Voltage-gated L-type calcium channel Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nitrendipine	IC50	0.15 [1], 0.35 [2], 1.0 [3], 30.0 [4]
	Nifedipine	IC50	10.0 [1], 60.0 [2]
	Nifedipine	Ki	14.45 [1]
	N-[4,6-Dimethoxy-2-(3-morpholin-4-ylpropylamino)pyrimidin-5-yl]-5-[(3,3,6-trimethyl-1,2-dihydroinden-5-yl)oxy]furan-2-carboxamide	Ki	145.0 [1], 166.0 [2], 370.0 [3]
	Haloperidol	IC50	1300.0 [1], 1700.0 [2]
	Amiodarone	IC50	270.0 [1], 1900.0 [2]
	Diltiazem	IC50	450.0 [1], 760.0 [2]
	Pimozide	IC50	162.0 [1], 240.0 [2]
	Dofetilide	IC50	26700.0 [1], 60000.0 [2]
	Mibefradil	IC50	156.0 [1], 510.0 [2]
	Sertindole	IC50	6300.0 [1], 8900.0 [2]
	(R)-Sila-Venlafaxine	IC50	2700.0 [1], 8600.0 [2]
	(2R)-3-Cyclobutyl-2-[(3S,4S)-3-phenyl-4-[[4-(3-phenylpropyl)piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid	IC50	2700.0 [1]
	Diazepam	IC50	30500.0 [1]
	Verapamil	IC50	200.0 [1]
	Phenytoin	IC50	21900.0 [1]
	Chlorpromazine	IC50	3400.0 [1]
	Clozapine	IC50	3600.0 [1]
	Metronidazole	IC50	177900.0 [1]
	Methadone	IC50	37400.0 [1]
	Risperidone	IC50	34200.0 [1]
	Ribavirin	IC50	622500.0 [1]
	Imipramine	IC50	8300.0 [1]
	Pentobarbital	IC50	299000.0 [1]
	Amitriptyline	IC50	11600.0 [1]
	Quinidine	IC50	6400.0 [1]
	Paroxetine	IC50	3900.0 [1]
	Mitoxantrone	IC50	22500.0 [1]
	Lamivudine	IC50	54200.0 [1]
	Voriconazole	IC50	414200.0 [1]
	Ceftriaxone	IC50	153800.0 [1]
	Linezolid	IC50	105400.0 [1]
	Moxifloxacin	IC50	173000.0 [1]
	Donepezil	IC50	34300.0 [1]
	Piperacillin	IC50	1226000.0 [1]
	Procainamide	IC50	389500.0 [1]
	Sunitinib	IC50	33400.0 [1]
	Dasatinib	IC50	81100.0 [1]
	Sotalol	IC50	193300.0 [1]
	Duloxetine	IC50	2800.0 [1]
	Saquinavir	IC50	1900.0 [1]
	Droperidol	IC50	7600.0 [1]
	Thioridazine	IC50	3500.0 [1]
	Terfenadine	IC50	930.0 [1]
	Cisapride	IC50	11800.0 [1]
	Sitagliptin	IC50	147100.0 [1]
	Cilostazol	IC50	91200.0 [1]
	Nilotinib	IC50	4700.0 [1]
	Loratadine	IC50	11400.0 [1]
	Disopyramide	IC50	1036700.0 [1]
	Raltegravir	IC50	246700.0 [1]
	Flecainide	IC50	27100.0 [1]
	Mexiletine	IC50	100000.0 [1]
	Gallopamil	IC50	11.0 [1]
	Sparfloxacin	IC50	88800.0 [1]
	Paliperidone	IC50	193900.0 [1]
	Bepridil	IC50	1000.0 [1]
	Astemizole	IC50	1100.0 [1]
	Telbivudine	IC50	713900.0 [1]
	Nisoldipine	IC50	0.01 [1]
	Solifenacin	IC50	4300.0 [1]
	Halofantrine	IC50	1900.0 [1]
	2-(Diphenylmethyl)-N-((2-methoxyphenyl)methyl)-1-azabicyclo(2.2.2)octan-3-amine	IC50	240.0 [1]
	Cibenzoline	IC50	30000.0 [1]
	Ibutilide	IC50	62500.0 [1]
	Terodiline	IC50	4800.0 [1]
	3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine	IC50	9000.0 [1]
	Diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	IC50	0.05 [1]
	(18R)-13-Ethyl-8-methyl-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-14,18-diol	IC50	71000.0 [1]
	PF-Cbp1	IC50	3000.0 [1]
	Cyclohexyl-{3-phenyl-4-[4-(3-phenyl-propyl)-piperidin-1-ylmethyl]-pyrrolidin-1-yl}-acetic acid	IC50	5300.0 [1]
	(2R)-2-[(3S,4S)-3-[[4-(4-Fluorophenyl)piperidin-1-yl]methyl]-4-phenylpyrrolidin-1-yl]-3-methylbutanoic acid	IC50	10000.0 [1]
	1-[[(3S,4S)-1-(Cyclohexylmethyl)-4-phenylpyrrolidin-3-yl]methyl]-4-[3-[4-(2H-tetrazol-5-yl)phenyl]propyl]piperidin-4-ol	IC50	10000.0 [1]
	(1R,3R)-1-(Oxan-4-yl)-3-(5-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole	IC50	1900.0 [1]
