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Thymidine kinase, cytosolic Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
1-[(Z)-4-(Triphenylmethoxy)-2-butenyl]thymineIC508700.0 [1]
ThymidineIC5016.0 [1], 26.0 [2], 1800.0 [3], 500000.0 [4]
ThymidineKi200.0 [1], 2000.0 [2]
5-Methyl-1-[(E)-4-trityloxybut-2-enyl]pyrimidine-2,4-dioneIC503000.0 [1]
1-(4,5-Dihydroxyoxolan-2-yl)-5-methylsulfanylpyrimidin-2-oneKi2000.0 [1], 4100.0 [2], 160000.0 [3], 400000.0 [4]
ZidovudineIC503000.0 [1]
ZidovudineKi2900.0 [1], 7000.0 [2]
5-Methyl-1-[4-(trityl-amino)-but-2-enyl]-1H-pyrimidine-2,4-dioneIC502300.0 [1], 26000.0 [2], 500000.0 [3]
1-(4-Dibenzylamino-but-2-enyl)-5-methyl-1H-pyrimidine-2,4-dioneIC503500.0 [1], 500000.0 [2]
1-[(Z)-4-(4-Biphenylylacetylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dioneIC504100.0 [1], 119000.0 [2], 500000.0 [3]
CytarabineIC501000000.0 [1]
5-Bromo-2'-deoxyuridineKi5060.0 [1], 25000.0 [2]
2'-DeoxyguanosineIC50115000.0 [1], 364000.0 [2]
StavudineKi580000.0 [1], 615000.0 [2]
ClevudineKi180.0 [1], 1400.0 [2]
FialuridineKi140.0 [1], 950.0 [2]
1-beta-D-ArabinofuranosylthymineIC501000000.0 [1]
1-(2-Deoxy-2-fluoroarabinofuranosyl)-5-ethyluracilKi90.0 [1], 440.0 [2]
1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-(4-phenyltriazol-1-yl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5054000.0 [1], 99000.0 [2]
5'-O-TritylthymidineIC507800.0 [1], 33000.0 [2]
1-[(2R,4S,5S)-4-(4-Benzyltriazol-1-yl)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5078000.0 [1], 318000.0 [2]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] octanoateIC501000000.0 [1]
[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] decanoateIC501000000.0 [1]
[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] pentanoateIC501000000.0 [1]
1-(3-Hydroxy-4-trityloxy-butyl)-5-methyl-pyrimidine-2,4-dioneIC501200.0 [1], 3600.0 [2]
1-[(2R,4S,5R)-5-(Hydroxymethyl)-4-(methyldisulfanyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5073000.0 [1], 333000.0 [2]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] 2-methoxyacetateIC501000000.0 [1]
5'-O-Benzoyl-3'-deoxythymidineKi425000.0 [1], 580000.0 [2]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] decanoateIC501000000.0 [1]
2-Amino-9-(2-hydroxyethoxymethyl)-5H-purin-6-oneKi45000.0 [1], 180000.0 [2]
[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] dodecanoateIC501000000.0 [1]
1-[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-octoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC501000000.0 [1]
1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-(4-pyridin-2-yltriazol-1-yl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5053000.0 [1], 316000.0 [2]
5-Methyl-1-(4-trityloxybutyl)pyrimidine-2,4-dioneIC503300.0 [1], 10000.0 [2]
5-Methyl-1-(2-trityloxymethyl-benzyl)-1H-pyrimidine-2,4-dioneIC502.0 [1], 8.0 [2]
[(2S,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)oxolan-2-yl]methyl benzoateKi975000.0 [1], 1000000.0 [2]
1-[(2R,4S,5R)-5-Ethynyl-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dioneIC503000.0 [1]
1-[(2R,4S,5R)-5-Ethynyl-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dioneKi2000.0 [1]
1-[(Z)-4-(9H-Xanthene-9-ylcarbonylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dioneIC5033000.0 [1], 131000.0 [2]
N-[(Z)-4-(5-Methyl-2,4-dioxopyrimidin-1-yl)but-2-enyl]-3-(trifluoromethyl)benzamideIC5028000.0 [1], 72000.0 [2]
1-[4-(4-Benzyl-piperazin-1-yl)-but-2-enyl]-5-methyl-1H-pyrimidine-2,4-dioneIC50180000.0 [1], 500000.0 [2]
2-(4-Chlorophenyl)-N-[(Z)-4-(5-methyl-2,4-dioxopyrimidin-1-yl)but-2-enyl]acetamideIC5023000.0 [1], 198000.0 [2]
5-Methyl-1-[4-(4-methyl-piperazin-1-yl)-but-2-enyl]-1H-pyrimidine-2,4-dioneIC50491000.0 [1], 500000.0 [2]
1-[(Z)-4-(Diphenylacetylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dioneIC5027000.0 [1], 115000.0 [2]
5-Iodo-1-(3-trityloxy-propenyl)-1H-pyrimidine-2,4-dioneIC504600.0 [1], 48000.0 [2]
1-(2,3-Dihydroxy-4-trityloxybutyl)-5-methylpyrimidine-2,4-dioneIC5013000.0 [1], 17000.0 [2]
1-[(2R,4S,5R)-5-(Hydroxymethyl)-4-(trichloromethyldisulfanyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5013000.0 [1], 365000.0 [2]
1-[(2R,4S,5R)-4-(2-Hydroxyethyldisulfanyl)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5018000.0 [1], 405000.0 [2]
1-[(2R,4S,5R)-4-(2-Aminoethyldisulfanyl)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5010000.0 [1], 418000.0 [2]
