 | 2-[(3S)-3-(Benzylsulfonylamino)-2-oxopiperidin-1-yl]-N-[(3S)-1-carbamimidoyl-2-hydroxypiperidin-3-yl]acetamide | IC50 | 791.0 [1], 1271.0 [2] |
 | Acetylphenylalanyl-prolyl-boroarginine | Ki | 0.04 [1], 9.0 [2] |
 | N-[(6-Amino-2-methylpyridin-3-yl)methyl]-2-[6-methyl-2-oxo-3-(2-phenylethylamino)pyrazin-1-yl]acetamide | Ki | 1800.0 [1] |
 | N-[(6-Amino-2-methylpyridin-3-yl)methyl]-2-[3-(benzylsulfonylamino)-6-methyl-2-oxopyridin-1-yl]acetamide | Ki | 3200.0 [1] |
 | 4-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]cyclohexane-1-carboxylic acid | Ki | 1.7 [1], 2.57 [2] |
 | (6S,8As)-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-oxo-2-(3-phenylpropanoyl)-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide | IC50 | 1.0 [1] |
 | (6S,8As)-N-[(2S)-3-(1-carbamimidoylpiperidin-3-yl)-1-oxo-1-(1,3-thiazol-2-yl)propan-2-yl]-4-oxo-2-(3-phenylpropanoyl)-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide | IC50 | 4350.0 [1], 4360.0 [2] |
| (6S,8As)-N-[(2S)-3-(1-carbamimidoylpiperidin-3-yl)-1-oxo-1-(1,3-thiazol-2-yl)propan-2-yl]-4-oxo-2-(3-phenylpropanoyl)-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide | Ki | 4000.0 [1] |
 | Nafamostat | IC50 | 17.0 [1], 20.0 [2] |
 | Naphthalene-2-carboximidamide | Ki | 7780.0 [1], 7800.0 [2] |
 | 1-[n-(Naphthalen-2-Ylsulfonyl)glycyl-4-Carbamimidoyl-D-Phenylalanyl]piperidine | IC50 | 169.0 [1], 170.0 [2] |
 | 2-(3-Carbamimidoylphenyl)-5-methyl-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamide | Ki | 16.0 [1] |
 | 2-{5-[Amino(iminio)methyl]-1H-indol-2-YL}-6-bromo-4-methylbenzenolate | Ki | 320.0 [1], 640.0 [2] |
 | 6-(N-Phenylcarbamyl)-2-naphthalenecarboxamidine | Ki | 325.0 [1], 330.0 [2] |
 | (2S)-N-[(4-Aminocyclohexyl)methyl]-1-(9-hydroxyfluorene-9-carbonyl)pyrrolidine-2-carboxamide | Ki | 860.0 [1] |
 | (2R,3R)-3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-butyric acid methyl ester | Ki | 69.0 [1] |
 | [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylate | Ki | 39000.0 [1] |
 | Methyl 2-[3-(3-carbamimidoylphenyl)-5-[[4-(2-sulfamoylphenyl)phenyl]carbamoyl]-4H-1,2-oxazol-5-yl]acetate;2,2,2-trifluoroacetic acid | Ki | 110.0 [1] |
 | 2-[(2S)-4-Benzyl-2-(naphthalen-2-ylmethyl)-3,6-dioxopiperazin-1-yl]-N-[(2S)-3-(1-carbamimidoylpiperidin-3-yl)-1-oxo-1-(1,3-thiazol-2-yl)propan-2-yl]acetamide | IC50 | 11000.0 [1], 11100.0 [2] |
 | 3-(3-Carbamimidoylphenyl)-N-[5-(2-sulfamoylphenyl)pyridin-2-yl]-5-(tetrazol-1-ylmethyl)-4H-1,2-oxazole-5-carboxamide | Ki | 18.0 [1], 31.0 [2] |
 | Methyl 2-[3-(3-carbamimidoylphenyl)-5-[(4-carbamimidoylphenyl)carbamoyl]-4H-1,2-oxazol-5-yl]acetate | Ki | 480.0 [1] |
 | N-[(4-Aminocyclohexyl)methyl]-2-[3-(benzylsulfonylamino)-6-methyl-2-oxopyridin-1-yl]acetamide | Ki | 3000.0 [1] |
 | N-[(6-Amino-2-methylpyridin-3-yl)methyl]-2-[3-(benzylsulfonylamino)-2-oxopyridin-1-yl]acetamide | Ki | 20000.0 [1] |
 | [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(benzylcarbamoyl)piperazine-1-carboxylate | Ki | 182000.0 [1] |
 | [5-[4-(Benzylcarbamoyl)piperazine-1-carbonyl]oxycyclooctyl] 4-(benzylcarbamoyl)piperazine-1-carboxylate | Ki | 44000.0 [1] |
