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Vitamin K-dependent protein C Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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RazaxabanKi2300.0 [1], 19700.0 [2], 20000.0 [3]
2-[[(1R)-2-[[2-[(4-Carbamimidoylphenyl)methylcarbamoyl]-1,3-dihydroinden-2-yl]amino]-1-cyclohexyl-2-oxoethyl]amino]acetic acidIC50820.0 [1], 1700.0 [2]
2-[[(1R)-2-[[2-[(4-Carbamimidoylphenyl)methylcarbamoyl]-1,3-dihydroinden-2-yl]amino]-1-cyclohexyl-2-oxoethyl]amino]acetic acidKi500.0 [1]
2-[3-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide;hydrochlorideKi1800.0 [1]
Ethyl N-[(2S)-6-amino-1-oxo-1-[5-[[4-(2-phenylethoxy)phenyl]methyl]-1,2,4-oxadiazol-3-yl]hexan-2-yl]carbamateKi150000.0 [1]
CID 76328755IC50130.0 [1]
CID 76328755Ki40.0 [1]
N-[(1S)-1-[4-(3-Amino-1H-indazol-6-yl)pyridin-2-yl]-2-phenylethyl]-4-(aminomethyl)cyclohexane-1-carboxamideKi21400.0 [1]
2-[[(2R)-1-[[1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-3-piperidin-4-ylpropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC501300.0 [1]
2-[[(2R)-1-[[1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-3-piperidin-4-ylpropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi400.0 [1]
3-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]propanoic acidIC502800.0 [1]
3-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]propanoic acidKi800.0 [1]
2-[[(2R)-1-[[3-[4-(Aminomethyl)phenyl]-1-[(4-carbamimidoylphenyl)methylamino]-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC501100.0 [1]
2-[[(2R)-1-[[3-[4-(Aminomethyl)phenyl]-1-[(4-carbamimidoylphenyl)methylamino]-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi300.0 [1]
(2S)-2-[[(2R)-2-Amino-2-cyclohexylacetyl]amino]-N-[(4-carbamimidoylphenyl)methyl]-5-(diaminomethylideneamino)pentanamideIC501600.0 [1]
(2S)-2-[[(2R)-2-Amino-2-cyclohexylacetyl]amino]-N-[(4-carbamimidoylphenyl)methyl]-5-(diaminomethylideneamino)pentanamideKi500.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-3-naphthalen-1-yl-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC501100.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-3-naphthalen-1-yl-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi300.0 [1]
2-[[(2R)-2-Amino-3-cyclohexylpropanoyl]amino]-N-[(4-carbamimidoylphenyl)methyl]-4-piperidin-4-ylbutanamideIC503100.0 [1]
2-[[(2R)-2-Amino-3-cyclohexylpropanoyl]amino]-N-[(4-carbamimidoylphenyl)methyl]-4-piperidin-4-ylbutanamideKi900.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC50980.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi300.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC50260.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi100.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-3-pyrrolidin-2-ylpropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC505600.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-3-pyrrolidin-2-ylpropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi1600.0 [1]
2-[[(2R)-1-[[(1S)-2-[(4-Carbamimidoylphenyl)methylamino]-2-oxo-1-piperidin-4-ylethyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC503100.0 [1]
2-[[(2R)-1-[[(1S)-2-[(4-Carbamimidoylphenyl)methylamino]-2-oxo-1-piperidin-4-ylethyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi900.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC50670.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi200.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC50470.0 [1]
2-[[(2R)-1-[[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi100.0 [1]
2-[[(2R)-1-[[1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-4-piperidin-4-ylbutan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC50920.0 [1]
2-[[(2R)-1-[[1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-4-piperidin-4-ylbutan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi300.0 [1]
