 | 7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-Amine | IC50 | 250.0 [1], 5850.0 [2] |
 | 1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea | IC50 | 720.0 [1], 724.44 [2], 730.0 [3] |
 | Staurosporine | IC50 | 50.9 [1], 52.0 [2], 213.2 [3] |
 | Sorafenib | IC50 | 0.83 [1], 6.77 [2], 7.85 [3] |
 | Cabozantinib | IC50 | 14.3 [1] |
 | Nvp-tae 684 | IC50 | 12.0 [1], 1167.0 [2], 12000.0 [3] |
 | 4-Amino-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl-Cyclopentane | IC50 | 1980.0 [1], 9070.0 [2] |
 | 3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide | IC50 | 10.1 [1], 18.0 [2], 620.0 [3] |
 | 3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione | IC50 | 740.0 [1], 2633.0 [2], 2800.0 [3] |
 | AMG-Tie2-1 | IC50 | 1.0 [1], 10.0 [2] |
 | GW768505A (free base) | IC50 | 2.0 [1], 6.3 [2] |
 | Thienopyrimidine deriv. 11 | IC50 | 109.65 [1], 110.0 [2] |
 | 3-(2-Aminoquinazolin-6-Yl)-4-Methyl-N-[3-(Trifluoromethyl)phenyl]benzamide | IC50 | 1.0 [1], 2.0 [2] |
 | 4-Methyl-3-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxy-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]benzamide | IC50 | 10.0 [1], 317.0 [2] |
 | N-[3-Methyl-4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]-1H-benzimidazol-2-amine | IC50 | 2.0 [1] |
 | N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine | IC50 | 1.0 [1], 20.0 [2] |
 | Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate | IC50 | 6.9 [1], 8.7 [2], 10.0 [3] |
 | Crizotinib | IC50 | 5.0 [1], 448.0 [2] |
 | Vandetanib | IC50 | 567.0 [1], 2500.0 [2] |
 | Doramapimod | IC50 | 25.0 [1], 10000.0 [2] |
 | 4-[4-(6-Methoxy-2-naphthalenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine | IC50 | 250.0 [1], 20000.0 [2] |
 | 3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea | IC50 | 13.49 [1], 18.3 [2] |
 | 3-(3-Hydroxypropyl)-7-(propan-2-yloxymethyl)-3,13-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-14-one | IC50 | 10000.0 [1] |
 | 1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea | IC50 | 20.0 [1], 100.0 [2] |
 | Cep-11981 | IC50 | 22.0 [1], 50.0 [2] |
 | 4-(5-(6-Methoxynaphthalen-2-yl)-1-methyl-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridine | IC50 | 60.0 [1] |
 | Methyl N-[6-[4-[(3-ethylphenyl)carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate | IC50 | 18.0 [1], 170.0 [2] |
 | Methyl N-[6-[4-[(3-bromophenyl)carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate | IC50 | 8.0 [1], 13.0 [2] |
 | Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]sulfanyl-1H-benzimidazol-2-yl]carbamate | IC50 | 10.0 [1], 76.0 [2] |
 | Methyl N-(5-(4-((3-chlorophenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate | IC50 | 40.0 [1], 50.0 [2] |
 | N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]furan-2-carboxamide | IC50 | 5.2 [1], 6.2 [2] |
 | Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1,3-benzothiazol-2-yl]carbamate | IC50 | 6.5 [1], 7.2 [2] |
 | Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]sulfonyl-1H-benzimidazol-2-yl]carbamate | IC50 | 120.0 [1], 160.0 [2] |
 | Methyl N-[6-[3-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate | IC50 | 28.0 [1], 81.0 [2] |
 | N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]benzamide | IC50 | 13.0 [1], 120.0 [2] |
 | Thienopyrimidine deriv. 20 | IC50 | 208.93 [1], 210.0 [2] |
 | Thienopyrimidine deriv. 24 | IC50 | 100.0 [1] |
 | Thienopyrimidine deriv. 26 | IC50 | 169.82 [1], 170.0 [2] |
 | N-[3-[3-(Dimethylamino)propyl]-5-(trifluoromethyl)phenyl]-4-methyl-3-[(3-pyrimidin-4-ylpyridin-2-yl)amino]benzamide | IC50 | 1.0 [1] |
 | 5-(4-Phenoxyphenyl)-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine | IC50 | 430.0 [1] |
 | Pyrazolo[3,4-d]pyrimidine 5 | IC50 | 4680.0 [1] |
 | Thienopyrimidine deriv. 74 | IC50 | 338.84 [1], 340.0 [2] |
 | Thienopyrimidine deriv. 10 | IC50 | 1288.25 [1], 1300.0 [2] |
 | Thienopyrimidine deriv. 12 | IC50 | 890.0 [1], 891.25 [2] |
 | Thienopyrimidine deriv. 13 | IC50 | 912.01 [1], 920.0 [2] |
 | Thienopyrimidine deriv. 14 | IC50 | 360.0 [1], 363.08 [2] |
 | Thienopyrimidine deriv. 15 | IC50 | 1584.89 [1], 1600.0 [2] |
 | Thienopyrimidine deriv. 17 | IC50 | 398.11 [1], 400.0 [2] |
