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Vasopressin V1b receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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NelivaptanKi0.6 [1], 1.7 [2], 58.88 [3]
ArgipressinKi0.49 [1], 0.68 [2], 2.0 [3]
OxytocinKi1782.0 [1], 6000.0 [2]
CID 6918854Ki6309.57 [1]
1-[1-[2-[2-(2-Fluoroethoxy)-4-(1-methylsulfonylpiperidin-4-yl)oxyphenyl]acetyl]piperidin-4-yl]-3,4-dihydroquinolin-2-oneKi1000.0 [1], 10000.0 [2]
(2R)-2-[(2R,5R)-5-(2,3-Dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-2-(4-fluorophenyl)-N-propan-2-ylacetamideKi6309.57 [1]
(2R)-2-[(2R,5R)-5-(2,3-Dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-2-[4-(dimethylamino)phenyl]-N-propan-2-ylacetamideKi50118.72 [1]
2-(N-(4-Ethoxyphenyl)sulfonyl-4-methylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi10000.0 [1]
(2R)-2-(2,4-Difluorophenyl)-2-[(2R,5R)-5-(2,3-dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-N,N-dimethylacetamideKi6309.57 [1], 12589.25 [2]
5-[3-(Ethoxymethyl)-5-(4-ethoxy-3-methylphenyl)-1,2,4-triazol-4-yl]-2-methoxypyridineKi10000.0 [1]
N-(Cyclohexylmethyl)-1-[2-[1-(2,4-dimethoxyphenyl)sulfonyl-3,4-dihydro-2H-quinolin-2-yl]ethylsulfonyl]piperidin-4-amineKi43.65 [1], 70.0 [2]
Vasopressin antagonist 1867IC503.0 [1]
2-[2-(3-Chlorophenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)quinazolin-3-yl]-N-propan-2-ylacetamideIC506.0 [1]
N-(Cyclopropylmethyl)-3-methyl-N-(oxolan-2-ylmethyl)-4-phenylbenzamideKi1258.93 [1], 12589.25 [2]
1,4-Diazepan-1-yl-[5-methoxy-1-(4-methoxy-2,3-dimethylphenyl)sulfonyl-2-methylindol-3-yl]methanoneIC50371.0 [1]
1,4-Diazepan-1-yl-[5-methoxy-1-(4-methoxy-2,3-dimethylphenyl)sulfonyl-2-methylindol-3-yl]methanoneKi190.0 [1]
DesmopressinKi5.8 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi0.37 [1]
AtosibanKi44.0 [1]
RetosibanKi10000.0 [1]
CID 3038506IC50100000.0 [1]
N-[4-[(5Z)-4,4-Difluoro-5-[2-oxo-2-(4-piperidin-1-ylpiperidin-1-yl)ethylidene]-2,3-dihydro-1-benzazepine-1-carbonyl]phenyl]-2-methylfuran-3-carboxamideKi25500.0 [1]
CligosibanKi10000.0 [1]
Way-vna-932Ki1000.0 [1]
EpelsibanKi7943.28 [1]
4-[(3,5-Dihydroxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamideKi1000.0 [1]
2-(4-Fluoro-2-methylphenyl)-5-[4-(6-methoxypyridin-3-yl)-5-methyl-1,2,4-triazol-3-yl]pyrazineKi10000.0 [1]
3-[4-[(4-Chlorophenyl)-[2-[(2-hydroxy-1H-indol-3-yl)diazenyl]-2-oxoethyl]sulfamoyl]phenyl]-N-[3-(dimethylamino)propyl]propanamideKi3539.0 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-10-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi1.0 [1]
d[Orn4]AVPKi0.49 [1]
(4-Benzyl-4-hydroxypiperidin-1-yl)-(2-ethoxynaphthalen-1-yl)methanoneKi12000.0 [1]
N-(6-Methoxypyridin-3-yl)-1,2-dimethyl-N-[[5-(2-methylphenyl)pyridin-2-yl]methyl]imidazole-4-sulfonamideKi31.62 [1]
d[Val4]AVPKi0.29 [1]
d[Cha4]AVPKi1.2 [1]
d[Arg4]AVPKi0.37 [1]
(2R)-N-[(1R,5S)-8-Azabicyclo[3.2.1]octan-3-yl]-3-(4-chlorophenyl)-2-[[2-(4-chlorophenyl)acetyl]amino]propanamideKi5.0 [1]
(2S)-N-[(1S,2S,4R)-7,7-Dimethyl-1-[[4-(2-methylphenyl)piperazin-1-yl]sulfonylmethyl]-2-bicyclo[2.2.1]heptanyl]-2-(methylamino)-4-methylsulfonylbutanamideKi1300.0 [1]
(2S)-1-[(4R,7S,10S,13S,16S)-10-(2-Aminoethyl)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamideKi12.8 [1]
(2S)-1-[(4R,7S,10S,13S,16S)-10-(Aminomethyl)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamideKi3.4 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-10,16-bis[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi14.8 [1]
