 | Argipressin | Ki | 1.13 [1] |
 | Lixivaptan | IC50 | 150.0 [1], 180.0 [2], 230.0 [3], 5000.0 [4] |
| Lixivaptan | Ki | 44.0 [1], 6000.0 [2] |
 | Relcovaptan | IC50 | 13.0 [1] |
| Relcovaptan | Ki | 0.19 [1], 0.52 [2], 0.7 [3], 0.85 [4], 1.48 [5] |
 | 4-[(3,5-Dihydroxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamide | IC50 | 7.0 [1], 613.0 [2] |
 | Way-vna-932 | IC50 | 778.0 [1], 1660.0 [2] |
| Way-vna-932 | Ki | 344.0 [1], 465.0 [2] |
 | Oxytocin | IC50 | 10000.0 [1] |
| Oxytocin | Ki | 20.0 [1], 34.9 [2], 120.0 [3] |
 | 1-(1-(4-(3-Acetylaminopropoxy)benzoyl)-4-piperidyl)-3,4-dihydro-2(1H)-quinolinone | Ki | 350.0 [1], 10000.0 [2], 14000.0 [3], 52000.0 [4] |
 | 2-Phenyl-4'-[(2,3,4,5-tetrahydro-1H-1-benzoazepine-1-yl)carbonyl]benzanilide | IC50 | 2.74 [1] |
| 2-Phenyl-4'-[(2,3,4,5-tetrahydro-1H-1-benzoazepine-1-yl)carbonyl]benzanilide | Ki | 2.74 [1], 14.1 [2] |
 | (2S)-N-[(2S)-4-Amino-1-[[(2S)-1-[(3S)-3-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]-2-[[(2S)-2-[[(2R)-3-(4-hydroxyphenyl)-2-[[2-(4-hydroxyphenyl)acetyl]-methylamino]propanoyl]amino]-3-phenylpropanoyl]amino]pentanediamide | Ki | 0.03 [1], 0.04 [2], 0.21 [3], 0.28 [4] |
 | Vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O-methyl-L-tyrosine)-8-L-arginine- | IC50 | 0.63 [1], 0.99 [2], 1.9 [3] |
 | Nelivaptan | Ki | 22.0 [1], 58.88 [2], 94.0 [3] |
 | CID 6918320 | Ki | 1995.26 [1], 3200.0 [2] |
 | 2-(4-Fluoro-2-methylphenyl)-5-[4-(6-methoxypyridin-3-yl)-5-methyl-1,2,4-triazol-3-yl]pyrazine | Ki | 388.0 [1] |
 | 7-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)heptan-1-one | IC50 | 10000.0 [1] |
| 7-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)heptan-1-one | Ki | 194.7 [1], 195.0 [2] |
 | 4-[(3,5-Dimethoxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamide | IC50 | 1113.0 [1] |
| 4-[(3,5-Dimethoxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamide | Ki | 62.0 [1] |
 | 8-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)octan-1-one | IC50 | 4667.0 [1] |
| 8-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)octan-1-one | Ki | 64.0 [1], 64.1 [2] |
 | LIT-001 (free base) | IC50 | 100.0 [1], 2200.0 [2], 5900.0 [3] |
| LIT-001 (free base) | Ki | 1253.0 [1] |
 | 1-[4-[(5-Fluoro-2-methylbenzoyl)amino]benzoyl]-N-(2-piperidin-1-ylethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamide | IC50 | 10.0 [1], 16.0 [2], 48.0 [3], 71.0 [4] |
 | Atosiban | Ki | 0.15 [1], 0.63 [2], 4.7 [3] |
 | (2S)-2-(4-Methyl-1,4-diazepane-1-carbothioyl)-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]pyrrolidine-1-carboxamide | IC50 | 8.0 [1] |
| (2S)-2-(4-Methyl-1,4-diazepane-1-carbothioyl)-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]pyrrolidine-1-carboxamide | Ki | 196.0 [1], 330.0 [2] |
 | 3-[4-[(4-Chlorophenyl)-[2-[(2-hydroxy-1H-indol-3-yl)diazenyl]-2-oxoethyl]sulfamoyl]phenyl]-N-[3-(dimethylamino)propyl]propanamide | Ki | 0.65 [1], 42.0 [2] |
 | (2R)-N-[(1R,5S)-8-Azabicyclo[3.2.1]octan-3-yl]-3-(4-chlorophenyl)-2-[[2-(4-chlorophenyl)acetyl]amino]propanamide | IC50 | 54.95 [1] |
| (2R)-N-[(1R,5S)-8-Azabicyclo[3.2.1]octan-3-yl]-3-(4-chlorophenyl)-2-[[2-(4-chlorophenyl)acetyl]amino]propanamide | Ki | 0.23 [1] |
 | N-(2-Pyridin-2-ylpyrazol-3-yl)-4-(trifluoromethyl)benzenesulfonamide | IC50 | 10000.0 [1] |
| N-(2-Pyridin-2-ylpyrazol-3-yl)-4-(trifluoromethyl)benzenesulfonamide | Ki | 10000.0 [1] |
 | 4-Chloro-N-(2-pyridin-2-ylpyrazol-3-yl)benzenesulfonamide | IC50 | 10000.0 [1] |