 | Thienopyrimidine deriv. 18 | IC50 | 850.0 [1], 851.14 [2] |
 | Thienopyrimidine deriv. 19 | IC50 | 891.25 [1], 900.0 [2] |
 | Thienopyrimidine deriv. 21 | IC50 | 1200.0 [1], 1202.26 [2] |
 | Thienopyrimidine deriv. 23 | IC50 | 1096.48 [1], 1100.0 [2] |
 | Thienopyrimidine deriv. 27 | IC50 | 360.0 [1], 363.08 [2] |
 | Thienopyrimidine deriv. 28 | IC50 | 16.98 [1], 17.0 [2] |
 | Thienopyrimidine deriv. 51 | IC50 | 120.0 [1], 120.23 [2] |
 | Thienopyrimidine deriv. 52 | IC50 | 467.74 [1], 470.0 [2] |
 | Thienopyrimidine deriv. 53 | IC50 | 140.0 [1], 141.25 [2] |
 | Thienopyrimidine deriv. 59 | IC50 | 426.58 [1], 430.0 [2] |
 | Thienopyrimidine deriv. 60 | IC50 | 630.0 [1], 630.96 [2] |
 | Thienopyrimidine deriv. 79 | IC50 | 288.4 [1], 290.0 [2] |
 | Thienopyrimidine deriv. 83 | IC50 | 269.15 [1], 270.0 [2] |
 | Thienopyrimidine deriv. 84 | IC50 | 257.04 [1], 260.0 [2] |
 | Thienopyrimidine deriv. 85 | IC50 | 218.78 [1], 220.0 [2] |
 | Thienopyrimidine deriv. 86 | IC50 | 109.65 [1], 110.0 [2] |
 | Thienopyrimidine deriv. 87 | IC50 | 190.0 [1], 190.55 [2] |
 | 5,6-Bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine | IC50 | 1000.0 [1] |
 | 4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide | IC50 | 3.6 [1], 4.0 [2] |
 | 1-Methyl-1-[[5-[7-[(4-methylpiperazin-1-yl)methyl]-2,4-dihydroindeno[1,2-c]pyrazol-3-yl]thiophen-2-yl]methyl]-3-[3-(trifluoromethyl)phenyl]urea | IC50 | 259.0 [1] |
 | N-[2-[3-(Dimethylamino)propyl-methylamino]-5-(trifluoromethyl)phenyl]-2-fluoro-5-[3-[4-(methylamino)-1,3,5-triazin-2-yl]pyridin-2-yl]oxybenzamide | IC50 | 30.0 [1], 62.0 [2] |
 | 19-Methyl-3,13,19,20-tetrazahexacyclo[14.7.0.02,10.04,9.011,15.017,21]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | IC50 | 1300.0 [1], 1357.0 [2] |
 | N-[4-[3-[2-(Methylamino)pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine | IC50 | 27.0 [1] |
 | N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)benzo[d]oxazol-2-amine | IC50 | 16.0 [1] |
 | N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)benzo[d]thiazol-2-amine | IC50 | 44.0 [1] |
 | N-(4-(Benzo[d]thiazol-2-yl)-2-methylphenyl)-6,7-dimethoxyquinazolin-4-amine | IC50 | 840.0 [1] |
 | 1-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-3-phenylurea | IC50 | 5.0 [1] |
 | 6-(3,4-Dichlorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine | IC50 | 1778.28 [1], 1780.0 [2] |
 | 3-[4-Amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-6-yl]benzamide | IC50 | 537.03 [1], 540.0 [2] |
 | 3-[4-Amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-6-yl]-N,N-dimethylbenzamide | IC50 | 1479.11 [1], 1480.0 [2] |
 | Furo[2,3-d]pyrimidine deriv. 7d | IC50 | 300.0 [1], 302.0 [2] |
 | Furo[2,3-d]pyrimidine deriv. 7e | IC50 | 600.0 [1], 602.56 [2] |
 | Furo[2,3-d]pyrimidine deriv. 7f | IC50 | 190.0 [1], 190.55 [2] |
 | Furo[2,3-d]pyrimidine deriv. 7h | IC50 | 501.0 [1], 501.19 [2] |
 | Furo[2,3-d]pyrimidine deriv. 7i | IC50 | 851.0 [1], 851.14 [2] |
 | Furo[2,3-d]pyrimidine deriv. 7j | IC50 | 28.0 [1], 28.18 [2] |
 | Furo[2,3-d]pyrimidine deriv. 7l | IC50 | 21.88 [1], 22.0 [2] |
 | Furo[2,3-d]pyrimidine deriv. 7m | IC50 | 58.88 [1], 59.0 [2] |
 | Furo[2,3-d]pyrimidine deriv. 7n | IC50 | 275.0 [1], 275.42 [2] |
 | Pyrazolo[3,4-d]pyrimidine 6 | IC50 | 521.0 [1] |
 | Pyrazolo[3,4-d]pyrimidine 11 | IC50 | 2450.0 [1] |
 | Pyrazolo[3,4-d]pyrimidine 15 | IC50 | 1020.0 [1], 1130.0 [2] |
 | Thienopyrimidine deriv. 9 | IC50 | 1200.0 [1], 1202.26 [2] |
 | Thienopyrimidine deriv. 16 | IC50 | 1000.0 [1] |
 | Thienopyrimidine deriv. 22 | IC50 | 128.82 [1], 130.0 [2] |
 | Thienopyrimidine deriv. 80 | IC50 | 575.44 [1], 580.0 [2] |
 | Thienopyrimidine deriv. 81 | IC50 | 870.96 [1], 880.0 [2] |
 | Thienopyrimidine deriv. 82 | IC50 | 250.0 [1], 251.19 [2] |
 | 5-(4-Phenoxyphenyl)-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine | IC50 | 2680.0 [1] |
 | Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]imidazo[1,2-a]pyridin-2-yl]carbamate | IC50 | 1.5 [1], 3.4 [2] |
 | N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]pyridine-3-carboxamide | IC50 | 16.0 [1], 20.0 [2] |
 | N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]acetamide | IC50 | 2.6 [1], 3.3 [2] |
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