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Tyrosyl-DNA phosphodiesterase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
3,20-Dioxopregn-4-en-21-yl 4-bromobenzenesulfonateIC501000.0 [1], 7000.0 [2], 7700.0 [3], 8430.0 [4]
6-(3-Aminopropyl)-9-methoxy-3-nitroindeno[1,2-c]isoquinoline-5,11-dioneIC501000.0 [1], 11000.0 [2]
6-(3-Aminopropyl)-7-methoxy-3-nitroindeno[1,2-c]isoquinoline-5,11-dioneIC501000.0 [1], 5800.0 [2]
2-[(Z)-(2-Oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]benzoic acidIC508500.0 [1], 15000.0 [2], 138000.0 [3], 280000.0 [4]
FuramidineIC501230.0 [1], 30000.0 [2], 31000.0 [3]
6-(3-Aminopropyl)indeno[1,2-c]isoquinoline-5,11-dione;hydrochlorideIC5029500.0 [1]
6-(3-Aminopropyl)indeno[1,2-c]isoquinoline-5,11-dione;hydrochlorideKi3190.0 [1]
3-Amino-6-(3-aminopropyl)indeno[1,2-c]isoquinoline-5,11-dioneIC5012000.0 [1]
6-[3-[3-[3-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)propylamino]propylamino]propyl]indeno[1,2-c]isoquinoline-5,11-dioneIC501520.0 [1], 1900.0 [2], 12000.0 [3]
(5Z)-4-Sulfanylidene-5-[(2,3,4-trihydroxyphenyl)methylidene]-1,3-thiazolidin-2-oneIC50870.0 [1], 2800.0 [2], 35000.0 [3]
Ethyl 2-[[6-(3-aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]acetateIC5011000.0 [1]
2-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]acetic acidIC505000.0 [1]
6-(3-Aminopropyl)-8-methoxy-3-nitroindeno[1,2-c]isoquinoline-5,11-dioneIC5015000.0 [1]
CamptothecinIC500.0 [1], 111000.0 [2]
N-[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]acetamideIC5018000.0 [1]
N-[6-(3-Hydroxypropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]acetamideIC5018000.0 [1], 111000.0 [2]
6-[3-(Dimethylamino)propyl]indeno[1,2-c][2,7]naphthyridine-5,11-dioneIC5037000.0 [1], 63000.0 [2]
6-(6-Aminohexyl)-5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline HydrochlorideIC5025000.0 [1], 35000.0 [2]
(E)-3-[(4,6-Dimethylpyrimidin-2-yl)amino]-2-[3-(phenylsulfanylmethyl)benzoyl]prop-2-enenitrileIC5079430.0 [1], 100000.0 [2]
2-[(6-Methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]-2-oxoacetic acidIC5061000.0 [1]
Methyl 2-[[6-(3-aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-2-oxoacetateIC5045000.0 [1]
Methyl 3-[[6-(3-aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-3-oxopropanoateIC5018000.0 [1]
6-(4-Aminobutyl)indeno[1,2-c]isoquinoline-5,11-dioneIC5022300.0 [1], 23400.0 [2]
6-(2-Aminoethyl)indeno[1,2-c]isoquinoline-5,11-dioneIC5055300.0 [1], 78000.0 [2]
6-(Furan-2-yl)-4H-isoquinoline-1,3-dioneIC50111000.0 [1]
(5Z)-5-[(2,5-Dihydroxyphenyl)methylidene]-4-sulfanylidene-1,3-thiazolidin-2-oneIC507100.0 [1], 76000.0 [2]
(5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-4-sulfanylidene-1,3-thiazolidin-2-oneIC504100.0 [1], 76000.0 [2]
(5Z)-5-[(2,3-Dihydroxyphenyl)methylidene]-4-sulfanylidene-1,3-thiazolidin-2-oneIC505800.0 [1], 220000.0 [2]
(5Z)-5-[(3,4-Dihydroxyphenyl)methylidene]-4-sulfanylidene-1,3-thiazolidin-2-oneIC502600.0 [1], 41000.0 [2]
3-[(2,3-Dimethoxy-[1,3]benzodioxolo[5,6-c]phenanthridin-13-yl)oxy]-N,N-dimethylpropan-1-amineIC5013000.0 [1], 18000.0 [2]
3-[(2,3-Dimethoxy-[1,3]benzodioxolo[5,6-c]phenanthridin-13-yl)oxy]-N,N-diethylpropan-1-amineIC5015000.0 [1], 27000.0 [2]