1-(4-Benzylamino-but-2-enyl)-5-methyl-1H-pyrimidine-2,4-dioneIC5057000.0 [1], 500000.0 [2]
1-[(2R,4S,5S)-4-Hydroxy-5-methoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC505000.0 [1]
1-[(2R,4S,5S)-4-Hydroxy-5-methoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dioneKi2900.0 [1]
1-[(2R,4S,5S)-4-Hydroxy-5-(2-phenylethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5025000.0 [1]
1-[(2R,4S,5S)-4-Hydroxy-5-(2-phenylethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneKi26000.0 [1]
1-[(2R,4S,5S)-4-Hydroxy-5-(3-phenylpropoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5010000.0 [1]
1-[(2R,4S,5S)-4-Hydroxy-5-(3-phenylpropoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneKi4300.0 [1]
IdoxuridineKi90.0 [1]
BrivudineKi100.0 [1]
SorivudineIC50500000.0 [1]
9-beta-d-ArabinofuranosylguanineIC50500000.0 [1]
2',3'-Didehydro-2',3'-dideoxyuridineKi445000.0 [1]
North-methanocarbathymidineKi16100.0 [1]
9-(4-Hydroxybutyl)guanineKi2060.0 [1]
5-Propyl-2'-deoxyuridineKi20000.0 [1]
1-[(1R,3S,4R)-3-Hydroxy-4-(hydroxymethyl)cyclopentyl]-5-iodopyrimidine-2,4-dioneKi210.0 [1]
9-(4-Hydroxybutyl)-N2-phenylguanineKi50.0 [1]
3'-(Azidomethyl)-3'-deoxythymidineKi1040000.0 [1]
1-(4-Aminomethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dioneKi220000.0 [1]
2,4(1H,3H)-Pyrimidinedione, 5-((E)-2-bromoethenyl)-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-Ki220.0 [1]
9-(4-Hydroxy-3-hydroxymethyl-2-butenyl)guanineKi25000.0 [1]
5'-O-(4,4'-Dimethoxytrityl)thymidineIC5014000.0 [1]
3'-Deoxy-4-thiothymidineKi1600000.0 [1]
3'-Azido-3'-deoxy-4-thiothymidineKi54000.0 [1]
4-ThiothymidineKi12000.0 [1]
1-[(2R,4S,5S)-4-[4-(4-Chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5071000.0 [1]
1-(4-Fluoromethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dioneKi970000.0 [1]
2',3'-Didehydro-3'-deoxy-4-thiothymidineKi1690000.0 [1]
1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-(5-phenyltriazol-1-yl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC50500000.0 [1]
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(2S,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]thioureaIC50316000.0 [1]
3-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-2-oneIC50500000.0 [1]
1-(4-Aminomethyl-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dioneKi110000.0 [1]
1-[(2R,4S,5S)-4-[4-(3,4-Dichlorophenyl)triazol-1-yl]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5075000.0 [1]
1-[(2R,4S,5S)-4-[5-(4-Chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC50109000.0 [1]
1-(4,5-Bis-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dioneKi420000.0 [1]
1-[(1S,2S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-bicyclo[3.1.0]hexanyl]-5-iodopyrimidine-2,4-dioneKi85800.0 [1]
5-Bromo-1-[(1S,2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-bicyclo[3.1.0]hexanyl]pyrimidine-2,4-dioneKi69800.0 [1]
2',3'-Didehydro-2',3'-dideoxy-4-thiouridineKi1690000.0 [1]
2',3'-Dideoxy-4-thiouridineKi1275000.0 [1]
[(2S,3R,5R)-3-(Azidomethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphateKi32000.0 [1]
[(2S,3R,5R)-3-(Aminomethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphateKi4700.0 [1]
3-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(3-hydroxyphenyl)furo[2,3-d]pyrimidin-2-oneIC50500000.0 [1]
3'-Deoxy-3'-(1,2,3-triazol-1-yl)thymidineIC50500000.0 [1]
1-(3-Benzyloxy-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dioneIC501000000.0 [1]
5-Methyl-1-(4-trityloxybut-2-ynyl)pyrimidine-2,4-dioneIC503100.0 [1]
1-[(Z)-4-(Triphenylmethoxy)-2-butenyl]-5,6-dihydrothymineIC509800.0 [1]
1-[(Z)-4-Benzyloxybut-2-enyl]-5-methyl-pyrimidine-2,4-dioneIC5022000.0 [1]
5-[(E)-2-Bromoethenyl]-1-[(1S,2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-bicyclo[3.1.0]hexanyl]pyrimidine-2,4-dioneKi62900.0 [1]
[(Z)-4-(5-Methyl-2,4-dioxopyrimidin-1-yl)but-2-enyl] benzoateIC5030000.0 [1]
6-(4-Fluorophenyl)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]furo[2,3-d]pyrimidin-2-oneIC50500000.0 [1]
[(Z)-4-(5-Methyl-2,4-dioxopyrimidin-1-yl)but-2-enyl] 2,2-dimethylpropanoateIC5040000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Thymidine kinase, cytosolic Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/thymidine-kinase-cytosolic-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Thymidine kinase, cytosolic Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/thymidine-kinase-cytosolic-inhibitors-ic50-ki.
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