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Voltage-gated N-type calcium channel alpha-1B subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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5-(5-Chlorothiophen-3-yl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazoleIC506.0 [1], 28.0 [2], 62.0 [3]
2-[(1R,4S,7S,13S,19S,22R,27R,30S,33S,36S,39S,42S,45S,52R)-22-Amino-4,13,19-tris(4-aminobutyl)-52-[[(2S,3R)-1-[[2-[[(2S)-1-[[(4R,7S,13S,16S,19R)-7-(4-aminobutyl)-16-(3-carbamimidamidopropyl)-4-carbamoyl-13-(hydroxymethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]carbamoyl]-42-(3-carbamimidamidopropyl)-45-(hydroxymethyl)-33-[(4-hydroxyphenyl)methyl]-7-methyl-39-(2-methylpropyl)-36-(2-methylsulfanylethyl)-3,6,9,12,15,18,21,29,32,35,38,41,44,47,54-pentadecaoxo-24,25,49,50-tetrathia-2,5,8,11,14,17,20,28,31,34,37,40,43,46,53-pentadecazabicyclo[25.20.7]tetrapentacontan-30-yl]acetic acidIC5022.0 [1], 48.0 [2], 49.0 [3]
5-(4-Chlorophenyl)-3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-1-(2-methoxyphenyl)-1H-pyrazoleIC502.0 [1], 55.0 [2], 150.0 [3]
5-(4-Chlorophenyl)-3-[(2R,6S)-2,6-dimethyloxan-4-yl]-1-(2-methoxyphenyl)pyrazoleIC503.0 [1], 12.0 [2], 91.0 [3]
Cav 2.2 blocker 1IC501.0 [1], 16.0 [2], 24.0 [3]
4-[2-(2-Methoxyphenyl)-5-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-3-yl]benzonitrileIC501.0 [1], 85.0 [2], 130.0 [3]
5-(4-Ethoxyphenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazoleIC502.0 [1], 29.0 [2], 61.0 [3]
2-Chloro-4-[2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-3-yl]pyridineIC5011.0 [1], 250.0 [2], 740.0 [3]
2-[5-(4-Chlorophenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-1-yl]-N,N-diethylanilineIC501.0 [1], 100.0 [2], 590.0 [3]
2-Ethoxy-5-[2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-3-yl]pyridineIC505.0 [1], 44.0 [2], 200.0 [3]
omega-Conotoxin G viaIC5020.0 [1], 40.0 [2]
MibefradilIC50416.0 [1], 1340.0 [2]
ZiconotideIC50500.0 [1], 600.0 [2]
[(R)-2-Cyclopentylmethylsulfanyl-1-(4-methoxy-benzylcarbamoyl)-ethyl]-carbamic acid tert-butyl esterIC50630.0 [1], 640.0 [2]
[4-[(2S)-3-(Tert-butylamino)-2-[[(2S)-4-methyl-2-[methyl(3-methylbutyl)amino]pentanoyl]amino]-3-oxopropyl]phenyl] benzoateIC50320.0 [1]
[4-[(2S)-3-(Tert-butylamino)-2-[[(2S)-2-[cyclohexylmethyl(methyl)amino]-4-methylpentanoyl]amino]-3-oxopropyl]phenyl] benzoateIC50680.0 [1], 700.0 [2]
Tert-butyl (4R)-4-[[(2R)-3-(cyclohexylmethylsulfanyl)-1-oxo-1-[(4-phenoxyphenyl)methylamino]propan-2-yl]carbamoyl]-1,3-thiazolidine-3-carboxylateIC50140.0 [1]
[4-[(2S)-2-[[(2S)-2-(Azepane-1-carbonylamino)-4-methylpentanoyl]amino]-3-[(2-methylpropan-2-yl)oxy]-3-oxopropyl]phenyl] benzoateIC50320.0 [1]
[4-[(2S)-2-[[(2S)-2-(Azepane-1-carbonylamino)-4-methylpentanoyl]amino]-3-(tert-butylamino)-3-oxopropyl]phenyl] benzoateIC50590.0 [1]
N-[(2S)-4-Methyl-1-[4-[N-(3-methylbut-2-enyl)-4-phenylmethoxyanilino]piperidin-1-yl]-1-oxopentan-2-yl]azepane-1-carboxamideIC50340.0 [1]