2-[(2,3-Dimethoxy-[1,3]benzodioxolo[5,6-c]phenanthridin-13-yl)oxy]-N,N-dimethylethanamineIC5016000.0 [1], 24000.0 [2]
2,3-Dimethoxy-13-(3-pyrrolidin-1-ylpropoxy)-[1,3]benzodioxolo[5,6-c]phenanthridineIC5020000.0 [1], 21000.0 [2]
2-[(2,3-Dimethoxy-[1,3]benzodioxolo[5,6-c]phenanthridin-13-yl)oxy]-N,N-diethylethanamineIC5040000.0 [1], 58000.0 [2]
2,3-Dimethoxy-13-(3-piperidin-1-ylpropoxy)-[1,3]benzodioxolo[5,6-c]phenanthridineIC5019000.0 [1], 20000.0 [2]
(2Z,5Br)-7-acetyl-2-[(3,5-dibromophenyl)methylidene]-5,8-dihydroxy-4,5b-dimethyl-[1]benzofuro[4,5-b][1]benzofuran-1,6-dioneIC50530.0 [1], 640.0 [2]
6-(5-Aminopentyl)indeno[1,2-c]isoquinoline-5,11-dioneIC5017500.0 [1], 28000.0 [2]
Ethyl 2-[7-fluoro-1-(4-methylphenyl)-3,9-dioxo-1H-chromeno[2,3-c]pyrrol-2-yl]-4-methyl-1,3-thiazole-5-carboxylateIC5044670.0 [1], 50120.0 [2]
(2-Oxo-1-phenyl-2-piperidin-1-ylethyl) (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoateIC5070790.0 [1], 79430.0 [2]
2-(1H-Indol-3-yl)-2-oxoethyl 8-ethoxy-2-oxo-2H-chromene-3-carboxylateIC5014130.0 [1], 22390.0 [2]
[(2-Ethoxy-2-oxoethyl)(4-fluorophenyl)carbamoyl]methyl 2-(1H-indol-3-yl)acetateIC507940.0 [1], 11220.0 [2]
Methyl 4-[[4-(3-cyclopropyl-4-oxo-1,2-dihydroquinazolin-2-yl)-2-methoxyphenoxy]methyl]benzoateIC5044670.0 [1], 89130.0 [2]
[2-(Cyclopropylamino)-2-oxo-1-phenylethyl] (E)-3-[4-(trifluoromethyl)phenyl]prop-2-enoateIC5031620.0 [1], 44670.0 [2]
6-(6-Hydroxyhexyl)indeno[1,2-c]isoquinoline-5,11-dioneIC5045000.0 [1], 111000.0 [2]
6-(7-Hydroxyheptyl)indeno[1,2-c]isoquinoline-5,11-dioneIC5018000.0 [1], 111000.0 [2]
N-[6-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl]methanesulfonamideIC505200.0 [1], 111000.0 [2]
N-[11-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)undecyl]methanesulfonamideIC506700.0 [1], 111000.0 [2]
4-[(Z)-(2-Oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]benzoic acidIC5011000.0 [1], 16000.0 [2]
[4-[(Z)-(2-Oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenyl]phosphonic acidIC502200.0 [1], 69000.0 [2]
Sodium;4-[(Z)-(2-oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]benzoateIC506900.0 [1], 7800.0 [2]
Methyl 4-[(Z)-(2-oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]benzoateIC506700.0 [1], 38000.0 [2]
6-(3-Aminopropyl)-3-iodo-9-methoxyindeno[1,2-c]isoquinoline-5,11-dioneIC505200.0 [1]
{Imidazo[1,2-a]pyridin-2-yl}methyl 1H,2H,3H-cyclopenta[b]quinoline-9-carboxylateIC5035480.0 [1], 50120.0 [2]
6-(7-Aminoheptyl)indeno[1,2-c]isoquinoline-5,11-dioneIC5028800.0 [1], 31000.0 [2]
6-(8-Aminooctyl)indeno[1,2-c]isoquinoline-5,11-dioneIC5048000.0 [1], 49000.0 [2]
AchromycinIC50785000.0 [1]
NeomycinIC508000000.0 [1]
Tyrphostin B42IC50333000.0 [1]
Tyrphostin 47IC5012000.0 [1]
Tyrphostin A25IC50333000.0 [1]
Tyrphostin A46IC50333000.0 [1]
d-Usninic acidIC50100000.0 [1]
CID 70674149IC5010000.0 [1]
20-[3-(2-Hydroxyethylamino)propyl]-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dioneIC5012000.0 [1]
7-Benzyloxy-4-methyl-chromen-2-oneIC505280.0 [1]
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acidIC50333000.0 [1]
(-)-Usnic acidIC50100000.0 [1]
n,n'-DibenzoylcystineIC50111000.0 [1]
5-[(1-Methyl-1H-indol-3-yl)methylene]-4-thioxo-1,3-thiazolidin-2-oneIC5040000.0 [1]
