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Tyrosine-protein kinase receptor TYRO3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-[2-(Butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC505.83 [1], 17.0 [2], 301.0 [3]
CrizotinibIC50100.0 [1], 10000.0 [2]
BemcentinibIC5017.0 [1], 700.0 [2]
1-[(trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4-Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-AmineIC5048.0 [1]
4-[5-[4-[(4-Methyl-1,4-diazepan-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC503.1 [1], 9.1 [2]
3-Amino-N-(5-hydroxy-2-adamantyl)-6-[3-(1-methylpyrazol-4-yl)phenyl]pyrazine-2-carboxamideIC5020.0 [1], 40.0 [2]
4-(Cyclopentylamino)-2-[(2-methoxyphenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC50400.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC50355.0 [1], 360.0 [2]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamideIC5070.0 [1]
1-[(4-Aminocyclohexyl)methyl]-N-methyl-3-phenylpyrazolo[3,4-d]pyrimidin-6-amineIC501400.0 [1], 4800.0 [2]
4-[[6-(Methylamino)-3-phenylpyrazolo[3,4-d]pyrimidin-1-yl]methyl]cyclohexan-1-olIC502800.0 [1], 3500.0 [2]
3-Amino-N-(5-hydroxy-2-adamantyl)-6-[3-(methanesulfonamido)phenyl]pyrazine-2-carboxamideIC50380.0 [1], 650.0 [2]
3-Amino-N-(5-hydroxy-2-adamantyl)-6-[3-[1-(2-hydroxyethyl)pyrazol-4-yl]phenyl]pyrazine-2-carboxamideIC5060.0 [1]
3-Amino-N-(5-hydroxy-2-adamantyl)-6-(1H-indazol-6-yl)pyrazine-2-carboxamideIC50100.0 [1], 180.0 [2]
3-Amino-6-[3-(1-ethylpyrazol-4-yl)phenyl]-N-(5-hydroxy-2-adamantyl)pyrazine-2-carboxamideIC5020.0 [1], 30.0 [2]
StaurosporineIC5048.99 [1]
Bms-777607IC504.3 [1]
CID 59604787IC5010000.0 [1]
2-{[(3r,4r)-3-Aminotetrahydro-2h-Pyran-4-Yl]amino}-4-[(4-Methylphenyl)amino]pyrimidine-5-CarboxamideIC5040.0 [1]
Unii-T7755XP5Y6IC5060.0 [1]
4-[[2-(Butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-olIC50100.0 [1]
2-(Butylamino)-4-[(4-hydroxycyclohexyl)amino]-N-[(4-imidazol-1-ylphenyl)methyl]pyrimidine-5-carboxamideIC50250.0 [1]
6,6-Dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC5071.9 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC501030.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
1-[(4-Aminocyclohexyl)methyl]-N-methyl-3-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amineIC50260.0 [1]
CID 71553154IC500.7 [1]
6-(6-Fluoroindol-1-yl)-2-[2-[7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyethyl]pyridazin-3-oneIC501000.0 [1]
(7S)-7-Amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamideIC50220.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
4-[5-[4-(Morpholin-4-ylmethyl)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5010.0 [1]
4-[5-[3-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5029.0 [1]
4-[2-(Butylamino)-5-[4-(piperidin-4-ylamino)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5034.0 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2R)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5013.0 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-(pentan-2-ylamino)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC506.7 [1]
4-[2-[[(2S)-Heptan-2-yl]amino]-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC506.9 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5012.0 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-1,1,1-trifluoropentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50151.0 [1]
4-[2-(2-Methylbutylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5012.0 [1]
4-[2-(2-Ethylbutylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC506.7 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2R)-1,1,1-trifluoropentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5099.0 [1]
4-[2-[[(2S)-Hexan-2-yl]amino]-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC504.3 [1]
4-[5-[4-[[2-(Diethylamino)ethylamino]methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC504.4 [1]
4-[2-[[(2S)-Pentan-2-yl]amino]-5-[4-(piperidin-4-ylamino)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5026.0 [1]
4-[5-[4-(Cyclohexylamino)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50850.0 [1]
4-[5-[4-(7-Azabicyclo[2.2.1]heptan-7-ylmethyl)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC503.4 [1]
4-[5-[2-Fluoro-4-(4-methylpiperazin-1-yl)sulfonylphenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5033.0 [1]
4-[2-(Butylamino)-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC501662.0 [1]
4-[2-(Butylamino)-5-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5022.0 [1]
2-Fluoro-4-[8-fluoro-3-(quinolin-6-ylmethyl)imidazo[1,2-a]pyridin-6-yl]-N-methylbenzamideIC5010000.0 [1]
2-[4-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acidIC505200.0 [1]
1-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-olIC505000.0 [1]
6-(1-Methylpyrazol-4-yl)-2-[[3-[[5-(1-methylpyrazol-4-yl)pyrimidin-2-yl]amino]phenyl]methyl]pyridazin-3-oneIC501000.0 [1]
6-[Difluoro-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinolineIC501000.0 [1]
18-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,13,15,21-tetrazatricyclo[12.5.2.017,20]henicosa-14,16,18,20-tetraen-5-olIC5025.0 [1]
19-Pyridin-2-yl-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50690.0 [1]
19-(4-Fluorophenyl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC501300.0 [1]
