Voltage-gated L-type calcium channel alpha-1C subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Verapamil	IC50	150.0 [1], 23500.0 [2], 24000.0 [3], 47000.0 [4], 50000.0 [5]
	Nifedipine	IC50	22.0 [1], 50.0 [2], 55.0 [3]
	Nifedipine	Ki	1.0 [1]
	Mibefradil	IC50	202.0 [1], 250.0 [2], 108000.0 [3], 288000.0 [4]
	Nicardipine	IC50	250.0 [1], 9600.0 [2], 24100.0 [3]
	Testosterone	IC50	34.0 [1], 38.4 [2]
	Halothane	IC50	1800000.0 [1], 14500000.0 [2]
	Lamotrigine	IC50	1258925.41 [1], 1584893.19 [2]
	Moxifloxacin	IC50	168900.0 [1], 398107.17 [2]
	Amlodipine	IC50	1200.0 [1], 4200.0 [2]
	Sunitinib	IC50	79432.82 [1], 199526.23 [2]
	Dasatinib	IC50	251188.64 [1], 398107.17 [2]
	Duloxetine	IC50	25118.86 [1], 100000.0 [2]
	Lapatinib	IC50	1995262.31 [1], 15848931.92 [2]
	Nilotinib	IC50	199526.23 [1], 3162277.66 [2]
	Vardenafil	IC50	15848.93 [1], 251188.64 [2]
	Dofetilide	IC50	158489.32 [1], 1023000.0 [2]
	Paliperidone	IC50	398107.17 [1], 1000000.0 [2]
	Cilnidipine	IC50	5300.0 [1], 12700.0 [2]
	Barnidipine	IC50	1200.0 [1], 3100.0 [2]
	Omarigliptin	IC50	30000.0 [1]
	2-(2-Amino-1,3-thiazol-4-yl)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]acetamide	IC50	8200.0 [1]
	5-O-[(3R)-1-Benzylpiperidin-3-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	IC50	4900.0 [1], 13800.0 [2]
	(6S)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxamide	IC50	30000.0 [1]
	(4R)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide	IC50	30000.0 [1]
	Estradiol	IC50	50000.0 [1]
	Propranolol	IC50	21000.0 [1]
	Phenytoin	IC50	125000.0 [1]
	Fluoxetine	IC50	5400.0 [1]
	Ketamine	IC50	1800.0 [1]
	Risperidone	IC50	125000.0 [1]
	Sildenafil	IC50	100000.0 [1]
	Diltiazem	IC50	44000.0 [1]
	Quinidine	IC50	19820.0 [1]
	3-Isobutyl-1-methylxanthine	IC50	466000.0 [1]
	Remifentanil	IC50	38900.0 [1]
	Sotalol	IC50	1023000.0 [1]
	Clotrimazole	IC50	590.0 [1]
	Nimodipine	IC50	110.0 [1]
	Thioridazine	IC50	1320.0 [1]
	Tadalafil	IC50	398107.17 [1]
	Terfenadine	IC50	1320.0 [1]
	Sitagliptin	IC50	100000000.0 [1]
	Nitrendipine	Ki	0.25 [1]
	Darunavir	IC50	1584893.19 [1]
	Isradipine	IC50	2.2 [1]
	Tolterodine	IC50	25118.86 [1]
	Nebivolol	IC50	15848.93 [1]
	Deferasirox	IC50	1000000.0 [1]
	Gallopamil	IC50	17.0 [1]
	Bepridil	IC50	1400.0 [1]
	Seliciclib	IC50	23400.0 [1]
	Nisoldipine	IC50	3.0 [1]
	Alfuzosin	IC50	199526.23 [1]
	Solifenacin	IC50	6309.57 [1]
	Doripenem	IC50	1995.26 [1]
	Ambrisentan	IC50	2511886.43 [1]
	Palonosetron	IC50	398107.17 [1]
	Darifenacin	IC50	1584893.19 [1]
	Silodosin	IC50	794328.23 [1]
	Alvimopan	IC50	5011.87 [1]
	Lacosamide	IC50	50118.72 [1]
	Norfluoxetine	IC50	1130.0 [1]
	Propiverine	IC50	41700.0 [1]
	Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester	IC50	3200.0 [1]
	2-(4-((2,5-Difluorobenzyl)oxy)phenoxy)-5-ethoxyaniline	IC50	3600.0 [1]
	Pinaverium	IC50	1750.0 [1]
	Oliceridine	IC50	36000.0 [1]
	(R)-2-(4-Cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide	IC50	30000.0 [1]
	Vibegron	IC50	30000.0 [1]
	L-796568 Free base	IC50	1700.0 [1]
	2-[(8R)-8-(3,5-Difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]acetamide	IC50	20000.0 [1]
	Tert-butyl N-[(2R)-1-oxo-1-[[(3R)-2-oxo-1-propan-2-yl-4,5-dihydro-3H-1-benzazepin-3-yl]amino]-3-[2-(trifluoromethoxy)phenyl]propan-2-yl]carbamate	IC50	3500.0 [1]
