 | Tofacitinib | IC50 | 3.2 [1] |
| Tofacitinib | Ki | 0.68 [1], 0.7 [2] |
 | Ruxolitinib | IC50 | 3.3 [1] |
| Ruxolitinib | Ki | 0.09 [1], 0.2 [2] |
 | Filgotinib | IC50 | 10.0 [1] |
 | Baricitinib | IC50 | 0.99 [1], 4.0 [2], 6.0 [3] |
 | Staurosporine | IC50 | 1.0 [1], 1.01 [2], 3.0 [3], 12.5 [4] |
 | Decernotinib | IC50 | 11.0 [1], 13.2 [2], 50.0 [3], 112.0 [4] |
 | 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one | IC50 | 1640.0 [1], 10000.0 [2] |
 | 3-(4-Cyanoanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.07 [1], 0.15 [2], 13.0 [3], 220.0 [4] |
 | Pyridone 6 | IC50 | 4.0 [1], 15.0 [2], 600.0 [3] |
 | N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | IC50 | 29.0 [1], 572.0 [2] |
 | 3-[5-[4-(2-Hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione | IC50 | 311.0 [1], 344.0 [2], 1017.0 [3] |
 | 3-Cyclohexyl-4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene | IC50 | 20.0 [1] |
| 3-Cyclohexyl-4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene | Ki | 1.3 [1] |
 | 3-(4-Chloro-3-methoxyanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.1 [1], 13.0 [2], 1760.0 [3] |
 | 4-[(4-Aminocyclohexyl)amino]-3-(1h-Benzimidazol-2-Yl)-1h-Pyridin-2-One | IC50 | 0.1 [1], 0.6 [2], 3.0 [3] |
 | N-[5-[4-(Morpholin-4-ylmethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | IC50 | 52.11 [1], 92.0 [2], 5590.0 [3] |
 | N-[5-[4-[(4,4-Difluoropiperidin-1-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | IC50 | 7.69 [1], 27.0 [2], 2749.0 [3] |
 | 1-Cyclopropyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | IC50 | 42.0 [1], 1030.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[(2-fluoropyridin-4-yl)amino]pyrazole-4-carboxamide | IC50 | 0.2 [1], 0.24 [2], 42.0 [3] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]anilino]pyrazole-4-carboxamide | IC50 | 0.05 [1], 0.09 [2], 14.0 [3] |
 | 3-(4-Chloroanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.13 [1], 0.2 [2], 14.0 [3] |
 | 3-Anilino-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.4 [1], 10.0 [2], 33.0 [3] |
 | 3-(4-Chloroanilino)-1-[(1S,2S,4S)-2-cyano-4-(dimethylamino)cyclohexyl]pyrazole-4-carboxamide | IC50 | 0.55 [1], 1.5 [2], 64.0 [3] |
 | 4-[[4-(4,5,6,8,10-Pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-3-yl)cyclohexyl]amino]benzonitrile | IC50 | 2.2 [1], 3.9 [2], 22.0 [3] |
 | 4-(4,5,6,8,10-Pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-3-yl)-N-(2-phenylethyl)cyclohexan-1-amine | IC50 | 6.1 [1], 6.3 [2], 97.0 [3] |
 | 4-Fluoro-N-[4-(4,5,6,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-3-yl)cyclohexyl]aniline | IC50 | 5.4 [1], 6.6 [2], 69.0 [3] |
 | Nvp-aew541 | IC50 | 10000.0 [1] |
 | Momelotinib | IC50 | 11.0 [1] |
 | Oclacitinib | IC50 | 9.53 [1] |
 | 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl)amino]pyridin-4-Yl}benzamide | Ki | 83.8 [1], 84.0 [2] |
 | [2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanone | IC50 | 2.2 [1], 5.4 [2] |
 | [(1S)-6-(5-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 422.0 [1], 3345.0 [2] |
 | 1-(Piperidin-4-Yl)-1,6-Dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridine | Ki | 45.0 [1], 46.0 [2] |
 | cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenol | IC50 | 260.0 [1] |
 | 7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 10000.0 [1] |
 | CID 11993785 | IC50 | 47.0 [1] |
 | 1-(2-Aminoethyl)-2-(4-piperidinyl)-1H-benzoimidazole-5-carboxamide | IC50 | 50.0 [1], 5700.0 [2] |
 | Unii-7N5LJ2Z26C | IC50 | 2.0 [1], 3.0 [2] |