 | Methyl 2-[3-(3-carbamimidoylphenyl)-5-[[5-(2-sulfamoylphenyl)pyridin-2-yl]carbamoyl]-4H-1,2-oxazol-5-yl]acetate;2,2,2-trifluoroacetic acid | Ki | 25.0 [1], 52.0 [2] |
 | Methyl 2-[3-(3-carbamimidoylphenyl)-5-[[5-(2-sulfamoylphenyl)pyrimidin-2-yl]carbamoyl]-4H-1,2-oxazol-5-yl]acetate;2,2,2-trifluoroacetic acid | Ki | 170.0 [1], 330.0 [2] |
 | Tert-butyl (3S)-4-[[3-(1-aminoisoquinolin-6-yl)-1-oxo-1-piperidin-1-ylpropan-2-yl]amino]-3-[(4-methoxy-2,3,6-trimethylphenyl)sulfonylamino]-4-oxobutanoate | IC50 | 378000.0 [1] |
 | 1,4-Bis[[2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzene | Ki | 84000.0 [1] |
 | 3-(3-Carbamimidoylphenyl)-N-[4-(2-sulfamoylphenyl)phenyl]-5-(tetrazol-1-ylmethyl)-4H-1,2-oxazole-5-carboxamide | Ki | 45.0 [1], 91.0 [2] |
 | 2-(2-Hydroxy-3-phenyl-5-methylphenyl)-1H-indole-5-carboxamidine | Ki | 130.0 [1], 1800.0 [2] |
 | 2-[3-(Benzylsulfonylamino)-6-methyl-2-oxopyridin-1-yl]-N-[(1-carbamimidoylpiperidin-4-yl)methyl]acetamide | Ki | 570.0 [1] |
 | N-[(6-Amino-2-methylpyridin-3-yl)methyl]-2-[(3R)-3,6-dimethyl-3-(2-methylpropyl)-2,8-dioxo-1,4-dihydro-1,7-naphthyridin-7-yl]acetamide | Ki | 0.24 [1], 860.0 [2] |
 | N-[(6-Amino-2-methylpyridin-3-yl)methyl]-2-[6-methyl-3,3-bis(2-methylpropyl)-2,8-dioxo-1,4-dihydro-1,7-naphthyridin-7-yl]acetamide | Ki | 0.27 [1], 1500.0 [2] |
 | 4-[2-(Tert-butylsulfamoyl)phenyl]-N-[(1R)-4-(diaminomethylideneamino)-1-[(2S,6R)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-2-methylbenzamide | Ki | 0.7 [1] |
 | [5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[(4-aminocyclohexyl)methylcarbamoyl]piperazine-1-carboxylate | Ki | 141000.0 [1], 171000.0 [2] |
 | N-[(2S)-3-(1-Carbamimidoylpiperidin-3-yl)-1-oxo-1-(1,3-thiazol-2-yl)propan-2-yl]-2-[(2S)-2-(naphthalen-2-ylmethyl)-3,6-dioxo-4-(3-phenylpropyl)piperazin-1-yl]acetamide | IC50 | 27000.0 [1] |
| N-[(2S)-3-(1-Carbamimidoylpiperidin-3-yl)-1-oxo-1-(1,3-thiazol-2-yl)propan-2-yl]-2-[(2S)-2-(naphthalen-2-ylmethyl)-3,6-dioxo-4-(3-phenylpropyl)piperazin-1-yl]acetamide | Ki | 13.5 [1] |
 | 2-[3-(Benzylsulfonylamino)-2-oxopyridin-1-yl]-N-[(3S)-1-carbamimidoyl-2-hydroxypiperidin-3-yl]acetamide | IC50 | 26.2 [1] |
 | 2-[(3S)-3-(Benzylsulfonylamino)-2-oxoazepan-1-yl]-N-[(3S)-1-carbamimidoyl-2-hydroxypiperidin-3-yl]acetamide | IC50 | 101.0 [1], 151.8 [2] |
 | (4-Carbamimidoyl-2-fluorophenyl) 5-[2,2-dimethyl-3-oxo-3-[(2-oxo-1H-pyridin-3-yl)amino]propyl]thiophene-2-carboxylate | Ki | 4.54 [1] |
 | (3S)-1-[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]pyrrolidine-3-carboxylic acid | Ki | 1.33 [1], 2.0 [2] |
 | (2S)-2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]-2-(4-hydroxyphenyl)acetic acid | Ki | 0.96 [1], 1.14 [2] |
 | (2S)-2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]butanedioic acid | Ki | 1.04 [1] |
 | (2S)-2-[[1-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]cyclobutanecarbonyl]amino]butanedioic acid | Ki | 0.61 [1] |
 | 2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]acetic acid | Ki | 0.42 [1] |
