 [1]
1-({4-[5-(4-Tert-butylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC505.2 [1]
1-[(4-{5-[4-(Propan-2-yloxy)phenyl]-1,2,4-oxadiazol-3-yl}phenyl)methyl]azetidine-3-carboxylic acidIC5012.0 [1]
1-({4-[5-(4-Phenylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC5011.0 [1]
1-(3-Methyl-4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acidIC5013.0 [1]
1-[[3-Methoxy-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC5077.0 [1]
1-({4-[5-(4-Propylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC501.6 [1]
1-[[4-[5-[4-(2-Methylbutan-2-yl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC501.8 [1]
1-({4-[5-(4-Cyclopentylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC500.5 [1]
1-({4-[5-(4-Hexylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC506.4 [1]
1-[[4-[5-[4-(2,2-Dimethylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC506.6 [1]
1-[[4-[[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]-3-(trifluoromethyl)phenyl]methyl]azetidine-3-carboxylic acidIC5021.0 [1]
(5Z)-5-[[3-Chloro-4-[(2S)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-oneIC50142.0 [1]
1-[[3-Fluoro-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC5041.0 [1]
1-[[3-Ethyl-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC5010.0 [1]
1-[[3,5-Dimethyl-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC5012.0 [1]
1-[[3-Bromo-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC5053.0 [1]
2-(trans-5-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)phenyl)pyrrolidin-3-yl)acetic acidIC50300.0 [1]
1-({4-[5-(4-Ethoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC5048.0 [1]
(S)-2-Amino-3-(4-(3-(biphenyl-4-yl)propanoyl)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphateIC501360.0 [1]
1-[[4-[5-[4-[(1R)-3,3-Difluorocyclopentyl]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC500.4 [1]
1-({4-[5-(4-Cyclopropylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC5012.0 [1]
1-[[4-[5-[4-[(1S)-3,3-Difluorocyclopentyl]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC500.5 [1]
1-({4-[5-(4-Cyclobutylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methyl)azetidine-3-carboxylic acidIC504.0 [1]
(S)-2-Amino-3-(4-(biphenyl-4-ylmethoxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphateIC50104.0 [1]
(S)-2-Amino-3-(4-(biphenyl-4-yloxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphateIC50455.0 [1]
1-[[4-[5-[4-(3,3,3-Trifluoropropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acidIC500.3 [1]
1-[[3,5-Dichloro-4-[[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]methyl]azetidine-3-carboxylic acidIC5033.0 [1]
4-(2-Ethylbutyl)-N-[3-(4-fluorophenoxy)-5-pyridin-4-yloxyphenyl]-4-hydroxypiperidine-1-carboxamideIC5010000.0 [1]
1-[(4-Nonoxyphenyl)methyl]azetidine-3-carboxylic acidIC501.0 [1]
1-[(4-Heptoxyphenyl)methyl]azetidine-3-carboxylic acidIC509.0 [1]
1-[(4-Octoxyphenyl)methyl]azetidine-3-carboxylic acidIC505.0 [1]
6-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]-1H-benzimidazol-2-amineIC5010000.0 [1]
3-Phenyl-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazoleIC5010000.0 [1]
3-(2,4-Dichlorophenyl)-5-[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]-1,2,4-oxadiazoleIC5010000.0 [1]
[3-(Methyl-tetradecyl-amino)-propyl]-phosphonic acidIC5024.0 [1]
[3-(2-Tetradecyl-pyrrolidin-1-yl)-propyl]-phosphonic acidIC50680.0 [1]
[Hydroxy-(1-tetradecylpyrrolidin-3-yl)methyl]phosphonic acidIC5040.0 [1]
(3-Hydroxy-1-tetradecyl-pyrrolidin-3-yl)-phosphonic acidIC5034.0 [1]
[3-(2-Tridecyl-piperidin-1-yl)-propyl]-phosphonic acidIC50230.0 [1]
[2-(1-Tetradecyl-pyrrolidin-2-yl)-ethyl]-phosphonic acidIC50660.0 [1]
{2-[5-(4-Nonyl-phenyl)-pyrrolidin-2-yl]-ethyl}-phosphonic acidIC500.58 [1]
(4-Hydroxy-1-tetradecyl-piperidin-4-yl)-methyl-phosphinic acidIC50270.0 [1]
Methyl-[2-(6-tridecyl-piperidin-2-yl)-ethyl]-phosphinic acidIC5061.0 [1]
(3-Tetradecylamino-cyclohexyl)-phosphonic acidIC50110.0 [1]
(2-Tetradecylamino-cyclohexylmethyl)-phosphonic acidIC501000.0 [1]
(3-Tetradecylamino-cyclopentyl)-phosphonic acidIC501000.0 [1]
[(1S,3S)-3-(4-Nonyl-benzylamino)-cyclohexyl]-phosphonic acidIC501.2 [1]
[2-((2R,5S)-5-Tetradecyl-pyrrolidin-2-yl)-ethyl]-phosphonic acidIC5017.0 [1]
(4-Hydroxy-2-tetradecyl-piperidin-4-yl)-methyl-phosphinic acidIC501000.0 [1]
2-[(2S,5R)-5-[4-[5-[4-[(1R)-3,3-Difluorocyclopentyl]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-2-yl]acetic acidIC5015.0 [1]
(2S,5R)-5-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidine-2-carboxylic acidIC501280.0 [1]
(2S,5S)-5-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidine-2-carboxylic acidIC50180.0 [1]
2-[(2S,5R)-5-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-2-yl]acetic acidIC50200.0 [1]
2-[(2S,5S)-5-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-2-yl]acetic acidIC50100.0 [1]
3-[(2S,5R)-5-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-2-yl]propanoic acidIC5030.0 [1]
2-[(2S,5R)-5-[4-[5-(4-Cyclopentyl-3-fluorophenyl)-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-2-yl]acetic acidIC5030.0 [1]
2-[(2S,5R)-5-[4-[5-[4-[(1S)-3,3-Difluorocyclopentyl]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-2-yl]acetic acidIC5016.0 [1]
3-[(2S,5S)-5-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-2-yl]propanoic acidIC5080.0 [1]
2-[(2S,5R)-5-[4-[5-(4-Cyclohexylphenyl)-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-2-yl]acetic acidIC5020.0 [1]
2-[(2S,5R)-5-[4-[5-(4-Cyclopentyl-2-fluorophenyl)-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-2-yl]acetic acidIC5060.0 [1]
5-[4-[[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]methoxy]phenyl]pyrrolidine-3-carboxylic acidIC50130.0 [1]
2-[(3R,5R)-5-[4-[5-[4-[(1R)-3,3-Difluorocyclopentyl]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-3-yl]acetic acidIC505.1 [1]
2-[(3R,5R)-5-[4-[5-[4-(4,4-Difluorocyclohexyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyrrolidin-3-yl]acetic acidIC5021.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Sphingosine 1-phosphate receptor Edg-8 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/sphingosine-1-phosphate-receptor-edg-8-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Sphingosine 1-phosphate receptor Edg-8 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/sphingosine-1-phosphate-receptor-edg-8-inhibitors-ic50-ki.
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