Urokinase-type plasminogen activator Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Amiloride	IC50	7000.0 [1], 11980.0 [2], 107000.0 [3]
	Amiloride	Ki	2433.0 [1], 2511.89 [2], 7000.0 [3]
	3-[(7R,10S,13S,19S,25S,28R,31S,34S,37S,40S,43S,46S,49R)-7-[(2-Amino-2-oxoethyl)carbamoyl]-49-[[(2S)-2-aminopropanoyl]amino]-19,25,43-tris(3-carbamimidamidopropyl)-31-(carboxymethyl)-13,46-bis(hydroxymethyl)-40-[(4-hydroxyphenyl)methyl]-10-methyl-9,12,15,18,21,24,27,30,33,36,39,42,45,48-tetradecaoxo-34-propan-2-yl-5,51,56-trithia-8,11,14,17,20,23,26,29,32,35,38,41,44,47-tetradecazatricyclo[26.26.3.13,53]octapentaconta-1(54),2,53(58)-trien-37-yl]propanoic acid	Ki	53.0 [1]
	6-(N-Phenylcarbamyl)-2-naphthalenecarboxamidine	IC50	13000.0 [1]
	6-(N-Phenylcarbamyl)-2-naphthalenecarboxamidine	Ki	630.0 [1], 630.96 [2], 631.0 [3], 1900.0 [4]
	Benzo[b]thiophene-2-carboximidamide, 4-iodo-	IC50	210.0 [1]
	Benzo[b]thiophene-2-carboximidamide, 4-iodo-	Ki	79.43 [1], 210.0 [2], 320.0 [3]
	Razaxaban	Ki	2300.0 [1], 13000.0 [2]
	Wx-uk1 free base	IC50	410.0 [1]
	Wx-uk1 free base	Ki	410.0 [1]
	1-Phenylguanidine	IC50	20000.0 [1]
	1-Phenylguanidine	Ki	20600.0 [1], 20606.3 [2]
	Naphthalene-2-carboximidamide	Ki	5900.0 [1], 5910.0 [2], 6309.57 [3]
	1-(4-Chlorophenyl)guanidine	Ki	6067.36 [1], 6070.0 [2], 6700.0 [3]
	2-{5-[Amino(iminio)methyl]-1H-benzimidazol-2-YL}benzenolate	Ki	5500.0 [1]
	2-(2-Hydroxyphenyl)-1H-indole-5-carboxamidine	Ki	2400.0 [1]
	3-[4-Chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]benzoic Acid	IC50	37.0 [1]
	3-[4-Chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]benzoic Acid	Ki	37.0 [1]
	2-[[4-Chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid	IC50	890.0 [1]
	2-[[4-Chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid	Ki	10.0 [1]
	6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidine	IC50	1200.0 [1]
	6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidine	Ki	39.81 [1], 40.0 [2]
	6-[(Z)-Amino(imino)methyl]-N-[4-(aminomethyl)phenyl]-4-(pyrimidin-2-ylamino)-2-naphthamide	IC50	0.62 [1]
	6-[(Z)-Amino(imino)methyl]-N-[4-(aminomethyl)phenyl]-4-(pyrimidin-2-ylamino)-2-naphthamide	Ki	0.62 [1], 0.63 [2]
	8-(Pyrimidin-2-ylamino)naphthalene-2-carboximidamide	Ki	30.0 [1], 31.62 [2], 35.0 [3]
	Amiloride hydrochloride dihydrate	IC50	11000.0 [1]
	Amiloride hydrochloride dihydrate	Ki	7000.0 [1]
	(2R)-1-(2,6-Dimethylphenoxy)propan-2-amine	IC50	1000000.0 [1]
	5-(N,N-Hexamethylene)amiloride	IC50	2400.0 [1]
	5-(N,N-Hexamethylene)amiloride	Ki	1356.0 [1]
	1-(3-Chlorophenyl)guanidine	Ki	61659.5 [1], 61800.0 [2]
	4-Guanidinobenzoic acid	Ki	744731.97 [1], 745000.0 [2]
	6-[2-(2-Methyl-1-propan-2-yl-3,4-dihydro-1H-isoquinolin-7-yl)cyclopropyl]naphthalene-2-carboximidamide	Ki	47.0 [1], 50.12 [2]
	2-[3-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide;hydrochloride	Ki	19000.0 [1]
	Guanidine, N-2-pyridinyl-	Ki	29000.0 [1], 29500.0 [2]
	3-{5-[Amino(iminio)methyl]-1H-indol-2-YL}-1,1'-biphenyl-2-olate	Ki	8.0 [1]
	2-{5-[Amino(iminio)methyl]-1H-indol-2-YL}-6-bromo-4-methylbenzenolate	Ki	55.0 [1], 110.0 [2]
	N-(Benzylsulfonyl)seryl-N~1~-{4-[(Z)-amino(imino)methyl]benzyl}serinamide	IC50	20.0 [1]