 | 3-[(3r)-3-(Imidazo[4,5-D]pyrrolo[2,3-B]pyridin-1(6h)-Yl)piperidin-1-Yl]-3-Oxopropanenitrile | Ki | 0.4 [1] |
 | N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 47.0 [1] |
 | Jak-IN-1 | IC50 | 3.2 [1] |
 | 2-Methyl-1-(Piperidin-4-Yl)-1,6-Dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridine | Ki | 10.0 [1] |
 | 3-[4-(3,5,8,10-Tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]propanenitrile | Ki | 0.6 [1] |
 | 1-[(3Ar,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]prop-2-en-1-one | IC50 | 984.0 [1], 10000.0 [2] |
 | 1-[(3R,4R)-4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]prop-2-en-1-one | IC50 | 274.0 [1], 988.0 [2] |
 | (E)-1-[(3R)-3-(7H-Pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]but-2-en-1-one | IC50 | 2290.0 [1], 10000.0 [2] |
 | 1-[(3R)-3-(7H-Pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one | IC50 | 1400.0 [1], 10000.0 [2] |
 | 1-[(3R)-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]prop-2-en-1-one | IC50 | 1150.0 [1], 7820.0 [2] |
 | N-[5-[4-[[(2,2,2-Trifluoroacetyl)amino]methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | IC50 | 16.0 [1], 4467.0 [2] |
 | (2R)-N-[3-[2-[(1,3-Dimethylpyrazol-4-yl)amino]-5-fluoropyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)butanamide | IC50 | 4.0 [1], 75.1 [2] |
 | (2S)-2-[(2S)-2,4-Dimethylpiperazin-1-yl]-N-[3-[2-[(3-ethoxy-1-methylpyrazol-4-yl)amino]-5-fluoropyrimidin-4-yl]-1H-indol-7-yl]propanamide | IC50 | 3000.0 [1], 7600.0 [2] |
 | (2R)-N-[3-[2-[(3-Ethoxy-1-methylpyrazol-4-yl)amino]-5-methylpyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)butanamide | IC50 | 6.0 [1], 104.0 [2] |
 | (2R)-2-[(2S)-2,4-Dimethylpiperazin-1-yl]-N-[3-[2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]propanamide | IC50 | 643.0 [1], 847.0 [2] |
 | (2R)-N-[3-[5-Chloro-2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide | IC50 | 7.0 [1], 57.9 [2] |
 | (2R)-N-[3-[2-[(1,3-Dimethylpyrazol-4-yl)amino]-5-fluoropyrimidin-4-yl]-1H-indol-7-yl]-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide | IC50 | 3.0 [1], 56.6 [2] |
 | 6-Chloro-2-(2,5-difluoro-4-methoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 71.0 [1], 173.0 [2] |
 | 6-Chloro-2-(3,4-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 4.9 [1], 87.0 [2] |
 | 6-Chloro-2-(2-fluoro-4-methoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 34.0 [1], 106.0 [2] |
 | 6-Chloro-2-(4-methoxy-2-methylphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 9.0 [1], 37.0 [2] |
 | 6-Chloro-2-(2-fluoro-5-methoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 49.0 [1], 76.0 [2] |
 | 6-Chloro-2-(4-methoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 17.0 [1], 29.0 [2] |
 | N-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]prop-2-enamide | IC50 | 966.0 [1], 8710.0 [2] |
 | 3-(4-Cyano-3-methoxyanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.07 [1], 19.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[(2-fluoro-6-methoxypyridin-4-yl)amino]pyrazole-4-carboxamide | IC50 | 0.4 [1], 39.0 [2] |
 | [2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(4-fluorophenyl)methanone | IC50 | 0.1 [1], 0.7 [2] |
 | Methyl 2-[4-[(4-aminocyclohexyl)amino]-2-oxo-1H-pyridin-3-yl]-4,5,6,7-tetrahydro-3H-benzimidazole-5-carboxylate | IC50 | 0.8 [1], 44.0 [2] |
 | [(1S)-1-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydroinden-1-yl]cyanamide | IC50 | 5.0 [1], 57.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[[(3S)-3-methyl-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl]amino]pyrazole-4-carboxamide | IC50 | 0.04 [1], 16.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-(3,4-dicyanoanilino)pyrazole-4-carboxamide | IC50 | 0.9 [1], 77.0 [2] |
