Transient receptor potential cation channel subfamily A member 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	IC50	5300.0 [1]
	4-Methyl-N-[2,2,2-trichloro-1-(4-nitro-phenylsulfanyl)-ethyl]-benzamide	IC50	850.0 [1]
	4-(4-Chlorophenyl)-3-methylbut-3-EN-2-oxime	IC50	2200.0 [1], 2800.0 [2], 3100.0 [3]
	4-Methoxy-N-[2,2,2-trichloro-1-(4-chloro-phenylsulfanyl)-ethyl]-benzamide	IC50	29.0 [1], 91.0 [2], 260.0 [3]
	4-Nitro-N-{2,2,2-trichloro-1-[(4-chlorophenyl)sulfanyl]ethyl}benzamide	IC50	35.0 [1], 105.0 [2], 167.0 [3]
	4-Bromo-N-[2,2,2-trichloro-1-(4-chloro-phenylsulfanyl)-ethyl]-benzamide	IC50	28.0 [1], 51.0 [2], 252.0 [3]
	4-[3-(3-Methoxypropoxy)phenyl]-2-sulfanylidene-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-5-one	IC50	5.61 [1], 30.0 [2], 50.0 [3]
	4-(3-Methoxyphenyl)-2-sulfanylidene-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-5-one	IC50	128.0 [1], 130.0 [2], 1500.0 [3]
	1-(4-Chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)piperidin-1-yl]-3-phenylpropyl]cyclopentane-1-carboxamide	IC50	1.0 [1], 17.0 [2], 374.0 [3]
	N-(3,4-Difluorophenyl)-6-(trifluoromethoxy)-1H-pyrazolo[4,3-b]pyridin-3-amine	IC50	20.0 [1], 330.0 [2], 16000.0 [3]
	N-[2-[4-(Difluoromethoxy)phenyl]ethyl]-2-(8-methyl-4-oxoquinazolin-3-yl)acetamide	IC50	685.0 [1], 6270.0 [2], 25000.0 [3]
	N-[2,2,2-Trichloro-1-(4-chlorophenyl)sulfanylethyl]benzamide	IC50	7.0 [1], 21.0 [2], 120.0 [3]
	1-(4-Chlorophenyl)-N-[(2R)-2-[4-hydroxy-4-(trifluoromethyl)piperidin-1-yl]-3-phenylpropyl]cyclopentane-1-carboxamide	IC50	0.7 [1], 0.72 [2], 1578.0 [3]
	Resveratrol	IC50	750.0 [1], 30000.0 [2]
	(1e,3e)-1-(4-Fluorophenyl)-2-methylpent-1-en-3-one oxime	IC50	74.0 [1], 98.44 [2]
	D-Camphor	IC50	400000.0 [1], 660000.0 [2]
	Chembridge-5861528	IC50	14300.0 [1], 18700.0 [2]
	2-[(E)-2-Phenylethenyl]phenol	IC50	1700.0 [1], 30000.0 [2]
	1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one	IC50	20.0 [1], 131.0 [2]
	(4R)-4-[3-(3-Methoxypropoxy)phenyl]-2-sulfanylidene-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-5-one	IC50	13.0 [1], 26.0 [2]
	1-(4-Chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)piperidin-1-yl]-3-phenylpropyl]cyclopropane-1-carboxamide	IC50	14.0 [1], 73.0 [2]
	1-[[3-[(E)-2-(4-Chlorophenyl)prop-1-enyl]-1,2,4-oxadiazol-5-yl]methyl]-7-methylpurin-6-one	IC50	63.0 [1], 71.0 [2]
	3-[[5-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-3-yl]methyl]pyrido[2,3-d]pyrimidin-4-one	IC50	156.0 [1], 1580.0 [2]
	3-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]pyrido[2,3-d]pyrimidin-4-one	IC50	41.0 [1], 376.0 [2]
	3-[[3-[2-(4-Chlorophenyl)-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]methyl]pyrido[2,3-d]pyrimidin-4-one	IC50	58.0 [1], 251.0 [2]
	3-[[5-[(E)-2-(4-Chlorophenyl)prop-1-enyl]-1,2,4-oxadiazol-3-yl]methyl]pyrido[2,3-d]pyrimidin-4-one	IC50	85.0 [1], 116.0 [2]
	4-[6-(Trifluoromethoxy)-1H-indazol-3-yl]benzonitrile	IC50	686.0 [1], 10000.0 [2]
	N-[3-Methyl-1-(4-nitrophenyl)-1-oxobutan-2-yl]benzamide	IC50	251.19 [1], 316.23 [2]
	N-[1-(4-Fluorophenyl)-3-methyl-1-oxobutan-2-yl]benzamide	IC50	5011.87 [1], 7943.28 [2]
	5-Chloro-N-[1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl]-2-(trifluoromethyl)benzamide	IC50	316.23 [1], 398.11 [2]
	N-[1-(4-Cyanophenyl)-3-methyl-1-oxobutan-2-yl]-3-methyl-5-phenyl-1,2-oxazole-4-carboxamide	IC50	3981.07 [1], 7943.28 [2]
	N-[1-(4-Cyanophenyl)-3-methyl-1-oxobutan-2-yl]-1-methylindole-2-carboxamide	IC50	1584.89 [1], 3981.07 [2]
