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Thyroid hormone receptor beta-1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
LiothyronineIC500.26 [1], 2.9 [2]
LiothyronineKi0.08 [1], 0.55 [2], 0.68 [3], 2.29 [4]
{3,5-Dichloro-4-[4-Hydroxy-3-(Propan-2-Yl)phenoxy]phenyl}acetic AcidIC501.1 [1]
{3,5-Dichloro-4-[4-Hydroxy-3-(Propan-2-Yl)phenoxy]phenyl}acetic AcidKi0.24 [1], 0.37 [2]
2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuranIC504100.0 [1], 5100.0 [2], 5128.61 [3]
3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acidIC500.1 [1]
3,5-Dibromo-4-[4-hydroxy-3,5-bis(propan-2-yl)phenoxy]benzoic acidIC50910.0 [1], 912.01 [2], 4500.0 [3]
2-[3,5-Dibromo-4-(hexyloxy)phenyl]acetic acidIC50800.0 [1], 1500.0 [2], 1513.56 [3]
3-[3,5-Dibromo-4-(hexyloxy)phenyl]propanoic acidIC50360.0 [1], 363.08 [2], 1000.0 [3]
2-[3,5-Dibromo-4-(2-ethylbutoxy)phenyl]acetic AcidIC50700.0 [1], 794.33 [2], 800.0 [3]
TiratricolIC500.04 [1], 0.05 [2]
Thyropropic acidIC500.02 [1]
3,5-Dibromo-4-(3-Isopropyl-Phenoxy)benzoic AcidIC500.03 [1]
2-[4-(3-Bromo-4-propanamidophenoxy)-3,5-dichlorophenyl]acetic acidIC50140.0 [1], 141.25 [2]
2-{4-[3-Bromo-4-(2-ethylbutanamido)phenoxy]-3,5-dichlorophenyl}acetic acidIC5015.85 [1], 16.0 [2]
3-{3,5-Dichloro-4-[4-hydroxy-3-(propan-2-yl)phenoxy]phenyl}propanoic acidIC500.15 [1]
2-[3,5-Dibromo-4-(3-methylbutoxy)phenyl]acetic AcidIC501819.7 [1], 18000.0 [2]
3-[3,5-Dibromo-4-(2-ethylbutoxy)phenyl]propanoic AcidIC50810.0 [1], 812.83 [2]
2-[3,5-Dibromo-4-(pentyloxy)phenyl]acetic acidIC505700.0 [1], 5754.4 [2]
3-[3,5-Dibromo-4-(3-methylbutoxy)phenyl]propanoic AcidIC501800.0 [1], 1819.7 [2]
2-{4-[3-Bromo-4-(2-methylpentanamido)phenoxy]-3,5-dichlorophenyl}acetic acidIC5046.77 [1], 47.0 [2]
2-{4-[3-Bromo-4-(2-propylpentanamido)phenoxy]-3,5-dichlorophenyl}acetic acidIC5044.67 [1], 45.0 [2]
DetrothyronineIC500.26 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(piperidine-1-carbonyl)-phenoxy]-phenyl}-2H-[1,2,4]triazine-3,5-dioneIC505.25 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(piperidine-1-carbonyl)-phenoxy]-phenyl}-2H-[1,2,4]triazine-3,5-dioneKi0.63 [1], 1.0 [2]
3,5-Dichloro-4-[4-hydroxy-3-(propan-2-yl)phenoxy]benzoic acidIC5020.89 [1], 21.0 [2]
2-(3,5-Dibromo-4-butoxyphenyl)acetic acidIC501900.0 [1], 1905.46 [2]
3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)benzoic acidIC502.09 [1], 2.1 [2]
3,5-Dichloro-4-(3-bromo-4-isobutyramidophenoxy)phenylacetic acidIC5018.0 [1], 18.2 [2]
4,6-Dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-indole-2-carboxylic acidIC500.06 [1]
4,6-Dichloro-5-(4-hydroxy-3-isopropylphenoxy)-1H-indole-2-carboxylic acidKi0.06 [1]
2-[3,5-Dibromo-4-(cyclohexylmethoxy)phenyl]acetic AcidIC50520.0 [1], 770.0 [2], 776.25 [3]
3-[3,5-Dibromo-4-(cyclohexylmethoxy)phenyl]propanoic AcidIC50120.0 [1], 190.0 [2], 190.55 [3]
(2-Butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethyl]-3,5-diiodophenyl]methanoneIC50600.0 [1], 602.56 [2], 10000.0 [3]
Phosphonic acid, p-((4-((4-hydroxy-3-(1-methylethyl)phenyl)methyl)-3,5-dimethylphenoxy)methyl)-Ki2.17 [1], 2.95 [2]
2-[3,5-Dichloro-4-(4-hydroxy-3-phenylphenoxy)phenyl]acetic acidIC502.88 [1]
2-(3,5-Dibromo-4-{4-hydroxy-3-[(2-phenylethyl)carbamoyl]phenoxy}phenyl)acetic acidIC500.62 [1]
N-Cyclohexyl-5-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-2-hydroxybenzamideIC500.2 [1]
N-Cyclohexyl-5-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-2-hydroxybenzamideKi0.07 [1]
