Voltage-gated calcium channel alpha2/delta subunit 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Gabapentin	IC50	27.0 [1]
	6-(4-Ethoxy-phenyl)-1,4,5,7-tetramethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	180.0 [1]
	[6-(4-Ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-yl]-methyl-amine	IC50	40.0 [1]
	4-N-Acridin-9-yl-1-N,1-N-diethylpentane-1,4-diamine	IC50	220.0 [1]
	6-(4-Methoxyphenyl)-1,4,5,7-tetramethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	10000.0 [1]
	6-(4-Ethoxy-phenyl)-1-(2-methoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	737.0 [1]
	1-(4-Chloro-phenyl)-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	701.0 [1]
	6-(4-Ethoxy-phenyl)-1,5,7-trimethyl-4-(4-trifluoromethoxy-phenyl)-6H-pyrrolo[3,4-d]pyridazine	IC50	1729.0 [1]
	6-(4-Ethoxy-phenyl)-1,5,7-trimethyl-4-p-tolyl-6H-pyrrolo[3,4-d]pyridazine	IC50	86.0 [1]
	1,6-Bis-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	153.0 [1]
	(1S)-N-(2-Phenylethyl)-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]ethanamine	IC50	30.0 [1]
	6-(4-Ethoxy-phenyl)-1-isobutyl-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	171.0 [1]
	6-(4-Ethoxy-phenyl)-1-(4-fluoro-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	528.0 [1]
	1-(3-Chloro-phenyl)-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	1597.0 [1]
	1-(2-Chloro-phenyl)-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	4367.0 [1]
	6-(4-Ethoxyphenyl)-N-(4-methoxyphenyl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-amine	IC50	440.0 [1]
	1-Cyclopentyl-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	185.0 [1]
	6-(4-Ethoxyphenyl)-1,5,7-trimethyl-4-pentylpyrrolo[3,4-d]pyridazine	IC50	360.0 [1]
	[6-(4-Ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-yl]-p-tolyl-amine	IC50	240.0 [1]
	6-(4-Ethoxy-phenyl)-1-ethyl-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	250.0 [1]
	1,4,5,7-Tetramethyl-6-(4-propoxy-phenyl)-6H-pyrrolo[3,4-d]pyridazine	IC50	5180.0 [1]
	1-Cyclopentylmethyl-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	211.0 [1]
	6-(4-Ethoxy-phenyl)-1-(3-methoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	335.0 [1]
	6-(2-Ethoxyphenyl)-1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazine	IC50	1850.0 [1]
	1-Cyclohexyl-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	235.0 [1]
	(4S)-4-N-Acridin-9-yl-1-N,1-N-diethylheptane-1,4-diamine	IC50	9.0 [1]
	[6-(4-Ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-yl]-phenyl-amine	IC50	75.0 [1]
	[6-(4-Ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-yl]-dimethyl-amine	IC50	170.0 [1]
	6-(4-Ethoxy-phenyl)-1,5,7-trimethyl-4-phenyl-6H-pyrrolo[3,4-d]pyridazine	IC50	382.0 [1]
	6-(4-Ethoxy-phenyl)-1-(4-methoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	154.0 [1]
	6-(4-Ethoxyphenyl)-1,5,7-trimethyl-4-(2,4,4-trimethylpentyl)pyrrolo[3,4-d]pyridazine	IC50	577.0 [1]
	1-Biphenyl-4-yl-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	1263.0 [1]
	N-Acridin-9-yl-1-cyclopropyl-N',N'-diethylbutane-1,4-diamine	IC50	52.0 [1]
	2-(3-Methylphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamine	IC50	15.0 [1]
	2-Phenyl-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]propan-1-amine	IC50	198.0 [1]
	[6-(3-Ethyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-phenethyl-amine	IC50	241.0 [1]