6-(Azepan-1-ylmethyl)-2-(4,4-diphenylbutyl)-3,4-dihydro-1H-isoquinolin-5-olIC50460.0 [1]
1-(4-Amino-piperidin-1-yl)-4,4-bis-(4-fluoro-phenyl)-butan-1-one; hydrochlorideIC501030.0 [1], 2400.0 [2]
2-(3,4-Dimethoxyphenyl)-5-[4-(2-phenoxyethylamino)piperidin-1-yl]-2-propan-2-ylpentanenitrile;oxalic acidIC50400.0 [1], 700.0 [2]
N-[1-[(2,6-Dimethoxyphenyl)methyl]piperidin-4-yl]-N-propyl-3-(trifluoromethyl)benzenesulfonamideIC50120.0 [1], 4800.0 [2]
5-(4-Chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazoleIC5030.0 [1], 30000.0 [2]
4-[5-(4-Chlorophenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-1-yl]pyridineIC507.0 [1], 22000.0 [2]
2-[5-(4-Chlorophenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-1-yl]pyridineIC5012.0 [1], 1000.0 [2]
5-[2-(2-Methoxyphenyl)-5-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-3-yl]-2-methylpyridineIC506.0 [1], 13000.0 [2]
5-(4-Chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyl-3H-pyran-4-yl)pyrazoleIC503.0 [1], 26000.0 [2]
5-(4-Chlorophenyl)-1-(2-methoxyphenyl)-3-[(2S,4R)-2-propan-2-yloxan-4-yl]pyrazoleIC507.0 [1], 55000.0 [2]
5-(4-Chlorophenyl)-3-[(2S,6S)-2,6-dimethyloxan-4-yl]-1-(2-methoxyphenyl)pyrazoleIC502.0 [1], 61000.0 [2]
2-(3,4-Dimethoxyphenyl)-5-[[1-(2-phenoxyethyl)piperidin-4-yl]amino]-2-propan-2-ylpentanenitrileIC503100.0 [1], 3800.0 [2]
FlunarizineIC501670.0 [1]
CilnidipineIC501600.0 [1]
LomerizineIC502430.0 [1]
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamideIC5010000.0 [1]
NNC 55-0396 dihydrochlorideIC507000.0 [1]
(R)-2-(4-Cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamideIC5030000.0 [1]
1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanoneIC5039000.0 [1]
(2S)-N-[(2S)-1-(Tert-butylamino)-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-[(4-tert-butylphenyl)methyl-methylamino]-4-methylpentanamideIC5040.0 [1]
N-Benzyl-2-[2-[5-(dimethylamino)pentyl-methylamino]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]acetamide;dihydrochlorideIC504900.0 [1]
2,6-Dimethyl-4-(3-nitrophenyl)-5-[(E)-3-phenylprop-2-enoxy]carbonyl-1,4-dihydropyridine-3-carboxylic acidIC503500.0 [1]
4-(3-Chlorophenyl)-6-(dimethoxymethyl)-2-methyl-5-[(E)-3-phenylprop-2-enoxy]carbonyl-1,4-dihydropyridine-3-carboxylic acidIC503000.0 [1]
4-(3-Chlorophenyl)-5-(3,3-diphenylpropoxycarbonyl)-2-methyl-6-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylic acidIC501700.0 [1]
4-(3-Chlorophenyl)-2,6-dimethyl-5-[(E)-3-phenylprop-2-enoxy]carbonyl-1,4-dihydropyridine-3-carboxylic acidIC501000.0 [1]
N-Cyclopropyl-N-[1-(5-fluoro-2-methylsulfonylbenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamideIC50560.0 [1]
3-(Trifluoromethyl)benzenesulfonamideIC5010000.0 [1]
2-(3-Bromo-4-fluorophenyl)-3-(2-(pyridin-2-yl)ethyl)thiazolidin-4-oneIC501680.0 [1]
N-[4,6-Dimethoxy-2-(3-morpholin-4-ylpropylamino)pyrimidin-5-yl]-5-[(3,3,6-trimethyl-1,2-dihydroinden-5-yl)oxy]furan-2-carboxamideKi5240.0 [1]
(2S)-2-Amino-4-methyl-1-[4-[N-(3-methylbut-2-enyl)-4-phenylmethoxyanilino]piperidin-1-yl]pentan-1-oneIC50670.0 [1]