1-PiperidineacetanilideIC5010000.0 [1]
6-(3-Aminopropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dioneIC5037000.0 [1]
n,n'-Bis(phenylacetyl)cystineIC50111000.0 [1]
6-(2-Hydroxyethyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dioneIC50111000.0 [1]
7-[(3-Methoxybenzyl)oxy]-4-methyl-2H-chromen-2-oneIC5010000.0 [1]
6-(3-Aminopropyl)indeno[1,2-c]isoquinoline-5,11-dioneIC5012000.0 [1]
6-(3-Hydroxypropyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dioneIC50111000.0 [1]
6-(Furan-2-yl)-2-hydroxy-4H-isoquinoline-1,3-dioneIC50111000.0 [1]
6-(5-Hydroxypentyl)indeno[1,2-c]isoquinoline-5,11-dioneIC50111000.0 [1]
7-[(3,4,5-Trimethoxybenzyl)oxy]-2,3-dihydrocyclopenta[c]chromen-4(1H)-oneIC5010000.0 [1]
(5Z)-5-[(4-Fluorophenyl)methylidene]-1,3-thiazolidine-2,4-dioneIC50333000.0 [1]
5-[(4-Hydroxy-3-methoxyphenyl)methylene]-4-thioxo-1,3-thiazolidin-2-oneIC5011000.0 [1]
7-[(3-Methoxybenzyl)oxy]-2,3-dihydrocyclopenta[c]chromen-4(1H)-oneIC5010000.0 [1]
(5Z)-5-[(3,4-Dihydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dioneIC50111000.0 [1]
3-(Benzyloxy)-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-oneIC505620.0 [1]
7-(Benzyloxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-oneIC509170.0 [1]
6-(3-Aminopropyl)-3-(methylamino)indeno[1,2-c]isoquinoline-5,11-dioneIC5037000.0 [1]
N-[6-(3-Azidopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]acetamideIC50111000.0 [1]
6-(3-Hydroxypropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dioneIC50111000.0 [1]
(Z)-4-((2,4-Dioxothiazolidin-5-ylidene)methyl)benzoic acidIC50111000.0 [1]
9-Hydroxy-2,3,8-trimethoxy-6-(3-morpholin-4-ylpropyl)indeno[1,2-c]isoquinoline-5,11-dioneIC50111000.0 [1]
6-(3-Imidazol-1-ylpropyl)-5,11-dioxoindeno[1,2-c]isoquinoline-3-carbonitrileIC50111000.0 [1]
6-(3-Morpholin-4-ylpropyl)-5,11-dioxoindeno[1,2-c]isoquinoline-3-carbonitrileIC50111000.0 [1]
5,6-Dihydro-6-(4-hydroxy-1-butyl)-5,11-diketo-11H-indeno[1,2-c]isoquinolineIC50111000.0 [1]
(2Z,5Br)-7-acetyl-5,8-dihydroxy-2-[(2-methoxyphenyl)methylidene]-4,5b-dimethyl-[1]benzofuro[4,5-b][1]benzofuran-1,6-dioneIC50390.0 [1]
(2Z,5Br)-7-acetyl-2-[(4-bromophenyl)methylidene]-5,8-dihydroxy-4,5b-dimethyl-[1]benzofuro[4,5-b][1]benzofuran-1,6-dioneIC50150.0 [1]
(2Z,5Br)-7-acetyl-5,8-dihydroxy-4,5b-dimethyl-2-(pyridin-4-ylmethylidene)-[1]benzofuro[4,5-b][1]benzofuran-1,6-dioneIC50810.0 [1]
(2Z,5Br)-7-acetyl-5,8-dihydroxy-4,5b-dimethyl-2-(pyridin-3-ylmethylidene)-[1]benzofuro[4,5-b][1]benzofuran-1,6-dioneIC50450.0 [1]
2,2,2-Trifluoro-N-[8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-yl]acetamideIC5010000.0 [1]
6-(3-Morpholin-4-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dioneIC50111000.0 [1]
6-(3-Imidazol-1-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dioneIC50111000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosyl-DNA phosphodiesterase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/tyrosyl-dna-phosphodiesterase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Tyrosyl-DNA phosphodiesterase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosyl-dna-phosphodiesterase-1-inhibitors-ic50-ki.
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