Thyrotropin-releasing hormone receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Protirelin	Ki	20.0 [1]
	(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(1-methylimidazol-4-yl)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide	Ki	3.2 [1]
	(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-1-oxo-3-(2-propan-2-yl-1H-imidazol-5-yl)propan-2-yl]-6-oxopiperidine-2-carboxamide	Ki	100000.0 [1]
	(2S)-N-[(2S)-3-(2-Tert-butyl-1H-imidazol-5-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide	Ki	100000.0 [1]
	(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(2-cyclohexyl-1H-imidazol-5-yl)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide	Ki	100000.0 [1]
	N-[(1R)-3-Oxocyclopentane-1-carbonyl]-2-propyl-L-histidyl-L-prolinamide	Ki	100000.0 [1]
	(2S)-1-[(2S)-2-[[(1R)-3-Oxocyclopentanecarbonyl]amino]-3-(2-propan-2-yl-1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxamide	Ki	100000.0 [1]
	(2S)-1-[(2S)-3-(2-Tert-butyl-1H-imidazol-5-yl)-2-[[(1R)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide	Ki	100000.0 [1]
	(2S)-1-[(2S)-3-(2-Cyclohexyl-1H-imidazol-5-yl)-2-[[(1R)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide	Ki	100000.0 [1]
	N-[(1S)-3-Oxocyclopentane-1-carbonyl]-2-propyl-L-histidyl-L-prolinamide	Ki	100000.0 [1]
	(2S)-1-[(2S)-2-[[(1S)-3-Oxocyclopentanecarbonyl]amino]-3-(2-propan-2-yl-1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxamide	Ki	100000.0 [1]
	(2S)-1-[(2S)-3-(2-Tert-butyl-1H-imidazol-5-yl)-2-[[(1S)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide	Ki	100000.0 [1]
	(2S)-1-[(2S)-3-(2-Cyclohexyl-1H-imidazol-5-yl)-2-[[(1S)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide	Ki	100000.0 [1]
	(2S)-1-[(2S)-2-Amino-3-(3-methyl-1H-imidazol-3-ium-4-yl)propanoyl]-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide	Ki	3.0 [1]
	(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(1-ethylimidazol-4-yl)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide	Ki	11.0 [1]
	(2S)-N-[(2S)-3-(1-Benzylimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide	Ki	100000.0 [1]
	(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-1-oxo-3-(1-prop-2-enylimidazol-4-yl)propan-2-yl]-6-oxopiperidine-2-carboxamide	Ki	7500.0 [1]
	(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-1-oxo-3-(2-propyl-1H-imidazol-5-yl)propan-2-yl]-6-oxopiperidine-2-carboxamide	Ki	400.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 18 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Thyrotropin-releasing hormone receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/thyrotropin-releasing-hormone-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Thyrotropin-releasing hormone receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/thyrotropin-releasing-hormone-receptor-inhibitors-ic50-ki.
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