| 4-Chloro-N-(2-pyridin-2-ylpyrazol-3-yl)benzenesulfonamide | Ki | 10000.0 [1] |
 | (2S)-N-[(2S)-4-Amino-1-[[(2S)-1-[(4R)-4-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]-1,3-selenazolidin-3-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]-2-[[(2S)-2-[[(2R)-2-[3-(4-hydroxyphenyl)propanoylamino]-3-(4-methoxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]pentanediamide | Ki | 0.4 [1], 0.9 [2], 3.8 [3] |
 | 4-Chloro-N-(2-methylpyrazol-3-yl)benzenesulfonamide | IC50 | 10000.0 [1] |
| 4-Chloro-N-(2-methylpyrazol-3-yl)benzenesulfonamide | Ki | 10000.0 [1] |
 | N-(2-Methylpyrazol-3-yl)-4-(trifluoromethyl)benzenesulfonamide | IC50 | 10000.0 [1] |
| N-(2-Methylpyrazol-3-yl)-4-(trifluoromethyl)benzenesulfonamide | Ki | 10000.0 [1] |
 | Conivaptan | IC50 | 3.0 [1] |
| Conivaptan | Ki | 0.43 [1] |
 | Satavaptan | Ki | 304.0 [1], 2949.0 [2] |
 | Unii-ER33G946JT | Ki | 180.0 [1] |
 | Cligosiban | Ki | 1120.0 [1] |
 | Unii-4V7CN33O10 | IC50 | 5.0 [1], 38.0 [2] |
 | CID 6918854 | Ki | 6309.57 [1] |
 | 1-[1-[2-[2-(2-Fluoroethoxy)-4-(1-methylsulfonylpiperidin-4-yl)oxyphenyl]acetyl]piperidin-4-yl]-3,4-dihydroquinolin-2-one | Ki | 8700.0 [1] |
 | [6-Chloro-1-[2-(dimethylamino)ethyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone | Ki | 1.0 [1] |
 | (2R)-2-[(2R,5R)-5-(2,3-Dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-2-(4-fluorophenyl)-N-propan-2-ylacetamide | Ki | 6309.57 [1] |
 | (2R)-2-[(2R,5R)-5-(2,3-Dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-2-[4-(dimethylamino)phenyl]-N-propan-2-ylacetamide | Ki | 39810.72 [1] |
 | 2,4-Dichloro-N-[4-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl)phenyl]benzamide | IC50 | 15.0 [1] |
 | N-[[5-[4-(2-Oxo-4H-3,1-benzoxazin-1-yl)piperidine-1-carbonyl]-1-benzofuran-2-yl]methyl]-2-[2-oxo-5-(trifluoromethyl)pyridin-1-yl]acetamide | Ki | 1258.93 [1], 1260.0 [2] |
 | 2-(N-(4-Ethoxyphenyl)sulfonyl-4-methylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamide | Ki | 1410.0 [1] |
 | (2R)-2-(2,4-Difluorophenyl)-2-[(2R,5R)-5-(2,3-dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-N,N-dimethylacetamide | Ki | 630.96 [1], 6309.57 [2] |
 | 5-[3-[3-(2-Chloro-4-fluorophenoxy)azetidin-1-yl]-5-methyl-1,2,4-triazol-4-yl]-2-methoxypyridine | Ki | 2400.0 [1], 2430.0 [2] |
 | 5-[3-[3-(4-Fluoro-2-methylphenoxy)azetidin-1-yl]-5-methyl-1,2,4-triazol-4-yl]-2-methoxypyridine | Ki | 608.0 [1] |
 | (4-Benzyl-4-hydroxypiperidin-1-yl)-(2-ethoxynaphthalen-1-yl)methanone | Ki | 2830.0 [1] |
 | (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2R)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide | Ki | 3.4 [1], 3.8 [2] |
 | [2-Chloro-4-(3-methylpyrazol-1-yl)phenyl]-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)methanone | Ki | 27.0 [1] |
 | Benzyl 2-(2-methyl-1,3-dioxolan-2-yl)-2-[(3S,4R)-2-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-4-[(E)-2-phenylethenyl]azetidin-1-yl]acetate | IC50 | 45.0 [1] |
 | (6-Chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone | Ki | 4.0 [1] |
 | (1-Benzyl-2-methylindol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone | Ki | 2.0 [1] |
 | (2-Ethoxynaphthalen-1-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone | Ki | 81.0 [1] |
 | (2Z)-2-[1-[2-Chloro-4-(3-methylpyrazol-1-yl)benzoyl]-4,4-difluoro-2,3-dihydro-1-benzazepin-5-ylidene]-N-(2-hydroxyethyl)acetamide | Ki | 28.0 [1] |