3-Cyclopentyl-2-(3-(4-(dimethylamino)phenyl)pyridin-4-yl)thiazolidin-4-oneIC5010700.0 [1]
3-Isobutyl-2-(2-(4-vinylphenyl)pyridin-3-yl)thiazolidin-4-oneIC501330.0 [1]
2-(4-(4-Ethylphenyl)pyridin-3-yl)-3-isobutylthiazolidin-4-oneIC50880.0 [1]
2-(4-(4-Fluorophenyl)pyridin-3-yl)-3-isobutylthiazolidin-4-oneIC501290.0 [1]
2-(3-(4-Bromophenyl)pyridin-4-yl)-3-isobutylthiazolidin-4-oneIC50500.0 [1]
2-(2-(4-Bromophenyl)pyridin-3-yl)-3-isobutylthiazolidin-4-oneIC50700.0 [1]
N-[(2S)-1-[4-[4-(3,3-Dimethylbutylamino)-N-(3-methylbutyl)anilino]piperidin-1-yl]-4-methyl-1-oxopentan-2-yl]azepane-1-carboxamideIC50180.0 [1]
2-(4-(4-Chlorophenyl)pyridin-3-yl)-3-isobutylthiazolidin-4-oneIC50600.0 [1]
3-Isobutyl-2-(4-p-tolylpyridin-3-yl)thiazolidin-4-oneIC50490.0 [1]
3-Isobutyl-2-(3-(4-vinylphenyl)pyridin-4-yl)thiazolidin-4-oneIC50530.0 [1]
4-[2-[3-[2-(3-Hydroxyphenethyl)benzyloxy]-5-isopropoxyphenoxy]ethyl]benzamidineIC502700.0 [1]
3-Isobutyl-2-(4-phenylpyridin-3-yl)thiazolidin-4-oneIC503980.0 [1]
3-Isobutyl-2-(4-(4-vinylphenyl)pyridin-3-yl)thiazolidin-4-oneIC50510.0 [1]
2-(4-(4-Bromophenyl)pyridin-3-yl)-3-cyclopentylthiazolidin-4-oneIC50630.0 [1]
4-[2-[3-[2-(4-Hydroxyphenethyl)benzyloxy]-5-isopropoxyphenoxy]ethyl]benzamidineIC503300.0 [1]
2-(1-Azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-hydroxyphenyl]-1-methyl-4,4-diphenylbutyl}phenolIC50740.0 [1]
3-Isobutyl-2-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)thiazolidin-4-oneIC501070.0 [1]
N-[(2S)-4-Methyl-1-[[2-methyl-1-[N-(3-methylbut-2-enyl)-4-phenylmethoxyanilino]propan-2-yl]amino]-1-oxopentan-2-yl]azepane-1-carboxamideIC50260.0 [1]
(2S)-4-Methyl-1-[4-[N-(3-methylbut-2-enyl)-4-phenylmethoxyanilino]piperidin-1-yl]-2-(3-methylbutylamino)pentan-1-oneIC50480.0 [1]
N-[(2S)-4-Methyl-1-[[(2S)-1-[N-(3-methylbut-2-enyl)-4-phenylmethoxyanilino]propan-2-yl]amino]-1-oxopentan-2-yl]azepane-1-carboxamideIC501000.0 [1]
(4-Benzyloxy-phenyl)-(3-methyl-but-2-enyl)-piperidin-4-yl-amineIC504700.0 [1]
(2S)-4-Methyl-1-[4-[N-(3-methylbut-2-enyl)-4-phenylmethoxyanilino]piperidin-1-yl]-2-(propan-2-ylamino)pentan-1-oneIC50750.0 [1]
N-[(2S)-4-Methyl-1-oxo-1-[4-(4-phenylmethoxyanilino)piperidin-1-yl]pentan-2-yl]azepane-1-carboxamideIC502500.0 [1]
(2S)-2-(Cyclohexylamino)-4-methyl-1-[4-[N-(3-methylbut-2-enyl)-4-phenylmethoxyanilino]piperidin-1-yl]pentan-1-oneIC50510.0 [1]
N-[(2S)-1-[4-[N-(3-Hydroxybutyl)-4-phenylmethoxyanilino]piperidin-1-yl]-4-methyl-1-oxopentan-2-yl]azepane-1-carboxamideIC504600.0 [1]
N-[(2S)-1-[4-(N-Ethyl-4-phenylmethoxyanilino)piperidin-1-yl]-4-methyl-1-oxopentan-2-yl]azepane-1-carboxamideIC50830.0 [1]
N-[(2S)-1-[4-(N-Benzyl-4-phenylmethoxyanilino)piperidin-1-yl]-4-methyl-1-oxopentan-2-yl]azepane-1-carboxamideIC50430.0 [1]
3-Cyclopentyl-2-(3-(4-(trifluoromethyl)phenyl)pyridin-4-yl)thiazolidin-4-oneIC501370.0 [1]
2-(4-(4-Bromophenyl)pyridin-3-yl)-3-cyclohexylthiazolidin-4-oneIC501320.0 [1]
