Vascular endothelial growth factor receptor 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	3.27 [1]
	Nintedanib	IC50	3.0 [1], 3.2 [2], 5.0 [3], 13.0 [4]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	5.0 [1], 22.0 [2]
	4-[2-[3-(2-Aminoethyl)-1-[[4-[3-(trifluoromethyl)phenyl]phenyl]methyl]indol-5-yl]oxyethyl]phenol	IC50	2980.0 [1], 3010.0 [2], 3080.0 [3]
	4-[2-[[6-Amino-9-(5-phenylpentyl)-5,6,7,8-tetrahydrocarbazol-3-yl]oxy]ethyl]phenol	IC50	2110.0 [1], 2170.0 [2], 2190.0 [3]
	Dovitinib	IC50	2.51 [1], 3.0 [2], 8.0 [3]
	Foretinib	IC50	2.8 [1]
	Linifanib	IC50	12.59 [1], 190.0 [2]
	Sorafenib	IC50	3.0 [1], 16.0 [2]
	Sunitinib	IC50	8.9 [1]
	Sunitinib	Ki	17.0 [1]
	Pazopanib	IC50	46.0 [1], 47.0 [2]
	Vatalanib	IC50	195.0 [1]
	Semaxanib	IC50	50.0 [1], 500.0 [2]
	Tivozanib	IC50	0.24 [1], 3.11 [2]
	2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide	IC50	18.0 [1]
	Tak-593	IC50	1.1 [1]
	1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea	IC50	13.0 [1]
	(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamine	IC50	50000.0 [1]
	9-(2,6-Dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-9H-purin-6-amine	IC50	151.0 [1], 1000.0 [2]
	2-[2-[2-[5-Chloro-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrimidin-4-yl]ethyl]phenyl]propanamide	IC50	9.0 [1], 52.0 [2]
	2-[2-[2-[5-Chloro-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]ethyl]phenyl]-2-methylpropanamide	IC50	3.0 [1], 23.0 [2]
	2-(2-(2-(5-Methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)propanamide	IC50	15.0 [1], 526.0 [2]
	2-[2-[2-[2-[(1-Piperidin-4-ylpyrazol-4-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]propanamide	IC50	27.0 [1], 68.0 [2]
	2-[2-[2-[2-[[1-(1-Methylpiperidin-4-yl)pyrazol-4-yl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]propanamide	IC50	27.0 [1]
	1-[2-[2-[2-[(6-Methoxypyridin-3-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	8.0 [1], 394.0 [2]
	2-[2-[2-[2-(4-Piperidin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]butanamide	IC50	91.0 [1], 173.0 [2]
	1-[2-[2-[2-(4-Piperidin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	10.0 [1], 26.0 [2]
	1-[2-[2-[2-[4-(1-Methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	9.0 [1], 27.0 [2]
	1-[2-[2-[2-[4-(Azetidin-3-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	22.0 [1], 38.0 [2]
	1-[2-[2-[2-[(6-Piperidin-4-ylpyridin-3-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	28.0 [1], 51.0 [2]
	1-(2-(2-(5-Chloro-2-(pyridin-3-ylamino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide	IC50	8.0 [1], 17.0 [2]
	1-[2-[2-[5-Chloro-2-[4-(1-methylpiperidin-4-yl)anilino]pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	10.0 [1], 19.0 [2]
	1-[2-[2-[5-Chloro-2-[[6-(trifluoromethyl)pyridin-3-yl]amino]pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	75.0 [1], 92.0 [2]
	1-(2-(2-(5-Chloro-2-(pyrimidin-5-ylamino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide	IC50	39.0 [1], 267.0 [2]
	1-[2-[2-[5-Chloro-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	4.0 [1], 9.0 [2]
	1-[2-[2-[2-[[1-(Azetidin-3-yl)pyrazol-4-yl]amino]-5-chloropyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	6.0 [1], 30.0 [2]
	1-[2-[2-[5-Chloro-2-[(6-piperidin-4-ylpyridin-3-yl)amino]pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	11.0 [1], 51.0 [2]
	1-[2-[2-[5-Chloro-2-[(1-piperidin-4-ylpyrazol-4-yl)amino]pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	9.0 [1], 62.0 [2]
	1-[2-[2-[5-Chloro-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	3.0 [1], 5.0 [2]
	1-(2-(2-(2-(1H-Pyrazol-4-ylamino)-5-chloropyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide	IC50	3.0 [1], 11.0 [2]
	1-[2-[2-[5-Chloro-2-[(1-pyrrolidin-3-ylpyrazol-4-yl)amino]pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	7.0 [1], 38.0 [2]
	1-[2-[2-[5-Chloro-2-[[1-(1-methylpyrrolidin-3-yl)pyrazol-4-yl]amino]pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	7.0 [1], 14.0 [2]
