Tyrosine-protein phosphatase non-receptor type 5 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine;hydrochloride	IC50	24.6 [1], 8800.0 [2]
	8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine;hydrochloride	Ki	115.0 [1]
	2,2,2-Trifluoro-N-[8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-yl]acetamide	IC50	24.0 [1], 15000.0 [2]
	2,2,2-Trifluoro-N-[8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-yl]acetamide	Ki	235.0 [1]
	N-[8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-yl]acetamide	IC50	49.0 [1], 24000.0 [2]
	N-[8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-yl]acetamide	Ki	123.0 [1]
	N-Ethyl-8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine	IC50	59.0 [1], 50000.0 [2]
	N-Ethyl-8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine	Ki	230.0 [1]
	N-Benzyl-8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine	IC50	78.0 [1], 27000.0 [2]
	N-Benzyl-8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine	Ki	175.0 [1]
	4-Nitro-6-(trifluoromethyl)-1,2,3-benzotrithiole	IC50	145.0 [1], 34000.0 [2]
	4-Nitro-6-(trifluoromethyl)-1,2,3-benzotrithiole	Ki	210.0 [1]
	7-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepine	IC50	10.0 [1], 17000.0 [2]
	7-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepine	Ki	109.0 [1]
	8-Methyl-1,2,3,4,5-benzopentathiepin-6-amine	IC50	25.0 [1], 17000.0 [2]
	8-Methyl-1,2,3,4,5-benzopentathiepin-6-amine	Ki	116.0 [1]
	1,2,3,4,5-Benzopentathiepin-6-amine	IC50	32.0 [1], 33000.0 [2]
	1,2,3,4,5-Benzopentathiepin-6-amine	Ki	183.0 [1]
	8,17-Bis(trifluoromethyl)-2,3,4,11,12,13-hexathiatricyclo[12.4.0.05,10]octadeca-1(18),5,7,9,14,16-hexaene-6,15-diamine	IC50	33.0 [1], 20000.0 [2]
	8,17-Bis(trifluoromethyl)-2,3,4,11,12,13-hexathiatricyclo[12.4.0.05,10]octadeca-1(18),5,7,9,14,16-hexaene-6,15-diamine	Ki	124.0 [1]
	[[4-[3-[(3,4-Dichlorophenyl)methyl]phenyl]phenyl]-difluoromethyl]phosphonic acid	Ki	9600.0 [1]
	[[4-[3-[(3,4-Dichlorophenyl)-hydroxymethyl]phenyl]phenyl]-difluoromethyl]phosphonic acid	Ki	16000.0 [1]
	5,7-Dichloro-4-((3-(4-methoxyphenylthio)benzyl)(methyl)amino)quinoline-2-carboxylic acid	IC50	60600.0 [1]
	Biphenyl-4-yldifluoromethylphosphonic acid	Ki	120000.0 [1]
	3-Biphenylyldifluoromethylphosphonic acid	Ki	337000.0 [1]
	[[3-(3-Cyclohexyl-2-hydroxyphenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	20000.0 [1]
	[(S)-[4-[3-[(R)-(3,4-Dichlorophenyl)-hydroxymethyl]phenyl]phenyl]-hydroxymethyl]phosphonic acid	Ki	8900.0 [1]
	[(S)-[4-[3-[(S)-(3,4-Dichlorophenyl)-hydroxymethyl]phenyl]phenyl]-hydroxymethyl]phosphonic acid	Ki	7800.0 [1]
	4-[[4-[(E)-[5-[4-(Dimethylamino)phenyl]-6-ethoxycarbonyl-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]methyl]benzoic acid	IC50	16600.0 [1]
	2-Hydroxy-4-[1-(cyclohexylcarbamoyl)pentyloxy]-5-[2-(trifluoromethoxy)phenylethynyl]benzoic acid	IC50	50000.0 [1]
	[(R)-[4-[2-Fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-hydroxymethyl]phosphonic acid	Ki	15000.0 [1]
