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Tyrosine-protein kinase HCK Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
DoramapimodIC501700.0 [1], 1894.0 [2], 19000.0 [3]
7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-AmineIC500.4 [1], 0.43 [2]
2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]acetic acidIC503.7 [1], 4.2 [2], 12.0 [3]
(2S)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methylpentanoic acidIC504.4 [1], 11.0 [2], 105.0 [3]
IbrutinibIC503.7 [1]
1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC508.0 [1]
N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamideIC502.0 [1]
3-[4-Amino-1-(1-Methylethyl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]phenolIC5023.0 [1]
1-Methyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-AmineIC50260.0 [1]
1-(1-Methylethyl)-3-Quinolin-6-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-AmineIC5088.0 [1]
1-Cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50130.0 [1]
N-[4-[4-Amino-7-[(E)-3-[(4-aminocyclohexyl)amino]prop-1-enyl]thieno[3,2-c]pyridin-3-yl]-2-methoxyphenyl]-1-methylindole-2-carboxamideIC5020100.0 [1], 24100.0 [2]
(2R)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-3-(4-hydroxyphenyl)propanoic acidIC5013.0 [1], 15.0 [2]
(2S)-1-[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]pyrrolidine-2-carboxylic acidIC5052.0 [1], 79.0 [2]
(2R)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-3-phenylpropanoic acidIC5018.0 [1], 24.0 [2]
(2R)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methylpentanoic acidIC5027.0 [1], 137.0 [2]
(2R)-1-[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]pyrrolidine-2-carboxylic acidIC5065.0 [1], 200.0 [2]
(2S)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-3-(4-hydroxyphenyl)propanoic acidIC507.4 [1], 39.0 [2]
(2S)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]propanoic acidIC506.9 [1], 73.0 [2]
7-[4-(3-Methylbutylamino)cyclohexyl]-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amineIC50119.0 [1], 226.0 [2]
(2S)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-3-hydroxypropanoic acidIC501.8 [1], 40.0 [2]
(2R)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]propanoic acidIC5036.0 [1]
(2S)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-3-phenylpropanoic acidIC507.5 [1], 74.0 [2]
(2R)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-3-hydroxypropanoic acidIC506.3 [1], 23.0 [2]
(3S)-3-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]oxolan-2-oneIC505.4 [1], 28.0 [2]
Unii-I92MU0V408IC5047.0 [1], 52.0 [2]
2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]-IC501.0 [1]
GefitinibIC50110.0 [1]
SorafenibIC50530.0 [1]
SunitinibIC50190.0 [1]
DasatinibIC501.0 [1]
1-Tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC505.0 [1]
BosutinibIC503.2 [1]
SotrastaurinIC5010000.0 [1]
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-olIC501200.0 [1]
LinifanibIC5050000.0 [1]
Pyridone 6IC507700.0 [1]
A-770041IC501220.0 [1]
CID 44219749IC5050000.0 [1]
2-[[4-Amino-3-(3-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-oneIC5050000.0 [1]
CID 59604787IC5010000.0 [1]
3-[[2-[3-(Morpholin-4-ylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenolIC5050.7 [1]
1-Isopropyl-3-(quinolin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50422.0 [1]
CID 44814409IC5010000.0 [1]
1-Isopropyl-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50380.0 [1]
Unii-8FX9DP2Y1WIC5023.0 [1]
N-(2-Chloro-6-methylphenyl)-2-[(cyclopropylcarbonyl)amino]-1,3-thiazole-5-carboxamideIC50310.0 [1]
1-(5-Tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-pyridin-4-yl-ethoxy)-naphthalen-1-yl]-ureaIC50901.0 [1]
Tert-Butyl {4-[4-Amino-1-(Propan-2-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]-2-Methoxyphenyl}carbamateIC501.0 [1]
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amineIC501000.0 [1]
1-Isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5096.0 [1]
1-Isopropyl-3-(1-methyl-1H-indol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50153.0 [1]
1-Isopropyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC501100.0 [1]
1-(5-Tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-imidazol-1-yl-ethoxy)-naphthalen-1-yl]-ureaIC504937.0 [1]
1-(5-Tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-pyridin-3-yl-ethoxy)-naphthalen-1-yl]-ureaIC5019000.0 [1]
3-[4-(3-Amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl]-1-[3-(trifluoromethyl)phenyl]ureaIC5050000.0 [1]
3-[5-[3-(2-Methoxyethoxy)prop-1-ynyl]thiophen-3-yl]-7-(1,2,4-triazol-1-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazoleIC5050000.0 [1]
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenolIC5047.0 [1]
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenolIC5026.0 [1]
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-3-methylphenolIC5023.0 [1]
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2,5-difluorophenolIC5076.0 [1]
6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinazolin-4(3H)-oneIC50248.0 [1]
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenolIC50100.0 [1]
6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)naphthalen-2-olIC5020.0 [1]
Ripk1-IN-7IC50142.0 [1]
6-[(4-Methylpiperazin-1-yl)methyl]-3-[5-(3-phenoxyprop-1-ynyl)thiophen-3-yl]-1,4-dihydroindeno[1,2-c]pyrazoleIC5050000.0 [1]
5-(4-Phenoxyphenyl)-7-(Tetrahydro-2h-Pyran-4-Yl)-7h-Pyrrolo[2,3-D]pyrimidin-4-AmineIC5031.0 [1]
5-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-bromophenolIC504.0 [1]
1-Cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC508900.0 [1]
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-dihydrothiazol-2-yl)benzamideIC502400.0 [1]
1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)ethanoneIC501400.0 [1]
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-3-methylthiophene-2-carbaldehydeIC507900.0 [1]
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)furan-3-carbaldehydeIC504400.0 [1]
N-[3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]-methanesulfonamideIC503600.0 [1]
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzonitrileIC5050000.0 [1]
N-[4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]-methanesulfonamideIC502300.0 [1]
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-benzenesulfonamideIC505300.0 [1]
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[b]thiophene-5-carbaldehydeIC5012000.0 [1]
3-(Benzo[c][1,2,5]oxadiazol-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC501300.0 [1]
2-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetonitrileIC50510.0 [1]
2-(3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetonitrileIC505000.0 [1]
1-Isopropyl-3-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50180.0 [1]
1-Isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC509200.0 [1]
1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5013000.0 [1]
3-(4-Fluoro-3-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5037.0 [1]
3-(2,5-Difluoro-4-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50113.0 [1]
1-Isopropyl-3-(2,3-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50733.0 [1]
1-Isopropyl-3-(2,4-dimethoxypyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC501600.0 [1]
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenolIC5076.0 [1]
3-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenolIC5028.0 [1]
1-Cyclopentyl-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC504.4 [1]
3-(4-Amino-3-methoxyphenyl)-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC502.0 [1]
3-(3-Bromo-5-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50436.0 [1]
Tert-butyl 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indole-1-carboxylateIC509.0 [1]
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-5-bromophenolIC5010.0 [1]
Tert-butyl 5-(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indole-1-carboxylateIC5048.0 [1]
3-(1H-Indol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5015.0 [1]
1-Cyclopentyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50117.0 [1]
3-(1H-Indol-4-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC501200.0 [1]
1-Cyclopentyl-3-(1H-indol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5057.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase HCK Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-hck-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Tyrosine-protein kinase HCK Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-hck-inhibitors-ic50-ki.
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