Vascular endothelial growth factor receptor 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Sorafenib	IC50	68.0 [1]
	Sorafenib	Ki	0.02 [1], 0.12 [2], 22.0 [3]
	Sunitinib	IC50	37.0 [1]
	Sunitinib	Ki	2.9 [1], 9.0 [2]
	Vatalanib	IC50	43.0 [1]
	Vandetanib	IC50	41.8 [1]
	Semaxanib	IC50	884.0 [1]
	Staurosporine	IC50	10.36 [1]
	Staurosporine	Ki	1.7 [1]
	2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide	IC50	32.0 [1]
	Cabozantinib	IC50	0.48 [1]
	Foretinib	IC50	0.9 [1]
	Erlotinib	IC50	1000.0 [1]
	Linifanib	IC50	5.0 [1]
	2-{[(Pyridin-4-yl)methyl]amino}-N-(quinolin-3-yl)benzamide	IC50	50.0 [1]
	Pazopanib	IC50	30.0 [1]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	2.5 [1]
	1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea	IC50	0.03 [1], 4.7 [2], 6.2 [3], 14.0 [4]
	1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea	Ki	0.02 [1], 0.04 [2], 4.6 [3], 23.0 [4]
	Nintedanib	IC50	5.0 [1]
	Gefitinib	IC50	10000.0 [1]
	Ponatinib	IC50	1.7 [1]
	Orantinib	IC50	680.0 [1]
	N-(4-Chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	IC50	0.48 [1]
	4-N-(3,5-Dimethoxyphenyl)-4-N-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-1-N-propan-2-ylcyclohexane-1,4-diamine	IC50	954.99 [1]
	4-[3-Hydroxyanilino]-6,7-dimethoxyquinazoline	IC50	50.0 [1], 66.0 [2], 890.0 [3]
	3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide	IC50	1.27 [1], 6.0 [2], 10.55 [3], 11.0 [4]
	MGCD-265 analog	IC50	1.0 [1], 6.0 [2], 10.0 [3], 26.0 [4], 30.0 [5]
	N-(3-Chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	510.0 [1], 800.0 [2], 5300.0 [3]
	Ilorasertib	IC50	1.59 [1], 2.0 [2], 3.0 [3], 4.0 [4]
	1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea	IC50	1.0 [1], 3.0 [2], 3.02 [3]
	Thienopyrimidine deriv. 11	IC50	3.0 [1], 6.0 [2], 6.03 [3], 10.0 [4]
	N-(4-Bromo-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	460.0 [1], 1650.0 [2], 2900.0 [3]
	N-[5-(Ethylsulfonyl)-2-methoxyphenyl]-5-[3-(2-pyridinyl)phenyl]-1,3-oxazol-2-amine	IC50	17.1 [1], 22.0 [2]
	2-(Benzyloxy)-5-(6-methoxy-7-(2-methoxyethoxy)quinazolin-4-ylamino)cyclohexa-2,5-diene-1,4-dione	IC50	43.0 [1], 50.3 [2], 53.7 [3], 140.0 [4], 366.1 [5]
	2-[(3-Fluorophenyl)methoxy]-5-[[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino]cyclohexa-2,5-diene-1,4-dione	IC50	31.2 [1], 41.9 [2], 46.1 [3], 188.0 [4], 256.3 [5]
	2-(4-Benzylpiperazin-1-yl)-5-[[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino]cyclohexa-2,5-diene-1,4-dione	IC50	75.5 [1], 84.8 [2], 125.4 [3], 1000.0 [4]
	2-(1,3-Difluoropropan-2-yloxy)-5-[[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino]cyclohexa-2,5-diene-1,4-dione	IC50	9.1 [1], 18.5 [2], 21.3 [3], 24.8 [4], 212.0 [5]
	2-[[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino]-5-methylsulfanylcyclohexa-2,5-diene-1,4-dione	IC50	30.1 [1], 43.3 [2], 114.7 [3], 456.0 [4], 1000.0 [5]
	2-(4-Imidazol-1-ylphenoxy)-5-[[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino]cyclohexa-2,5-diene-1,4-dione	IC50	5.8 [1], 7.6 [2], 310.0 [3], 1000.0 [4]
	2-(1,3-Difluoropropan-2-yloxy)-5-[[6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-yl]amino]cyclohexa-2,5-diene-1,4-dione	IC50	3.7 [1], 5.1 [2], 6.9 [3], 11.2 [4], 189.0 [5]
	2-[[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino]-5-propan-2-yloxycyclohexa-2,5-diene-1,4-dione	IC50	481.0 [1], 491.3 [2], 542.9 [3], 1000.0 [4]
	2-Methoxy-5-(6-methoxy-7-(2-methoxyethoxy)quinazolin-4-ylamino)cyclohexa-2,5-diene-1,4-dione	IC50	25.0 [1], 240.9 [2], 436.3 [3], 558.6 [4], 1000.0 [5]
	3-Chloro-2-methoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone	IC50	1.0 [1], 5.1 [2], 20.9 [3], 466.0 [4]
	2-Methoxy-5-({6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-yl}amino)benzo-1,4-quinone	IC50	5.0 [1], 129.9 [2], 239.3 [3], 239.7 [4], 3020.7 [5]
	2-Methoxy-5-{[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]amino}benzo-1,4-quinone	IC50	3.0 [1], 158.6 [2], 271.8 [3], 406.3 [4], 1274.0 [5]
	2-[[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino]-5-(pyridin-3-ylmethoxy)cyclohexa-2,5-diene-1,4-dione	IC50	88.7 [1], 107.8 [2], 110.5 [3], 193.0 [4], 1000.0 [5]
	2-[[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino]-5-(5-methyl-2-oxo-1,3-oxazolidin-3-yl)cyclohexa-2,5-diene-1,4-dione	IC50	7.3 [1], 10.3 [2], 59.7 [3], 1000.0 [4]
	N'-(2,5-Dimethoxyphenyl)-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine	IC50	1000.0 [1], 1698.24 [2], 10000.0 [3]
	Imatinib	IC50	25000.0 [1], 25800.0 [2], 27186.0 [3]
	Crizotinib	IC50	1000.0 [1], 10000.0 [2]
	Dorsomorphin	IC50	4.0 [1], 21.8 [2], 25.14 [3], 220.0 [4]
	Axitinib	IC50	0.1 [1], 0.2 [2], 0.25 [3]
	Axitinib	Ki	3.8 [1]
	3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone	IC50	20.0 [1], 50.0 [2]
	Brivanib	IC50	25.0 [1], 26.0 [2]
	Brivanib	Ki	26.0 [1]
	Tivozanib	IC50	0.16 [1], 2.14 [2], 340.0 [3]
	3-{4-[(6,7-Dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1-(2-phenylacetyl)thiourea	IC50	32.0 [1]
	3-{4-[(6,7-Dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1-(2-phenylacetyl)thiourea	Ki	103.0 [1]
	Tak-593	IC50	0.09 [1], 0.95 [2], 1.1 [3]
	6-(4-Methoxyphenyl)-3-(3-thienyl)-pyrazolo(1,5-a)pyrimidine	IC50	19.0 [1], 185.0 [2]
	4-[2-[4-(3-Phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine	IC50	9.0 [1], 32.0 [2], 234.5 [3]
	N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide	IC50	7.8 [1], 10.0 [2]
	Exelixis	IC50	0.04 [1], 1.9 [2], 7.0 [3]
	1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-(4-methoxy-phenyl)-urea	IC50	2.2 [1], 70.0 [2]
	N-Cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	IC50	0.6 [1]
	3-(2-Aminoquinazolin-6-Yl)-4-Methyl-N-[3-(Trifluoromethyl)phenyl]benzamide	IC50	2.0 [1]
	4-N-(3-Bromophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	200.0 [1], 250.0 [2]
	4-N-(3-Bromophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	600.0 [1], 620.0 [2], 45400.0 [3]
	Thienopyrimidine deriv. 20	IC50	28.0 [1], 34.67 [2], 35.0 [3]
	Thienopyrimidine deriv. 24	IC50	10.0 [1], 52.0 [2], 52.48 [3]
	Thienopyrimidine deriv. 91	IC50	2.0 [1], 19.0 [2], 19.05 [3]
	2,4-Difluoro-N-methoxy-5-[[6-(5-methyl-1,3,4-oxadiazol-2-yl)-5-propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]benzamide	IC50	18.0 [1], 86.0 [2]
	1-(4-(4-Aminothieno[3,2-c]pyridin-3-yl)phenyl)-3-m-tolylurea	IC50	9.0 [1], 32.0 [2]
	Pyrazolo[1,5-a]pyrimidine 4e	IC50	3.0 [1], 4.0 [2], 18.0 [3]
	N-[3-[2-(Cyclopropanecarbonylamino)imidazo[1,2-b]pyridazin-6-yl]oxyphenyl]-2,5-dimethylpyrazole-3-carboxamide	IC50	0.19 [1], 1.4 [2], 1.8 [3]
