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Tyrosine-protein kinase SYK Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 44462758IC50178.0 [1]
StaurosporineIC501.08 [1]
TamatinibIC5041.0 [1]
TamatinibKi30.0 [1]
3-{[(1r,2s)-2-Aminocyclohexyl]amino}-5-(1h-Indol-7-Ylamino)-1,2,4-Triazine-6-CarboxamideIC5099.0 [1]
7-{[(1r,2s)-2-Aminocyclohexyl]amino}-5-(1h-Indol-7-Ylamino)pyrido[4,3-D]pyrimidin-4(3h)-OneIC5090.0 [1]
6-[[(3R,4R)-3-Aminooxan-4-yl]amino]-8-(1H-indol-7-ylamino)-2H-2,7-naphthyridin-1-oneIC5055.0 [1]
N-(3-Amino-1-methylcyclobutyl)-2-(6-fluoro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC50427.0 [1]
EntospletinibIC507.7 [1], 147.0 [2], 377.0 [3], 878.0 [4], 19416.0 [5]
N-{7-[4-(Dimethylamino)phenyl]-1,6-Naphthyridin-5-Yl}propane-1,3-DiamineIC5034.0 [1], 552.0 [2], 951.0 [3]
ImatinibIC505000.0 [1], 10000.0 [2]
ImatinibKi5000.0 [1]
2-{[(1r,2s)-2-Aminocyclohexyl]amino}-4-[(3-Methylphenyl)amino]pyrimidine-5-CarboxamideIC504.0 [1], 5.0 [2], 6.31 [3]
5-[Methyl(3-aminopropyl)amino]-7-[4-(dimethylamino)phenyl]-1,6-naphthyridineIC5072.0 [1]
5-(4-Aminobutoxy)-7-[4-(dimethylamino)phenyl]-1,6-naphthyridineIC50160.0 [1]
7-[[(1R,2S)-2-Aminocyclohexyl]amino]-5-[3-(triazol-2-yl)anilino]-3H-pyrido[4,3-d]pyrimidin-4-oneIC505.0 [1], 778.0 [2]
4-(3-(7-(3,4-Dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzamido)benzoic acidIC507.0 [1], 156.0 [2], 11900.0 [3]
CID 71280008IC5026.0 [1], 450.0 [2], 634.0 [3]
3-[[(1R,2S)-2-Aminocyclohexyl]amino]-5-(1H-indol-4-ylamino)-1,2,4-triazine-6-carboxamideIC501.0 [1], 14.0 [2], 177.0 [3]
5-[[(1R,2S)-2-Aminocyclohexyl]amino]-3-(1H-indol-7-ylamino)pyrazine-2-carboxamideIC502.7 [1], 5.0 [2], 30.0 [3], 302.0 [4]
PiceatannolIC5010000.0 [1], 38000.0 [2]
FostamatinibIC5017.0 [1], 267.0 [2], 12000.0 [3]
Syk Inhibitor IIIC5041.0 [1]
CID 9904854IC50300.0 [1]
CID 9904854Ki96.0 [1]
5-(4-Aminobutylamino)-7-[4-(dimethylamino)phenyl]-1,6-naphthyridineIC5019.0 [1]
2-(2-Aminoethylamino)-4-(m-tolylamino)pyrimidine-5-carboxamideIC5030.0 [1], 63.1 [2]
5-(3-Aminopropylamino)-7-(3-chlorophenyl)-1,6-naphthyridineIC50260.0 [1]
5-(3-Aminopropylamino)-7-(4-isopropylphenyl)-1,6-naphthyridineIC5090.0 [1]
5-(3-Aminopropylamino)-7-(4-methoxyphenyl)-1,6-naphthyridineIC50140.0 [1]
5-(3-Aminopropylamino)-7-(3-fluorophenyl)-1,6-naphthyridineIC50850.0 [1]
5-(3-Aminopropylamino)-7-phenyl-1,6-naphthyridineIC50140.0 [1], 410.0 [2]
5-(2-Aminoethylamino)-7-[4-(dimethylamino)phenyl]-1,6-naphthyridineIC50190.0 [1]
5-(3-Hydroxypropoxy)-7-[4-(dimethylamino)phenyl]-1,6-naphthyridineIC50200.0 [1]
5-(3-Aminopropylamino)-7-(4-chlorophenyl)-1,6-naphthyridineIC501200.0 [1]
5-(4-Hydroxybutylamino)-7-[4-(dimethylamino)phenyl]-1,6-naphthyridineIC50200.0 [1]
