Transmembrane domain-containing protein TMIGD3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N-Benzoyl-N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)benzamide	IC50	187.0 [1]
	N-Benzoyl-N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)benzamide	Ki	64.0 [1]
	N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)-4-methoxybenzamide	IC50	73.0 [1]
	N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)-4-methoxybenzamide	Ki	25.0 [1]
	N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)pyridine-3-carboxamide	IC50	172.0 [1]
	N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)pyridine-3-carboxamide	Ki	54.0 [1]
	N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)benzamide	IC50	235.0 [1]
	N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)benzamide	Ki	82.0 [1]
	N-(2-Phenylimidazo[1,2-a]pyrazin-8-yl)benzamide	IC50	163.0 [1]
	N-(2-Phenylimidazo[1,2-a]pyrazin-8-yl)benzamide	Ki	52.0 [1]
	Theophylline	Ki	86400.0 [1]
	5'-N-Ethylcarboxamidoadenosine	Ki	16.0 [1]
	Propyl 6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-4-propylpyridine-3-carboxylate	Ki	19.0 [1]
	Diethyl 2-methyl-6-phenyl-4-[(E)-2-phenylethenyl]-1,4-dihydropyridine-3,5-dicarboxylate	Ki	108.0 [1]
	6-Ethylthieno[2,3-d]pyrimidin-4(3H)-one	Ki	13489.63 [1]
	6-Ethyl-2-(pyrrolidin-1-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one	Ki	2290.87 [1]
	6-Ethyl-2-(4-pyridinyl)thieno[2,3-d]pyrimidin-4(3H)-one	Ki	1995.26 [1]
	(2R,3R,4S,5S)-3,4-Dihydroxy-2-[6-[(3-iodophenyl)methylamino]purin-9-yl]-1-oxa-7-azaspiro[4.4]nonan-6-one	IC50	42.0 [1]
	9-Propyl-9h-purin-6-amine	Ki	100000.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[(3-chlorophenyl)methylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol	Ki	4900.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-(dicyclopropylmethylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol	Ki	470.0 [1]
	8-Bromo-9-propyl-9H-purin-6-ylamine	Ki	100000.0 [1]
	(1S,2R,3S,4R,5S)-4-[5-[2-(5-Chlorothiophen-2-yl)ethynyl]-7-(ethylamino)imidazo[4,5-b]pyridin-3-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	1.69 [1]
	(1S,2R,3S,4R,5S)-4-[2-[4-(5-Chlorothiophen-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	0.73 [1]
	(1S,2R,3S,4R,5S)-4-[2-[4-(5-Chlorothiophen-2-yl)triazol-1-yl]-6-(ethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	1.22 [1]
	2-Chloro-N-[(3-chlorophenyl)methyl]-7H-purin-6-amine	Ki	165.0 [1]
	3-O-Ethyl 5-O-phenyl 2-methyl-6-phenyl-4-(2-phenylethynyl)-1,4-dihydropyridine-3,5-dicarboxylate	Ki	31.4 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-phenyltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide	Ki	0.96 [1]
	(1S,2R,3S,4R,5S)-4-[2-[4-(2-Chlorophenyl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	0.95 [1]
	(1S,2R,3S,4R,5S)-4-[2-[4-(3,4-Difluorophenyl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	1.06 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-pyridin-2-yltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide	Ki	1.84 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-pyrimidin-2-yltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide	Ki	3.48 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-pyrazin-2-yltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide	Ki	2.21 [1]
	(1S,2R,3S,4R,5S)-4-[2-[4-(5-Bromothiophen-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	0.58 [1]
	(1S,2R,3S,4R,5S)-4-[6-(Ethylamino)-2-iodopurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	1.22 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-4-[2-iodo-6-(2-phenylethylamino)purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	0.91 [1]
	(1S,2R,3S,4R,5S)-4-[2-Azido-6-(2-phenylethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	0.85 [1]
	(1S,2R,3S,4R,5S)-4-[6-(Cyclobutylamino)-2-iodopurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	1.53 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-(methylamino)-2-[4-(1-methylpyrazol-4-yl)triazol-1-yl]purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide	Ki	2.16 [1]
	(1S,2R,3S,4R,5S)-4-[2-[4-(Furan-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	0.96 [1]
	(1S,2R,3S,4R,5S)-4-[2-Azido-6-[(3-chlorophenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	1.08 [1]
	(1S,2R,3S,4R,5S)-4-[2-Azido-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	0.54 [1]
	(1S,2R,3S,4R,5S)-4-[2-Azido-6-(ethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	0.69 [1]
	(1S,2R,3S,4R,5S)-4-[2-Azido-6-(cyclobutylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	0.85 [1]
	(1S,2R,3S,4R,5S)-4-[2-[4-(1-Benzofuran-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	1.25 [1]
	(1S,2R,3S,4R,5S)-4-[2-[4-(5-Chlorothiophen-2-yl)triazol-1-yl]-6-(cyclobutylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	7.05 [1]
	(1S,2R,3S,4R,5S)-4-[6-[(3-Chlorophenyl)methylamino]-2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	9.02 [1]
	(1S,2R,3S,4R,5S)-4-[2-[4-(5-Chlorothiophen-2-yl)triazol-1-yl]-6-(2-phenylethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	6.66 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[2-(methylamino)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide	Ki	604.0 [1]
	(1S,2R,3S,4R,5S)-4-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]-6-methylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	42.2 [1]
	(1S,2R,3S,4R,5S)-4-[2-[2-(3,4-Difluorophenyl)ethynyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	124.0 [1]
	(1S,2R,3S,4R,5S)-4-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	60.0 [1]
	(1S,2R,3S,4R,5S)-4-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]-6-methoxypurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	684.0 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-methyl-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide	Ki	6.01 [1]