	N-(5-Tert-butyl-1,2-oxazol-3-yl)-5-(6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yloxy)indole-1-carboxamide	IC50	3.0 [1], 9.0 [2], 59.0 [3], 59.4 [4]
	Thienopyrimidine deriv. 96	IC50	3.0 [1], 3.02 [2], 9.0 [3]
	1-[4-(3-Amino-1H-pyrazolo[3,4-c]pyridin-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea	IC50	1.0 [1], 2.1 [2]
	1-[4-(3-Amino-1H-pyrazolo[3,4-c]pyridin-4-yl)phenyl]-3-(3-methylphenyl)urea	IC50	0.6 [1], 0.7 [2]
	1-[4-(3-Amino-1-methylpyrazolo[3,4-c]pyridin-4-yl)phenyl]-3-(3-methylphenyl)urea	IC50	1.8 [1], 4.6 [2]
	1-[4-(3-Amino-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-(4-fluoro-3-methylphenyl)urea	IC50	1.1 [1], 1.2 [2]
	1-[4-(3-Amino-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	2.4 [1], 7.9 [2]
	1-[4-(3-Amino-1-methylpyrazolo[3,4-c]pyridin-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea	IC50	3.0 [1], 7.7 [2]
	1-[4-(3-Amino-1-methylpyrazolo[3,4-c]pyridin-4-yl)phenyl]-3-(3-chlorophenyl)urea	IC50	1.5 [1], 8.8 [2]
	1-(4-(4-Amino-7-phenylthieno[3,2-c]pyridin-3-yl)phenyl)-3-m-tolylurea	IC50	13.0 [1], 33.0 [2]
	1-(3-Methylphenyl)-3-[[5-[6-[(4-methylpiperazin-1-yl)methyl]-2,4-dihydroindeno[1,2-c]pyrazol-3-yl]thiophen-2-yl]methyl]urea	IC50	61.0 [1], 146.0 [2]
	1-Methyl-3-(3-methylphenyl)-1-[[5-[6-[(4-methylpiperazin-1-yl)methyl]-2,4-dihydroindeno[1,2-c]pyrazol-3-yl]thiophen-2-yl]methyl]urea	IC50	146.0 [1], 159.0 [2]
	5-Phenyl-N-[5-(pyrrolidin-1-ylmethyl)pyridin-2-yl]-1,3-thiazol-2-amine	IC50	6.0 [1], 24.0 [2], 28.0 [3]
	N-[6-[3-[[3-(Trifluoromethyl)benzoyl]amino]phenoxy]imidazo[1,2-b]pyridazin-2-yl]oxane-4-carboxamide	IC50	1.1 [1], 3.1 [2], 6.9 [3], 10.0 [4]
	1-[4-(3-Amino-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea	IC50	1.7 [1], 2.6 [2]
	1-[4-(3-Amino-1H-pyrazolo[3,4-c]pyridin-4-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	1.0 [1], 1.3 [2]
	1-[4-(3-Amino-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-(3,5-difluorophenyl)urea	IC50	6.3 [1], 8.1 [2]
	2-(Dimethylamino)-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone	IC50	31.0 [1], 1144.1 [2], 5000.3 [3], 20000.0 [4]
	1-[4-(3-Amino-1H-pyrazolo[4,3-c]pyridin-4-yl)phenyl]-3-(3-chlorophenyl)urea	IC50	12.0 [1], 46.0 [2]
	2-[[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino]-5-(2-phenoxyethoxy)cyclohexa-2,5-diene-1,4-dione	IC50	1.7 [1], 4.8 [2], 117.8 [3], 1000.0 [4]
	1-[4-(3-Amino-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-(3-methoxyphenyl)urea	IC50	3.8 [1], 3.9 [2]
	2-[[6-Methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-yl]amino]-5-phenylmethoxycyclohexa-2,5-diene-1,4-dione	IC50	13.6 [1], 26.1 [2], 29.5 [3], 536.0 [4]
	2-Ethoxy-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone	IC50	1000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Vascular endothelial growth factor receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/vascular-endothelial-growth-factor-receptor-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Vascular endothelial growth factor receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/vascular-endothelial-growth-factor-receptor-2-inhibitors-ic50-ki.
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