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Tyrosine-protein kinase TEC Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
▲
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Standard Values (in nM)
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▼
IbrutinibIC500.5 [1], 1.86 [2], 7.0 [3], 77.8 [4]
1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-oneIC50592.0 [1]
1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-oneKi679.0 [1]
4-Tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzamideIC5014.0 [1]
2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]-IC50108.0 [1]
StaurosporineIC50128000.0 [1]
DasatinibIC50297.0 [1]
BosutinibIC50282.0 [1]
SpebrutinibIC506.2 [1]
CID 46908026IC5064.0 [1]
N-[2-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]-3-methylphenyl]prop-2-enamideIC5010000.0 [1]
EvobrutinibIC5037.9 [1]
Bms-509744IC5017000.0 [1]
Bms-986142IC5010.0 [1]
N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-4-cyanobenzamideIC5010000.0 [1]
2-Methyl-N-[2-[3-[[2-(prop-2-enoylamino)acetyl]amino]anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamideIC506.3 [1]
JAK3 covalent inhibitor-1IC5010000.0 [1]
2-Methyl-N-[2-[3-(prop-2-enoylamino)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamideIC508.2 [1]
(S)-IbrutinibIC5078.0 [1]
N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-4-chlorobenzamideIC5010000.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
4-[[4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]pyrimidin-2-yl]amino]cyclohexan-1-olIC50251.19 [1]
2,3-Dimethyl-4-[2-methyl-3-(prop-2-enoylamino)phenyl]-1H-indole-7-carboxamideIC506.4 [1]
4-[3-(Ethenylsulfonylamino)-2-methylphenyl]-2,3-dimethyl-1H-indole-7-carboxamideIC500.9 [1]
4-[3-[[4-(Dimethylamino)benzoyl]amino]-2-fluorophenyl]-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamideIC5041.0 [1]
N-[(3R,4S)-4-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]oxolan-3-yl]prop-2-enamideIC5010000.0 [1]
N-[2-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamideIC5010000.0 [1]
N-[3-[3-[(2-Chloro-6-fluorophenyl)methylamino]-1H-1,2,4-triazol-5-yl]phenyl]prop-2-enamideIC50306.45 [1]
7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(prop-2-enoylamino)phenyl]-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamideIC502.3 [1]
5-(Difluoromethyl)-N-[5-[[[(2S)-3,3-dimethylbutan-2-yl]amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamideIC501.78 [1]
5-(Difluoromethyl)-N-[5-(morpholin-4-ylmethyl)-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamideIC502.27 [1]
5-(2-Oxo-1H-pyridin-4-yl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamideIC500.09 [1]
4-Cyano-N-[5-[[[(2S)-3,3-dimethylbutan-2-yl]amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]benzamideIC504.32 [1]
N-[5-[[[(2S)-3,3-Dimethylbutan-2-yl]amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamideIC501.65 [1]
5-(2-Aminopyridin-4-yl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamideIC500.2 [1]
N-[5-(Methylamino)-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamideIC500.67 [1]
5-[2-(Methylamino)pyridin-4-yl]-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamideIC500.16 [1]
N-[5-[[[(2S)-3,3-Dimethylbutan-2-yl]amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-1,3-thiazole-5-carboxamideIC504.5 [1]
N-[5-[[(4-Hydroxycyclohexyl)amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamideIC502.0 [1]
5-(Difluoromethyl)-N-[5-[[(3-hydroxy-2,2-dimethylpropyl)amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamideIC503.13 [1]
N-[5-[[[(2S)-3,3-Dimethylbutan-2-yl]amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-1,2-thiazole-5-carboxamideIC503.16 [1]
N-[5-[[(3-Hydroxy-2,2-dimethylpropyl)amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamideIC501.96 [1]
5-(1,1-Difluoroethyl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamideIC500.98 [1]
5-(1,3-Oxazol-5-yl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamideIC500.62 [1]
5-(2-Aminopyrimidin-4-yl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamideIC500.1 [1]
N-[5-Fluoro-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamideIC500.74 [1]
5-(2-Methylpyrimidin-4-yl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamideIC500.11 [1]
4-[8-Amino-3-[(3R)-1-(2-methylpropanoyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50378.0 [1]
4-[8-Amino-3-[(2R)-4-(oxan-4-yl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50191.0 [1]
4-[8-Amino-3-[(3R)-1-(oxan-4-yl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50170.0 [1]
4-[8-Amino-3-[(2R)-4-(2-methylpropanoyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50428.0 [1]
5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amineIC50114.8 [1]
7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxoquinazolin-3-yl)phenyl]-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamideIC5056.0 [1]
N-[(7S)-4-Amino-6-methylidene-5-(4-phenoxyphenyl)-7,8-dihydropyrimido[5,4-b]pyrrolizin-7-yl]prop-2-enamideIC501.4 [1]
[(1S)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamideIC5010000.0 [1]
[(1S)-6-[5-[3-(Hydroxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1H-inden-1-yl]cyanamideIC508960.0 [1]
N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(ethyl)amino]benzimidazol-2-yl]-4-cyanobenzamideIC5010000.0 [1]
N-[1-(3-Aminopropyl)-5-[cyclohexanecarbonyl(methyl)amino]benzimidazol-2-yl]thiophene-2-carboxamideIC5022000.0 [1]
4-(2-Fluorophenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamideIC50116.0 [1]
N-[6-Fluoro-2-methyl-3-[5-[(5-methyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1H-pyridazin-3-yl]phenyl]-1-benzothiophene-2-carboxamideIC50230.0 [1]
4-[[(3S,4R)-1-(5-Cyanopyridin-2-yl)-3-fluoropiperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamideIC501000.0 [1]
4-(3-Acetamido-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamideIC50162.0 [1]
4-[8-Amino-3-[(3R)-1-(2-methoxyacetyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC5063.0 [1]
4-[8-Amino-3-[(2R)-4-(2-methoxyacetyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50232.0 [1]
4-Amino-8-(5-Methyl-1h-Indazol-6-Yl)cinnoline-3-CarboxamideIC5057.0 [1]
4-Amino-8-(6-methyl-1H-indazol-5-yl)cinnoline-3-carboxamideIC5057.0 [1]
6-Amino-9-[(3R)-1-but-2-ynoylpiperidin-3-yl]-7-(4-phenoxyphenyl)purin-8-oneIC505.3 [1]
Items per page: 1 - 10 of 68
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase TEC Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-tec-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Tyrosine-protein kinase TEC Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-tec-inhibitors-ic50-ki.
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