N-[(2S)-4-Methyl-1-[3-[N-(3-methylbut-2-enyl)-4-phenylmethoxyanilino]piperidin-1-yl]-1-oxopentan-2-yl]azepane-1-carboxamideIC501500.0 [1]
1-[5-[3-(Trifluoromethyl)phenyl]furan-2-yl]-N-[(3,4,5-trimethoxyphenyl)methyl]methanamineIC506700.0 [1]
1-[5-(4-Chlorophenyl)furan-2-yl]-N-[(3,4,5-trimethoxyphenyl)methyl]methanamineIC504300.0 [1]
1-[5-(3-Chloro-4-methoxyphenyl)furan-2-yl]-N-[(3,4,5-trimethoxyphenyl)methyl]methanamineIC505900.0 [1]
4-[4-[[(3,4,5-Trimethoxyphenyl)methylamino]methyl]phenoxy]benzonitrileIC509400.0 [1]
N-[(5-Chloro-1H-indol-3-yl)methyl]-1-(3,4,5-trimethoxyphenyl)methanamineIC509500.0 [1]
5-[[8-Hydroxy-7-(piperidin-1-ylmethyl)isoquinolin-5-yl]methyl]-7-(piperidin-1-ylmethyl)quinolin-8-olIC504400.0 [1]
6-[(Z)-Cyclohexyliminomethyl]-isoquinolin-5-olIC5035000.0 [1]
N-[[4-(3-Aminopropoxy)phenyl]methyl]-N-methyl-6-[3-(trifluoromethyl)phenoxy]-1,3-benzothiazol-2-amine;2,2,2-trifluoroacetic acidIC5077000.0 [1]
4-[[2-[[4-[3-(Dimethylamino)propoxy]phenyl]methylamino]-1,3-benzothiazol-6-yl]oxy]benzonitrile;2,2,2-trifluoroacetic acidIC50105000.0 [1]
N-[[4-(3-Aminopropoxy)phenyl]methyl]-6-(4-fluorophenoxy)-N-methyl-1,3-benzothiazol-2-amine;2,2,2-trifluoroacetic acidIC5098000.0 [1]
N-[[4-(3-Aminopropoxy)phenyl]methyl]-N-methyl-6-phenoxy-1,3-benzothiazol-2-amine;2,2,2-trifluoroacetic acidIC5049000.0 [1]
2-[3-[4-[[Methyl-[6-[3-(trifluoromethyl)phenoxy]-1,3-benzothiazol-2-yl]amino]methyl]phenoxy]propyl]guanidine;2,2,2-trifluoroacetic acidIC50202000.0 [1]
2-[3-[4-[[[6-(4-Fluorophenoxy)-1,3-benzothiazol-2-yl]amino]methyl]phenoxy]propyl]guanidine;2,2,2-trifluoroacetic acidIC50244000.0 [1]
N-[[4-(3-Aminopropoxy)phenyl]methyl]-6-[4-(trifluoromethyl)phenoxy]-1,3-benzothiazol-2-amine;2,2,2-trifluoroacetic acidIC5059000.0 [1]
N-[[4-[3-(Dimethylamino)propoxy]phenyl]methyl]-6-[3-(trifluoromethyl)phenoxy]-1,3-benzothiazol-2-amine;2,2,2-trifluoroacetic acidIC5051000.0 [1]
2,2,2-Trifluoroacetic acid;2-[3-[4-[[[6-[3-(trifluoromethyl)phenoxy]-1,3-benzothiazol-2-yl]amino]methyl]phenoxy]propyl]guanidineIC50130000.0 [1]
2-[3-[4-[[(6-Phenoxy-1,3-benzothiazol-2-yl)amino]methyl]phenoxy]propyl]guanidine;2,2,2-trifluoroacetic acidIC50103000.0 [1]
N-[[4-[3-(Dimethylamino)propoxy]phenyl]methyl]-N-methyl-6-[4-(trifluoromethyl)phenoxy]-1,3-benzothiazol-2-amine;2,2,2-trifluoroacetic acidIC5046000.0 [1]
4-[[2-[[4-(3-Aminopropoxy)phenyl]methylamino]-1,3-benzothiazol-6-yl]oxy]phenol;2,2,2-trifluoroacetic acidIC50205000.0 [1]
4-[[2-[[4-(3-Aminopropoxy)phenyl]methyl-methylamino]-1,3-benzothiazol-6-yl]oxy]benzonitrile;2,2,2-trifluoroacetic acidIC5065000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Voltage-gated N-type calcium channel alpha-1B subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/voltage-gated-n-type-calcium-channel-alpha-1b-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Voltage-gated N-type calcium channel alpha-1B subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-n-type-calcium-channel-alpha-1b-subunit-inhibitors-ic50-ki.
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