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Tissue-type plasminogen activator Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
RazaxabanKi33000.0 [1]
6-(N-Phenylcarbamyl)-2-naphthalenecarboxamidineIC50125000.0 [1]
6-(N-Phenylcarbamyl)-2-naphthalenecarboxamidineKi31800.0 [1], 32000.0 [2]
3-{5-[Amino(iminio)methyl]-1H-indol-2-YL}-1,1'-biphenyl-2-olateKi35.0 [1], 100.0 [2]
AmilorideIC50220000.0 [1], 250000.0 [2]
EfegatranIC5034.0 [1], 21000.0 [2]
Naphthalene-2-carboximidamideKi100000.0 [1]
2-[3-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide;hydrochlorideKi45000.0 [1]
6-Chloro-2-(2-Hydroxybiphenyl-3-yl)-1H-Indole-5-CarboxamidineKi110.0 [1], 8800.0 [2]
1-[[5-(5-Chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl]-N-(1-propan-2-ylpiperidin-4-yl)indole-2-carboxamideKi100000.0 [1]
4-[(E)-(5-Oxo-2-phenyl-1,3-oxazol-4-ylidene)methyl]benzenecarboximidamideIC5068510.0 [1], 100000.0 [2]
6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidineIC5062000.0 [1]
6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidineKi58400.0 [1]
Diphenyl N-(benzyloxycarbonyl)amino(4-amidinophenyl)methanephosphonateIC502500.0 [1], 66000.0 [2]
2-(3-Bromo-5-chloro-2-pyridinyl)guanidineKi272000.0 [1]
6-Carbamimidoyl-4-(furan-3-yl)-N-phenylnaphthalene-2-carboxamideKi176.0 [1], 180.0 [2]
6-Carbamimidoyl-N-phenyl-4-(pyrimidin-2-ylamino)naphthalene-2-carboxamideKi810.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]amino]-1-oxopropan-2-yl]-3-hydroxypropanamideIC50280.0 [1]
N-[(1S)-1-[4-(3-Amino-1H-indazol-6-yl)pyridin-2-yl]-2-phenylethyl]-4-(aminomethyl)cyclohexane-1-carboxamideKi21900.0 [1]
Benzyl N-[(2R)-1-[[(2S)-1-[[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamateIC504600.0 [1], 14000.0 [2]
6-Methyl-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidineKi210.0 [1], 39000.0 [2]
6-Methoxy-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidineKi3900.0 [1], 18000.0 [2]
4-Chloro-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidineKi3000.0 [1], 3300.0 [2]
6-Hydroxy-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidineKi19000.0 [1], 46000.0 [2]
Benzyl N-[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]carbamateIC5012000.0 [1]
Benzyl N-[3-(4-carbamimidoylphenyl)-1-diphenoxyphosphorylpropyl]carbamateIC5068000.0 [1]
Benzyl N-[4-(diaminomethylideneamino)-1-diphenoxyphosphorylbutyl]carbamateIC5044000.0 [1]
2-(2-Hydroxy-3-biphenylyl)-6-fluoro-1H-indole-5-carboxamidineKi350.0 [1], 3600.0 [2]
DabigatranKi45360.0 [1]
BenzamidineKi910000.0 [1]
ArgatrobanKi87800.0 [1]
GabexateIC5015360.0 [1]
MelagatranKi1510.0 [1]
5-(N,N-Hexamethylene)amilorideIC5010000.0 [1]
BetrixabanIC5010000.0 [1]
1-PhenylguanidineKi733000.0 [1]
VaborbactamIC501000000.0 [1]
Acetylphenylalanyl-prolyl-boroarginineKi5.7 [1]
Tert-butyloxy carbonyl-D-Phe-pro-Arg-HIC50950.0 [1]
(2S)-3-(7-Carbamimidoylnaphthalen-2-yl)-2-[4-[(3S)-1-ethanimidoylpyrrolidin-3-yl]oxyphenyl]propanoic acidKi21000.0 [1]
6-[2-(2-Methyl-1-propan-2-yl-3,4-dihydro-1H-isoquinolin-7-yl)cyclopropyl]naphthalene-2-carboximidamideKi6230.0 [1]
Bms-262084IC508250.0 [1]
Unii-IF979jqu3SKi27200.0 [1]
LetaxabanIC5044000.0 [1]