(6S)-6-Amino-20-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,8,15,17,23-pentazatricyclo[14.5.2.019,22]tricosa-16,18,20,22-tetraen-7-oneIC5013.0 [1]
19-(4-Methoxyphenyl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50940.0 [1]
19-Pyridin-3-yl-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50210.0 [1]
19-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC5031.0 [1]
17-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,12,14,20-tetrazatricyclo[11.5.2.016,19]icosa-13,15,17,19-tetraen-6-olIC50170.0 [1]
19-(Oxan-4-yl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC501200.0 [1]
N-[4-(6-Hydroxy-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-19-yl)phenyl]morpholine-4-carboxamideIC50300.0 [1]
19-(3-Methoxyphenyl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC501200.0 [1]
[4-(6-Hydroxy-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-19-yl)phenyl]-morpholin-4-ylmethanoneIC5078.0 [1]
19-Phenyl-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC501800.0 [1]
18-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,13,15,21-tetrazatricyclo[12.5.2.017,20]henicosa-14,16,18,20-tetraen-6-olIC5094.0 [1]
19-(2-Methoxyphenyl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC501100.0 [1]
19-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-5-olIC5054.0 [1]
16-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,11,13,19-tetrazatricyclo[10.5.2.015,18]nonadeca-12,14,16,18-tetraen-5-olIC5053.0 [1]
20-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,15,17,23-tetrazatricyclo[14.5.2.019,22]tricosa-16,18,20,22-tetraen-7-olIC5038.0 [1]
16-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,6,11,13,19-pentazatricyclo[10.5.2.015,18]nonadeca-12,14,16,18-tetraen-5-oneIC502000.0 [1]
18-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,13,15,21-tetrazatricyclo[12.5.2.017,20]henicosa-14,16,18,20-tetraen-7-olIC5057.0 [1]
(5S)-5-Amino-19-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,7,14,16,22-pentazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-oneIC50110.0 [1]
(6S)-6-Amino-22-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,8,17,19,25-pentazatricyclo[16.5.2.021,24]pentacosa-18,20,22,24-tetraen-7-oneIC507.5 [1]
19-(4-Morpholin-4-ylsulfonylphenyl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50190.0 [1]
20-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,15,17,23-tetrazatricyclo[14.5.2.019,22]tricosa-16,18,20,22-tetraen-6-olIC5022.0 [1]
(5S)-5-Amino-21-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,7,16,18,24-pentazatricyclo[15.5.2.020,23]tetracosa-17,19,21,23-tetraen-6-oneIC50170.0 [1]
19-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-7-olIC5044.0 [1]
(5S)-5-Amino-17-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,7,12,14,20-pentazatricyclo[11.5.2.016,19]icosa-13,15,17,19-tetraen-6-oneIC5039.0 [1]
19-Pyridin-4-yl-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50170.0 [1]
19-(4-Morpholin-4-ylphenyl)-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50350.0 [1]
(6S)-6-Amino-18-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,8,13,15,21-pentazatricyclo[12.5.2.017,20]henicosa-14,16,18,20-tetraen-7-oneIC50130.0 [1]
17-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,12,14,20-tetrazatricyclo[11.5.2.016,19]icosa-13,15,17,19-tetraen-5-olIC5060.0 [1]
19-[4-(Morpholin-4-ylmethyl)phenyl]-1,14,16,22-tetrazatricyclo[13.5.2.018,21]docosa-15,17,19,21-tetraen-6-olIC50300.0 [1]
21-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-1,16,18,24-tetrazatricyclo[15.5.2.020,23]tetracosa-17,19,21,23-tetraen-7-olIC5049.0 [1]
4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-isoquinolin-6-ylpyridin-2-yl]phenolIC501000.0 [1]
5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-oneIC5010000.0 [1]
4-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC501000.0 [1]
5-Fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC501000.0 [1]
4-Chloro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenolIC501000.0 [1]
4-[2-[[(2R)-1-Hydroxyhexan-2-yl]amino]-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50143.0 [1]
1-(Cyclopentylmethyl)-3-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]-N-methylpyrazolo[3,4-d]pyrimidin-6-amineIC5010000.0 [1]
1-[(1-Benzyltriazol-4-yl)methyl]-N-methyl-3-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amineIC5010000.0 [1]
1-(Cyclopentylmethyl)-N-methyl-3-(6-piperazin-1-ylpyridin-3-yl)pyrazolo[3,4-d]pyrimidin-6-amineIC5010000.0 [1]
1-[(1-Benzyltriazol-4-yl)methyl]-N-methyl-3-(6-piperazin-1-ylpyridin-3-yl)pyrazolo[3,4-d]pyrimidin-6-amineIC5010000.0 [1]
1-(Cyclopentylmethyl)-N-methyl-3-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]pyrazolo[3,4-d]pyrimidin-6-amineIC503670.0 [1]
Items per page: 1 - 10 of 100
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References

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MLA

"Quest Database™ Tyrosine-protein kinase receptor TYRO3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-receptor-tyro3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Tyrosine-protein kinase receptor TYRO3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-receptor-tyro3-inhibitors-ic50-ki.
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