	N-[1-(4-Cyanophenyl)-3-methyl-1-oxobutan-2-yl]decanamide	IC50	1000.0 [1], 1995.26 [2]
	Tert-butyl N-[1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl]carbamate	IC50	794.33 [1], 1000.0 [2]
	N-[1-(4-Cyanophenyl)-3-methyl-1-oxobutan-2-yl]-2-(trifluoromethyl)benzamide	IC50	3162.28 [1], 5011.87 [2]
	N-[1-(4-Cyanophenyl)-3-methyl-1-oxobutan-2-yl]-3-methyl-5-propan-2-yl-1,2-oxazole-4-carboxamide	IC50	1584.89 [1], 1995.26 [2]
	N-[1-(4-Cyanophenyl)-3-methyl-1-oxobutan-2-yl]-3,4-dihydro-1H-isoquinoline-2-carboxamide	IC50	5011.87 [1]
	N-[1-(4-Chlorophenyl)-3,3-dimethyl-1-oxobutan-2-yl]benzamide	IC50	398.11 [1], 1000.0 [2]
	1-Tert-butyl-3-[1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl]-1-methylurea	IC50	251.19 [1], 630.96 [2]
	Tert-butyl N-[1-(4-cyano-3-fluorophenyl)-3-methyl-1-oxobutan-2-yl]carbamate	IC50	1258.93 [1], 1995.26 [2]
	N-[1-(4-Bromophenyl)-3-methyl-1-oxobutan-2-yl]benzamide	IC50	1258.93 [1], 7943.28 [2]
	N-[1-(4-Cyanophenyl)-3-methyl-1-oxobutan-2-yl]-4-methoxybenzamide	IC50	6309.57 [1], 12589.25 [2]
	2,4-Dichloro-N-[1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl]benzamide	IC50	2511.89 [1], 5011.87 [2]
	4-Chloro-N-[1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl]-2-fluorobenzamide	IC50	3162.28 [1], 3981.07 [2]
	Tert-butyl N-[1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl]carbamate	IC50	2511.89 [1], 6309.57 [2]
	N-[2-(4-Chlorophenyl)-1-cyclopropyl-2-oxoethyl]benzamide	IC50	1995.26 [1]
	5-Tert-butyl-N-[1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl]-1,2-oxazole-4-carboxamide	IC50	501.19 [1], 1000.0 [2]
	1-Tert-butyl-3-[1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl]urea	IC50	1995.26 [1], 2511.89 [2]
	Tert-butyl N-[1-(5-chloropyridin-2-yl)-3-methyl-1-oxobutan-2-yl]carbamate	IC50	5011.87 [1], 15848.93 [2]
	N-(6-Chloropyridin-3-yl)-6-(trifluoromethyl)-1H-indazol-3-amine	IC50	550.0 [1], 2500.0 [2]
	3-Butylidenephthalide	IC50	23000.0 [1]
	Dihydroresveratrol	IC50	30000.0 [1]
	(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one oxime	IC50	701.0 [1]
	7-Bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide	IC50	25000.0 [1]
	N,N'-Dibenzylthiourea	IC50	10000.0 [1]
	2-Thioxo-4-phenyl-1,2,3,4,7,8-hexahydroquinazoline-5(6H)-one	IC50	10000.0 [1]
	4,6-Diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione	IC50	10000.0 [1]
	trans-3,3',5-Trihydroxystilbene	IC50	30000.0 [1]
	4-Phenyl-3,4-dihydro-2H-indeno[1,2-d]pyrimidine-2,5(1H)-dione	IC50	10000.0 [1]
	8-Benzylidene-4-phenyl-3,4,5,6,7,8-hexahydro-2(1H)-quinazolinethione	IC50	10000.0 [1]
	2-Methoxystilbene	IC50	1700.0 [1]
	P-Methoxystilbene	IC50	12100.0 [1]
	4-Phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione	IC50	10000.0 [1]
	4-Phenyl-2-thioxo-1,2,3,4-tetrahydro-5H-indeno[1,2-d]pyrimidin-5-one	IC50	1800.0 [1]
	CID 49783953	IC50	10000.0 [1]
	3-Methyl-4-phenyl-but-3-en-2-one oxime	IC50	2700.0 [1]
	[2-(4-Chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2S,3S)-2,3-dimethylpiperidin-1-yl]methanone	IC50	25000.0 [1]
	N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetamide	IC50	1000.0 [1]
	5-[(1E)-2-(4-Chlorophenyl)ethenyl]-1,3-Benzenediol	IC50	30000.0 [1]
	2,6-Dibromo-4-[(E)-2-(4-hydroxyphenyl)ethenyl]phenol	IC50	16100.0 [1]
	1,3-Dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-benzene	IC50	30000.0 [1]
	2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide	IC50	1000.0 [1]
