Tyrosine-protein kinase receptor FLT3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Quizartinib	IC50	39.0 [1]
	Staurosporine	IC50	1.0 [1]
	Sorafenib	IC50	33.0 [1]
	Sunitinib	IC50	9.9 [1]
	N-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-4-(thieno[2,3-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide	IC50	1.85 [1]
	Tandutinib	IC50	102.0 [1]
	4-[(2-Methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino]-N-(4-piperazin-1-ylphenyl)-1H-pyrazole-5-carboxamide	IC50	8.74 [1]
	Linifanib	IC50	7.0 [1]
	3-[1-[3-(Dimethylamino)propyl]pyrazol-4-yl]-7-(1H-pyrazol-4-yl)-5H-indeno[1,2-b]indol-10-one	IC50	4.0 [1]
	Cabozantinib	IC50	6.0 [1], 11.3 [2], 25.0 [3], 7500.0 [4]
	Tozasertib	IC50	30.0 [1]
	Tozasertib	Ki	30.0 [1]
	Lestaurtinib	IC50	1.5 [1], 2.5 [2], 2.6 [3], 5.0 [4], 8.2 [5]
	Foretinib	IC50	3.6 [1], 5.58 [2]
	3-N-[4-(4-Morpholin-4-ylcyclohexyl)phenyl]-1-pyridin-2-yl-1,2,4-triazole-3,5-diamine	IC50	1.3 [1]
	3-N-[4-(4-Morpholin-4-ylcyclohexyl)phenyl]-1-pyridin-2-yl-1,2,4-triazole-3,5-diamine	Ki	0.17 [1], 2.0 [2], 5.0 [3]
	1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[4-(1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)phenyl]urea	IC50	1.0 [1], 3.0 [2], 4.0 [3], 39.0 [4]
	1-(5-Ethyl-1,2-oxazol-3-yl)-3-[4-[2-[[6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl]amino]-1,3-thiazol-5-yl]phenyl]urea	IC50	10.0 [1], 38.0 [2]
	(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione	IC50	1.59 [1], 11.0 [2], 36.0 [3], 62.0 [4]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	18.0 [1], 166.0 [2], 270.0 [3]
	Flt-3 Inhibitor II	IC50	33.0 [1], 40.0 [2], 100.0 [3]
	1-[(5,6-Dimethyl-2-thiophen-2-ylthieno[2,3-d]pyrimidin-4-yl)amino]-3-methylpyrrole-2,5-dione	IC50	11.38 [1], 13.68 [2]
	1-[[6-(Hydroxymethyl)-5-methyl-2-thiophen-2-ylthieno[2,3-d]pyrimidin-4-yl]amino]-3-methylpyrrole-2,5-dione	IC50	91.23 [1], 112.0 [2], 156.0 [3], 175.0 [4]
	4-N-(3,5-Dimethoxyphenyl)-4-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-1-N-propan-2-ylcyclohexane-1,4-diamine	IC50	3801.89 [1], 5370.32 [2], 8511.38 [3], 10000.0 [4]
	3-Methyl-1-[[5-methyl-6-[4-[2-(methylamino)ethoxy]phenyl]-2-thiophen-2-ylthieno[2,3-d]pyrimidin-4-yl]amino]pyrrole-2,5-dione	IC50	8.03 [1], 10.15 [2], 11.1 [3]
	Palbociclib	IC50	3000.0 [1], 3480.0 [2], 10000.0 [3]
	Midostaurin	IC50	13.0 [1], 15.0 [2], 37.0 [3]
	Nvp-tae 684	IC50	3.0 [1], 554.0 [2], 3000.0 [3]
	Bemcentinib	IC50	0.9 [1], 2.0 [2], 6.0 [3]
	(16E)-14-Methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaene	IC50	21.0 [1], 42.0 [2], 56.0 [3]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	IC50	25.12 [1], 88.0 [2]
	4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine	Ki	44.0 [1]
	4-[2-(Butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	0.35 [1], 0.8 [2], 14.0 [3]
	Amg-925	IC50	1.0 [1], 1.5 [2], 5.0 [3]
	4-[5-[4-[(4-Methyl-1,4-diazepan-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	2.5 [1], 39.0 [2], 70.0 [3]
	Flt3-IN-3	IC50	3.0 [1], 8.0 [2], 13.0 [3]
	2-N-(4-Aminocyclohexyl)-9-cyclopentyl-6-N-(4-morpholin-4-ylphenyl)purine-2,6-diamine	IC50	2.0 [1], 7.0 [2], 21.0 [3]
	Propan-2-yl 2-hydroxy-4-methoxy-6-[(E)-3-(prop-2-enoylamino)prop-1-enyl]benzoate	IC50	30000.0 [1]
	Propan-2-yl 4-[2-(4-fluorophenyl)ethoxy]-2-hydroxy-6-[(E)-3-(prop-2-enoylamino)prop-1-enyl]benzoate	IC50	8310.0 [1], 30000.0 [2]