5-[3-(Methylamino)propylamino]-7-[4-(dimethylamino)phenyl]-1,6-naphthyridineIC5078.0 [1]
2-(4-Methoxyphenyl)-4-(methylamino)quinazolineIC5040000.0 [1]
5-(3-Aminopropylamino)-7-[4-[methyl[3-(dimethylamino)propyl]amino]phenyl]-1,6-naphthyridineIC50420.0 [1]
3-[(5-Methoxy-1-methylindol-3-yl)methyl]-2-oxo-1,3-dihydroindole-5-sulfonamideIC508100.0 [1]
3-((1-(3-Hydroxypropyl)-5-methoxy-1H-indol-3-yl)methylene)-2-oxoindoline-5-sulfonamideIC5032.0 [1]
3-((5-Methoxy-1-methyl-1H-indol-3-yl)methylene)-2-oxoindoline-5-carboxylic acidIC50273.0 [1]
3-((5-Methoxy-1-methyl-1H-indol-3-yl)methylene)-N-methyl-2-oxoindoline-5-carboxamideIC50145.0 [1]
5-(3-Aminopropylamino)-7-(4-morpholinophenyl)-1,6-naphthyridineIC508.0 [1]
5-[[(1R,2S)-2-Aminocyclohexyl]amino]-3-(1H-indol-2-yl)pyrazine-2-carboxamideIC500.5 [1], 130.0 [2]
5-[[(3R,4R)-3-Aminooxan-4-yl]amino]-3-(4-methoxy-1H-indol-2-yl)pyrazine-2-carboxamideIC500.7 [1], 62.0 [2]
2-[2-(3,5-Dimethylanilino)pyrimidin-4-yl]-N-[(2S)-1-hydroxypropan-2-yl]-4-methyl-1,3-thiazole-5-carboxamideIC506.0 [1], 70.0 [2]
2-[2-(3,5-Dimethylanilino)pyrimidin-4-yl]-N-[(2S)-1-hydroxypropan-2-yl]-4-methyl-1,3-thiazole-5-carboxamideKi9.0 [1]
3-[3-[[4-(1,3-Thiazol-2-yl)pyrimidin-2-yl]amino]-5-(trifluoromethyl)phenoxy]propan-1-olIC5026.0 [1], 90.0 [2]
3-[3-[[4-(1,3-Thiazol-2-yl)pyrimidin-2-yl]amino]-5-(trifluoromethyl)phenoxy]propan-1-olKi26.0 [1]
2-(4-Methyl-2-(2-(3-methyl-5-(trifluoromethyl)phenylamino)pyrimidin-4-yl)thiazol-5-yl)ethanolIC5022.0 [1], 180.0 [2]
2-(4-Methyl-2-(2-(3-methyl-5-(trifluoromethyl)phenylamino)pyrimidin-4-yl)thiazol-5-yl)ethanolKi22.0 [1]
2-(2-(2-(3,5-Dimethylphenylamino)pyrimidin-4-yl)-4-methylthiazol-5-yl)ethanolIC5032.0 [1], 70.0 [2]
2-(2-(2-(3,5-Dimethylphenylamino)pyrimidin-4-yl)-4-methylthiazol-5-yl)ethanolKi32.0 [1]
N-(3,5-Dimethylphenyl)-4-(4-methyl-1,3-thiazol-2-yl)pyrimidin-2-amineIC5056.0 [1], 1550.0 [2]
N-(3,5-Dimethylphenyl)-4-(4-methyl-1,3-thiazol-2-yl)pyrimidin-2-amineKi56.0 [1]
N-[3-Methyl-5-(trifluoromethyl)phenyl]-4-(1,3-thiazol-2-yl)pyrimidin-2-amineIC50110.0 [1], 120.0 [2]
N-[3-Methyl-5-(trifluoromethyl)phenyl]-4-(1,3-thiazol-2-yl)pyrimidin-2-amineKi110.0 [1]
2-[2-(3,5-Dimethylanilino)pyrimidin-4-yl]-N-[(2R)-1-hydroxypropan-2-yl]-4-methyl-1,3-thiazole-5-carboxamideIC509.0 [1], 4200.0 [2]
2-[2-(3,5-Dimethylanilino)pyrimidin-4-yl]-N-[(2R)-1-hydroxypropan-2-yl]-4-methyl-1,3-thiazole-5-carboxamideKi210.0 [1]
5-{[(1R,2S)-2-Aminocyclohexyl]amino}-3-[(4,6-dimethylpyridin-2-yl)amino]pyridine-2-carboxamideIC500.06 [1], 58.0 [2]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-(1H-indol-7-ylamino)pyrimidine-5-carboxamideIC5094.0 [1], 170.0 [2], 782.0 [3]
(5R)-5-[(1R)-1-[[6-[1-(Difluoromethyl)pyrazol-4-yl]-[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy]ethyl]-1,3-oxazolidin-2-oneIC5038.0 [1], 284.0 [2], 522.0 [3]
