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Toll-like receptor 7 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-[3-(4-Amino-1-benzylimidazo[4,5-c]quinolin-2-yl)propyl]-1-benzylimidazo[4,5-c]quinolin-4-amineIC5050.0 [1]
3,5-Bis[(4-methoxyphenyl)methyl]-2-phenyl-imidazo[4,5-c]quinolin-5-iumIC50820.0 [1], 2790.0 [2], 4550.0 [3]
2-Nonyl-3-prop-2-ynyl-imidazo[4,5-c]quinolineIC508580.0 [1], 10070.0 [2]
2-Phenyl-3-prop-2-ynylimidazo[4,5-c]quinolineIC5013710.0 [1], 14850.0 [2]
2-Cyclohexyl-3-methylimidazo[4,5-c]quinolineIC5022040.0 [1], 24300.0 [2]
3-Methyl-2-nonyl-imidazo[4,5-c]quinolineIC5010140.0 [1], 68800.0 [2]
2-Cyclohexyl-3-[(4-methoxyphenyl)methyl]imidazo[4,5-c]quinolineIC5019900.0 [1], 40010.0 [2]
2-Cyclohexyl-3-prop-2-ynyl-imidazo[4,5-c]quinolineIC5021120.0 [1], 21870.0 [2]
N-[(3-Prop-2-ynylimidazo[4,5-c]quinolin-2-yl)methyl]ethanamineIC5026100.0 [1], 28130.0 [2]
N-[(3-Methylimidazo[4,5-c]quinolin-2-yl)methyl]ethanamineIC5030440.0 [1], 35430.0 [2]
2-Methyl-1-(2-nonylimidazo[4,5-c]quinolin-3-yl)propan-2-olIC5014400.0 [1], 52940.0 [2]
3-[(4-Methoxyphenyl)methyl]-2-nonyl-imidazo[4,5-c]quinolineIC5019440.0 [1], 46400.0 [2]
N-[[3-[(4-Methoxyphenyl)methyl]imidazo[4,5-c]quinolin-2-yl]methyl]ethanamineIC5028020.0 [1], 59640.0 [2]
3-Methyl-2-phenylimidazo[4,5-c]quinolineIC5021630.0 [1], 25810.0 [2]
HydroxychloroquineIC50800.0 [1]
N'-[(4-Chlorophenyl)-oxomethyl]-2-methyl-4-thiazolecarbohydrazideIC5044800.0 [1]
3-Amino-N'-[3-(trifluoromethyl)benzoyl]pyrazine-2-carbohydrazideIC5038000.0 [1]
N'-(4-Chlorobenzoyl)pyridine-2-carbohydrazideIC5024700.0 [1]
6-Methoxy-N,N-dimethyl-7-phenylmethoxy-4-piperazin-1-ylquinazolin-2-amineIC501400.0 [1]
4-(4-Cyclopentylpiperazin-1-yl)-N-(3-imidazol-1-ylpropyl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amineIC5017000.0 [1]
Cyclopentyl-[4-[2-(dimethylamino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]piperazin-1-yl]methanoneIC5011000.0 [1]
4-[4-(Cyclopentylmethyl)piperazin-1-yl]-6-methoxy-N,N-dimethyl-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amineIC50700.0 [1]
Tert-butyl 4-[2-(dimethylamino)-6-methoxy-7-phenylmethoxyquinazolin-4-yl]piperazine-1-carboxylateIC5053000.0 [1]
4-(4-Cyclopentylpiperazin-1-yl)-6-methoxy-2-(4-methylpiperazin-1-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolineIC501200.0 [1]
[4-[2-(Dimethylamino)-6-methoxy-7-phenylmethoxyquinazolin-4-yl]piperazin-1-yl]-phenylmethanoneIC5031000.0 [1]
4-[2-(Dimethylamino)-6-methoxy-7-phenylmethoxyquinazolin-4-yl]-N,N-dimethylpiperazine-1-sulfonamideIC5052000.0 [1]
6-Methoxy-N,N-dimethyl-4-piperazin-1-yl-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amineIC505600.0 [1]
7-Cyclopentyloxy-6-methoxy-N,N-dimethyl-4-(4-methylpiperazin-1-yl)quinazolin-2-amineIC501300.0 [1]
4-(4-Benzylpiperazin-1-yl)-6-methoxy-N,N-dimethyl-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amineIC504400.0 [1]
4-(4-Cyclopentylpiperazin-1-yl)-6-methoxy-N-[3-(4-methylpiperazin-1-yl)propyl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amineIC5016000.0 [1]
4-(4-Cyclopentylpiperazin-1-yl)-N-[(4-fluorophenyl)methyl]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amineIC504900.0 [1]
1-[4-[7-Cyclopentyloxy-2-(dimethylamino)-6-methoxyquinazolin-4-yl]piperazin-1-yl]-2-methylpropan-1-oneIC5020700.0 [1]
[4-[2-(Dimethylamino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]piperazin-1-yl]-phenylmethanoneIC501200.0 [1]