	Propan-2-yl 2-hydroxy-4-(3-morpholin-4-ylpropoxy)-6-[(E)-3-(prop-2-enoylamino)prop-1-enyl]benzoate	IC50	500.0 [1], 2810.0 [2], 9610.0 [3]
	Propan-2-yl 2-[(E)-3-[[(E)-4-(diethylamino)but-2-enoyl]amino]prop-1-enyl]-4-[2-(4-fluorophenyl)ethoxy]-6-hydroxybenzoate	IC50	1110.0 [1], 30000.0 [2]
	Propan-2-yl 2-[(E)-3-(ethenylsulfonylamino)prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	2250.0 [1], 10820.0 [2], 12030.0 [3]
	Propan-2-yl 2-[3-(ethenylsulfonylamino)propyl]-6-hydroxy-4-(2-morpholin-4-ylethoxy)benzoate	IC50	4230.0 [1], 18590.0 [2], 30000.0 [3]
	(4-Bromophenyl)methyl 2-[(E)-3-(ethenylsulfonylamino)prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	30000.0 [1]
	(4-Fluorophenyl)methyl 2-[(E)-3-(ethenylsulfonylamino)prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	30000.0 [1]
	Cyclohexylmethyl 2-[(E)-3-(ethenylsulfonylamino)prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	30000.0 [1]
	2-Phenylpropyl 2-[(E)-3-(ethenylsulfonylamino)prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	30000.0 [1]
	Propan-2-yl 2-acetyloxy-6-[(E)-3-(2,5-dioxopyrrol-1-yl)prop-1-enyl]-4-methoxybenzoate	IC50	3370.0 [1], 3610.0 [2], 21800.0 [3]
	Propan-2-yl 2-[(E)-3-(2,5-dioxopyrrol-1-yl)prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	540.0 [1], 1340.0 [2], 9790.0 [3]
	Propan-2-yl 2-[3-(2,5-dioxopyrrol-1-yl)propyl]-6-hydroxy-4-methoxybenzoate	IC50	430.0 [1], 3030.0 [2], 13180.0 [3]
	Propan-2-yl 2-[(E)-3-(2,5-dioxopyrrol-1-yl)prop-1-enyl]-6-hydroxy-4-(3-morpholin-4-ylpropoxy)benzoate	IC50	150.0 [1], 940.0 [2], 980.0 [3]
	Propan-2-yl 2-[3-(2,5-dioxopyrrol-1-yl)propyl]-6-hydroxy-4-(2-morpholin-4-ylethoxy)benzoate	IC50	580.0 [1], 810.0 [2], 8870.0 [3]
	(4-Bromophenyl)methyl 2-[(E)-3-(2,5-dioxopyrrol-1-yl)prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	1740.0 [1], 1900.0 [2], 30000.0 [3]
	(4-Fluorophenyl)methyl 2-[(E)-3-(2,5-dioxopyrrol-1-yl)prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	950.0 [1], 1640.0 [2], 30000.0 [3]
	Cyclohexylmethyl 2-[(E)-3-(2,5-dioxopyrrol-1-yl)prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	2100.0 [1], 2690.0 [2], 30000.0 [3]
	2-Phenylpropyl 2-[(E)-3-(2,5-dioxopyrrol-1-yl)prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	3010.0 [1], 5200.0 [2], 30000.0 [3]
	Propan-2-yl 2-[(E)-3-[[(E)-but-2-enoyl]amino]prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	30000.0 [1]
	Propan-2-yl 2-[(E)-3-[[(E)-but-2-enoyl]amino]prop-1-enyl]-4-[2-(4-fluorophenyl)ethoxy]-6-hydroxybenzoate	IC50	30000.0 [1]
	[(2S)-3-Methylbutan-2-yl] 2-hydroxy-4-methoxy-6-[(E)-3-(prop-2-enoylamino)prop-1-enyl]benzoate	IC50	30000.0 [1]
	[(2S)-3-Methylbutan-2-yl] 2-[(E)-3-[[(E)-4-(diethylamino)but-2-enoyl]amino]prop-1-enyl]-6-hydroxy-4-methoxybenzoate	IC50	30000.0 [1]
	2-N-(5-Aminopentyl)-9-cyclopentyl-6-N-[4-(morpholin-4-ylmethyl)phenyl]purine-2,6-diamine	IC50	5.0 [1], 25.0 [2], 65.0 [3]
	2-N-(4-Aminocyclohexyl)-9-cyclopentyl-6-N-(4-pyrrolidin-1-ylphenyl)purine-2,6-diamine	IC50	3.0 [1], 11.0 [2], 21.0 [3]
	2-N-(4-Aminobutyl)-9-cyclopentyl-6-N-(4-morpholin-4-ylphenyl)purine-2,6-diamine	IC50	4.0 [1], 7.0 [2], 23.0 [3]
	2-N-(6-Aminohexyl)-9-cyclopentyl-6-N-[4-(morpholin-4-ylmethyl)phenyl]purine-2,6-diamine	IC50	10.0 [1], 21.0 [2], 69.0 [3]
	2-N-(4-Aminobutyl)-9-cyclopentyl-6-N-[4-(morpholin-4-ylmethyl)phenyl]purine-2,6-diamine	IC50	1.0 [1], 5.0 [2], 6.0 [3]