3-[(4R,7S,10S,13S,16S)-7-(2-Amino-2-oxoethyl)-4-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-10-yl]propanoic acidKi156.0 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-10-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi7.8 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10,13-dibenzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi9.5 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-10-(hydroxymethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi2.0 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-10-[4-(diaminomethylideneamino)butyl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi0.52 [1]
(2S)-1-[(4R,7S,10S,13S,16S)-10-(4-Aminobutyl)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamideKi1.8 [1]
(2R)-2-(1-Benzofuran-5-yl)-2-[(2R,5R)-5-(2,3-dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-N-propan-2-ylacetamideKi6309.57 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7,10-bis(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi1.5 [1]
2-[6-[5-[(Dimethylamino)methyl]-2-fluorophenyl]-2-(3-methoxyphenyl)-4-oxoquinazolin-3-yl]-N-propan-2-ylacetamideIC507.0 [1]
2-[6-[3-[(Dimethylamino)methyl]phenyl]-2-(3-methoxyphenyl)-4-oxoquinazolin-3-yl]-N-propan-2-ylacetamideIC509.0 [1]
Dilithium;2-(3-amino-6-imino-5-sulfo-4-sulfonatoxanthen-9-yl)-5-[[(5S)-5-[[(2S)-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-10-(2-methylpropyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carbonyl]amino]-6-(carboxymethylamino)-6-oxohexyl]carbamoyl]benzoateKi1.2 [1]
Dilithium;3-amino-9-[4-[[(5S)-5-[[(2S)-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-19-hydroxy-16-[(4-hydroxyphenyl)methyl]-10-(2-methylpropyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carbonyl]amino]-6-(carboxymethylamino)-6-oxohexyl]carbamoyl]-2-carboxyphenyl]-6-iminoxanthene-4,5-disulfonateKi149.0 [1]
N-(Cyclopropylmethyl)-2-[2-(1H-indol-3-yl)-6-(3-morpholin-4-ylpropoxy)-4-oxoquinazolin-3-yl]acetamideIC50387.0 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-2,21-dithia-5,8,11,14,17-pentazabicyclo[21.2.2]heptacosa-1(25),23,26-triene-4-carbonyl]pyrrolidine-2-carboxamideKi6000.0 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(5R,8S,11S,14S,17S)-8-(2-amino-2-oxoethyl)-11-(3-amino-3-oxopropyl)-14-[(2S)-butan-2-yl]-17-[(4-hydroxyphenyl)methyl]-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18-pentazabicyclo[22.4.0]octacosa-1(28),24,26-triene-5-carbonyl]pyrrolidine-2-carboxamideKi6000.0 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(5R,8S,11S,14S,17S)-8-(2-amino-2-oxoethyl)-11-(3-amino-3-oxopropyl)-14-[(2S)-butan-2-yl]-17-[(4-hydroxyphenyl)methyl]-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18-pentazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]pyrrolidine-2-carboxamideKi6000.0 [1]
(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(5R,8S,11S,14S,17S)-8-(2-amino-2-oxoethyl)-11-(3-amino-3-oxopropyl)-14-[(2S)-butan-2-yl]-17-[(4-hydroxyphenyl)methyl]-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18-pentazabicyclo[22.4.0]octacosa-1(28),24,26-triene-5-carbonyl]pyrrolidine-2-carboxamideKi6000.0 [1]
N-[3-Chloro-4-(2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-3-methylpyrazole-1-carboxamideIC501000.0 [1]
5-Chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxypyridin-3-yl)-3-(3-oxo-4-pyridin-3-ylpiperazin-1-yl)indol-2-oneKi82.0 [1]