	[Difluoro-[4-[2-fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]methyl]phosphonic acid	Ki	2400.0 [1]
	[2-Cyclohexyl-1-fluoro-1-[4-[2-fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-2-oxoethyl]phosphonic acid	Ki	1000.0 [1]
	[Difluoro-[4-[3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]methyl]phosphonic acid	Ki	4700.0 [1]
	[(S)-[4-[2-Fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-hydroxymethyl]phosphonic acid	Ki	2600.0 [1]
	[1-Fluoro-1-[4-[2-fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-2-oxo-2-piperidin-1-ylethyl]phosphonic acid	Ki	3000.0 [1]
	[2-(Dimethylamino)-1-[4-[2-fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-2-oxoethyl]phosphonic acid	Ki	2400.0 [1]
	[Fluoro-[4-[2-fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-morpholin-4-ylsulfonylmethyl]phosphonic acid	Ki	110.0 [1]
	[[4-[2-Fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-morpholin-4-ylsulfonylmethyl]phosphonic acid	Ki	430.0 [1]
	[1-[4-[2-Fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-2-(methylamino)-2-oxoethyl]phosphonic acid	Ki	6800.0 [1]
	[[4-[3-[(4,5-Dichloro-2-fluorophenyl)-hydroxymethyl]phenyl]phenyl]-difluoromethyl]phosphonic acid	Ki	14000.0 [1]
	[1-Fluoro-1-[4-[2-fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-2-oxo-2-phenylethyl]phosphonic acid	Ki	540.0 [1]
	[[4-[3-[(2-Bromo-4,5-dichlorophenyl)methyl]phenyl]phenyl]-difluoromethyl]phosphonic acid	Ki	3700.0 [1]
	[Difluoro-[4-[3-[hydroxy-(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]methyl]phosphonic acid	Ki	10000.0 [1]
	[1-[4-[2-Fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-2-oxo-2-piperidin-1-ylethyl]phosphonic acid	Ki	2700.0 [1]
	[1-[4-[2-Fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-2-morpholin-4-yl-2-oxoethyl]phosphonic acid	Ki	1700.0 [1]
	[Fluoro-[4-[2-fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]methyl]phosphonic acid	Ki	1500.0 [1]
	[[4-[3-[(4,5-Dichloro-2-fluorophenyl)methyl]phenyl]phenyl]-difluoromethyl]phosphonic acid	Ki	5600.0 [1]
	2-[[6-(1,3-Dioxoisoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl]-N-[5-[(3-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]acetamide	IC50	96040.0 [1]
	4-({4-[(E)-(1-Ethyl-2,5-dioxoimidazolidin-4-ylidene)methyl]-2-iodophenoxy}methyl)benzoic acid	IC50	100000.0 [1]
	N-(4-Fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine	IC50	100000.0 [1]
	[Difluoro-[3-(4-methylphenyl)phenyl]methyl]phosphonic acid	Ki	205000.0 [1]
	[Difluoro-[3-(4-propan-2-ylphenyl)phenyl]methyl]phosphonic acid	Ki	222000.0 [1]
	[Difluoro-[3-(3-methylphenyl)phenyl]methyl]phosphonic acid	Ki	137000.0 [1]
	[Difluoro-[3-(3-propan-2-ylphenyl)phenyl]methyl]phosphonic acid	Ki	81000.0 [1]
	[Difluoro-[3-(2-hydroxyphenyl)phenyl]methyl]phosphonic acid	Ki	168000.0 [1]
	[Difluoro-[3-(2-methoxyphenyl)phenyl]methyl]phosphonic acid	Ki	271000.0 [1]
	[Difluoro-[3-(2-hydroxy-3-propan-2-ylphenyl)phenyl]methyl]phosphonic acid	Ki	69000.0 [1]