	(2S,4R)-4-Fluoro-1-(4-fluorophenyl)sulfonyl-N-[[6-[6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]methyl]pyrrolidine-2-carboxamide	IC50	1200.0 [1]
	(2S,4S)-4-Fluoro-1-(4-fluorophenyl)sulfonyl-N-[[6-[6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]methyl]pyrrolidine-2-carboxamide	IC50	4400.0 [1]
	(2S,4R,5S)-4-Fluoro-1-(4-fluorophenyl)sulfonyl-5-methyl-N-[[2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl]methyl]pyrrolidine-2-carboxamide	IC50	69.0 [1]
	(2S,5R)-1-(4-Fluorophenyl)sulfonyl-5-methyl-N-[[6-[6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]methyl]pyrrolidine-2-carboxamide	IC50	239.0 [1]
	(2S)-1-(4-Fluorophenyl)sulfonyl-N-[[6-[6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]methyl]azetidine-2-carboxamide	IC50	1500.0 [1]
	(2S,5S)-1-(4-Fluorophenyl)sulfonyl-5-methyl-N-[[6-[6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]methyl]pyrrolidine-2-carboxamide	IC50	13.0 [1]
	N-[(1R)-2-Amino-2-oxo-1-phenylethyl]-N-[(1R)-1-(3,5-difluorophenyl)ethyl]benzamide	IC50	30000.0 [1]
	N-[3-(Thiophen-2-ylmethylamino)-5-(trifluoromethyl)phenyl]thiophene-2-carboxamide	IC50	2700.0 [1]
	N-[3-(Benzylamino)-5-(trifluoromethyl)phenyl]thiophene-2-carboxamide	IC50	2900.0 [1]
	N-[3-(2-Phenylethylamino)-5-(trifluoromethyl)phenyl]thiophene-2-carboxamide	IC50	3900.0 [1]
	Methyl N-[3-(thiophene-2-carbonylamino)-5-(trifluoromethyl)phenyl]carbamate	IC50	2300.0 [1]
	N-[3-(Dipropylamino)-5-(trifluoromethyl)phenyl]thiophene-2-carboxamide	IC50	32000.0 [1]
	N-[3-(3-Methylbutan-2-ylamino)-5-(trifluoromethyl)phenyl]thiophene-2-carboxamide	IC50	1300.0 [1]
	N-[3-(2-Methylpropylamino)-5-(trifluoromethyl)phenyl]thiophene-2-carboxamide	IC50	790.0 [1]
	N-[3-(Propylamino)-5-(trifluoromethyl)phenyl]thiophene-2-carboxamide	IC50	390.0 [1]
	N-[3-(Propan-2-ylamino)-5-(trifluoromethyl)phenyl]thiophene-2-carboxamide	IC50	290.0 [1]
	N-[3-(Propylamino)-5-(trifluoromethyl)phenyl]benzamide	IC50	200.0 [1]
	N-[3-(Propylamino)-5-(trifluoromethyl)phenyl]pyridine-2-carboxamide	IC50	32000.0 [1]
	N-[3-(Propylamino)-5-(trifluoromethyl)phenyl]pyridine-3-carboxamide	IC50	940.0 [1]
	N-[3-(Propylamino)-5-(trifluoromethyl)phenyl]pyridine-4-carboxamide	IC50	2600.0 [1]
	4-Fluoro-N-[3-(propylamino)-5-(trifluoromethyl)phenyl]benzamide	IC50	1400.0 [1]
	3,4-Difluoro-N-[3-(propylamino)-5-(trifluoromethyl)phenyl]benzamide	IC50	1200.0 [1]
	2,6-Difluoro-N-[3-(propylamino)-5-(trifluoromethyl)phenyl]benzamide	IC50	110.0 [1]
	3-N-Propyl-5-(trifluoromethyl)benzene-1,3-diamine	IC50	32000.0 [1]
	N-[3-(Ethylamino)-5-(trifluoromethyl)phenyl]-2,6-difluorobenzamide	IC50	74.0 [1]
	2,6-Difluoro-N-[3-(propan-2-ylamino)-5-(trifluoromethyl)phenyl]benzamide	IC50	91.0 [1]
	2,6-Difluoro-N-[3-[methyl(propyl)amino]-5-(trifluoromethyl)phenyl]benzamide	IC50	32000.0 [1]
	2,6-Difluoro-N-[3-propoxy-5-(trifluoromethyl)phenyl]benzamide	IC50	32000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Transient receptor potential cation channel subfamily A member 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/transient-receptor-potential-cation-channel-subfamily-a-member-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Transient receptor potential cation channel subfamily A member 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/transient-receptor-potential-cation-channel-subfamily-a-member-1-inhibitors-ic50-ki.
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