(4R)-4-[(1R)-1-[[5-(1-Methylpyrazol-4-yl)-1,3-benzothiazol-7-yl]oxy]ethyl]pyrrolidin-2-oneIC5033.0 [1], 89.0 [2], 186.0 [3]
(4R)-4-[(1R)-1-[[6-(1-Methylpyrazol-4-yl)-[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy]ethyl]pyrrolidin-2-oneIC5026.0 [1], 284.0 [2], 538.0 [3]
(4R)-4-[(1R)-1-[[6-(1-Methylpyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy]ethyl]pyrrolidin-2-oneIC5046.0 [1], 161.0 [2], 298.0 [3]
(4R)-4-[(1R)-1-[[6-(1-Methylpyrazol-4-yl)-[1,2]thiazolo[4,3-c]pyridin-4-yl]oxy]ethyl]pyrrolidin-2-oneIC5040.0 [1], 247.0 [2], 290.0 [3]
(4R)-4-[(1R)-1-[[6-[1-(Difluoromethyl)pyrazol-4-yl]-2,1-benzothiazol-4-yl]oxy]ethyl]pyrrolidin-2-oneIC5057.0 [1], 340.0 [2], 1018.0 [3]
(5R)-5-[(1R)-1-[[6-[1-(Difluoromethyl)pyrazol-4-yl]-2,1-benzothiazol-4-yl]oxy]ethyl]-1,3-oxazolidin-2-oneIC5016.0 [1], 197.0 [2], 328.0 [3]
(5R)-5-[(1R)-1-[[5-[1-(Difluoromethyl)pyrazol-4-yl]-1,3-benzothiazol-7-yl]oxy]ethyl]-1,3-oxazolidin-2-oneIC509.0 [1], 107.0 [2], 230.0 [3]
7-[[(1R,2S)-2-Aminocyclohexyl]amino]-5-[(3-methyl-1H-indol-7-yl)amino]-3H-pyrido[4,3-d]pyrimidin-4-oneIC502.0 [1], 47.0 [2], 805.0 [3]
7-[[(1R,2S)-2-Aminocyclohexyl]amino]-5-(1H-indol-4-ylamino)-3H-pyrido[4,3-d]pyrimidin-4-oneIC501.0 [1], 35.0 [2], 322.0 [3]
7-[[(3R,4R)-3-Aminooxan-4-yl]amino]-5-(1H-indol-7-ylamino)-3H-pyrido[4,3-d]pyrimidin-4-oneIC5020.0 [1], 60.0 [2], 232.0 [3]
7-[[(2S)-2-Aminopropyl]amino]-5-(1H-indol-7-ylamino)-3H-pyrido[4,3-d]pyrimidin-4-oneIC5021.0 [1], 209.0 [2], 1009.0 [3]
5-(1H-Indol-7-ylamino)-7-[[(3R)-piperidin-3-yl]amino]-3H-pyrido[4,3-d]pyrimidin-4-oneIC50165.0 [1], 378.0 [2], 1994.0 [3]
7-[[(3R,4R)-3-Aminooxan-4-yl]amino]-5-[(3-methyl-1H-indol-7-yl)amino]-3H-pyrido[4,3-d]pyrimidin-4-oneIC501.0 [1], 37.0 [2], 299.0 [3]
N-(Propan-2-Yl)-2-(3,4,5-Trimethoxyphenyl)-5h-Pyrrolo[2,3-B]pyrazine-7-CarboxamideIC5014.0 [1], 190.0 [2], 7090.0 [3]
2-(3,4-Dimethoxyphenyl)-N-(1-hydroxypropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5035.0 [1], 256.0 [2], 911.0 [3]
2-(1,6-Dimethylindazol-3-yl)-N-(3-methylpyrrolidin-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5034.0 [1], 1310.0 [2], 1770.0 [3]
N-Tert-butyl-2-[6-fluoro-1-(3-methylsulfonylpropyl)indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC505.0 [1], 57.0 [2], 285.0 [3]
N-Tert-butyl-2-(6-chloro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC507.0 [1], 31000.0 [2], 50000.0 [3]
N-Tert-butyl-2-[5-(hydroxymethyl)-1-methylindazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC505.0 [1], 119.0 [2], 839.0 [3]
N-(5-Aminooxan-3-yl)-2-(6-fluoro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5061.0 [1], 643.0 [2], 1477.0 [3]