	N-[[6-[[3-(Methoxymethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]-2-phenylethanamine	IC50	131.0 [1]
	N-[2-(3-Methylphenyl)ethyl]-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]ethanamine	IC50	29.0 [1]
	Phenethyl-[6-(3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-amine	IC50	195.0 [1]
	N-(2-Phenylethyl)-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]propan-1-amine	IC50	183.0 [1]
	Phenethyl-[6-([1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-amine	IC50	230.0 [1]
	2-Methyl-N-(2-phenylethyl)-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]propan-1-amine	IC50	174.0 [1]
	4-N-Acridin-9-yl-1-N,1-N-diethylheptane-1,4-diamine	IC50	18.0 [1]
	(1R)-N-(2-Phenylethyl)-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]ethanamine	IC50	10000.0 [1]
	2-(4-Methoxyphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamine	IC50	829.0 [1]
	2-(2-Methylphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamine	IC50	448.0 [1]
	2-(4-Methylphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamine	IC50	260.0 [1]
	2-(3-Methoxyphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamine	IC50	116.0 [1]
	N-[[6-[(3-Methylsulfanyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)oxymethyl]pyridin-2-yl]methyl]-2-phenylethanamine	IC50	194.0 [1]
	1-Phenyl-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]propan-2-amine	IC50	1369.0 [1]
	[6-(3-Methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-phenethyl-amine	IC50	145.0 [1]
	2-(3-Fluorophenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamine	IC50	161.0 [1]
	N-Acridin-9-yl-N',N'-diethyl-1-phenylbutane-1,4-diamine	IC50	1100.0 [1]
	(2S)-1-Phenyl-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]propan-2-amine	IC50	700.0 [1]
	2-(2-Methoxyphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamine	IC50	3163.0 [1]
	2-(2-Fluorophenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamine	IC50	291.0 [1]
	(4S)-4-N-Acridin-9-yl-1-N,1-N-diethylpentane-1,4-diamine	IC50	110.0 [1]
	4-N-Acridin-9-yl-1-N,1-N-diethylhexane-1,4-diamine	IC50	38.0 [1]
	[6-(3-Cyclohexyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-phenethyl-amine	IC50	145.0 [1]
	4-N-Acridin-9-yl-1-N,1-N-diethyl-4-methylpentane-1,4-diamine	IC50	270.0 [1]
	[6-(3-Isopropyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-phenethyl-amine	IC50	342.0 [1]
	(1S)-N-[2-(3-Bromophenyl)ethyl]-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]ethanamine	IC50	28.0 [1]
	6-(4-Ethoxyphenyl)-N-(1H-indol-5-yl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-amine	IC50	30.0 [1]
	6-(4-Ethoxyphenyl)-N-(1H-indazol-5-yl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-amine	IC50	36.0 [1]
	(4S)-1-N,1-N-Diethyl-4-N-(1,2,3,4,5,6,7,8-octahydroacridin-9-yl)pentane-1,4-diamine	IC50	43.0 [1]
	N-[[6-[(3-Cyclopropyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)oxymethyl]pyridin-2-yl]methyl]-2-phenylethanamine	IC50	272.0 [1]
	2-(4-Fluorophenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamine	IC50	630.0 [1]
	2-(4-Ethoxyphenyl)-3,4-dimethyl-7-piperidin-1-ylpyrazolo[3,4-d]pyridazine	IC50	42.0 [1]
	3-N-Acridin-9-yl-1-N,1-N-diethylbutane-1,3-diamine	IC50	10000.0 [1]
	1-N,1-N-Diethyl-4-N-(1,2,3,4-tetrahydroacridin-9-yl)pentane-1,4-diamine	IC50	420.0 [1]
	(4R)-4-N-Acridin-9-yl-1-N,1-N-diethylpentane-1,4-diamine	IC50	11000.0 [1]