	[Difluoro-[3-(2-hydroxy-5-propan-2-ylphenyl)phenyl]methyl]phosphonic acid	Ki	95000.0 [1]
	[[3-(3-Ethyl-2-hydroxyphenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	124000.0 [1]
	[[3-(3-Tert-butyl-2-hydroxyphenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	63000.0 [1]
	[[3-(3-Cyclobutyl-2-hydroxyphenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	45000.0 [1]
	[[3-(3-Cyclopentyl-2-hydroxyphenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	25000.0 [1]
	[[3-(3-Cycloheptyl-2-hydroxyphenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	62000.0 [1]
	[[3-(3-Cyclohexyl-2-hydroxyphenyl)phenyl]-hydroxymethyl]phosphonic acid	Ki	36000.0 [1]
	[[4-(2-Cyanophenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	375000.0 [1]
	[[4-(3-Cyanophenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	400000.0 [1]
	[[4-(4-Cyanophenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	617000.0 [1]
	[Difluoro-[4-(3-propan-2-yloxyphenyl)phenyl]methyl]phosphonic acid	Ki	200000.0 [1]
	[Difluoro-[4-(4-propan-2-yloxyphenyl)phenyl]methyl]phosphonic acid	Ki	231000.0 [1]
	[Difluoro-[4-(3-propan-2-ylphenyl)phenyl]methyl]phosphonic acid	Ki	132000.0 [1]
	[Difluoro-[4-(4-propan-2-ylphenyl)phenyl]methyl]phosphonic acid	Ki	185000.0 [1]
	[Difluoro-[4-[2-(methanesulfonamido)phenyl]phenyl]methyl]phosphonic acid	Ki	673000.0 [1]
	[Difluoro-[4-[3-(methanesulfonamido)phenyl]phenyl]methyl]phosphonic acid	Ki	113000.0 [1]
	[Difluoro-[4-[3-(1-hydroxyethyl)phenyl]phenyl]methyl]phosphonic acid	Ki	88000.0 [1]
	[Difluoro-[4-[4-(1-hydroxyethyl)phenyl]phenyl]methyl]phosphonic acid	Ki	450000.0 [1]
	[[4-(3-Anilinophenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	112000.0 [1]
	[Difluoro-[4-[3-[(4-fluorophenyl)methyl]phenyl]phenyl]methyl]phosphonic acid	Ki	35000.0 [1]
	[[4-[3-[(4-Chlorophenyl)methyl]phenyl]phenyl]-difluoromethyl]phosphonic acid	Ki	19000.0 [1]
	[[4-[3-[(3,4-Dichlorophenyl)methyl]phenyl]phenyl]-hydroxymethyl]phosphonic acid	Ki	8300.0 [1]
	[[4-(3-Benzylphenyl)phenyl]-difluoromethyl]phosphonic acid	Ki	73000.0 [1]
	[(R)-[4-[3-[(R)-(3,4-Dichlorophenyl)-hydroxymethyl]phenyl]phenyl]-hydroxymethyl]phosphonic acid	Ki	88000.0 [1]
	[(R)-[4-[3-[(S)-(3,4-Dichlorophenyl)-hydroxymethyl]phenyl]phenyl]-hydroxymethyl]phosphonic acid	Ki	93000.0 [1]
	[4-[3-[(3,4-Dichlorophenyl)-hydroxymethyl]phenyl]phenyl]methylphosphonic acid	Ki	97000.0 [1]
	6-Hydroxy-3-iodo-1-methyl-2-[3-[[2-oxo-2-(4-thiophen-3-ylanilino)acetyl]amino]phenyl]indole-5-carboxylic acid	IC50	4000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 85 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Tyrosine-protein phosphatase non-receptor type 5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-phosphatase-non-receptor-type-5-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Tyrosine-protein phosphatase non-receptor type 5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-phosphatase-non-receptor-type-5-inhibitors-ic50-ki.
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