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-11-(carboxymethyl)-20-[3-(diaminomethylideneamino)propyl]-23-(hydroxymethyl)-17,26-bis[(4-hydroxyphenyl)methyl]-29-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acidKi1000000.0 [1]
Wx-uk1 free baseKi4900.0 [1]
4-[[(3S)-3-[(7-Methoxynaphthalen-2-yl)sulfonyl-methylamino]-2-oxopyrrolidin-1-yl]methyl]thiophene-2-carboximidamideKi8600.0 [1]
2-{5-[Amino(iminio)methyl]-1H-benzimidazol-2-YL}benzenolateKi75000.0 [1]
Bms-740808Ki2800.0 [1]
Unii-1Y3JD5pemsIC5025100.0 [1]
Cyanopeptolin 1020IC502500.0 [1]
Unii-vwj4vvz3OUKi6200.0 [1]
6-[1-[3-(6-Chloronaphthalen-2-yl)sulfonylpropanoyl]piperidin-4-yl]-3-methyl-7H-imidazo[1,5-c]imidazol-5-oneKi60000.0 [1]
2-(2-Hydroxy-biphenyl)-1h-benzoimidazole-5-carboxamidineKi1000.0 [1]
2-(2-Hydroxyphenyl)-1H-indole-5-carboxamidineKi9400.0 [1]
2-{5-[Amino(iminio)methyl]-1H-indol-2-YL}-6-bromo-4-methylbenzenolateKi460.0 [1]
3-[[(3S)-3-[(7-Methoxynaphthalen-2-yl)sulfonylamino]-2-oxopyrrolidin-1-yl]methyl]benzenecarboximidamideKi10000.0 [1]
N-[(1R,2S,5S)-2-[(5-Chloro-1H-indole-2-carbonyl)amino]-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamideKi68200.0 [1]
Unii-FS64O4K98AKi433.0 [1]
2-[[4-Chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acidKi40000.0 [1]
3-[[(3S)-3-(Naphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-yl]methyl]benzenecarboximidamideKi10000.0 [1]
3-Chloro-N-[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl]-4-[[4,5-dihydro-1,3-oxazol-2-yl(methyl)amino]methyl]thiophene-2-carboxamideKi5000.0 [1]
1-Cyano-3-(2-methyl-1-benzofuran-5-yl)-2-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]guanidineKi3700.0 [1]
Bms-344577Ki665.0 [1]
Methyl N-[4-[5-chloro-2-[(1S)-1-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-2-phenylethyl]-1H-imidazol-4-yl]phenyl]carbamateKi6150.0 [1]
2-[2-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-sulfamoylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi33000.0 [1]
Tert-butyl N-[(1R)-2-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamateIC508700.0 [1]
5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N-dimethyl-carbamimidoyl)-benzoylamino]-benzamideIC5010000.0 [1]
5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(2-imino-oxazolidin-3-ylmethyl)-benzoylamino]-benzamideIC5011000.0 [1]
6-Fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidineKi61000.0 [1]
6-[(Z)-Amino(imino)methyl]-N-[3-(cyclopentyloxy)phenyl]-2-naphthamideKi3390.0 [1]
6-[(Z)-Amino(imino)methyl]-N-[4-(aminomethyl)phenyl]-4-(pyrimidin-2-ylamino)-2-naphthamideKi680.0 [1]
8-(Pyrimidin-2-ylamino)naphthalene-2-carboximidamideKi24000.0 [1]
6-[1-[(2S)-3-(6-Chloronaphthalen-2-yl)sulfonyl-2-hydroxypropanoyl]piperidin-4-yl]-3-methyl-7H-imidazo[1,5-c]imidazol-5-oneKi60000.0 [1]
3-[6-[4-[2-[(Dimethylamino)methyl]phenyl]phenyl]-7-oxo-3-(trifluoromethyl)-4,5-dihydropyrazolo[3,4-c]pyridin-1-yl]benzamideKi1800.0 [1]
N-[2-(Diaminomethylideneamino)oxyethyl]-2-[3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxopyrazin-1-yl]acetamideKi2400.0 [1]
2-[(3S)-3-(Benzylsulfonylamino)-2-oxopiperidin-1-yl]-N-[(3S)-1-carbamimidoyl-2-hydroxypiperidin-3-yl]acetamideIC502500.0 [1]
5-Chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-YL)benzamido) cyclopentyl)thiophene-2-carboxamideKi20000.0 [1]