 | 3-(3-Chloro-4-cyanoanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.4 [1], 26.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[(8-fluoro-4-methoxyquinolin-6-yl)amino]pyrazole-4-carboxamide | IC50 | 0.19 [1], 24.0 [2] |
 | 3-[(4-Chloro-8-fluoroquinolin-6-yl)amino]-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.24 [1], 14.0 [2] |
 | 1-[(3Ar,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone | IC50 | 863.0 [1], 10000.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-(1-methylpyrazol-4-yl)anilino]pyrazole-4-carboxamide | IC50 | 0.02 [1], 6.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-(4-cyclopropylanilino)pyrazole-4-carboxamide | IC50 | 0.5 [1], 37.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[(4-methylquinazolin-6-yl)amino]pyrazole-4-carboxamide | IC50 | 0.16 [1], 24.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[[2-(dimethylamino)-6-fluoropyridin-4-yl]amino]pyrazole-4-carboxamide | IC50 | 0.18 [1], 28.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-(triazol-1-yl)anilino]pyrazole-4-carboxamide | IC50 | 0.06 [1], 23.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-(4-fluoroanilino)pyrazole-4-carboxamide | IC50 | 0.3 [1], 31.0 [2] |
 | 3-(4-Cyano-3-cyclopropylanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 1.4 [1], 72.0 [2] |
 | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-(difluoromethoxy)anilino]pyrazole-4-carboxamide | IC50 | 0.1 [1], 5.0 [2] |
 | 2-Cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylprop-2-enamide | IC50 | 52.0 [1], 668.0 [2] |
 | 1-[6-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1,4-benzoxazin-4-yl]prop-2-en-1-one | IC50 | 10000.0 [1] |
 | [(1R,2R)-2-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 94.0 [1], 973.0 [2] |
 | [(1S)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 82.0 [1], 644.0 [2] |
 | Methyl-[6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 814.0 [1], 7624.0 [2] |
 | [(1R,2S)-2-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 100.0 [1], 705.0 [2] |
 | [(1R,2R)-2-Hydroxy-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 105.0 [1], 1266.0 [2] |
 | [(4R)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-3,4-dihydro-2H-chromen-4-yl]cyanamide | IC50 | 81.0 [1], 665.0 [2] |
 | [(1R)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 96.0 [1], 844.0 [2] |
 | N-[(1R,3S)-3-(Cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]methanesulfonamide | IC50 | 97.0 [1], 1918.0 [2] |
 | [1-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydroinden-1-yl]cyanamide | IC50 | 8.0 [1], 94.0 [2] |
 | [(1S)-6-[5-[3-(Hydroxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 733.0 [1], 9604.0 [2] |
 | N-[(1R,3S)-3-(Cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2-methoxyethanesulfonamide | IC50 | 775.0 [1], 8652.0 [2] |
 | [6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 113.0 [1], 909.0 [2] |
 | 6-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1,4-benzoxazine-4-carbonitrile | IC50 | 991.0 [1], 6501.0 [2] |
 | [6-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3,4-dihydro-2H-chromen-4-yl]cyanamide | IC50 | 369.0 [1], 3776.0 [2] |
 | N-[3-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]prop-2-enamide | IC50 | 4163.0 [1], 10000.0 [2] |
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