2-[[(2R)-1-[[1-[(4-Carbamimidoylphenyl)methylamino]-3-(4-cyanophenyl)-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC503800.0 [1]
2-[[(2R)-1-[[1-[(4-Carbamimidoylphenyl)methylamino]-3-(4-cyanophenyl)-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi1100.0 [1]
DabigatranKi20930.0 [1]
MelagatranIC501300.0 [1]
5-(N,N-Hexamethylene)amilorideIC5050000.0 [1]
BetrixabanIC5010000.0 [1]
2-[3-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi1800.0 [1]
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-11-(carboxymethyl)-20-[3-(diaminomethylideneamino)propyl]-23-(hydroxymethyl)-17,26-bis[(4-hydroxyphenyl)methyl]-29-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acidKi1000000.0 [1]
4-[[(3S)-3-[(7-Methoxynaphthalen-2-yl)sulfonyl-methylamino]-2-oxopyrrolidin-1-yl]methyl]thiophene-2-carboximidamideKi2400.0 [1]
Bms-740808Ki2800.0 [1]
Unii-1Y3JD5pemsIC5020000.0 [1]
Grassystatin AIC5050000.0 [1]
Unii-vwj4vvz3OUKi21000.0 [1]
3-[[(3S)-3-[(7-Methoxynaphthalen-2-yl)sulfonylamino]-2-oxopyrrolidin-1-yl]methyl]benzenecarboximidamideKi1200.0 [1]
3-[[(3S)-3-(Naphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-yl]methyl]benzenecarboximidamideKi7000.0 [1]
1-Cyano-3-(2-methyl-1-benzofuran-5-yl)-2-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]guanidineKi18000.0 [1]
Bms-344577Ki18000.0 [1]
Methyl N-[4-[5-chloro-2-[(1S)-1-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-2-phenylethyl]-1H-imidazol-4-yl]phenyl]carbamateKi21500.0 [1]
2-[2-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-sulfamoylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi4600.0 [1]
5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N-dimethyl-carbamimidoyl)-benzoylamino]-benzamideIC5010000.0 [1]
5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(2-imino-oxazolidin-3-ylmethyl)-benzoylamino]-benzamideIC5011000.0 [1]
(E)-2-(5-Chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-morpholin-4-yl-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]prop-1-ene-1-sulfonamideIC5025100.0 [1]
2-[4-[(6-Chloro-1-benzothiophen-2-yl)sulfonyl]-2-oxopiperazin-1-yl]-N-[2-(3-methylimidazol-4-yl)ethyl]acetamideKi18000.0 [1]
2-(5-Chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-morpholin-4-yl-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]ethanesulfonamideIC5025100.0 [1]
4-[(2R)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N,N-dimethylpiperazine-1-carboxamideKi13500.0 [1]
2-(3-Amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi28000.0 [1]
N-[4-(N,N-Dimethylcarbamimidoyl)-2-fluorophenyl]-2-(3-fluoronaphthalen-2-yl)-5-(trifluoromethyl)pyrazole-3-carboxamideIC5010000.0 [1]
4-Hydroxy-3-[[(3S)-3-[(7-methoxynaphthalen-2-yl)sulfonylamino]-2-oxopyrrolidin-1-yl]methyl]benzenecarboximidamideKi1970.0 [1]
(2S)-2-[[(2S)-2-[[(1R)-1-(4-Bromophenyl)ethyl]carbamoylamino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-methylbutanamideIC5020700.0 [1]
3-[(S)-2-Oxo-3-(thieno[3,2-b]pyridine-2-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidineKi12000.0 [1]
1-(3-Amino-1,2-benzoxazol-5-yl)-6-[4-[2-[(dimethylamino)methyl]phenyl]phenyl]-5-methyl-3-(trifluoromethyl)pyrazolo[4,3-d]pyrimidin-7-oneKi37000.0 [1]
Methyl (2R,3R)-2-[(3-carbamimidoylphenyl)methyl]-3-[[4-(3-carbamoylphenyl)benzoyl]amino]butanoateKi18500.0 [1]
5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(2-imino-imidazolidin-1-ylmethyl)-benzoylamino]-benzamideIC5011000.0 [1]
5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylaminomethyl-benzoylamino)-benzamideIC5011000.0 [1]
5-Chloro-N-(5-chloropyridin-2-yl)-2-[[4-[[ethanimidoyl(methyl)amino]methyl]benzoyl]amino]benzamideIC5011000.0 [1]
4-Hydroxy-3-[2-oxo-3-(thieno[3,2-B]pyridine-2-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidineKi5200.0 [1]
Methyl N-[(14S)-14-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-9-oxo-8,16,18-triazatricyclo[13.2.1.02,7]octadeca-1(17),2(7),3,5,15-pentaen-5-yl]carbamateKi21500.0 [1]
