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Tyrosine-protein kinase Lyn Inhibitors (IC50, Ki)

Structure
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Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
StaurosporineIC501.3 [1]
IbrutinibIC5016.2 [1], 200.0 [2]
(E)-4-(Dimethylamino)-N-[7-fluoro-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamideIC50353.0 [1], 624.0 [2]
NintedanibIC50195.0 [1]
BosutinibIC508.0 [1]
CeritinibIC50840.0 [1], 2306.0 [2]
Tak-285IC505200.0 [1], 10000.0 [2]
CID 44462758IC50199.0 [1], 238.0 [2]
7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-AmineIC5029.0 [1], 430.0 [2]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineKi25.9 [1]
CID 118295624IC50631.0 [1], 639.0 [2]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
N-[4-[4-Amino-7-[(E)-3-[(4-aminocyclohexyl)amino]prop-1-enyl]thieno[3,2-c]pyridin-3-yl]-2-methoxyphenyl]-1-methylindole-2-carboxamideIC5012900.0 [1], 18500.0 [2]
2-Amino-N-[2-[4-[4-(1,2-benzothiazol-4-yloxy)-3-chloroanilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-2-methylpropanamideIC503000.0 [1], 7100.0 [2]
Infigratinib phosphateIC50300.0 [1], 3019.0 [2]
(E)-N-[7-Chloro-4-(5-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamideIC503020.0 [1], 3390.0 [2]
N-[2-[4-[3-Chloro-4-(3-chlorophenoxy)anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-2-methyl-2-methylsulfonylpropanamide;4-methylbenzenesulfonic acidIC503300.0 [1], 3600.0 [2]
4-[4-(1-Benzothiophen-4-yloxy)-3-chloroanilino]-N-(2-hydroxyethyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxamideIC503000.0 [1], 9800.0 [2]
4-Amino-8-(5-Methyl-1h-Indazol-6-Yl)cinnoline-3-CarboxamideIC5054.0 [1], 82.0 [2]
2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]-IC501.2 [1]
ImatinibIC50220.0 [1]
NilotinibIC501281.0 [1]
HarmineIC50250000.0 [1]
PCI-32765 RacemateKi14.0 [1]
NiclosamideIC5023800.0 [1]
PonatinibIC500.24 [1]
Su6656IC50130.0 [1]
DoramapimodIC50960.0 [1]
Nvp-aew541IC501400.0 [1]
LinifanibIC5050000.0 [1]
Nvp-tae 684IC501308.0 [1]
DanusertibIC5010000.0 [1]
BafetinibIC5011.0 [1]
Cudc-101IC50840.0 [1]
TamatinibIC50732.0 [1]
MilciclibIC5010000.0 [1]
4-(4-Butylpiperidin-1-yl)-1-o-tolylbutan-1-oneKi1000.0 [1]
4-Amino-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl-CyclopentaneIC50420.0 [1]
1,4-DiaminoanthraquinoneIC5040000.0 [1]
Amg-458IC50506.0 [1]
1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-olIC500.4 [1]
SpebrutinibIC504400.0 [1]
A-770041IC501180.0 [1]
CID 44219749IC5050000.0 [1]
JNK Inhibitor VIIIKi1700.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
CID 59604787IC5010000.0 [1]
3-[[2-[3-(Morpholin-4-ylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenolIC504.3 [1]
2-{[(3r,4r)-3-Aminotetrahydro-2h-Pyran-4-Yl]amino}-4-[(4-Methylphenyl)amino]pyrimidine-5-CarboxamideIC503981.07 [1]
N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamideIC504.0 [1]
CID 44814409IC5010000.0 [1]
N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamideIC5010000.0 [1]
N-Cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamideIC5027.0 [1]
3-N-[4-(4-Morpholin-4-ylcyclohexyl)phenyl]-1-pyridin-2-yl-1,2,4-triazole-3,5-diamineKi400.0 [1]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC5021.0 [1]
N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-4-cyanobenzamideIC5010000.0 [1]
Lck inhibitor 2IC503.0 [1]
N-[1-[3-(3-Oxo-1,4-benzoxazin-4-yl)propyl]piperidin-4-yl]-2-phenylacetamideKi1000.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC5010000.0 [1]
(2R)-2-[(2S)-4-[3-Chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi1000.0 [1]
Unii-8FX9DP2Y1WIC500.5 [1]
3-Fluoro-4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC5035.0 [1]
4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamideIC504.8 [1]
3-Bromo-4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamideIC503.1 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi1700.0 [1]
Lck InhibitorIC5021.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi1600.0 [1]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-[2-(1-oxidopyrrolidin-1-ium-1-yl)ethoxy]phenyl]-1,2,4-benzotriazin-3-amineKi4.19 [1]
8-Bromo-4-(3-chloro-4-fluoroanilino)-6-[(1-methylimidazol-4-yl)methylamino]quinoline-3-carbonitrileIC5030000.0 [1]
1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-7-(4-piperidinyl)-1,2,3,4-tetrahydroquinazoline-2-oneIC5010000.0 [1]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrileIC5010000.0 [1]
(2e)-3-{3-[6-(4-Methyl-1,4-Diazepan-1-Yl)pyrazin-2-Yl]phenyl}prop-2-Enoic AcidKi10000.0 [1]
4-(4-Methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrileIC5010000.0 [1]
Pyrazolo[1,5-a]pyrimidine-3-carboxylateIC5010000.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi1667.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamideIC508.5 [1]
Tert-butyl N-[3-[3-[4-(2-methoxyphenyl)-2,5-dioxopyrrol-3-yl]pyrrolo[2,3-b]pyridin-1-yl]propyl]carbamateIC501800.0 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
6-(6,7-Dimethoxyquinolin-4-yl)oxy-N-(2-methoxyethyl)naphthalene-1-carboxamideIC50275.0 [1]
3-[4-(3-Amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl]-1-[3-(trifluoromethyl)phenyl]ureaIC5050000.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
6-(6,7-Dimethoxyquinolin-4-yl)oxynaphthalene-1-carboxamideIC5088.0 [1]
4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamideIC5025.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi1700.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi1700.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi1700.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi1700.0 [1]
3-[(4-Morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[3,2-c]pyrazole-5-carboxamideIC5010000.0 [1]
2-[[N-[2-[3-Ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-5-(hydroxymethyl)-2-methylanilino]methyl]benzonitrileIC5031.0 [1]
7-{[(1r,2s)-2-Aminocyclohexyl]amino}-5-(1h-Indol-7-Ylamino)pyrido[4,3-D]pyrimidin-4(3h)-OneIC50112.0 [1]
Ripk1-IN-7IC5085.0 [1]
N-(2-Chloro-6-fluorobenzyl)-5-(furan-2-yl)-2H-1,2,4-triazol-3-amineIC50500.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
N-[2-[3-(Dimethylamino)propyl-methylamino]-5-(trifluoromethyl)phenyl]-2-fluoro-5-[3-[4-(methylamino)-1,3,5-triazin-2-yl]pyridin-2-yl]oxybenzamideIC504900.0 [1]
3-[[4-(5-Hydroxy-2-methylanilino)pyrimidin-2-yl]amino]benzenesulfonamideIC501.0 [1]
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC5050000.0 [1]
(S)-IbrutinibIC50200.0 [1]
2-[3-[(Dimethylamino)methyl]phenyl]-4-[(4-methyl-1H-indol-5-yl)amino]thieno[2,3-b]pyridine-5-carbonitrileIC50520.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase Lyn Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-lyn-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Tyrosine-protein kinase Lyn Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-lyn-inhibitors-ic50-ki.
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