5-Chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-3-ylpiperazin-1-yl)indol-2-oneKi45.0 [1]
5-Chloro-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-3-ylpiperazin-1-yl)-1-quinolin-8-ylsulfonylindol-2-oneKi15.2 [1]
5-Chloro-3-(2-methoxyphenyl)-3-(4-pyridin-3-ylpiperazin-1-yl)-1-quinolin-8-ylsulfonylindol-2-oneKi8.0 [1]
1-(Benzenesulfonyl)-5-chloro-3-(2-methoxyphenyl)-3-(4-pyridin-3-ylpiperazin-1-yl)indol-2-oneKi233.0 [1]
5-Chloro-3-(2-methoxyphenyl)-1-(4-methoxyphenyl)sulfonyl-3-(4-pyridin-3-ylpiperazin-1-yl)indol-2-oneKi104.0 [1]
3-(2-Methoxypyridin-3-yl)-2-oxo-3-(4-pyridin-3-ylpiperazin-1-yl)-1-quinolin-8-ylsulfonylindole-5-carbonitrileKi30.2 [1]
5-Chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-[(2R)-2,4-dimethyl-3-oxopiperazin-1-yl]-3-(2-methoxypyridin-3-yl)indol-2-oneKi41.0 [1]
5-Chloro-3-(2-methoxyphenyl)-1-(2-methoxyphenyl)sulfonyl-3-(4-pyridin-3-ylpiperazin-1-yl)indol-2-oneKi47.0 [1]
5-Chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxypyridin-3-yl)-3-(4-methyl-3-oxopiperazin-1-yl)indol-2-oneKi192.0 [1]
5-Chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxypyridin-3-yl)-3-(3-oxopiperazin-1-yl)indol-2-oneKi1340.0 [1]
2-[6-[3-[(Dimethylamino)methyl]phenyl]-2-(4-fluoro-3-methoxyphenyl)-4-oxoquinazolin-3-yl]-N-propan-2-ylacetamideIC501.0 [1]
3-(2-Ethoxy-5-methoxyphenyl)-2-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)-1-quinolin-8-ylsulfonylindole-5-carbonitrileKi5.0 [1]
2-Methoxy-5-[3-[4-(2-methoxyphenyl)phenyl]-5-methyl-1,2,4-triazol-4-yl]pyridineKi10000.0 [1]
2-[6-(3-Chlorophenyl)-4-oxo-2-(3-piperidin-1-ylpropoxy)pyrazolo[1,5-a]pyrazin-5-yl]-N-propan-2-ylacetamideIC5015.85 [1]
(2S)-N-[(2S)-4-Amino-1-[[(2S)-1-[(2S)-2-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]-2-[[(2S)-2-[[(2R)-3-(4-hydroxyphenyl)-2-[[2-(4-hydroxyphenyl)acetyl]-methylamino]propanoyl]amino]-3-phenylpropanoyl]amino]pentanediamideKi5.9 [1]
(2S)-N-[(2S)-4-Amino-1-[[(2S)-1-[(2S)-2-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]-2-[[(2S)-2-[[(2R)-3-(4-hydroxyphenyl)-2-[methyl-(2-phenylacetyl)amino]propanoyl]amino]-3-phenylpropanoyl]amino]pentanediamideKi9.4 [1]
(2S)-N-[(2S)-4-Amino-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-[[(2S)-1,6-diamino-1-oxohexan-2-yl]-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl)carbamoyl]pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]-2-[[(2S)-2-[[(2R)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanoyl-methylamino]propanoyl]amino]-3-phenylpropanoyl]amino]pentanediamideKi142.0 [1]
(2S)-N-[(2S)-4-Amino-1-[[(2S)-1-[(2S)-2-[[3',6'-bis(dimethylamino)-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl]-[(2S)-1,6-diamino-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]-2-[[(2S)-2-[[(2R)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanoyl-methylamino]propanoyl]amino]-3-phenylpropanoyl]amino]pentanediamideKi27.0 [1]
(2R)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4S,7R,10S,13R,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi6.5 [1]
(2R)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4S,7R,13R,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi22.9 [1]
(2R)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4S,7R,10S,13R,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-10-(2-methylpropyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideKi0.23 [1]