Bis-triazole derivative 10Ki3000.0 [1]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6(21),7,9,16(20),17-hexaene-3,12-dioneKi2800.0 [1]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-ethylsulfonyl-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-3,12-dioneKi1300.0 [1]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-ethylsulfonyl-17-methyl-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi830.0 [1]
Methyl N-[4-[2-[(1S)-1-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-2-phenylethyl]pyridin-4-yl]phenyl]carbamateKi30220.0 [1]
Methyl N-[(12E,15S)-15-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-9-oxo-8,17,19-triazatricyclo[14.2.1.02,7]nonadeca-1(18),2(7),3,5,12,16-hexaen-5-yl]carbamateKi21500.0 [1]
[4-[(5-Chloro-1H-indol-2-yl)sulfonyl]piperazin-1-yl]-[4-(1-methyl-4,5-dihydroimidazol-2-yl)phenyl]methanoneIC5010000.0 [1]
1-(4-Methoxyphenyl)-7-oxo-6-[4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl]pyrazolo[4,3-d]pyrimidine-3-carboxamideKi76000.0 [1]
N-[2-(3-Carbamimidoylphenoxy)phenyl]-4-(2-sulfamoylphenyl)benzamideIC50181000.0 [1]
2-(6-Chloronaphthalen-2-yl)-5-methyl-N-[4-(2-sulfamoylphenyl)phenyl]pyrazole-3-carboxamideIC5011000.0 [1]
N-[2-(3-Carbamimidoylphenoxy)ethyl]-4-(2-sulfamoylphenyl)benzamideIC503700.0 [1]
2-[3-(Benzylsulfonylamino)-6-methyl-2-oxopyridin-1-yl]-N-[(1-carbamimidoylpiperidin-4-yl)methyl]acetamideKi20000.0 [1]
N-[4-[2-[(Dimethylamino)methyl]phenyl]-2-fluorophenyl]-5-methyl-2-(3-methylsulfonylnaphthalen-2-yl)pyrazole-3-carboxamideIC5010000.0 [1]
1-(4-Aminoquinazoline-7-ylmethyl)-4-(5-chloro-1H-benzimidazole-2-ylsulfonyl)piperazine-2-oneKi18000.0 [1]
3-(4-Amidinophenyl)-2-[[[(4-amidinophenylsulfonyl)amino]acetyl]amino]propionic acidKi180000.0 [1]
N-[1-[2-[5-(Aminomethyl)-2-methylanilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-phenylbenzamideIC50450.0 [1]
N-{1-[(3-Aminomethyl-phenylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-3,3-diphenyl-propionamideIC50170.0 [1]
N-(4-Chloro-2-(5-chloropyridin-2-ylcarbamoyl)phenyl)-4-(N,N-dimethylcarbamimidoyl)-2-fluorobenzamideIC5010000.0 [1]
2-[[(2R)-1-[[2-[(4-Carbamimidoylphenyl)methylcarbamoyl]-1,3-dihydroinden-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC50100.0 [1]
5-(2-(2-Fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)acetyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamideKi38000.0 [1]
N-[2-[(5-Chloropyridin-2-yl)carbamoyl]-4-methoxyphenyl]-4-(N,N-dimethylcarbamimidoyl)-2-fluorobenzamideIC5010000.0 [1]
{(R)-1-[2-(4-Carbamimidoyl-benzylcarbamoyl)-indan-2-ylcarbamoyl]-2-methyl-propylamino}-acetic acidIC50800.0 [1]
2-(6-Chloronaphthalen-2-yl)-N-[4-(N,N-dimethylcarbamimidoyl)-2-fluorophenyl]-5-methylpyrazole-3-carboxamideIC5010000.0 [1]
N-[2-Fluoro-4-(3-oxomorpholin-4-yl)phenyl]-5-methyl-2-(3-methylsulfonylnaphthalen-2-yl)pyrazole-3-carboxamideIC5010000.0 [1]
3-(4-Amidinophenyl)-2-[[[(4-amidinophenylsulfonyl)amino]acetyl]amino]propionic acid ethyl esterKi43000.0 [1]
2-[4-[(6-Chloro-1-benzothiophen-2-yl)sulfonyl]-2-oxopiperazin-1-yl]-N-[2-(1H-imidazol-5-yl)ethyl]acetamideKi18000.0 [1]
2-[3-(6-Carbamimidoyl-4-methyl-4-phenyl-2,3-dihydro-1H-quinolin-2-yl)-5-(3-methylbutanoylamino)phenyl]-5-carbamoylbenzoic acidKi73.0 [1]
Ethyl 3-(3-carbamimidoylphenyl)-2-[[2-[(4-carbamothioylphenyl)sulfonylamino]acetyl]amino]propanoateKi48000.0 [1]
3-[(2R)-3-(4-Formylpiperazin-1-yl)-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamideKi10300.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Vitamin K-dependent protein C Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/vitamin-k-dependent-protein-c-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Vitamin K-dependent protein C Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/vitamin-k-dependent-protein-c-inhibitors-ic50-ki.
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