4,6-Dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-indole-2-carboxylic acidIC500.28 [1]
3,5-Dibromo-4-ethoxyphenylacetic acidIC5032000.0 [1], 32359.37 [2]
2-{3,5-Dichloro-4-[4-hydroxy-3-(pyridin-2-yl)phenoxy]phenyl}acetic acidIC50138.04 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(pyridin-4-yl)phenoxy]phenyl}acetic acidIC50123.03 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(1,3-thiazol-2-yl)phenoxy]phenyl}acetic acidIC5028.18 [1]
5-[2,6-Dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-2-hydroxy-N-phenylbenzenesulfonamideIC500.28 [1]
5-[2,6-Dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-2-hydroxy-N-phenylbenzenesulfonamideKi0.1 [1]
5-[2,6-Dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-N-(6,6-dimethyl-2-bicyclo[3.1.1]heptanyl)-2-hydroxybenzamideIC500.17 [1]
5-[2,6-Dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-N-(6,6-dimethyl-2-bicyclo[3.1.1]heptanyl)-2-hydroxybenzamideKi0.06 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(morpholine-4-carbonyl)-phenoxy]-phenyl}-2H-[1,2,4]triazine-3,5-dioneIC502.0 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(morpholine-4-carbonyl)-phenoxy]-phenyl}-2H-[1,2,4]triazine-3,5-dioneKi0.72 [1]
N-Cyclobutyl-5-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-2-hydroxybenzamideIC501.78 [1]
N-Cyclobutyl-5-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-2-hydroxybenzamideKi0.64 [1]
2-[3-Chloro-4-(4-hydroxy-3-piperidin-1-ylsulfonylphenoxy)-5-methylphenyl]-1,2,4-triazine-3,5-dioneIC500.36 [1]
2-[3-Chloro-4-(4-hydroxy-3-piperidin-1-ylsulfonylphenoxy)-5-methylphenyl]-1,2,4-triazine-3,5-dioneKi0.13 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(piperidine-1-sulfonyl)-phenoxy]-phenyl}-2H-[1,2,4]triazine-3,5-dioneIC500.06 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(piperidine-1-sulfonyl)-phenoxy]-phenyl}-2H-[1,2,4]triazine-3,5-dioneKi0.02 [1]
2-[3-Chloro-4-(4-hydroxy-3-morpholin-4-ylsulfonylphenoxy)-5-methylphenyl]-1,2,4-triazine-3,5-dioneIC5075.86 [1]
2-[3-Chloro-4-(4-hydroxy-3-morpholin-4-ylsulfonylphenoxy)-5-methylphenyl]-1,2,4-triazine-3,5-dioneKi27.0 [1]
N-Cyclobutyl-5-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-2-hydroxybenzenesulfonamideIC501.12 [1]
N-Cyclobutyl-5-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-2-hydroxybenzenesulfonamideKi0.4 [1]
2-{4-[4-Hydroxy-3-(piperidine-1-sulfonyl)-phenoxy]-3,5-dimethyl-phenyl}-2H-[1,2,4]triazine-3,5-dioneIC501.29 [1]
2-{4-[4-Hydroxy-3-(piperidine-1-sulfonyl)-phenoxy]-3,5-dimethyl-phenyl}-2H-[1,2,4]triazine-3,5-dioneKi0.46 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(pyrimidin-5-yl)phenoxy]phenyl}acetic acidIC5067.61 [1]
(2R)-2-Amino-3-{4-[4-hydroxy-3-(propan-2-yl)phenoxy]-3,5-diiodophenyl}propanoic acidIC500.11 [1]
2-{4-[3-Bromo-4-(2-methylbutanamido)phenoxy]-3,5-dichlorophenyl}acetic acidIC504.27 [1], 4.3 [2]
2-(3,5-Dichloro-4-{4-hydroxy-3-[3-(trifluoromethyl)phenyl]phenoxy}phenyl)acetic acidIC500.85 [1], 0.93 [2]
2-(3,5-Dichloro-4-{4-hydroxy-3-[3-(propan-2-yl)phenyl]phenoxy}phenyl)acetic acidIC503.98 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(3-phenylphenyl)phenoxy]phenyl}acetic acidIC5020.89 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(3-methoxyphenyl)phenoxy]phenyl}acetic acidIC5010.96 [1]
2-(3,5-Dichloro-4-{3-[3-(difluoromethoxy)phenyl]-4-hydroxyphenoxy}phenyl)acetic acidIC500.78 [1]
