Tyrosine-protein kinase receptor UFO Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Cabozantinib	IC50	7.0 [1]
	Crizotinib	IC50	1.0 [1], 100.0 [2], 294.0 [3], 300.0 [4]
	Bosutinib	IC50	174.0 [1], 340.0 [2], 560.0 [3]
	Bemcentinib	IC50	0.7 [1], 14.0 [2], 30.0 [3]
	4-[2-(Butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	1.65 [1], 14.0 [2], 122.0 [3]
	1-[(trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4-Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-Amine	IC50	37.0 [1]
	4-[5-[4-[(4-Methyl-1,4-diazepan-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	12.1 [1], 80.0 [2], 859.0 [3]
	Staurosporine	IC50	3.0 [1], 40.0 [2]
	Sunitinib	IC50	9.0 [1]
	Foretinib	IC50	11.0 [1], 100.0 [2]
	Bms-777607	IC50	1.1 [1]
	Merestinib	IC50	2.0 [1], 11.0 [2]
	JNJ-28312141 free base	IC50	12.0 [1], 2600.0 [2]
	c-FMS inhibitor	IC50	6.4 [1]
	CID 46194178	IC50	10.0 [1], 500.0 [2]
	Exelixis	IC50	7.0 [1], 42.0 [2]
	CID 49870909	IC50	7.0 [1], 56.0 [2]
	CID 46870258	IC50	58.0 [1], 1000.0 [2]
	1-[(4-Aminocyclohexyl)methyl]-N-methyl-3-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amine	IC50	14.0 [1], 140.0 [2]
	6-[6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]-1'-methylspiro[1H-indole-3,4'-piperidine]-2-one	IC50	28.9 [1], 300000.0 [2]
	1-[(4-Aminocyclohexyl)methyl]-N-methyl-3-phenylpyrazolo[3,4-d]pyrimidin-6-amine	IC50	81.0 [1], 370.0 [2]
	4-[[6-(Methylamino)-3-phenylpyrazolo[3,4-d]pyrimidin-1-yl]methyl]cyclohexan-1-ol	IC50	83.0 [1], 190.0 [2]
	Quercetin	IC50	960.0 [1]
	Doramapimod	IC50	30000.0 [1]
	Sotrastaurin	IC50	9100.0 [1]
	Nvp-aew541	IC50	10000.0 [1]
	CID 53469448	IC50	2705.0 [1]
	Gilteritinib	IC50	1.0 [1]
	Amuvatinib	IC50	1000.0 [1]
	1-(3-Chlorophenyl)-3-{5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)ethyl]-1,3-Thiazol-2-Yl}urea	IC50	84.0 [1]
	Norlichexanthone	IC50	100000.0 [1]
	TP-0903	IC50	27.0 [1]
	(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione	IC50	10000.0 [1]
	CID 59604787	IC50	10000.0 [1]
	CID 44155856	IC50	3.0 [1]
	Unii-T7755XP5Y6	IC50	85.0 [1]
	4-[[2-(Butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-ol	IC50	270.0 [1]
	R428 (BGB324; Bemcentinib)	IC50	14.0 [1]
	CID 56847486	IC50	19.0 [1]
	2,3,6,8-Tetrahydroxy-1-methylxanthone	IC50	6600.0 [1]
	Epicoccolide B	IC50	220.0 [1]
	4-(5-Phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	IC50	182.0 [1]
	3-N-[4-(4-Morpholin-4-ylcyclohexyl)phenyl]-1-pyridin-2-yl-1,2,4-triazole-3,5-diamine	Ki	40.0 [1]
	Astrogorgiadiol B	IC50	16900.0 [1]
	2-(Butylamino)-4-[(4-hydroxycyclohexyl)amino]-N-[(4-imidazol-1-ylphenyl)methyl]pyrimidine-5-carboxamide	IC50	360.0 [1]
	(1S,9R)-5,6,12,13,14-Pentahydroxy-4,11-dimethyl-16-oxo-8,17-dioxatetracyclo[7.7.1.02,7.010,15]heptadeca-2(7),3,5,10,12,14-hexaene-3-carbaldehyde	IC50	160.0 [1]
	(1R,3As,4S,5R,7aR)-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-1-[(2R)-6-methyl-5-methylideneheptan-2-yl]-1,2,3,3a,4,5,6,7-octahydroinden-5-ol	IC50	100000.0 [1]
	Calicoferol B	IC50	100000.0 [1]
	6,6-Dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile	IC50	170.0 [1]
	Calicoferol E	IC50	32600.0 [1]
	2-Amino-N-[3-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]acetamide	IC50	1000.0 [1]
	1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanone	IC50	100000.0 [1]
	Ripk1-IN-7	IC50	35.0 [1]
	(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dione	IC50	1000.0 [1]
	8-(2,3-Dihydro-1H-inden-5-yl)-2-[4-(4-methylpiperazin-1-yl)anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide	IC50	300.0 [1]
	8-(2,3-Dihydro-1H-inden-5-yl)-2-[4-[2-(4-methylpiperazin-1-yl)ethyl]anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide	IC50	500.0 [1]
	Methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate	IC50	10000.0 [1]
	[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	IC50	50000.0 [1]
	1-(2,6-Dichlorophenyl)-3-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimidin-4-yl)urea	IC50	10000.0 [1]
	3-Hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenylamino-phenylamino)-isothiazole-4-carboxamidine	IC50	389.0 [1]
	3-(4-(1H-Tetrazol-5-yl)phenyl)-5-phenyl-1H-pyrrolo[2,3-b]pyridine	IC50	524.0 [1]
