Tumour suppressor p53/oncoprotein Mdm2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nutlin-3A	IC50	70.0 [1]
	Nutlin-3A	Ki	55.0 [1], 230.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	IC50	1.0 [1], 1.1 [2], 4.2 [3], 6.0 [4]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-pentan-3-ylpiperidin-3-yl]acetic acid	IC50	2.8 [1], 3.0 [2], 36.3 [3], 55.0 [4]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-propan-2-ylpiperidin-3-yl]acetic acid	IC50	6.0 [1], 9.0 [2], 30.0 [3], 119.0 [4]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-2-methyl-1-pyridin-2-ylpropyl]-2-oxopiperidin-3-yl]acetic acid	IC50	2.0 [1], 9.0 [2], 25.0 [3], 30.0 [4]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	IC50	1.7 [1], 2.0 [2], 6.8 [3], 20.0 [4]
	Tert-butyl (2S)-2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-3-(2H-tetrazol-5-ylmethyl)piperidin-1-yl]butanoate	IC50	0.9 [1], 1.0 [2], 9.0 [3], 10.0 [4]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyridin-2-ylpropyl]piperidin-3-yl]acetic acid	IC50	3.0 [1], 10.0 [2], 28.0 [3], 30.0 [4]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyridin-4-ylpropyl]piperidin-3-yl]acetic acid	IC50	9.0 [1], 31.0 [2], 40.0 [3]
	(2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	IC50	9.0 [1], 21.0 [2]
	(2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	Ki	3.0 [1]
	2-[(3S,5S,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid	IC50	2420.0 [1], 18900.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-1-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acid	IC50	2.2 [1], 19.9 [2]
	2-Amino-4,5-bis(4-chlorophenyl)-N-cyclopropylthiophene-3-carboxamide	IC50	2080.0 [1]
	2-Amino-4,5-bis(4-chlorophenyl)-N-cyclopropylthiophene-3-carboxamide	Ki	540.0 [1]
	Methyl 2-amino-4,5-bis(4-chlorophenyl)thiophene-3-carboxylate	IC50	4230.0 [1]
	Methyl 2-amino-4,5-bis(4-chlorophenyl)thiophene-3-carboxylate	Ki	1520.0 [1]
	2-Amino-4,5-bis(4-chlorophenyl)-N-cyclohexylthiophene-3-carboxamide	IC50	900.0 [1]
	2-Amino-4,5-bis(4-chlorophenyl)-N-cyclohexylthiophene-3-carboxamide	Ki	230.0 [1]
	[2-Amino-4,5-bis(4-chlorophenyl)thiophen-3-yl]-pyrrolidin-1-ylmethanone	IC50	2840.0 [1]
	[2-Amino-4,5-bis(4-chlorophenyl)thiophen-3-yl]-pyrrolidin-1-ylmethanone	Ki	740.0 [1]
	(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-3-(2H-tetrazol-5-ylmethyl)piperidin-2-one	IC50	14.0 [1], 90.0 [2], 190.0 [3]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetamide	IC50	270.0 [1], 1370.0 [2], 7630.0 [3]
	Methyl 2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetate	IC50	790.0 [1], 3630.0 [2], 30000.0 [3]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyridin-2-ylbutyl]piperidin-3-yl]acetic acid	IC50	6.0 [1], 80.0 [2], 92.0 [3]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-1-(6-methylpyridin-2-yl)propyl]-2-oxopiperidin-3-yl]acetic acid	IC50	2.0 [1], 10.0 [2], 32.0 [3]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyrimidin-2-ylpropyl]piperidin-3-yl]acetic acid	IC50	7.0 [1], 50.0 [2], 60.0 [3]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-(1,3-thiazol-2-yl)propyl]piperidin-3-yl]acetic acid	IC50	6.0 [1], 50.0 [2], 66.0 [3]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyridin-3-ylpropyl]piperidin-3-yl]acetic acid	IC50	1.5 [1], 80.0 [2], 85.0 [3]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-(6-chloropyridin-2-yl)propyl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	IC50	0.7 [1], 1.0 [2], 23.0 [3]
	Idasanutlin	IC50	9.0 [1], 10.0 [2]
	Nutlin-1	IC50	4780.0 [1]
	Nutlin-1	Ki	1240.0 [1]
	Nvp-cgm097	IC50	1.7 [1], 224.0 [2]
	DI-Chloro-benzo-diazepine	IC50	420.0 [1]
	DI-Chloro-benzo-diazepine	Ki	80.0 [1]
	2-Benzyl-3-(4-chlorophenyl)-3-(3-hydroxypropoxy)-2,3-dihydroisoindol-1-one	IC50	15900.0 [1]