6-Methoxy-N,N-dimethyl-4-(4-propan-2-ylsulfonylpiperazin-1-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amineIC509600.0 [1]
7-Cyclopentyloxy-6-methoxy-N,N-dimethyl-4-piperazin-1-ylquinazolin-2-amineIC504600.0 [1]
4-[7-Cyclopentyloxy-2-(dimethylamino)-6-methoxyquinazolin-4-yl]-N,N-dimethylpiperazine-1-carboxamideIC5017000.0 [1]
6-Methoxy-N,N-dimethyl-4-(4-methylpiperazin-1-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amineIC505800.0 [1]
4-(4-Cyclopentylpiperazin-1-yl)-6-methoxy-N,N-dimethyl-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amineIC501400.0 [1]
[4-(Aminomethyl)phenyl]-[4-[2-(dimethylamino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]piperazin-1-yl]methanoneIC508700.0 [1]
1-[(3R,5S)-3-Methyl-5-[8-(trifluoromethyl)quinolin-5-yl]piperidin-1-yl]-3-pyrazol-1-ylpropan-1-oneIC5020000.0 [1]
(1S,3S,5R)-3-Methyl-5-[8-(trifluoromethyl)quinoxalin-5-yl]cyclohexan-1-amineIC501000.0 [1]
5-[(3R,5R)-5-Methyl-1-[2-(1-methylpiperidin-4-yl)acetyl]piperidin-3-yl]quinoline-8-carbonitrileIC501000.0 [1]
5-[(3R,5R)-5-Methyl-1-[2-(4-methylpiperazin-1-yl)acetyl]piperidin-3-yl]quinoline-8-carbonitrileIC501000.0 [1]
(1S,3S,5S)-3-Methyl-5-[8-(trifluoromethyl)quinoxalin-5-yl]cyclohexan-1-amineIC501000.0 [1]
5-[(3R,5R)-5-Methyl-1-[2-(3-methyl-3-azabicyclo[3.1.1]heptan-6-yl)acetyl]piperidin-3-yl]quinoline-8-carbonitrileIC501000.0 [1]
1-[(3R,5R)-3-Methyl-5-(8-methylquinolin-5-yl)piperidin-1-yl]-2-(1-methylpiperidin-4-yl)ethanoneIC501000.0 [1]
5-[5-Methyl-1-[(1-methylpyrrolidin-3-yl)methyl]piperidin-3-yl]quinoline-8-carbonitrileIC501000.0 [1]
5-[(3S,5R)-1-[2-[(1S,5R)-3-Azabicyclo[3.1.0]hexan-6-yl]acetyl]-5-methylpiperidin-3-yl]quinoline-8-carbonitrileIC501000.0 [1]
(3R,5R)-3-(8-Cyanoquinolin-5-yl)-5-methyl-N-(1-methylpiperidin-4-yl)piperidine-1-carboxamideIC501000.0 [1]
(3R,5R)-N-Cyclopropyl-3-methyl-5-[8-(trifluoromethyl)quinolin-5-yl]piperidine-1-carboxamideIC501000.0 [1]
2-(3-Piperidin-4-ylphenyl)-6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazoleIC504990.0 [1]
1-[3-[4-[6-[3-(3-Aminopyrrolidin-1-yl)propoxy]-1,3-benzoxazol-2-yl]phenoxy]propyl]pyrrolidin-3-amineIC5010840.0 [1]
6-(3-Pyrrolidin-1-ylpropoxy)-2-[3-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]-1,3-benzoxazoleIC508300.0 [1]
N-[3-[6-(3-Pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amineIC507550.0 [1]
4-(Aminomethyl)-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamideIC5066170.0 [1]
1-Methyl-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amineIC504570.0 [1]
4-[(Dimethylamino)methyl]-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamideIC504710.0 [1]
1-Benzyl-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amineIC508090.0 [1]
3-Amino-N'-[4-(trifluoromethoxy)benzoyl]pyrazine-2-carbohydrazideIC5027000.0 [1]
2-(2,4-Dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC50260.0 [1]
2-Propan-2-yl-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC5014000.0 [1]
N'-(Pyridine-2-carbonyl)-2-pyridin-3-yl-1,3-thiazole-4-carbohydrazideIC5023200.0 [1]
N'-(4-Chlorobenzoyl)-3-hydroxypyridine-2-carbohydrazideIC5027800.0 [1]
3-Amino-N'-[4-(trifluoromethyl)benzoyl]pyrazine-2-carbohydrazideIC5025000.0 [1]
2-(2,3-Dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC50500.0 [1]
2-(3-Fluorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC502600.0 [1]
N'-(4-Bromobenzoyl)-3-hydroxypyridine-2-carbohydrazideIC5017260.0 [1]
3-Hydroxy-N'-[4-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazideIC5013400.0 [1]