	1-(Cyclopentylmethyl)-N-methyl-3-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]pyrazolo[3,4-d]pyrimidin-6-amine	IC50	8.0 [1], 12.0 [2], 30.0 [3]
	2-N-Benzyl-9-cyclopentyl-6-N-[4-(morpholin-4-ylmethyl)phenyl]purine-2,6-diamine	IC50	26.0 [1], 83.0 [2], 624.0 [3]
	2-N-(4-Aminobutyl)-9-cyclopentyl-6-N-[4-(4-ethylpiperazin-1-yl)phenyl]purine-2,6-diamine	IC50	1.0 [1], 3.0 [2], 13.0 [3]
	1-(Cyclopentylmethyl)-N-methyl-3-[4-(4-methylpiperazin-1-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-amine	IC50	1.4 [1], 4.0 [2], 11.0 [3]
	2-N-(4-Aminocyclohexyl)-9-cyclopentyl-6-N-[4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl]purine-2,6-diamine	IC50	4.0 [1], 13.0 [2], 28.0 [3]
	2-N-(4-Aminocyclohexyl)-6-N-(4-bromophenyl)-9-cyclopentylpurine-2,6-diamine	IC50	4.0 [1], 16.0 [2]
	2-N-(4-Aminocyclohexyl)-9-cyclopentyl-6-N-[4-(4-ethylpiperazin-1-yl)phenyl]purine-2,6-diamine	IC50	2.0 [1], 3.0 [2], 10.0 [3]
	N-[5-[6-(Methylamino)pyrazin-2-yl]-2-oxo-1H-pyridin-3-yl]-4-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]benzamide	Ki	20.0 [1], 1000.0 [2]
	5-Fluoro-3-[[4-[2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethoxy]-3-methylazulen-1-yl]methylidene]-1H-indol-2-one	IC50	67.0 [1], 70.0 [2], 98.0 [3]
	N-[5-[4-[[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]methyl]phenyl]-1H-pyrazol-3-yl]-4-(2-morpholin-4-ylethoxy)benzamide	IC50	1.0 [1], 18.0 [2]
	Nintedanib	IC50	26.0 [1]
	Ceritinib	IC50	60.0 [1], 3143.0 [2]
	Dovitinib	IC50	1.0 [1], 3.0 [2]
	Pexidartinib	IC50	5.0 [1], 130.0 [2]
	6,7-Dimethyl-2-phenylquinoxaline	IC50	1100.0 [1]
	Crenolanib	IC50	3.0 [1], 4.0 [2]
	Bms-777607	IC50	16.0 [1], 18.0 [2]
	1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea	IC50	10.0 [1]
	Erdafitinib	IC50	5.0 [1], 10000.0 [2]
	KW-2449	IC50	13.1 [1], 14.8 [2]
	3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine	IC50	4.0 [1], 560.0 [2]
	JNJ-28312141 free base	IC50	21.0 [1], 30.0 [2]
	Flt-3 inhibitor	IC50	42.0 [1], 2900.0 [2]
	CID 44545852	IC50	134.0 [1], 10000.0 [2]
	Mivavotinib	IC50	4.6 [1], 22.0 [2]
	Tafetinib	IC50	1.3 [1], 5.0 [2]
	2-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide	IC50	7.0 [1]
	11-(2-Pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(24),2(27),3,5,8(26),9,11,16,21(25),22-decaene	IC50	6.0 [1], 22.0 [2]
	2-(6,7-Dimethoxyquinazolin-4-yl)sulfanyl-1,3-thiazole	IC50	7.0 [1]
	CID 56673651	IC50	11.0 [1], 13.0 [2]
	2-[4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenyl]-N-(1-propan-2-ylpyrazol-4-yl)acetamide	IC50	20.0 [1]
	N-Phenyl-1H-indazole-3-carboxamide	IC50	350.0 [1], 417.0 [2]
	2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]acetic acid	IC50	28.0 [1], 32.0 [2]
	(2S)-2-[[4-[4-Amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methylpentanoic acid	IC50	14.0 [1], 23.0 [2]
	3-Methyl-1-[(6-methyl-2-thiophen-2-ylthieno[2,3-d]pyrimidin-4-yl)amino]pyrrole-2,5-dione	IC50	14.66 [1], 16.78 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Tyrosine-protein kinase receptor FLT3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-receptor-flt3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Tyrosine-protein kinase receptor FLT3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-receptor-flt3-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan