Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Sildenafil	IC50	158489.32 [1], 398107.17 [2]
	Moxifloxacin	IC50	158489.32 [1], 398107.17 [2]
	Tadalafil	IC50	158489.32 [1], 251188.64 [2]
	Darunavir	IC50	50118.72 [1], 316227.77 [2]
	Nebivolol	IC50	15848.93 [1], 39810.72 [2]
	Dofetilide	IC50	158489.32 [1], 251188.64 [2]
	Ambrisentan	IC50	63095.73 [1], 501187.23 [2]
	Chromanol 293B	IC50	0.0 [1], 5000.0 [2]
	N-[(3S,4R)-6-Cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide	IC50	5000.0 [1], 44500.0 [2]
	Unii-4IF4R31066	IC50	120.0 [1]
	(2-Fluorophenyl)-(4-fluorophenyl)phenylacetamide	IC50	9.0 [1], 2000.0 [2]
	Lamotrigine	IC50	158489.32 [1]
	Everolimus	IC50	100000.0 [1]
	Sunitinib	IC50	63095.73 [1]
	Dasatinib	IC50	251188.64 [1]
	Duloxetine	IC50	10000.0 [1]
	Lapatinib	IC50	251188.64 [1]
	Nelfinavir	IC50	79432.82 [1]
	Sitagliptin	IC50	316227.77 [1]
	Nilotinib	IC50	398107.17 [1]
	Raltegravir	IC50	25118.86 [1]
	Vardenafil	IC50	630957.34 [1]
	Tolterodine	IC50	79432.82 [1]
	Maraviroc	IC50	63095.73 [1]
	Paliperidone	IC50	251188.64 [1]
	Etravirine	IC50	1258925.41 [1]
	Telbivudine	IC50	251188.64 [1]
	Alfuzosin	IC50	125892.54 [1]
	Solifenacin	IC50	31622.78 [1]
	Doripenem	IC50	316227.77 [1]
	Palonosetron	IC50	50118.72 [1]
	Darifenacin	IC50	19952.62 [1]
	Silodosin	IC50	251188.64 [1]
	Alvimopan	IC50	50118.72 [1]
	Lacosamide	IC50	251188.64 [1]
	N-(6-Cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-methylethanesulfonamide	IC50	6900.0 [1]
	N-(6-Chloropyridin-3-yl)-3,4-difluorobenzamide	IC50	41000.0 [1]
	N-(6-Chloropyridin-3-yl)-4-fluorobenzamide	IC50	66000.0 [1]
	Zuranolone	IC50	30000.0 [1]
	N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide	IC50	100000.0 [1]
	(2S)-2-Phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamide	IC50	8120.0 [1]
	4-Chloro-N-(6-chloropyridin-3-yl)benzamide	IC50	15000.0 [1]
	N-[3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluoro-butoxy)-chroman-4-yl]-N-methyl-methanesulfonamide	IC50	240.0 [1]
	CID 10171527	IC50	93000.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluorobenzamide	IC50	77000.0 [1]
	N-(2-Chloropyrimidin-5-yl)-3-fluorobenzamide	IC50	100000.0 [1]
	3-Chloro-N-(2-chloropyrimidin-5-yl)benzamide	IC50	78000.0 [1]
	N-(2-Chloropyrimidin-5-yl)-3-(trifluoromethyl)benzamide	IC50	35000.0 [1]
	N-[(3R,4S)-6-Fluoro-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide	IC50	700.0 [1]
	N-[(3S,4R)-3-Hydroxy-2,2-dimethyl-6-phenylmethoxy-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide	IC50	400.0 [1]
	N-[(3R,4S)-3-Hydroxy-2,2-dimethyl-6-phenylmethoxy-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide	IC50	50.0 [1]
	N-[6-[(1S)-1-(4-Fluorophenyl)-2,2-dipyridin-3-ylethyl]pyridin-2-yl]methanesulfonamide	IC50	790.0 [1]
	N-(6-Benzyloxy-3-hydroxy-2,2-dimethyl-chroman-4-yl)-N-methyl-methanesulfonamide	IC50	200.0 [1]
	N-[(3S,4R)-6-Fluoro-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide	IC50	2200.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-(2-methylpropylsulfonyl)benzamide	IC50	54000.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-(2-methylpropylsulfanyl)benzamide	IC50	100000.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-[(4-fluorophenyl)methylsulfonyl]benzamide	IC50	100000.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-(2-phenylethylamino)benzamide	IC50	100000.0 [1]