	(3R)-1,1-Dibutyl-3-(5-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indole	IC50	128.0 [1]
	3-Methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	IC50	0.01 [1]
	3-[1-[(6-Chloro-1,3-benzodioxol-5-yl)methyl]piperidin-4-yl]-5-methyl-1H-benzimidazol-2-one	IC50	1710.0 [1]
	(3R)-1-Cyclohexyl-3-(5-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole	IC50	308.0 [1]
	8-[(6-Chloro-1,3-benzodioxol-5-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	IC50	1110.0 [1]
	8-(3-Phenoxybenzyl)-1-phenyl-1,3,8-triazaspiro[4.5]decane-4-one	IC50	552.0 [1]
	Ethyl 2-methoxy-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylate	IC50	710.0 [1]
	Diethyl 2,6-dimethyl-4-(3-phenyl-5-propan-2-yl-1,2-oxazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate	Ki	254.0 [1]
	Diethyl 6-methyl-4-(3-nitrophenyl)-2-sulfanylidene-1,4-dihydropyrimidine-3,5-dicarboxylate	IC50	17.0 [1]
	Diethyl 6-methyl-2-sulfanylidene-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyrimidine-3,5-dicarboxylate	IC50	26.0 [1]
	Diethyl 4-(3,5-dimethyl-1,2-oxazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate	Ki	32.8 [1]
	Diethyl 2,6-dimethyl-4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate	Ki	21.7 [1]
	Ethyl 6-methyl-2-methylsulfanyl-4-(3-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylate	IC50	130.0 [1]
	Diethyl 2-ethoxy-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	IC50	26.0 [1]
	Diethyl 2-ethylsulfanyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	IC50	4.0 [1]
	2-[[(2S)-3-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-1,1-diphenylpropan-2-yl]amino]acetamide	IC50	1670.0 [1]
	(S)-Hexyl 2-benzamido-5-(2-(1-benzylpiperidin-4-yl)ethylamino)-5-oxopentanoate	IC50	14070.0 [1]
	1-[4-[(4-Methoxy-3-phenylmethoxyphenyl)methyl]piperazin-1-yl]-3-(3-methylindol-1-yl)propan-1-one	IC50	4840.0 [1]
	4-[4,4-Bis(4-fluorophenyl)butyl]piperazine-1-carboxylic acid 4-cyanophenethyl ester	IC50	1720.0 [1]
	4-[4,4-Bis(4-fluorophenyl)butyl]-N-[2-(4-ethoxyphenyl)ethyl]piperazine-1-carboxamide	IC50	860.0 [1]
	2-(4-Cyanophenyl)ethyl N-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]carbamate	IC50	284.0 [1]
	4-[4,4-Bis(4-fluorophenyl)butyl]piperazine-1-carboxylic acid 4-fluorophenethyl ester	IC50	2730.0 [1]
	1-[3-(4-Fluorophenyl)propionyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine	IC50	4300.0 [1]
	1-[4-[4,4-Bis(4-fluorophenyl)butyl]piperazin-1-yl]-4-phenylbutan-1-one	IC50	2350.0 [1]
	ABT-639 hydrochloride	IC50	10000.0 [1]
	5-O-[6-[5-Ethoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]oxyhexyl] 3-O-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	IC50	0.04 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Voltage-gated L-type calcium channel Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 17 May. 2025, https://www.aatbio.com/data-sets/voltage-gated-l-type-calcium-channel-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, May 17). Quest Database™ Voltage-gated L-type calcium channel Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-l-type-calcium-channel-inhibitors-ic50-ki.
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