	N-(Benzylsulfonyl)seryl-N~1~-{4-[(Z)-amino(imino)methyl]benzyl}serinamide	Ki	20.0 [1]
	1-(4-Methoxyphenyl)guanidine	Ki	676000.0 [1], 676082.98 [2]
	N-p-Tolyl-guanidine	Ki	15595.53 [1], 15600.0 [2]
	N-(2-Chloro-phenyl)-guanidine	Ki	103000.0 [1], 103038.61 [2]
	Benzenebutanamide, N-(4-(aminoiminomethyl)phenyl)-alpha-(((4-methylphenyl)sulfonyl)amino)-	IC50	10000.0 [1], 26000.0 [2]
	1-(4-Fluorophenyl)guanidine	Ki	38904.51 [1], 72400.0 [2]
	Ethyl N-[(2S)-6-amino-1-oxo-1-[5-[[4-(2-phenylethoxy)phenyl]methyl]-1,2,4-oxadiazol-3-yl]hexan-2-yl]carbamate	Ki	150000.0 [1]
	4-[(E)-(5-Oxo-2-phenyl-1,3-oxazol-4-ylidene)methyl]benzenecarboximidamide	IC50	200.0 [1], 8670.0 [2]
	2-Amino-1H-benzo[d]imidazol-5-ol	IC50	10000.0 [1], 200000.0 [2]
	4-(4-Phenyl-2-thiazolyl)-5-(methylthio)thiophene-2-carboxamidine	Ki	90.0 [1], 101.0 [2]
	N-[4-(Trifluoromethyl)phenyl]guanidine	Ki	6486.34 [1], 6490.0 [2]
	1-Piperazino-2-[(2-naphthyl)sulfonylamino]-3-(3-amidinophenyl)-1-propanone	Ki	48000.0 [1]
	6-[(Z)-Amino(imino)methyl]-N-[3-(cyclopentyloxy)phenyl]-2-naphthamide	Ki	25.12 [1], 28.0 [2]
	3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperidin-1-yl-propyl]-benzamidine	Ki	38000.0 [1]
	N-[3-(Trifluoromethyl)phenyl]guanidine	Ki	418793.57 [1], 419000.0 [2]
	Diphenyl N-(benzyloxycarbonyl)amino(4-amidinophenyl)methanephosphonate	IC50	2500.0 [1], 60000.0 [2]
	4-[4-(4-Chlorophenyl)-2-thiazolyl]-5-(methylthio)thiophene-2-carboxamidine	Ki	102.0 [1], 99000.0 [2]
	6-(2-(1-Isopropyl-3,4-dihydroisoquinolin-7-yl)cyclopropyl)-2-naphthimidamide	Ki	125.89 [1], 139.0 [2]
	2-(3-Bromo-5-chloro-2-pyridinyl)guanidine	Ki	4830.0 [1]
	6-Carbamimidoyl-4-(furan-3-yl)-N-phenylnaphthalene-2-carboxamide	Ki	91.0 [1]
	6-Carbamimidoyl-N-phenyl-4-(pyrimidin-2-ylamino)naphthalene-2-carboxamide	Ki	2.0 [1], 200.0 [2]
	6-Carbamimidoyl-4-(oxolan-3-yl)-N-phenylnaphthalene-2-carboxamide	Ki	100.0 [1], 106.0 [2]
	5-Methylsulfanyl-thiophene-2-carboxamidine	Ki	6000.0 [1]
	4-[(2R)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N,N-dimethylpiperazine-1-carboxamide	IC50	10000.0 [1]
	4-[(2R)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N,N-dimethylpiperazine-1-carboxamide	Ki	28000.0 [1]
	Benzyl N-[(2R)-1-[[(2S)-1-[[4-(diaminomethylideneamino)-1-diphenoxyphosphorylbutyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamate	IC50	61.0 [1]
	6-Carbamimidoyl-N-(1-propan-2-yl-1,2,3,4-tetrahydroisoquinolin-7-yl)naphthalene-2-carboxamide	Ki	23.5 [1], 25.12 [2]
	6-Carbamimidoyl-N-(3,5-dimethoxyphenyl)naphthalene-2-carboxamide	IC50	2600.0 [1]
	6-Carbamimidoyl-N-(3,5-dimethoxyphenyl)naphthalene-2-carboxamide	Ki	139.0 [1]
	6-Carbamimidoyl-N-(3-propan-2-yloxyphenyl)naphthalene-2-carboxamide	Ki	63.0 [1], 63.1 [2]
	3-Amino-N-[3-[[(2S)-3-(3-carbamimidoylphenyl)-1-[4-[2-(diaminomethylideneamino)ethyl]piperidin-1-yl]-1-oxopropan-2-yl]sulfamoyl]phenyl]propanamide	Ki	1700.0 [1]
	3-Amino-N-[3-[[(2S)-1-[4-(2-aminoethyl)piperidin-1-yl]-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl]sulfamoyl]phenyl]propanamide	Ki	3600.0 [1]
	6-Carbamimidoyl-N-(1,2,3,4-tetrahydroisoquinolin-6-yl)naphthalene-2-carboxamide	Ki	15.85 [1], 16.5 [2]