2-[6-Fluoro-1-(3-methylsulfonylpropyl)indazol-3-yl]-N-(1-hydroxy-2-methylpropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5016.0 [1], 78.0 [2], 94.0 [3]
N-Tert-butyl-2-[1-(3,4-dihydroxybutyl)-6-fluoroindazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC505.0 [1], 360.0 [2], 366.0 [3]
N-Tert-butyl-2-[5-(difluoromethoxy)-1H-indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC502.0 [1], 88.0 [2], 2450.0 [3]
N-Tert-butyl-2-[5-(difluoromethoxy)-1-(3,4-dihydroxybutyl)indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC502.0 [1], 80.0 [2], 534.0 [3]
N-Tert-butyl-2-[5-(difluoromethoxy)-1-[(1-methylazetidin-3-yl)methyl]indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5019.0 [1], 546.0 [2], 2790.0 [3]
N-Tert-butyl-2-[7-(hydroxymethyl)-2H-indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC503.0 [1], 86.0 [2], 412.0 [3]
N-Tert-butyl-2-[1-[3-(3-cyanoazetidin-1-yl)propyl]-5-(difluoromethoxy)indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC504.0 [1], 211.0 [2], 534.0 [3]
2-(6-Chloro-1-Methyl-1h-Indazol-3-Yl)-N-(Propan-2-Yl)-5h-Pyrrolo[2,3-B]pyrazine-7-CarboxamideIC5036.0 [1], 512.0 [2], 16600.0 [3]
N-Tert-butyl-2-(6-fluoro-1-piperidin-4-ylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC504.0 [1], 142.0 [2], 852.0 [3]
2-[1-[3-(Dimethylamino)propyl]-6-methylindazol-3-yl]-N-(1-hydroxy-2-methylpropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5068.0 [1], 191.0 [2], 6920.0 [3]
N-Tert-butyl-2-[5-(difluoromethoxy)-1-(3-morpholin-4-ylpropyl)indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC503.0 [1], 195.0 [2], 277.0 [3]
N-Tert-butyl-2-[7-(2-hydroxypropan-2-yl)-2H-indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5010.0 [1], 76.0 [2], 534.0 [3]
N-Tert-butyl-2-[5-(difluoromethoxy)-1-[3-(dimethylamino)propyl]indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC505.0 [1], 140.0 [2], 184.0 [3]
N-Tert-butyl-2-[5-(difluoromethoxy)-1-methylindazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC501.0 [1], 179.0 [2], 2580.0 [3]
N-Tert-butyl-2-[5-(difluoromethoxy)-1-(3-methylsulfonylpropyl)indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC503.0 [1], 170.0 [2], 335.0 [3]
2-[5-(Difluoromethoxy)-1-[3-(dimethylamino)propyl]indazol-3-yl]-N-(1-hydroxy-2-methylpropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5030.0 [1], 101.0 [2], 127.0 [3]
2-(6-Fluoro-1-methylindazol-3-yl)-N-(3-hydroxycyclobutyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamideIC5047.0 [1], 151.0 [2], 1430.0 [3]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase SYK Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-syk-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Tyrosine-protein kinase SYK Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-syk-inhibitors-ic50-ki.
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