4-[2-[[6-[[(3S)-1-[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2R)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanoyl-methylamino]propanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-3-carbonyl]-[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethyl]sulfanyl-2,3,5-trichloro-6-(7,7,9,17,19,19-hexamethyl-4,22-disulfo-2-oxa-6,20-diazapentacyclo[12.8.0.03,12.05,10.016,21]docosa-1(14),5,12,15,21-pentaen-13-yl)benzoic acidKi100.0 [1]
5-[[(3S)-1-[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2R)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanoyl-methylamino]propanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-3-carbonyl]-[(2S)-1,6-diamino-1-oxohexan-2-yl]carbamoyl]-2-(3-amino-6-imino-4,5-disulfoxanthen-9-yl)benzoic acidKi1000.0 [1]
2-[6-(3-Chlorophenyl)-4-oxo-2-(2-piperidin-1-ylethoxy)pyrazolo[1,5-a]pyrazin-5-yl]-N-propan-2-ylacetamideIC50316.23 [1]
2-[6-(3-Chlorophenyl)-4-oxo-2-(4-piperidin-1-ylbutoxy)pyrazolo[1,5-a]pyrazin-5-yl]-N-propan-2-ylacetamideIC501000.0 [1]
2-[6-(3-Chloro-4-fluorophenyl)-4-oxo-2-(3-piperidin-1-ylpropoxy)pyrazolo[1,5-a]pyrazin-5-yl]-N-propan-2-ylacetamideIC505.01 [1]
2-[6-[4-Fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-(3-piperidin-1-ylpropoxy)pyrazolo[1,5-a]pyrazin-5-yl]-N-propan-2-ylacetamideIC503.98 [1]
2-[6-(3-Chloro-2-fluorophenyl)-4-oxo-2-(3-piperidin-1-ylpropoxy)pyrazolo[1,5-a]pyrazin-5-yl]-N-propan-2-ylacetamideIC50158.49 [1]
2-[3-(3-Methoxyphenyl)-1-oxo-7-(3-piperidin-1-ylpropoxy)pyrrolo[1,2-a]pyrazin-2-yl]-N-propan-2-ylacetamideIC5012.59 [1]
2-[3-(3-Chlorophenyl)-1-oxo-7-(3-piperidin-1-ylpropoxy)pyrrolo[1,2-a]pyrazin-2-yl]-N-propan-2-ylacetamideIC5010.0 [1]
N-Tert-butyl-2-[3-(3-chlorophenyl)-1-oxo-7-(3-piperidin-1-ylpropoxy)pyrrolo[1,2-a]pyrazin-2-yl]acetamideIC502.51 [1]
2-[3-(3-Chlorophenyl)-1-oxo-7-(3-piperidin-1-ylpropoxy)pyrrolo[1,2-a]pyrazin-2-yl]-N-(cyclopropylmethyl)acetamideIC5063.1 [1]
N-Ethyl-2-[3-(3-methoxyphenyl)-1-oxo-7-(3-piperidin-1-ylpropoxy)pyrrolo[1,2-a]pyrazin-2-yl]acetamideIC50794.33 [1]
2-[3-(3-Fluorophenyl)-1-oxo-7-(3-piperidin-1-ylpropoxy)pyrrolo[1,2-a]pyrazin-2-yl]-N-propan-2-ylacetamideIC5079.43 [1]
2-[3-(3-Chlorophenyl)-7-(4-methylpiperazin-1-yl)-1-oxopyrrolo[1,2-a]pyrazin-2-yl]-N-propan-2-ylacetamideIC50251.19 [1]
2-[3-(3-Chlorophenyl)-7-[4-(dimethylamino)piperidin-1-yl]-1-oxopyrrolo[1,2-a]pyrazin-2-yl]-N-propan-2-ylacetamideIC5063.1 [1]
2-[3-(3-Chlorophenyl)-7-(4-methyl-1,4-diazepan-1-yl)-1-oxopyrrolo[1,2-a]pyrazin-2-yl]-N-propan-2-ylacetamideIC5012.59 [1]
2-[3-(3-Chlorophenyl)-7-[methyl-(1-methylpiperidin-4-yl)amino]-1-oxopyrrolo[1,2-a]pyrazin-2-yl]-N-propan-2-ylacetamideIC5050.12 [1]
2-[3-(3-Chlorophenyl)-1-oxo-7-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrrolo[1,2-a]pyrazin-2-yl]-N-propan-2-ylacetamideIC506.31 [1]
2-[3-(3-Chlorophenyl)-7-[(1-methylpiperidin-3-yl)methoxy]-1-oxopyrrolo[1,2-a]pyrazin-2-yl]-N-propan-2-ylacetamideIC50501.19 [1]
2-[3-(5-Chloro-2-methylphenyl)-1-oxo-7-(3-piperidin-1-ylpropoxy)pyrrolo[1,2-a]pyrazin-2-yl]-N-propan-2-ylacetamideIC5079.43 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Vasopressin V1b receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/vasopressin-v1b-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Vasopressin V1b receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/vasopressin-v1b-receptor-inhibitors-ic50-ki.
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