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Vanilloid receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
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▼
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideIC504.5 [1]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideKi0.3 [1]
BctcIC509.6 [1]
BctcKi4.32 [1], 10.5 [2]
(2S)-2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideIC500.8 [1], 6.3 [2]
(2S)-2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideKi0.2 [1]
CapsazepineIC5074.0 [1]
CapsazepineKi120.0 [1]
Amg-517IC500.76 [1]
1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ureaIC503.0 [1], 4.0 [2]
1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ureaKi5.0 [1], 18.3 [2]
(2S)-N-[(4-Tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC50174.0 [1], 1210.0 [2], 1281.0 [3]
(2S)-N-[(4-Tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi6.6 [1], 20.0 [2], 28.0 [3]
ResiniferatoxinKi0.48 [1], 1.23 [2], 14.0 [3], 23.1 [4]
IodoresiniferatoxinIC504000.0 [1]
IodoresiniferatoxinKi5.87 [1], 5.9 [2], 11.8 [3]
(R)-1-(5-Tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)ureaIC500.7 [1], 3.0 [2], 4.0 [3]
N-(4-(Trifluoromethyl)phenyl)-4-(3-(trifluoromethyl)pyridin-2-yl)benzamideIC503.0 [1], 13.0 [2], 14.0 [3]
N-[(4-Tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC501990.0 [1]
N-[(4-Tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi5.1 [1], 12.7 [2], 44.5 [3], 89.0 [4]
(R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazol-2-ylamino}-1,2,3,4-tetrahydronaphthalen-2-olIC5012.0 [1], 15.0 [2], 180.0 [3], 100000.0 [4]
N-[[2-Cyclohexyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC5014.1 [1], 43.4 [2]
N-[[2-Cyclohexyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.2 [1], 0.6 [2]
1-[3-Fluoro-4-(methanesulfonamidomethyl)phenyl]-3-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]ureaKi5.0 [1], 6.77 [2], 11.5 [3], 12.5 [4]
(2S)-N-[[2-Cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC5022.3 [1], 1000.0 [2]
(2S)-N-[[2-Cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.05 [1], 0.4 [2]
(2S)-N-[[2-(3-Chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC508.0 [1], 8.1 [2]
(2S)-N-[[2-(3-Chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.1 [1]
CapsaicinIC508.0 [1]
CapsaicinKi6.0 [1], 1140.0 [2], 2530.0 [3]
(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamideIC5025.0 [1], 93.0 [2], 1200.0 [3], 3200.0 [4]
PpahvKi0.12 [1], 0.45 [2], 2100.0 [3], 6400.0 [4]
Pinosylvin methyl etherIC5010000.0 [1], 15000.0 [2], 23700.0 [3], 30000.0 [4]
N-[4-(Trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amineIC500.8 [1], 1.1 [2]
3-(2-Morpholino-6-(trifluoromethyl)pyridin-3-yl)-N-(quinolin-7-yl)acrylamideIC501.3 [1], 1.9 [2], 116.0 [3]
3-(2-Morpholino-6-(trifluoromethyl)pyridin-3-yl)-N-(quinolin-7-yl)acrylamideKi1.2 [1]
(2R)-4-(6-Chloro-4-methylpyridazin-3-yl)-N-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazine-1-carboxamideIC50103.0 [1], 103.3 [2], 226.0 [3], 226.3 [4]
(R)-6-Tert-butyl-2-(4-(3-chloropyridin-2-yl)-2-methylpiperazin-1-yl)-1H-benzo[d]imidazoleIC5090.0 [1], 90.4 [2], 104.0 [3]
(R)-6-Tert-butyl-2-(2-methyl-4-(3-methylpyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazoleIC5070.0 [1], 70.4 [2], 597.0 [3]
(R)-6-Tert-butyl-2-(2-methyl-4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazoleIC5032.0 [1], 32.4 [2], 1778.0 [3]
N-[4-(Trifluoromethyl)phenyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamideIC503.0 [1], 4.0 [2], 57.0 [3]
N-[4-(Trifluoromethyl)phenyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamideKi38.0 [1]
N-[[2-Cyclopentylsulfanyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC5032.0 [1], 37.2 [2]
N-[[2-Cyclopentylsulfanyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.03 [1], 0.3 [2]
2-(4-Amino-3,5-dichlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamideIC5012.8 [1], 158.0 [2]
2-(4-Amino-3,5-dichlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamideKi0.1 [1], 0.3 [2]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methylpropoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideIC5052.6 [1], 67.5 [2]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methylpropoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideKi0.29 [1], 0.5 [2]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideKi0.4 [1], 0.84 [2], 25.9 [3], 130.8 [4]
N-[[2-Butoxy-6-[chloro(difluoro)methyl]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC507.0 [1], 8.3 [2]
N-[[2-Butoxy-6-[chloro(difluoro)methyl]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.02 [1], 0.3 [2]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-2-(3-methylphenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamideIC5036.2 [1], 86.7 [2]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-2-(3-methylphenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamideKi0.1 [1], 0.25 [2]