2-[4-(Dimethylamino)phenyl]-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC501900.0 [1]
3-Amino-N'-[3-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazideIC5016000.0 [1]
N'-(3-Chlorobenzoyl)-2-methyl-1,3-thiazole-4-carbohydrazideIC5060000.0 [1]
2-(3,5-Dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC50440.0 [1]
N'-(Pyridine-2-carbonyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4-carbohydrazideIC50990.0 [1]
3-Hydroxy-N'-[4-(trifluoromethoxy)benzoyl]pyridine-2-carbohydrazideIC507900.0 [1]
N'-(Pyridine-2-carbonyl)-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-4-carbohydrazideIC501020.0 [1]
3-Hydroxy-N'-[3-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazideIC5014200.0 [1]
2-(3-Bromophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC50900.0 [1]
[4-[2-(Dimethylamino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]piperazin-1-yl]-(4-fluorophenyl)methanoneIC504200.0 [1]
(2S)-2-Hydroxy-3,3-dimethyl-N-[(1R,3R,5R)-3-methyl-5-[8-(trifluoromethyl)quinoxalin-5-yl]cyclohexyl]butanamideIC501000.0 [1]
4-(4-Cyclopentylpiperazin-1-yl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolineIC505700.0 [1]
7-Cyclopentyloxy-6-methoxy-N,N-dimethyl-4-piperidin-1-ylquinazolin-2-amineIC5011000.0 [1]
6-Methoxy-N,N-dimethyl-4-(4-methylpiperazin-1-yl)-7-phenylmethoxyquinazolin-2-amineIC5022000.0 [1]
1-[4-[2-(Dimethylamino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]piperazin-1-yl]-2-methylpropan-1-oneIC505400.0 [1]
6-Methoxy-4-(4-methylpiperazin-1-yl)-N-[3-(4-methylpiperazin-1-yl)propyl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amineIC5017000.0 [1]
2-(4-Ethylphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC502400.0 [1]
2-(3,4-Dimethoxyphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC503900.0 [1]
2-(4-Fluorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC504400.0 [1]
N'-[3-(Trifluoromethyl)benzoyl]pyridine-2-carbohydrazideIC5015000.0 [1]
2-(4-Methylphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC501830.0 [1]
2-(4-Methoxyphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC503090.0 [1]
2-(4-Chlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC502100.0 [1]
1-[2-(Ethylaminomethyl)imidazo[4,5-c]quinolin-3-yl]-2-methylpropan-2-olIC5056310.0 [1]
1-[4-Amino-2-(ethylaminomethyl)imidazo[4,5-c]quinolin-3-yl]-2-methylpropan-2-ol;2,2,2-trifluoroacetic acidIC5025000.0 [1]
1-[2-(Ethylaminomethyl)imidazo[4,5-c]quinolin-3-yl]-2-methylpropan-2-ol;2,2,2-trifluoroacetic acidIC507500.0 [1]
6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazoleIC501990.0 [1]
2-Phenyl-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC505800.0 [1]
2-Methyl-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC5030000.0 [1]
2-(3-Chlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC501000.0 [1]
2-[4-[4-[7-(3-Morpholin-4-ylpropyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]phenyl]piperazin-1-yl]ethanolIC50970.0 [1]
1-(2-Cyclohexylimidazo[4,5-c]quinolin-3-yl)-2-methyl-propan-2-olIC5038730.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Toll-like receptor 7 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/toll-like-receptor-7-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Toll-like receptor 7 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/toll-like-receptor-7-inhibitors-ic50-ki.
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