(5S,11R)-24-Chloro-11-cyclohexyl-20-oxa-3,9,12,17-tetrazatricyclo[19.4.0.05,9]pentacosa-1(21),22,24-triene-4,10,13,18-tetroneKi8900.0 [1]
1H-Indole-1-acetamide,N-(5-chloro-2-pyridinyl)-2-[[[1-(1-methylethyl)-4-piperidinyl]amino]carbonyl]-Ki100000.0 [1]
(E)-2-(5-Chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-morpholin-4-yl-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]prop-1-ene-1-sulfonamideIC505010.0 [1]
3-(6-Chloronaphthalen-2-yl)sulfonyl-N-methyl-N-[1-(2-methylpyridin-4-yl)piperidin-4-yl]propanamideKi67000.0 [1]
6-(2-(1-Isopropyl-3,4-dihydroisoquinolin-7-yl)cyclopropyl)-2-naphthimidamideKi4740.0 [1]
2-(3-Amino-1,2-benzoxazol-5-yl)-N-[4-[2-[(dimethylamino)methyl]phenyl]-2-fluorophenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi33000.0 [1]
2-[4-[(6-Chloro-1-benzothiophen-2-yl)sulfonyl]-2-oxopiperazin-1-yl]-N-[2-(3-methylimidazol-4-yl)ethyl]acetamideKi8700.0 [1]
6-Carbamimidoyl-4-(oxolan-3-yl)-N-phenylnaphthalene-2-carboxamideKi870.0 [1]
6-[1-[3-(6-Chloronaphthalen-2-yl)sulfonylpropanoyl]piperidin-4-yl]-3-(hydroxymethyl)-7H-imidazo[1,5-c]imidazol-5-oneKi60000.0 [1]
2-(5-Chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-morpholin-4-yl-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]ethanesulfonamideIC5025100.0 [1]
(2S)-N-Cyclopentyl-N-methyl-5-[4-(methylamino)phenyl]-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)pent-4-ynamideKi200000.0 [1]
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-[(2R)-2-amino-3,3-dicyclohexylpropanoyl]pyrrolidine-2-carboxamideKi137000.0 [1]
(2S,3R)-4-Oxo-1-[4-(6-phenylhexanoyl)piperazine-1-carbonyl]-3-(2-piperidin-3-ylethyl)azetidine-2-carboxylic acidIC5033000.0 [1]
5-[4-[3-(6-Chloro-2-naphthylsulfonyl)propanoyl]piperazino]imidazo[1,2-a]pyridine-2-methanolKi60000.0 [1]
(5S,11R)-22-Chloro-11-cyclohexyl-18-oxa-3,9,12,15-tetrazatricyclo[17.4.0.05,9]tricosa-1(19),20,22-triene-4,10,13,16-tetroneKi7700.0 [1]
2-[[(2R)-1-[(2S)-2-[(5-Carbamimidoylthiophen-2-yl)methylcarbamoyl]-2,5-dihydropyrrol-1-yl]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC5070.0 [1]
2-[(E)-3-[3-(Pyridin-2-ylmethoxy)phenyl]but-2-enyl]-1,2,4-oxadiazolidine-3,5-dioneIC5024000.0 [1]
(2S)-1-[(2R)-2-Amino-2-cyclohexylacetyl]-N-[[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]methyl]pyrrolidine-2-carboxamideKi36000.0 [1]
4-[(2R)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N,N-dimethylpiperazine-1-carboxamideKi1000000.0 [1]
2-[(E)-3-[3-[[3,5-Bis(trifluoromethyl)phenoxy]methyl]phenyl]but-2-enyl]-1,2,4-oxadiazolidine-3,5-dioneIC505290.0 [1]
2-[(E)-3-[3-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]phenyl]but-2-enyl]-1,2,4-oxadiazolidine-3,5-dioneIC509400.0 [1]
(S)-1-(2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamideKi19000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tissue-type plasminogen activator Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/tissue-type-plasminogen-activator-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Tissue-type plasminogen activator Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tissue-type-plasminogen-activator-inhibitors-ic50-ki.
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