	5-[2-[4-[2-[4-(Tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one	IC50	100000.0 [1]
	4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide	IC50	15848.93 [1]
	Zuranolone	IC50	30000.0 [1]
	Diethyl 2,6-dimethyl-4-[3-methyl-5-(2-naphthalen-1-ylethyl)-1,2-oxazol-4-yl]-1,4-dihydropyridine-3,5-dicarboxylate	Ki	4.11 [1]
	3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	IC50	20000.0 [1]
	[2-(4-Chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2S,3S)-2,3-dimethylpiperidin-1-yl]methanone	IC50	10000.0 [1]
	Diethyl 2,6-dimethyl-4-[3-methyl-5-(2-phenylethyl)-1,2-oxazol-4-yl]-1,4-dihydropyridine-3,5-dicarboxylate	Ki	22.9 [1]
	Diethyl 2,6-dimethyl-4-[3-methyl-5-(2-naphthalen-2-ylethyl)-1,2-oxazol-4-yl]-1,4-dihydropyridine-3,5-dicarboxylate	Ki	20.2 [1]
	Diethyl 2,6-dimethyl-4-[3-phenyl-5-(2-phenylethyl)-1,2-oxazol-4-yl]-1,4-dihydropyridine-3,5-dicarboxylate	Ki	72.9 [1]
	Diethyl 2,6-dimethyl-4-[3-methyl-5-[2-(4-phenylphenyl)ethyl]-1,2-oxazol-4-yl]-1,4-dihydropyridine-3,5-dicarboxylate	Ki	18.2 [1]
	N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide	IC50	2410.0 [1]
	4-[4-[2-Chloro-5-(trifluoromethoxy)phenyl]-2,6-dimethylphenoxy]butanoic acid	IC50	12840.0 [1]
	3-[5-[2-Fluoro-5-(trifluoromethoxy)phenyl]-1-benzofuran-2-yl]propanoic acid	IC50	15090.0 [1]
	Diethyl 2,6-dimethyl-4-(3-phenyl-5-propan-2-yl-1,2-oxazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate	Ki	417.0 [1]
	6-[[[1-[2-(7-Methoxy-2-oxoquinoxalin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	IC50	92000.0 [1]
	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	IC50	30000.0 [1]
	N-[(4R)-4-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-2-oxoimidazolidin-1-yl]methanesulfonamide	IC50	30000.0 [1]
	Diethyl 4-(3,5-dimethyl-1,2-oxazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate	Ki	27.1 [1]
	Diethyl 2,6-dimethyl-4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate	Ki	13.9 [1]
	[(1S,2S)-2-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoate	IC50	347.0 [1]
	2-(3,4-Dimethoxyphenyl)-2-[3-(N-methyl-3,4-dimethoxyphenethylamino)cyclohexyl]-3-methylbutyronitrile	IC50	270.0 [1]
	Diethyl 2,6-dimethyl-4-[3-methyl-5-[2-(2-phenylphenyl)ethyl]-1,2-oxazol-4-yl]-1,4-dihydropyridine-3,5-dicarboxylate	Ki	91.1 [1]
	N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamide	IC50	7100.0 [1]
	2-(4-Tert-butylphenyl)-N-[1-[(5-cyanopyridin-2-yl)methyl]pyrazol-3-yl]acetamide	IC50	2420.0 [1]
	10-[4-(2,1,3-Benzoxadiazol-4-yl)-2,6-dimethyl-5-propan-2-yloxycarbonyl-1,4-dihydropyridine-3-carbonyl]oxydecyl-trimethylazanium	IC50	70.0 [1]
	8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one	IC50	30000.0 [1]
	(1S,3R)-3-[8-Amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]cyclohexane-1-carboxylic acid	IC50	30000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Voltage-gated L-type calcium channel alpha-1C subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/voltage-gated-l-type-calcium-channel-alpha-1c-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Voltage-gated L-type calcium channel alpha-1C subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-l-type-calcium-channel-alpha-1c-subunit-inhibitors-ic50-ki.
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