	N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamide	IC50	10000.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile	IC50	10000.0 [1]
	N-[5-[(Z)-(5-Fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-3-(4-methylpiperazin-1-yl)propanamide	Ki	63.0 [1]
	3,5-Diphenyl-1H-pyrrolo[2,3-b]pyridine	IC50	4060.0 [1]
	N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide	IC50	50000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	4-(Cyclopentylamino)-2-[(2-methoxyphenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamide	IC50	5700.0 [1]
	4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamide	IC50	3200.0 [1]
	4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide	IC50	3990.0 [1]
	6-(6-Fluoroindol-1-yl)-2-[2-[7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyethyl]pyridazin-3-one	IC50	1000.0 [1]
	(7S)-7-Amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide	IC50	120.0 [1]
	5-[1-(Cyclopropylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine	IC50	448.0 [1]
	(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one	IC50	100000.0 [1]
	Calicoferol A	IC50	14700.0 [1]
	(1R,3As,4S,7aR)-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-1-[(2R)-6-methyl-5-methylideneheptan-2-yl]-2,3,3a,4,6,7-hexahydro-1H-inden-5-one	IC50	20200.0 [1]
	5-Phenyl-1H-pyrrolo[2,3-b]pyridine	IC50	10000.0 [1]
	Methyl 3-[[(1R,2S,4aR,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-4,5-dihydroxybenzoate	IC50	13100.0 [1]
	N-(1H-Pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide	IC50	10000.0 [1]
	N-Pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide	IC50	10000.0 [1]
	5-Cyano-N-[2-(cyclohexen-1-yl)-4-[1-(2-methylsulfonylethyl)piperidin-4-yl]phenyl]-1H-imidazole-2-carboxamide	IC50	16.0 [1]
	5-Cyano-N-[2-(cyclohexen-1-yl)-4-[1-(2-morpholin-4-ylethyl)piperidin-4-yl]phenyl]-1H-imidazole-2-carboxamide	IC50	6.0 [1]
	4-[5-[4-(Morpholin-4-ylmethyl)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	218.0 [1]
	4-[5-[3-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	213.0 [1]
	4-[2-(Butylamino)-5-[4-(piperidin-4-ylamino)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	42.0 [1]
	4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2R)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	560.0 [1]
	4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-(pentan-2-ylamino)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	125.0 [1]
	4-[2-[[(2S)-Heptan-2-yl]amino]-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	81.0 [1]
	4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	118.0 [1]
	4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-1,1,1-trifluoropentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	11037.0 [1]
	4-[2-(2-Methylbutylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	100.0 [1]
	4-[2-(2-Ethylbutylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	206.0 [1]
	4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2R)-1,1,1-trifluoropentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	2543.0 [1]
	4-[2-[[(2S)-Hexan-2-yl]amino]-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	64.0 [1]
	4-[5-[4-[[2-(Diethylamino)ethylamino]methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	80.0 [1]
	4-[2-[[(2S)-Pentan-2-yl]amino]-5-[4-(piperidin-4-ylamino)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	206.0 [1]
	4-[5-[4-(Cyclohexylamino)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	7356.0 [1]
	4-[5-[4-(7-Azabicyclo[2.2.1]heptan-7-ylmethyl)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	84.0 [1]
	4-[5-[2-Fluoro-4-(4-methylpiperazin-1-yl)sulfonylphenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	191.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Tyrosine-protein kinase receptor UFO Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-receptor-ufo-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Tyrosine-protein kinase receptor UFO Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-receptor-ufo-inhibitors-ic50-ki.
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