	3-(4-Chlorophenyl)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methoxy]-2-propylisoindol-1-one	IC50	5300.0 [1]
	Methyl 3-(4-hydroxyphenyl)-2-(3-oxo-1-phenyl-1-propoxyisoindol-2-yl)propanoate	IC50	90000.0 [1]
	4-Tert-butyl-N-[3-oxo-2-propyl-1-[4-(2-trimethylsilylethoxymethoxy)phenyl]isoindol-1-yl]benzamide	IC50	27000.0 [1]
	2-Benzyl-3-[(4-hydroxy-3,5-dimethoxyphenyl)methoxy]-3-phenylisoindol-1-one	IC50	17900.0 [1]
	N-[2-[1-[(4-Tert-butylphenyl)methoxy]-3-oxo-1-phenylisoindol-2-yl]ethyl]acetamide	IC50	14000.0 [1], 14400.0 [2]
	2-Benzyl-3-(3-hydroxypropoxy)-3-phenylisoindol-1-one	IC50	245000.0 [1]
	3-[(4-Tert-butylphenyl)methoxy]-3-phenyl-2-propylisoindol-1-one	IC50	500000.0 [1]
	3-(3-Hydroxypropoxy)-3-phenyl-2-propylisoindol-1-one	IC50	500000.0 [1]
	2-Benzyl-3-[(4-tert-butylphenyl)methoxy]-3-(4-chlorophenyl)isoindol-1-one	IC50	99000.0 [1]
	2-Benzyl-3-(4-chlorophenyl)-3-(2-pyridin-2-ylethoxy)isoindol-1-one	IC50	26200.0 [1]
	3-(4-Chlorophenyl)-2-propyl-3-(2-pyridin-2-ylethoxy)isoindol-1-one	IC50	57000.0 [1]
	N-[2-[1-(4-Chlorophenyl)-1-[(4-hydroxy-3,5-dimethoxyphenyl)methoxy]-3-oxoisoindol-2-yl]ethyl]acetamide	IC50	76000.0 [1]
	3-[(4-Hydroxy-3,5-dimethoxyphenyl)methoxy]-2-propyl-3-[4-(2-trimethylsilylethoxymethoxy)phenyl]isoindol-1-one	IC50	118000.0 [1]
	2-Propyl-3-(2-pyridin-2-ylethoxy)-3-[4-(2-trimethylsilylethoxymethoxy)phenyl]isoindol-1-one	IC50	312000.0 [1]
	2-Benzyl-3-[(4-hydroxy-3,5-dimethoxyphenyl)methoxy]-3-[4-(2-trimethylsilylethoxymethoxy)phenyl]isoindol-1-one	IC50	257000.0 [1]
	2-Benzyl-3-[(4-tert-butylphenyl)methoxy]-3-phenylisoindol-1-one	IC50	92000.0 [1]
	N-[1-(4-Tert-butylphenyl)-3-oxo-2-propylisoindol-1-yl]benzamide	IC50	66000.0 [1]
	2-Benzyl-3-phenyl-3-(2-pyridin-2-ylethoxy)isoindol-1-one	IC50	206000.0 [1]
	3-[(4-Hydroxy-3,5-dimethoxyphenyl)methoxy]-3-phenyl-2-propylisoindol-1-one	IC50	82000.0 [1]
	3-Phenyl-2-propyl-3-(2-pyridin-2-ylethoxy)isoindol-1-one	IC50	100000.0 [1]
	2-Benzyl-3-(4-chlorophenyl)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methoxy]isoindol-1-one	IC50	42000.0 [1]
	3-[(4-Tert-butylphenyl)methoxy]-3-(4-chlorophenyl)-2-propylisoindol-1-one	IC50	187000.0 [1]
	3-(4-Chlorophenyl)-3-(3-hydroxypropoxy)-2-propylisoindol-1-one	IC50	16400.0 [1]
	N-[2-[1-[(4-Tert-butylphenyl)methoxy]-1-(4-chlorophenyl)-3-oxoisoindol-2-yl]ethyl]acetamide	IC50	91400.0 [1]
	3-[(4-Tert-butylphenyl)methoxy]-2-propyl-3-[4-(2-trimethylsilylethoxymethoxy)phenyl]isoindol-1-one	IC50	464000.0 [1]
	N-[4-[(3-Hydroxy-5-oxo-1,2-diphenylpyrazol-4-yl)diazenyl]phenyl]sulfonyl-4-propan-2-yloxybenzamide	IC50	30000.0 [1], 31800.0 [2]
	2-Benzyl-3-[[2-hydroxy-2-(4-methoxyphenyl)ethyl]amino]-3-phenylisoindol-1-one	IC50	70000.0 [1]
	2-Propyl-3-propoxy-3-phenyl-2H-isoindole-1(3H)-one	IC50	200000.0 [1]
	2-Benzyl-3-(propylamino)-3-phenyl-2H-isoindole-1(3H)-one	IC50	200000.0 [1]
	2-Benzyl-3-propoxy-3-phenyl-2H-isoindole-1(3H)-one	IC50	200000.0 [1]
	(2S)-1-[(5R,6S)-5,6-Bis(4-chlorophenyl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-N,N-dimethylpyrrolidine-2-carboxamide	IC50	8.3 [1], 9.2 [2]
	2-[(3S,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid	IC50	76.0 [1], 1110.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid	IC50	34.0 [1], 370.0 [2]
	(1R)-7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one	IC50	1171.0 [1], 1200.0 [2]
	(1S)-7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one	IC50	2.3 [1]
	7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one	IC50	8.0 [1]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-[cyclopropylsulfonyl(methyl)amino]ethyl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	IC50	1.0 [1], 10.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-(methanesulfonamido)butan-2-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	IC50	1.0 [1], 10.0 [2]