	(1S,2R,3S,4R,5S)-4-[2-[2-(3,4-Difluorophenyl)ethynyl]-6-methylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	98.5 [1]
	(1S,2R,3S,4R,5S)-4-[2-[2-(4-Tert-butylphenyl)ethynyl]-6-methylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	305.0 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-methyl-2-(2-pyrazin-2-ylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide	Ki	343.0 [1]
	3-(4-Bromothiophen-2-yl)-8-hydroxychromen-2-one	Ki	746.0 [1]
	N-[(3-Chlorophenyl)methyl]-2-[2-(3,4-difluorophenyl)ethynyl]-7H-purin-6-amine	Ki	120.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-(pentan-3-ylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol	Ki	1200.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(1R)-1-cyclopropyl-2-methylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol	Ki	1240.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(1R)-1-cyclopropylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol	Ki	160.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(R)-cyclobutyl(cyclopropyl)methyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol	Ki	3470.0 [1]
	(1S,2R,3S,4R,5S)-4-[2-Chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylic acid	Ki	5980.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-(dicyclopropylmethylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol	Ki	1600.0 [1]
	(1S,2R,3S,4R,5S)-N-(2-Acetamidoethyl)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamide	Ki	1650.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(S)-cyclobutyl(cyclopropyl)methyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol	Ki	3240.0 [1]
	Ethyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate	Ki	236.0 [1]
	Propyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate	Ki	499.0 [1]
	(1S,2R,3S,4R,5S)-4-[2-Chloro-6-(dimethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	1480.0 [1]
	(1S,2R,3S,4R,5S)-4-[2-Chloro-6-(dimethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylic acid	Ki	1080.0 [1]
	(1S,2R,3S,4R,5S)-4-[2-Chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	34.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(1S)-1-cyclopropylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol	Ki	1810.0 [1]
	Methyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate	Ki	766.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-(dimethylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol	Ki	2470.0 [1]
	(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(1S)-1-cyclopropyl-2-methylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol	Ki	3450.0 [1]
	(1S,2R,3S,4R,5S)-N-(3-Acetamidopropyl)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamide	Ki	1970.0 [1]
	(1S,2R,3S,4R,5S)-4-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]-6-(dimethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	23.5 [1]
	(1S,2R,3S,4R,5S)-4-[2-Chloro-6-[(Z)-2-hydroxy-2-phenylethenyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	1140.0 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-4-[6-[(Z)-2-hydroxy-2-phenylethenyl]-2-(2-phenylethynyl)purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	78.5 [1]
	(1S,2R,3S,4R,5S)-4-[2-[2-(2-Chlorophenyl)ethynyl]-6-[(Z)-2-(2-chlorophenyl)-2-hydroxyethenyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	515.0 [1]
	(1S,2R,3S,4R,5S)-4-[2-[2-(4-Tert-butylphenyl)ethynyl]-6-[(Z)-2-(4-tert-butylphenyl)-2-hydroxyethenyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	94.3 [1]
	(1S,2R,3S,4R,5S)-2,3-Dihydroxy-4-[2-[(Z)-2-hydroxy-2-pyrazin-2-ylethenyl]purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	1480.0 [1]
	2-Phenylethyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate	Ki	262.0 [1]
	Butyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate	Ki	17.5 [1]
	Methyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate	Ki	5.38 [1]
	4-Chloro-N-(2,6-diphenylimidazo[1,2-a]pyrazin-8-yl)benzamide	Ki	156.0 [1]
	(1S,2R,3S,4R,5S)-4-[6-[2-(5-Chlorothiophen-2-yl)ethynyl]-4-(methylamino)imidazo[4,5-c]pyridin-1-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide	Ki	9.33 [1]
	Methyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-bromothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate	Ki	8.56 [1]
	Propan-2-yl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate	Ki	42.9 [1]
	4-Methoxy-N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)benzamide	Ki	162.0 [1]
	(2S,3S,4R,5R)-5-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]-6-(propylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide	Ki	6.25 [1]
	N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)-4-methylbenzamide	Ki	223.0 [1]
	(2S,3S,4R,5R)-5-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide	Ki	1.55 [1]
	Benzyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate	Ki	7.31 [1]
	N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)-4-fluorobenzamide	Ki	38.0 [1]
	3-Methylbutyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate	Ki	24.4 [1]
	(1S,2R,3S,4R,5S)-N-(2-Aminoethyl)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamide	Ki	156.0 [1]
	N-[2-(4-Methoxyphenyl)imidazo[1,2-a]pyrazin-8-yl]benzamide	Ki	121.0 [1]
	N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)thiophene-2-carboxamide	Ki	185.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Transmembrane domain-containing protein TMIGD3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/transmembrane-domain-containing-protein-tmigd3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Transmembrane domain-containing protein TMIGD3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/transmembrane-domain-containing-protein-tmigd3-inhibitors-ic50-ki.
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