	N-[(1S)-5-Amino-1-cyanopentyl]-2-[[3-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-3-methylbenzimidazole-5-carboxamide	IC50	200000.0 [1]
	1-(4-Bromophenyl)guanidine	Ki	30690.22 [1], 30700.0 [2]
	Methyl 4-[(diaminomethylidene)amino]benzoate	Ki	1448771.85 [1], 1450000.0 [2]
	(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]amino]-1-oxopropan-2-yl]-3-hydroxypropanamide	IC50	3.5 [1], 4.0 [2]
	8-[(2-Pyrimidinyl)amino]quinoline-2-amine	Ki	370.0 [1], 2511.89 [2]
	6-Phenethyl-2-naphthimidamide	Ki	3162.28 [1], 3183.0 [2]
	8-(Furan-2-yl)-7-methoxy-2-naphthimidamide	Ki	1995.26 [1], 2100.0 [2]
	6-(2-Phenylcyclopropyl)-2-naphthimidamide	Ki	1258.93 [1], 1310.0 [2]
	8-Aminonaphthalene-2-Carboximidamide	Ki	450.0 [1], 501.19 [2]
	4-(2-Aminoethoxy)-N-(3-Chloro-2-Ethoxy-5-Piperidin-1-Ylphenyl)-3,5-Dimethylbenzamide	IC50	72.0 [1]
	(2-Nitro-phenyl)-guanidine	Ki	54300.0 [1], 54325.03 [2]
	N-(4-Ethylphenyl)guanidine	Ki	90700.0 [1], 90782.05 [2]
	6-(2-Phenylcyclopropyl)-8-(pyrimidin-2-ylamino)-2-naphthimidamide	Ki	5.0 [1], 5.01 [2]
	8-Bromo-6-phenethyl-2-naphthimidamide	Ki	1258.93 [1], 1370.0 [2]
	6-[N-(1-Isopropyl-3,4-dihydro-7-isoquinolinyl)carbamyl]-2-naphthalenecarboxamidine	Ki	48.0 [1], 50.12 [2]
	3-[3-(4-Methylpiperidin-1-yl)-3-oxo-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide	Ki	2000.0 [1]
	7-Methoxy-8-[1-(methylsulfonyl)-1H-pyrazol-4-YL]naphthalene-2-carboximidamide	Ki	630.0 [1], 630.96 [2]
	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[2,5-dioxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	IC50	200000.0 [1], 400000.0 [2]
	N-[(1S)-1-[4-(3-Amino-1H-indazol-6-yl)pyridin-2-yl]-2-phenylethyl]-4-(aminomethyl)cyclohexane-1-carboxamide	Ki	14060.0 [1]
	N-[(1S)-5-Amino-1-cyanopentyl]-6-[[3-(4-fluorophenyl)-2,5-dioxoimidazolidin-1-yl]methyl]-7-methylpyrrolo[2,3-d]pyrimidine-2-carboxamide	IC50	200000.0 [1], 1000000.0 [2]
	CID 9799627	Ki	6.3 [1], 6.31 [2]
	N-(Benzylsulfonyl)-D-Seryl-N-{4-[amino(Imino)methyl]benzyl}-L-Alaninamide	Ki	7.7 [1]
	2-(2-Hydroxy-3-phenyl-5-methylphenyl)-1H-indole-5-carboxamidine	Ki	38.0 [1], 110.0 [2]
	Benzyl N-[(2R)-1-[[(2S)-1-[[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamate	IC50	4.3 [1], 57.0 [2]
	N-(2-Methoxy-phenyl)-guanidine	Ki	136000.0 [1], 136144.47 [2]
	3-Amino-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-N-(diaminomethylidene)pyrazine-2-carboxamide	IC50	530.0 [1]
	3-Amino-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-N-(diaminomethylidene)pyrazine-2-carboxamide	Ki	183.0 [1]
	3-Amino-5-(azepan-1-yl)-N-(diaminomethylidene)-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide	IC50	39.0 [1]
	3-Amino-5-(azepan-1-yl)-N-(diaminomethylidene)-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide	Ki	53.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Urokinase-type plasminogen activator Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/urokinase-type-plasminogen-activator-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Urokinase-type plasminogen activator Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/urokinase-type-plasminogen-activator-inhibitors-ic50-ki.
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