	6-(4-Ethoxyphenyl)-1-methoxy-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazine	IC50	2181.0 [1]
	5-N-Acridin-9-yl-1-N,1-N-diethylhexane-1,5-diamine	IC50	6000.0 [1]
	Acridin-9-yl-(1-methyl-4-morpholin-4-yl-butyl)-amine	IC50	10000.0 [1]
	1-N,1-N-Diethyl-4-N-(1,2,3,4,5,6,7,8-octahydroacridin-9-yl)pentane-1,4-diamine	IC50	160.0 [1]
	1-N,1-N-Diethyl-4-N-[2-(trifluoromethyl)-5,6,7,8-tetrahydroquinolin-4-yl]pentane-1,4-diamine	IC50	10000.0 [1]
	N-[5-[(2S,6R)-2,6-Dimethylpiperidin-1-yl]pentan-2-yl]acridin-9-amine	IC50	5900.0 [1]
	N~4~-(Acridin-9-yl)-N~1~,N~1~-diethylbutane-1,4-diamine	IC50	13000.0 [1]
	Acridin-9-yl-(1-methyl-4-piperidin-1-yl-butyl)-amine	IC50	10000.0 [1]
	Acridin-9-yl-(1-methyl-4-pyrrolidin-1-yl-butyl)-amine	IC50	9900.0 [1]
	4-N-Acridin-9-yl-1-N,1-N-di(propan-2-yl)pentane-1,4-diamine	IC50	10000.0 [1]
	4-N-Acridin-9-yl-1-N-propan-2-ylpentane-1,4-diamine	IC50	5100.0 [1]
	(4R)-1-N,1-N-Diethyl-4-N-(1,2,3,4,5,6,7,8-octahydroacridin-9-yl)pentane-1,4-diamine	IC50	760.0 [1]
	N-(2,3-Dihydro-1H-inden-1-yl)-6-(4-ethoxyphenyl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-amine	IC50	54.0 [1]
	6-(4-Ethoxyphenyl)-1,5,7-trimethyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolo[3,4-d]pyridazin-4-amine	IC50	161.0 [1]
	(3Ar,9bR)-2-[6-(4-ethoxyphenyl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-yl]-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindole	IC50	84.0 [1]
	1,3,4-Trimethyl-7-(4-methylcyclohexyl)-2-(4-propylphenyl)-2H-indene	IC50	2926.0 [1]
	N-(4-Fluorobenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amine	IC50	94.0 [1]
	N-(3-Chlorobenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amine	IC50	37.0 [1]
	N-(4-Chlorobenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amine	IC50	65.0 [1]
	2-[6-(4-Ethoxyphenyl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-yl]-1,3,4,4b,8a,9-hexahydropyrido[3,4-b]indole	IC50	135.0 [1]
	N-[1-[6-(4-Ethoxyphenyl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-yl]pyrrolidin-3-yl]acetamide	IC50	144.0 [1]
	6-(4-Ethoxyphenyl)-4,5,7-trimethyl-N-(2-methylbutyl)-6H-pyrrolo[3,4-d]pyridazin-1-amine	IC50	84.0 [1]
	6-(4-Ethoxyphenyl)-4,5,7-trimethyl-N-(pyridin-2-ylmethyl)-6H-pyrrolo[3,4-d]pyridazin-1-amine	IC50	3000.0 [1]
	6-(4-Ethoxyphenyl)-1,5,7-trimethyl-N-(4-methylpentan-2-yl)pyrrolo[3,4-d]pyridazin-4-amine	IC50	296.0 [1]
	6-(4-Ethoxyphenyl)-1,5,7-trimethyl-N-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethyl)pyrrolo[3,4-d]pyridazin-4-amine	IC50	32.0 [1]
	6-(4-Ethoxyphenyl)-1,5,7-trimethyl-N-[(6-methylpyridin-2-yl)methyl]pyrrolo[3,4-d]pyridazin-4-amine	IC50	84.0 [1]
	N-(3-Fluorobenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amine	IC50	18.0 [1]
	N-(4-Methoxybenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amine	IC50	702.0 [1]
	N-(2-Methoxybenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amine	IC50	76.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Voltage-gated calcium channel alpha2/delta subunit 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/voltage-gated-calcium-channel-alpha2-delta-subunit-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Voltage-gated calcium channel alpha2/delta subunit 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-calcium-channel-alpha2-delta-subunit-1-inhibitors-ic50-ki.
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