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Thymidine kinase, mitochondrial Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] decanoateIC506800.0 [1], 40000.0 [2], 97000.0 [3]
1-[(Z)-4-(Triphenylmethoxy)-2-butenyl]thymineIC501500.0 [1]
1-[(Z)-4-(Triphenylmethoxy)-2-butenyl]thymineKi500.0 [1]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] octanoateIC506300.0 [1]
5-[(E)-2-Bromoethenyl]-1-[(2R,4S,5S)-4-[4-(4-chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dioneIC5036.0 [1]
5-[(E)-2-Bromoethenyl]-1-[(2R,4S,5S)-4-[4-(4-chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dioneKi12.0 [1], 410.0 [2]
CytarabineIC501000000.0 [1]
SorivudineIC5043000.0 [1]
SorivudineKi10400.0 [1]
1-beta-D-ArabinofuranosylthymineIC50285000.0 [1]
[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] decanoateIC5027000.0 [1]
[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] pentanoateIC501000000.0 [1]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] 2-methoxyacetateIC50402000.0 [1]
[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] dodecanoateIC5028000.0 [1]
1-[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-octoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC50120000.0 [1]
1-[6-[Diphenyl(pyridin-4-yl)methoxy]hexyl]-5-methylpyrimidine-2,4-dioneIC50470.0 [1]
1-[6-[Diphenyl(pyridin-4-yl)methoxy]hexyl]-5-methylpyrimidine-2,4-dioneKi290.0 [1]
9-beta-d-ArabinofuranosylguanineIC50500000.0 [1]
5-Propyl-2'-deoxyuridineKi20000.0 [1]
1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-(4-phenyltriazol-1-yl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC50320.0 [1]
1-[(2R,4S,5S)-4-[4-(4-Chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5046.0 [1]
1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-(5-phenyltriazol-1-yl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC501100.0 [1]
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(2S,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]thioureaIC50150.0 [1]
1-[(2R,4S,5S)-4-(4-Benzyltriazol-1-yl)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC50300.0 [1]
1-[(2R,4S,5S)-4-[4-(3,4-Dichlorophenyl)triazol-1-yl]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC5042.0 [1]
1-[(2R,4S,5S)-4-[5-(4-Chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC504000.0 [1]
3'-Deoxy-3'-(1,2,3-triazol-1-yl)thymidineIC504700.0 [1]
1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-(4-pyridin-2-yltriazol-1-yl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC501300.0 [1]
1-(3-Benzyloxy-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dioneIC50801000.0 [1]
[(2R,3S,4R,5R)-2-(2-Amino-6-oxo-1H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] pentanoateIC50500000.0 [1]
[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[2-(octanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl] octanoateIC50500000.0 [1]
[(2R,3S,4R,5R)-2-(2-Amino-6-oxo-1H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] octanoateIC50500000.0 [1]
1-[5-(Triphenylmethoxy)pentyl]thymineIC502500.0 [1]
1-[8-(Triphenylmethoxy)octyl]thymineIC5045000.0 [1]
1-[2-[2-[(4-Chlorophenyl)-diphenylmethoxy]ethoxy]ethyl]-5-methylpyrimidine-2,4-dioneIC505200.0 [1]
1-[(Z)-4-[(4-Chlorophenyl)-diphenylmethoxy]but-2-enyl]-5-methylpyrimidine-2,4-dioneIC502400.0 [1]
N-Methyl-4-[[(Z)-4-(5-methyl-2,4-dioxopyrimidin-1-yl)but-2-enoxy]-diphenylmethyl]benzamideIC501900.0 [1]
1-[3-(Triphenylmethoxy)propyl]thymineIC5045000.0 [1]
1-[7-(Triphenylmethoxy)heptyl]thymineIC504700.0 [1]
1-[2-(2-Triphenylmethoxyethoxy)ethyl]thymineIC509700.0 [1]
1-[6-[(4-Chlorophenyl)-diphenylmethoxy]hexyl]-5-methylpyrimidine-2,4-dioneIC501900.0 [1]
1-[2-[2-[Diphenyl(pyridin-4-yl)methoxy]ethoxy]ethyl]-5-methylpyrimidine-2,4-dioneIC5023000.0 [1]
1-[(Z)-4-[Diphenyl(pyridin-4-yl)methoxy]but-2-enyl]-5-methylpyrimidine-2,4-dioneIC501800.0 [1]
1-[(2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-phenylmethoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC50801000.0 [1]
1-[6-(Triphenylmethoxy)hexyl]thymineIC50500.0 [1]
N-Methyl-4-[6-(5-methyl-2,4-dioxopyrimidin-1-yl)hexoxy-diphenylmethyl]benzamideIC50390.0 [1]
[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] octanoateIC50120000.0 [1]
1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-3-octylpyrimidine-2,4-dioneIC50500000.0 [1]
1-[(2R,3S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-octoxyoxolan-2-yl]-5-methyl-3-octylpyrimidine-2,4-dioneIC501000000.0 [1]
N-[(2R,3S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]decanamideIC50480000.0 [1]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] 2-phenylacetateIC5074000.0 [1]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] 2-(4-methoxyphenyl)acetateIC5044000.0 [1]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] 4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoateIC5055000.0 [1]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] 6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoateIC5061000.0 [1]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] 8-[(2-methylpropan-2-yl)oxycarbonylamino]octanoateIC506400.0 [1]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] 12-[(2-methylpropan-2-yl)oxycarbonylamino]dodecanoateIC503800.0 [1]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] 4-aminobutanoateIC50187000.0 [1]
[(2R,3S,4R,5R)-2-[5-[(E)-2-Bromoethenyl]-2,4-dioxopyrimidin-1-yl]-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] 6-aminohexanoateIC50500000.0 [1]
[(2R,3S,4R,5R)-2-(4-Amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] nonanoateIC501000000.0 [1]
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(2S,3S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-2-(trityloxymethyl)oxolan-3-yl]thioureaIC50500000.0 [1]
5-[(E)-2-Bromoethenyl]-1-[(2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyltriazol-1-yl)oxolan-2-yl]pyrimidine-2,4-dioneIC50250.0 [1]
1-[(2R,4S,5S)-4-(4-Butyltriazol-1-yl)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC50230.0 [1]
5-[(Z)-2-Bromoethenyl]-1-[(3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dioneIC5043000.0 [1]
N-[(2S,3S,5R)-2-(Hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]hexanamideKi150.0 [1]
N-Methyl-4-[8-(5-methyl-2,4-dioxopyrimidin-1-yl)octoxy-diphenylmethyl]benzamideIC50400.0 [1]
1-[(2R,4S,5S)-4-[4-(Cyclopentylmethyl)triazol-1-yl]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC50150.0 [1]
4-Amino-1-(4-hydroxy-5-hydroxymethyl-3-octyloxy-tetrahydro-furan-2-yl)-1H-pyrimidin-2-oneIC501000000.0 [1]
5-Methyl-1-[6-[(1-methylpyridin-1-ium-4-yl)-diphenylmethoxy]hexyl]pyrimidine-2,4-dioneIC5023000.0 [1]
5-Methyl-1-[(Z)-4-[(1-methylpyridin-1-ium-4-yl)-diphenylmethoxy]but-2-enyl]pyrimidine-2,4-dioneIC50114000.0 [1]
Items per page: 1 - 10 of 69
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References

This online tool may be cited as follows

MLA

"Quest Database™ Thymidine kinase, mitochondrial Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/thymidine-kinase-mitochondrial-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Thymidine kinase, mitochondrial Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/thymidine-kinase-mitochondrial-inhibitors-ic50-ki.
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