	(2'R,3R,3'S,5'S)-N-[2-(4-Carbamoyl-2-methoxyphenyl)phenyl]-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	IC50	5.0 [1]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-[(2S)-oxolan-2-yl]propyl]piperidin-3-yl]acetic acid	IC50	1.0 [1], 20.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-1-(1,3-oxazol-5-yl)propyl]-2-oxopiperidin-3-yl]acetic acid	IC50	8.0 [1], 36.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyridin-2-ylethyl]piperidin-3-yl]acetic acid	IC50	10.0 [1], 62.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-1-(5-methylpyridin-2-yl)propyl]-2-oxopiperidin-3-yl]acetic acid	IC50	7.0 [1], 123.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-1-(4-methylpyridin-2-yl)propyl]-2-oxopiperidin-3-yl]acetic acid	IC50	3.0 [1], 60.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-1-(3-methylpyridin-2-yl)propyl]-2-oxopiperidin-3-yl]acetic acid	IC50	5.0 [1], 183.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-pyridin-2-ylpiperidin-3-yl]acetic acid	IC50	13.0 [1], 122.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-phenylpiperidin-3-yl]acetic acid	IC50	4.0 [1], 55.0 [2]
	(2'R,3R,3'S,5'S)-N-(4-Carbamoylphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	IC50	5.0 [1]
	4-[[(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carbonyl]amino]-2-methoxybenzoic acid	IC50	4.0 [1]
	(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-[4-(2-hydroxyethoxy)phenyl]-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	IC50	7.0 [1], 8.0 [2]
	(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-[4-(2-hydroxyethoxy)-2-methoxyphenyl]-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	IC50	5.0 [1]
	(2'R,3R,3'S,5'S)-N-(4-Carbamoyl-3-methoxyphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	IC50	5.0 [1]
	(2'R,3R,3'S,5'S)-N-(4-Carbamoylphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	IC50	6.0 [1]
	(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-N-(4-cyano-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	IC50	7.0 [1]
	(2'R,3R,3'S,5'S)-N-(4-Carbamoyl-2-methoxyphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-4-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	IC50	5.0 [1], 6.0 [2]
	4-[[(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carbonyl]amino]-3-methoxybenzoic acid	IC50	5.0 [1]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-ethoxy-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acid	IC50	7.6 [1], 86.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acid	IC50	4.2 [1], 43.3 [2]
	(2'R,3R,3'S,5'S)-N-(4-Carbamoyl-2-methoxyphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-7-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	IC50	15.0 [1], 18.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(3S)-2-hydroxy-2-methylpentan-3-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	IC50	2.0 [1], 10.0 [2]
	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(S)-cyclopropyl(pyridin-2-yl)methyl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	IC50	2.0 [1], 19.0 [2]
	(5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)piperidin-2-one	IC50	10000.0 [1], 30000.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Tumour suppressor p53/oncoprotein Mdm2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/tumour-suppressor-p53-oncoprotein-mdm2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Tumour suppressor p53/oncoprotein Mdm2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tumour-suppressor-p53-oncoprotein-mdm2-inhibitors-ic50-ki.
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