2-(3,5-Dichloro-4-{4-hydroxy-3-[3-(trifluoromethoxy)phenyl]phenoxy}phenyl)acetic acidIC503.39 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(2-hydroxyphenyl)phenoxy]phenyl}acetic acidIC5050.12 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(3-hydroxyphenyl)phenoxy]phenyl}acetic acidIC5075.86 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(4-hydroxyphenyl)phenoxy]phenyl}acetic acidIC5087.1 [1]
2-{3,5-Dichloro-4-[4-hydroxy-3-(pyridin-3-yl)phenoxy]phenyl}acetic acidIC5040.74 [1]
2-[3,5-Dibromo-4-(4-hydroxy-3-phenoxyphenoxy)phenyl]acetic acidIC506.03 [1]
2-(3,5-Dibromo-4-{4-hydroxy-3-[2-(trifluoromethyl)phenoxy]phenoxy}phenyl)acetic acidIC507.59 [1]
2-(3,5-Dibromo-4-{4-hydroxy-3-[3-(trifluoromethyl)phenoxy]phenoxy}phenyl)acetic acidIC501.1 [1]
2-{3,5-Dibromo-4-[4-hydroxy-3-(3-phenylphenoxy)phenoxy]phenyl}acetic acidIC5060.26 [1]
2-{3,5-Dibromo-4-[4-hydroxy-3-(2-hydroxyphenoxy)phenoxy]phenyl}acetic acidIC5083.18 [1]
2-{3,5-Dibromo-4-[4-hydroxy-3-(3-hydroxyphenoxy)phenoxy]phenyl}acetic acidIC5046.77 [1]
2-{3,5-Dibromo-4-[4-hydroxy-3-(4-hydroxyphenoxy)phenoxy]phenyl}acetic acidIC506.03 [1]
2-{3,5-Dibromo-4-[4-hydroxy-3-(phenylcarbamoyl)phenoxy]phenyl}acetic acidIC5034.67 [1], 35.48 [2]
2-(3,5-Dibromo-4-{4-hydroxy-3-[(3-phenylpropyl)carbamoyl]phenoxy}phenyl)acetic acidIC506.76 [1]
2-(3,5-Dibromo-4-{4-hydroxy-3-[(4-phenylbutyl)carbamoyl]phenoxy}phenyl)acetic acidIC5018.2 [1]
2-[3,5-Dibromo-4-(4-hydroxy-3-{[2-(4-methoxyphenyl)ethyl]carbamoyl}phenoxy)phenyl]acetic acidIC504.79 [1], 37.15 [2]
2-[3,5-Dibromo-4-(4-hydroxy-3-{[2-(3-methoxyphenyl)ethyl]carbamoyl}phenoxy)phenyl]acetic acidIC504.9 [1], 8.51 [2]
2-[3,5-Dibromo-4-(4-hydroxy-3-{[2-(2-methoxyphenyl)ethyl]carbamoyl}phenoxy)phenyl]acetic acidIC500.47 [1], 8.51 [2]
2-(3,5-Dibromo-4-{3-[(2,2-diphenylethyl)carbamoyl]-4-hydroxyphenoxy}phenyl)acetic acidIC500.47 [1], 37.15 [2]
2-[3,5-Dibromo-4-(4-hydroxy-3-{[2-(pyridin-2-yl)ethyl]carbamoyl}phenoxy)phenyl]acetic acidIC5067.61 [1]
2-[3,5-Dichloro-4-(4-hydroxy-3-spiro[8-azabicyclo[3.2.1]octane-3,2'-oxolane]-8-ylsulfonylphenoxy)phenyl]-1,2,4-triazine-3,5-dioneIC500.78 [1]
2-[3,5-Dichloro-4-(4-hydroxy-3-spiro[8-azabicyclo[3.2.1]octane-3,2'-oxolane]-8-ylsulfonylphenoxy)phenyl]-1,2,4-triazine-3,5-dioneKi0.28 [1]
2-[3,5-Dichloro-4-(4-hydroxy-3-spiro[1,3-dioxolane-2,3'-8-azabicyclo[3.2.1]octane]-8'-ylsulfonylphenoxy)phenyl]-1,2,4-triazine-3,5-dioneIC500.87 [1]
2-[3,5-Dichloro-4-(4-hydroxy-3-spiro[1,3-dioxolane-2,3'-8-azabicyclo[3.2.1]octane]-8'-ylsulfonylphenoxy)phenyl]-1,2,4-triazine-3,5-dioneKi0.31 [1]
6-(4-Hydroxy-3-isopropylphenoxy)-5,7-dimethylquinoline-2-carboxylic acidIC5015.0 [1], 15.14 [2]
5,7-Dibromo-6-(4-hydroxy-3-propan-2-ylphenoxy)-4-oxo-1H-quinoline-2-carboxylic acidIC5051.0 [1], 51.29 [2]
5,7-Dichloro-6-(4-hydroxy-3-propan-2-ylphenoxy)-4-oxo-1H-quinoline-2-carboxylic acidIC5015.14 [1], 870.0 [2]
6-(4-Hydroxy-3-propan-2-ylphenoxy)-5,7-dimethyl-4-oxo-1H-quinoline-2-carboxylic acidIC50239.88 [1], 240.0 [2]
N-Cyclohexyl-5-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-2-hydroxybenzenesulfonamideIC501.29 [1]
N-Cyclohexyl-5-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenoxy]-2-hydroxybenzenesulfonamideKi0.46 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Thyroid hormone receptor beta-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/thyroid-hormone-receptor-beta-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Thyroid hormone receptor beta-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/thyroid-hormone-receptor-beta-1-inhibitors-ic50-ki.
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