 | 4-[2-[2-[3-Methyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]phenoxy]ethyl]morpholine | Ki | 28.0 [1] |
 | 5-[3-(Ethoxymethyl)-5-(4-ethoxy-3-methylphenyl)-1,2,4-triazol-4-yl]-2-methoxypyridine | Ki | 549.0 [1], 594.0 [2] |
 | N-(Cyclohexylmethyl)-1-[2-[1-(2,4-dimethoxyphenyl)sulfonyl-3,4-dihydro-2H-quinolin-2-yl]ethylsulfonyl]piperidin-4-amine | Ki | 188.0 [1], 5623.41 [2] |
 | (4-Benzyl-4-hydroxypiperidin-1-yl)-(1-benzyl-2-methylindol-3-yl)methanone | Ki | 295.0 [1] |
 | N-[4-[(12S)-6-Chloro-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-triene-10-carbonyl]phenyl]-2-(trifluoromethyl)benzamide | IC50 | 4.0 [1] |
| N-[4-[(12S)-6-Chloro-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-triene-10-carbonyl]phenyl]-2-(trifluoromethyl)benzamide | Ki | 40.0 [1] |
 | N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]thiazino[3,4-c][1,4]benzodiazepine-6-carbonyl]phenyl]-2-phenylbenzamide | Ki | 84.0 [1], 1400.0 [2] |
 | N-[2-(Dimethylamino)ethyl]-1-[4-[(2-phenylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamide | IC50 | 4.0 [1], 5.0 [2] |
 | (4R)-1-[4-[(2-Chloro-5-fluorobenzoyl)amino]-3-ethoxybenzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxylic acid | IC50 | 8.0 [1], 50.0 [2] |
 | 1-[4-[(2-Chloro-5-fluorobenzoyl)amino]-3-methoxybenzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxylic acid | IC50 | 19.0 [1], 89.0 [2] |
 | (4R)-1-[4-[(2-Chloro-5-fluorobenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxylic acid | IC50 | 13.0 [1], 380.0 [2] |
 | 8-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)octan-1-one | IC50 | 7674.0 [1] |
| 8-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)octan-1-one | Ki | 248.0 [1] |
 | 5-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)pentan-1-one | IC50 | 10000.0 [1] |
| 5-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)pentan-1-one | Ki | 409.0 [1] |
 | 6-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)hexan-1-one | IC50 | 8203.0 [1] |
| 6-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)hexan-1-one | Ki | 266.0 [1] |
 | 5-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)pentan-1-one | IC50 | 10000.0 [1] |
| 5-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)pentan-1-one | Ki | 466.0 [1] |
 | 6-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)hexan-1-one | IC50 | 10000.0 [1] |
| 6-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)hexan-1-one | Ki | 449.0 [1] |
 | 7-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)heptan-1-one | IC50 | 10000.0 [1] |
| 7-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)heptan-1-one | Ki | 130.0 [1] |
 | 2-[4-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone | IC50 | 10000.0 [1] |
| 2-[4-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone | Ki | 795.1 [1] |
 | 2-[2-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone | IC50 | 10000.0 [1] |
| 2-[2-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone | Ki | 6807.0 [1] |
 | 2-[2-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone | IC50 | 10000.0 [1] |
| 2-[2-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone | Ki | 1938.0 [1] |
 | 2-[4-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone | IC50 | 10000.0 [1] |
| 2-[4-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone | Ki | 1910.0 [1] |
 | 3-[2-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)propan-1-one | IC50 | 10000.0 [1] |
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