(1S)-N-(4-Tert-butylcyclohexyl)-3-oxo-1,2-diphenyl-2,7-diazaspiro[3.5]nonane-7-carboxamideIC5032.0 [1], 49.0 [2], 232.0 [3], 528.0 [4]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-phenylmethoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideIC5018.6 [1], 52.3 [2]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-phenylmethoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideKi0.0 [1], 0.5 [2]
N-[[6-[Chloro(difluoro)methyl]-2-cyclopentyloxypyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC5018.5 [1], 19.3 [2]
N-[[6-[Chloro(difluoro)methyl]-2-cyclopentyloxypyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.04 [1], 0.5 [2]
(2S)-N-[[2-Cyclohexylsulfanyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC507.3 [1], 20.4 [2]
(2S)-N-[[2-Cyclohexylsulfanyl-4-(trifluoromethyl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.03 [1], 0.3 [2]
4-(3-Chloropyridin-2-yl)-4-fluoro-N-(6-fluoro-1,3-benzothiazol-2-yl)piperidine-1-carboxamideIC50508.0 [1], 1463.0 [2]
Jnj-17203212IC5016.0 [1], 65.0 [2], 160.0 [3]
1-[3-(Trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamideIC5024.0 [1], 14000.0 [2], 20200.0 [3]
1-Isoquinolin-5-yl-3-{1-[4-(trifluoromethyl)phenyl]ethyl}ureaIC5022.0 [1]
(E)-3-[2-Piperidin-1-yl-6-(trifluoromethyl)pyridin-3-yl]-N-quinolin-7-ylprop-2-enamideIC500.42 [1], 1.0 [2]
(E)-3-[2-Piperidin-1-yl-6-(trifluoromethyl)pyridin-3-yl]-N-quinolin-7-ylprop-2-enamideKi4.4 [1]
N-[[2-Cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.9 [1]
3-1H-Indazol-4-yl-1-{1-[4-(trifluoromethyl)phenyl]ethyl}ureaIC5047.0 [1]
3-(7-Hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)phenyl]ureaIC503.9 [1], 13.0 [2], 22.0 [3]
6-(4-Fluorophenyl)-2-methyl-N-(2-methylbenzothiazol-5-yl)nicotinamideIC509.0 [1], 39.81 [2], 49.0 [3]
3-Amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,2-dihydroquinoxalin-2-oneIC500.4 [1], 0.8 [2], 0.9 [3]
Urea, N-5-isoquinolinyl-N'-[[3-(trifluoromethyl)phenyl]methyl]-IC5011.0 [1], 51.0 [2]
Urea, N-5-isoquinolinyl-N'-[[3-(trifluoromethyl)phenyl]methyl]-Ki23.0 [1]
N-[[2-(Dipropylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC5014.7 [1]
N-[[2-(Dipropylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.2 [1]
N-[[2-(4-Benzylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC5040.0 [1]
N-[[2-(4-Benzylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.2 [1]
2-Morpholin-4-yl-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amineIC505.3 [1], 6.0 [2]
N-[[2-Cyclopentyloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC5028.7 [1]
N-[[2-Cyclopentyloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.9 [1]
2-Piperazin-1-yl-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amineIC503300.0 [1], 3350.0 [2]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-fluorophenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideIC5025.0 [1]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-fluorophenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideKi2.5 [1]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[4-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl]methyl]propanamideIC5031.0 [1]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[4-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl]methyl]propanamideKi0.4 [1], 0.6 [2]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methylbutoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideIC5015.1 [1]
2-[3-Fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methylbutoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideKi0.8 [1]
N-[[2-[(2-Chlorophenyl)methylsulfanyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideIC50620.0 [1]
N-[[2-[(2-Chlorophenyl)methylsulfanyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi4.9 [1]
1-(4-Tert-Butyl-benzyl)-3-isoquinolin-5-yl-ureaIC503.0 [1]
1-(4-Tert-Butyl-benzyl)-3-isoquinolin-5-yl-ureaKi0.3 [1], 13.8 [2]
Urea, N-5-isoquinolinyl-N'-[2-[3-(trifluoromethyl)phenyl]ethyl]-IC5019.0 [1], 20.0 [2]
Urea, N-5-isoquinolinyl-N'-[2-[3-(trifluoromethyl)phenyl]ethyl]-Ki41.0 [1]
Urea, N-5-isoquinolinyl-N'-[2-[4-(trifluoromethyl)phenyl]ethyl]-IC5019.0 [1]
Urea, N-5-isoquinolinyl-N'-[2-[4-(trifluoromethyl)phenyl]ethyl]-Ki22.0 [1]
N-(4-Nitrophenyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamideIC503.0 [1], 74.0 [2]
4-[2-(Trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamideIC503.0 [1], 5.0 [2], 65.0 [3]
N-[[2-(4-Tert-butylcyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamideKi0.3 [1], 1.3 [2]
1-[3-Fluoro-4-(methanesulfonamido)phenyl]-1-(3-methylphenyl)-3-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]ureaKi490.0 [1], 860.0 [2], 2200.0 [3]
2-[3,5-Difluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamideIC508.1 [1], 8.7 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Vanilloid receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/vanilloid-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Vanilloid receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/vanilloid-receptor-inhibitors-ic50-ki.
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