Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine	IC50	76.0 [1], 174.0 [2], 820.0 [3]
	Trifluoperazine	IC50	8000.0 [1]
	Pimozide	IC50	2000.0 [1]
	Flupentixol	IC50	7000.0 [1]
	Rottlerin	IC50	8000.0 [1]
	GW7647	IC50	5000.0 [1]
	N-(Thiophen-2-ylmethyl)-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	7900.0 [1]
	N-[Dideuterio-[4-(triazol-1-yl)phenyl]methyl]-2-[2-(1,1,1,2,3,3,3-heptadeuteriopropan-2-yl)phenyl]-5-methylpyrimidin-4-amine	IC50	190.0 [1]
	2-[2-(Trifluoromethyl)phenyl]-N-[[4-[2-(trifluoromethyl)pyridin-4-yl]phenyl]methyl]quinazolin-4-amine	IC50	4900.0 [1]
	N-[(4-Imidazol-1-ylphenyl)methyl]-5-methyl-2-(2-propan-2-ylphenyl)pyrimidin-4-amine	IC50	300.0 [1]
	2-(2-Cyclobutylphenyl)-5-methyl-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine	IC50	180.0 [1]
	5-Methyl-2-(2-propan-2-ylphenyl)-N-[2-[4-(triazol-1-yl)phenyl]propan-2-yl]pyrimidin-4-amine	IC50	590.0 [1]
	2-[2-(1,1,1,3,3,3-Hexadeuteriopropan-2-yl)phenyl]-5-methyl-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine	IC50	140.0 [1]
	2-[2-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-yl)phenyl]-5-methyl-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine	IC50	100.0 [1]
	2-[2-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-yl)phenyl]-5-methyl-N-[2-[4-(triazol-1-yl)phenyl]propan-2-yl]pyrimidin-4-amine	IC50	760.0 [1]
	N-[Dideuterio-[4-(triazol-1-yl)phenyl]methyl]-5-methyl-2-(2-propan-2-ylphenyl)pyrimidin-4-amine	IC50	120.0 [1]
	2-Phenyl-3a,9a-dihydrobenzo[f][1,3]benzoxazole-4,9-dione	IC50	540.0 [1]
	2-(4-Fluorophenyl)-3a,9a-dihydrobenzo[f][1,3]benzoxazole-4,9-dione	IC50	880.0 [1]
	N-[(4-Phenylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	3700.0 [1]
	N-[(3,4-Dichlorophenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	10400.0 [1]
	2-[2-(Trifluoromethyl)phenyl]-N-[[4-(trifluoromethyl)phenyl]methyl]quinazolin-4-amine	IC50	8900.0 [1]
	4-[[[2-[2-(Trifluoromethyl)phenyl]quinazolin-4-yl]amino]methyl]benzonitrile	IC50	5700.0 [1]
	N-[(4-Methoxyphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	6200.0 [1]
	N-[(5-Methylthiophen-2-yl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	5100.0 [1]
	N-(1,3-Benzodioxol-5-ylmethyl)-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	8400.0 [1]
	N-Benzyl-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	3100.0 [1]
	N-[(4-Fluorophenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	3400.0 [1]
	N-[(4-Chlorophenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	4800.0 [1]
	N-[[4-(3,4-Dichlorophenyl)phenyl]methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	2200.0 [1]
	N-[[4-(3-Chlorophenyl)phenyl]methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	2700.0 [1]
	N-[[4-(4-Chlorophenyl)phenyl]methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	3600.0 [1]
	N-[(4-Pyridin-4-ylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	1900.0 [1]
	2-(2-Methoxyphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amine	IC50	940.0 [1]
	1-[2-[5-Methyl-4-[(4-pyridin-3-ylphenyl)methylamino]pyrimidin-2-yl]phenyl]ethanone	IC50	8700.0 [1]
	2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]thieno[3,2-d]pyrimidin-4-amine	IC50	110.0 [1]
	2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]thieno[2,3-d]pyrimidin-4-amine	IC50	280.0 [1]
	5-Methyl-N-[[1-(oxetan-3-yl)piperidin-4-yl]methyl]-2-(2-propan-2-ylphenyl)pyrimidin-4-amine	IC50	13600.0 [1]
	N-[[4-(6-Fluoropyridin-3-yl)phenyl]methyl]-5-methyl-2-(2-propan-2-ylphenyl)pyrimidin-4-amine	IC50	80.0 [1]
	N-[(4-Pyrimidin-5-ylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	3000.0 [1]
	2-(2-Fluorophenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amine	IC50	6500.0 [1]
	5-Fluoro-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amine	IC50	110.0 [1]
	5-Methyl-N-[(3-methylphenyl)methyl]-2-(2-propan-2-ylphenyl)pyrimidin-4-amine	IC50	130.0 [1]
	N-[(4-Pyridin-3-ylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	1100.0 [1]
	5-Methyl-2-(2-propan-2-ylphenyl)-N-[(1-pyridin-3-ylazetidin-3-yl)methyl]pyrimidin-4-amine	IC50	21700.0 [1]