 | (2S)-2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]-3-hydroxypropanoic acid | Ki | 0.75 [1] |
 | 2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]-prop-2-enylamino]acetic acid | Ki | 0.5 [1] |
 | 2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]-2-methylpropanoic acid | Ki | 0.95 [1] |
 | 2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]-propylamino]acetic acid | Ki | 1.5 [1] |
 | (2S)-2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]-3-hydroxypropanoic acid | Ki | 1.78 [1] |
 | (2S)-2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]-3-methylbutanoic acid | Ki | 5.18 [1] |
 | 3-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]propanoic acid | Ki | 2.5 [1] |
 | 2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoic acid | Ki | 2.49 [1] |
 | (2S)-2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]butanoic acid | Ki | 1.93 [1] |
 | 2-[(2S)-1-[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]pyrrolidin-2-yl]acetic acid | Ki | 3.88 [1] |
 | (2S)-2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]pentanedioic acid | Ki | 1.96 [1] |
 | (2S)-4-Amino-2-[[2-[[5-(4-carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]-4-oxobutanoic acid | Ki | 1.69 [1] |
 | 5-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]-2-hydroxybenzoic acid | Ki | 0.92 [1] |
 | 1-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]cyclobutane-1-carboxylic acid | Ki | 1.49 [1] |
 | 4-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]-4-(2-carboxyethyl)heptanedioic acid | Ki | 1.59 [1] |
 | 5-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]benzene-1,3-dicarboxylic acid | Ki | 0.49 [1] |
 | (4-Carbamimidoyl-2-fluorophenyl) 5-[2,2-dimethyl-3-oxo-3-[2-(2H-tetrazol-5-yl)ethylamino]propyl]thiophene-2-carboxylate | Ki | 1.6 [1] |
 | (4-Carbamimidoyl-2-fluorophenyl) 5-[2,2-dimethyl-3-oxo-3-(2H-tetrazol-5-ylmethylamino)propyl]thiophene-2-carboxylate | Ki | 0.75 [1] |
 | 5-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]benzene-1,3-dicarboxylic acid | Ki | 1.58 [1] |
 | 4-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]phthalic acid | Ki | 0.21 [1] |
 | 1-[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]azetidine-3-carboxylic acid | Ki | 1.85 [1] |
 | 2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]-prop-2-enylamino]ethanesulfonic acid | Ki | 3.17 [1] |
 | (2S)-2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]-3-methylbutanoic acid | Ki | 2.02 [1] |
 | 2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]-methylamino]acetic acid | Ki | 1.76 [1] |
 | (2S)-2-[[1-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]cyclopentanecarbonyl]amino]butanedioic acid | Ki | 4.1 [1] |
 | (4-Carbamimidoyl-2-fluorophenyl) 5-[2-ethyl-2-(2H-tetrazol-5-ylmethylcarbamoyl)butyl]thiophene-2-carboxylate | Ki | 3.54 [1] |
 | 2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]-methylamino]acetic acid | Ki | 1.33 [1] |
 | (2S)-1-[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]pyrrolidine-2-carboxylic acid | Ki | 1.69 [1] |