	Tert-butyl N-[1-[4-[[4-[2-[2-(1-carbamoylcyclopropyl)phenyl]ethyl]-5-chloropyrimidin-2-yl]amino]phenyl]ethyl]carbamate	IC50	2.0 [1], 25.0 [2]
	2-(2-(2-(2-(1H-Pyrazol-4-ylamino)-5-chloropyrimidin-4-yl)ethyl)phenyl)propanamide	IC50	9.0 [1], 64.0 [2]
	2-(2-(5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)pyrimidin-4-ylethyl)phenyl)propanamide	IC50	16.0 [1], 76.0 [2]
	1-[2-[2-[5-Chloro-2-(4-piperidin-4-ylanilino)pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	10.0 [1], 38.0 [2]
	(2R)-2-[2-[2-[2-(4-Piperidin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]butanamide	IC50	103.0 [1], 329.0 [2]
	(2S)-2-[2-[2-[2-(4-Piperidin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]butanamide	IC50	75.0 [1], 315.0 [2]
	1-[2-[2-[5-Chloro-2-[[6-(1-methylpiperidin-4-yl)pyridin-3-yl]amino]pyrimidin-4-yl]ethyl]phenyl]cyclopropane-1-carboxamide	IC50	1.0 [1], 4.0 [2]
	Ellagic acid	IC50	1540.0 [1]
	Vandetanib	IC50	233.0 [1]
	Axitinib	IC50	0.1 [1]
	Nintedanib esylate	IC50	13.0 [1]
	Cediranib	IC50	3.0 [1]
	Lenvatinib	IC50	5.2 [1]
	Saracatinib	IC50	10000.0 [1]
	Doramapimod	IC50	270.0 [1]
	Sotrastaurin	IC50	4600.0 [1]
	Motesanib	IC50	6.0 [1]
	3,9-Bis((ethylthio)methyl)-K-252a	IC50	39.0 [1]
	Danusertib	IC50	161.0 [1]
	Pyridone 6	IC50	690.0 [1]
	Entrectinib	IC50	1000.0 [1]
	Filgotinib	IC50	274.0 [1]
	1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea	IC50	1.0 [1]
	Telatinib	IC50	4.0 [1]
	5-(5,6-Dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide	IC50	92.0 [1]
	2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one	IC50	10000.0 [1]
	VEGF receptor tyrosine kinase inhibitor III	IC50	125.0 [1]
	Milciclib	IC50	920.0 [1]
	3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea	IC50	74.0 [1]
	1-(3-Chlorophenyl)-3-{5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)ethyl]-1,3-Thiazol-2-Yl}urea	IC50	14.0 [1]
	Pha-793887	IC50	10000.0 [1]
	Lucitanib	IC50	10.0 [1]
	3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide	IC50	54.2 [1]
	MK-2461	IC50	78.0 [1]
	Serotonin hydrochloride	IC50	50000.0 [1]
	Cc-223	IC50	651.0 [1]
	N-(3-Chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	2400.0 [1]
	(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione	IC50	1.13 [1]
	JNK Inhibitor VIII	Ki	7100.0 [1]
	Nms-P937 (nms1286937)	IC50	10000.0 [1]
	Pyrimidone, 22	IC50	120.0 [1]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	7.59 [1]
	2-(4-Fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one	IC50	5.0 [1]
	Tafetinib	IC50	1.3 [1]
	3-(3-Hydroxypropyl)-7-(propan-2-yloxymethyl)-3,13-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-14-one	IC50	4.0 [1]
	5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-Carboxamide	IC50	10.0 [1]
	(12E,25E,28E)-5,16,21,32-Tetrabromo-4,20-dihydroxy-12,25-bis(hydroxyimino)-2,18-dioxa-10,27-diazapentacyclo[28.2.2.214,17.13,7.119,23]octatriaconta-1(32),3,5,7(38),14,16,19,21,23(35),28,30,33,36-tridecaene-11,26-dione	IC50	3200.0 [1]
	2-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide	IC50	8.0 [1]
	Alsterpaullone, 2-Cyanoethyl	IC50	1000.0 [1]
	N-(4-Chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	IC50	2.0 [1]
	(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide	IC50	48.0 [1]
	Flt3-IN-1	IC50	3700.0 [1]
	(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine	IC50	50000.0 [1]
	CID 118295624	IC50	410.0 [1]
	Unii-BL7xsd8R7B	IC50	360.0 [1]
	8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	587.0 [1]
	N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamide	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Vascular endothelial growth factor receptor 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/vascular-endothelial-growth-factor-receptor-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Vascular endothelial growth factor receptor 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/vascular-endothelial-growth-factor-receptor-3-inhibitors-ic50-ki.
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