	[2-[5-Methyl-4-[(4-pyridin-3-ylphenyl)methylamino]pyrimidin-2-yl]phenyl]methanol	IC50	10500.0 [1]
	1-[2-[5-Methyl-4-[(4-pyridin-3-ylphenyl)methylamino]pyrimidin-2-yl]phenyl]ethanol	IC50	2000.0 [1]
	5-Methyl-2-(2-propan-2-ylphenyl)-N-[(1-pyrazin-2-ylpiperidin-4-yl)methyl]pyrimidin-4-amine	IC50	140.0 [1]
	5-Methoxy-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amine	IC50	70.0 [1]
	2-(2-Ethylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amine	IC50	780.0 [1]
	5-Methyl-2-(2-propan-2-ylphenyl)-N-[(1-pyridin-3-ylpyrrolidin-3-yl)methyl]pyrimidin-4-amine	IC50	800.0 [1]
	5-N,5-N-Dimethyl-2-(2-propan-2-ylphenyl)-4-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidine-4,5-diamine	IC50	190.0 [1]
	2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	260.0 [1]
	N-(3-Pyridin-3-ylprop-2-ynyl)-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	8900.0 [1]
	2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine	IC50	160.0 [1]
	2-[2-(Difluoromethyl)phenyl]-5-methyl-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine	IC50	820.0 [1]
	6-Methyl-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amine	IC50	210.0 [1]
	2-(2-Nitrophenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amine	IC50	7800.0 [1]
	5-Methyl-N-[[1-(6-methylpyridin-3-yl)piperidin-4-yl]methyl]-2-(2-propan-2-ylphenyl)pyrimidin-4-amine	IC50	90.0 [1]
	2-(2-Methylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amine	IC50	1100.0 [1]
	2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine	IC50	860.0 [1]
	2-(2-Chlorophenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amine	IC50	2100.0 [1]
	2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amine	IC50	150.0 [1]
	5-Methyl-2-(2-propan-2-ylphenyl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine	IC50	1300.0 [1]
	5-Methyl-N-[[4-(6-methylpyridin-3-yl)phenyl]methyl]-2-(2-propan-2-ylphenyl)pyrimidin-4-amine	IC50	50.0 [1]
	2-(2-Cyclopropylphenyl)-5-methyl-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amine	IC50	180.0 [1]
	2-(3-Methylphenyl)-2-[[5-methyl-2-(2-propan-2-ylphenyl)pyrimidin-4-yl]amino]ethanol	IC50	21000.0 [1]
	5-Methyl-2-(2-propan-2-ylphenyl)-N-[[4-(2H-tetrazol-5-yl)phenyl]methyl]pyrimidin-4-amine	IC50	5900.0 [1]
	5-Methyl-2-(2-propan-2-ylphenyl)-N-[(1-pyridin-3-ylpiperidin-4-yl)methyl]pyrimidin-4-amine	IC50	80.0 [1]
	2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]furo[3,2-d]pyrimidin-4-amine	IC50	80.0 [1]
	2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]-7H-purin-6-amine	IC50	120.0 [1]
	5-Methyl-2-(2-propan-2-ylphenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine	IC50	270.0 [1]
	2-(2-Propan-2-ylphenyl)-4-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidine-4,5-diamine	IC50	310.0 [1]
	5-Methyl-2-(2-propan-2-ylphenyl)-N-[[4-[2-(trifluoromethyl)pyridin-4-yl]phenyl]methyl]pyrimidin-4-amine	IC50	320.0 [1]
	2-(2-Bromophenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amine	IC50	1600.0 [1]
	N-[(4-Cyclohexylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	9800.0 [1]
	5-Methylsulfanyl-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amine	IC50	110.0 [1]
	2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amine	IC50	180.0 [1]
	5-Methyl-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amine	IC50	70.0 [1]
	5,6-Dimethyl-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amine	IC50	120.0 [1]
	2-[2-(Difluoromethyl)phenyl]-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amine	IC50	1400.0 [1]
	N-[(4-Morpholin-4-ylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amine	IC50	10400.0 [1]
	2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-amine	IC50	2900.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 82 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/ubiquitin-carboxyl-terminal-hydrolase-1-wd-repeat-containing-protein-48-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ubiquitin-carboxyl-terminal-hydrolase-1-wd-repeat-containing-protein-48-inhibitors-ic50-ki.
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