 | (2S)-2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]-3-hydroxybutanoic acid | Ki | 1.74 [1] |
 | (2S)-2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]-3-phenylpropanoic acid | Ki | 8.3 [1] |
 | (2S)-1-[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]pyrrolidine-2-carboxylic acid | Ki | 3.57 [1] |
 | 2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]-propylamino]acetic acid | Ki | 7.91 [1] |
 | 1-[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]piperidine-4-carboxylic acid | Ki | 3.1 [1] |
 | (2S)-2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]propanoic acid | Ki | 1.67 [1] |
 | (2S)-2-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]pentanoic acid | Ki | 3.84 [1] |
 | 4-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]butanoic acid | Ki | 2.73 [1] |
 | 4-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]benzoic acid | Ki | 2.89 [1] |
 | 3-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]benzoic acid | Ki | 0.7 [1] |
 | (4-Carbamimidoyl-2-fluorophenyl) 5-[2-ethyl-2-[[(3S)-5-oxooxolan-3-yl]carbamoyl]butyl]thiophene-2-carboxylate | Ki | 2.73 [1] |
 | (2S)-2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]-2-cyclohexylacetic acid | Ki | 3.07 [1] |
 | (2S)-2-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]-2-phenylacetic acid | Ki | 1.45 [1] |
 | (4-Carbamimidoyl-2-fluorophenyl) 5-[2,2-dimethyl-3-oxo-3-(pyridin-3-ylamino)propyl]thiophene-2-carboxylate | Ki | 3.6 [1] |
 | (2S)-5-Amino-2-[[2-[[5-(4-carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]-5-oxopentanoic acid | Ki | 3.88 [1] |
 | (4-Carbamimidoyl-2-fluorophenyl) 5-[3-[(6-methoxypyridin-3-yl)amino]-2,2-dimethyl-3-oxopropyl]thiophene-2-carboxylate | Ki | 3.36 [1] |
 | (4-Carbamimidoyl-2-fluorophenyl) 5-[3-(3,3-difluoroazetidin-1-yl)-2,2-dimethyl-3-oxopropyl]thiophene-2-carboxylate | Ki | 3.89 [1] |
 | 2-[4-[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]phenyl]acetic acid | Ki | 3.35 [1] |
 | 2-[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]-3,4-dihydro-1H-isoquinoline-7-carboxylic acid | Ki | 3.49 [1] |
 | (4-Carbamimidoyl-2-fluorophenyl) 5-[3-[(2-methoxypyridin-3-yl)amino]-2,2-dimethyl-3-oxopropyl]thiophene-2-carboxylate | Ki | 1.87 [1] |
 | (2S)-2-Amino-5-[[2-[[5-(4-carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]pentanoic acid | Ki | 5.78 [1] |
 | 4-[[[2-[[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]methyl]-2-ethylbutanoyl]amino]methyl]benzoic acid | Ki | 9.27 [1] |
 | (4-Carbamimidoyl-2-fluorophenyl) 5-[3-[(6-fluoropyridin-3-yl)amino]-2,2-dimethyl-3-oxopropyl]thiophene-2-carboxylate | Ki | 3.3 [1] |
 | 1-[[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]cyclopropane-1-carboxylic acid | Ki | 1.01 [1] |
 | Dimethyl 5-[[3-[5-(4-carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]amino]benzene-1,3-dicarboxylate | Ki | 1.02 [1] |
 | (2S)-1-[3-[5-(4-Carbamimidoyl-2-fluorophenoxy)carbonylthiophen-2-yl]-2,2-dimethylpropanoyl]aziridine-2-carboxylic acid | Ki | 0.96 [1] |
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