	N-(6-Butoxy-3-hydroxy-2,2-dimethyl-chroman-4-yl)-N-methyl-methanesulfonamide	IC50	250.0 [1]
	N-(3-Hydroxy-2,2-dimethyl-6-propoxy-chroman-4-yl)-N-methyl-methanesulfonamide	IC50	900.0 [1]
	N-(6-Chloropyridin-3-yl)-4-(trifluoromethyl)benzamide	IC50	2900.0 [1]
	N-(6-Fluoro-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-methylethanesulfonamide	IC50	1200.0 [1]
	N-(6-Cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-methylbutane-1-sulfonamide	IC50	58000.0 [1]
	N-(3-Hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-methylethanesulfonamide	IC50	3100.0 [1]
	N-(6-Chloro-3-hydroxy-2,2-dimethyl-chroman-4-yl)-N-methyl-methanesulfonamide	IC50	1100.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-propan-2-yloxybenzamide	IC50	100000.0 [1]
	N-(6-Chloropyridin-3-yl)-3,4-dimethylbenzamide	IC50	100000.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-methoxybenzamide	IC50	100000.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-phenoxybenzamide	IC50	1300.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-propan-2-ylsulfanylbenzamide	IC50	5800.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-methylbenzamide	IC50	33000.0 [1]
	N-(6-Chloropyridin-3-yl)-4-cyano-3-fluorobenzamide	IC50	51000.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-(4-fluorophenyl)sulfonylbenzamide	IC50	100000.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-(4-fluorophenyl)sulfanylbenzamide	IC50	100000.0 [1]
	N-(6-Chloropyridin-3-yl)-4-ethoxy-3-fluorobenzamide	IC50	100000.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-[(4-fluorophenyl)methylsulfanyl]benzamide	IC50	100000.0 [1]
	N-[[1-[2-(Tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)piperidin-4-yl]methyl]-3,5-dichlorobenzamide	IC50	33000.0 [1]
	N-(6-Chloropyridin-3-yl)-4-phenoxybenzamide	IC50	1900.0 [1]
	2-Chloro-5-benzoylaminopyridine	IC50	100000.0 [1]
	N-(6-Chloropyridin-3-yl)-3-(trifluoromethyl)benzamide	IC50	5800.0 [1]
	N-(6-Chloropyridin-3-yl)-3-fluoro-4-(trifluoromethyl)benzamide	IC50	3400.0 [1]
	N-(6-Chloropyridin-3-yl)-4-fluoro-3-(trifluoromethyl)benzamide	IC50	3400.0 [1]
	N-[(3S,4R)-3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-3,4-dihydrochromen-4-yl]-N-methylmethanesulfonamide	IC50	440.0 [1]
	4-Chloro-N-(6-chloropyridin-3-yl)-3-fluorobenzamide	IC50	15000.0 [1]
	3,4-Dichloro-N-(6-chloropyridin-3-yl)benzamide	IC50	17000.0 [1]
	3-Chloro-N-(6-chloropyridin-3-yl)benzamide	IC50	41000.0 [1]
	3-Chloro-N-(6-chloropyridin-3-yl)-4-fluorobenzamide	IC50	22000.0 [1]
	N-(6-Chloropyridin-3-yl)-4-phenylbenzamide	IC50	30000.0 [1]
	CID 9947787	IC50	49000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 89 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/voltage-gated-potassium-channel-iks-kcnq1-kv7-1-kcne1-mink-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-potassium-channel-iks-kcnq1-kv7-1-kcne1-mink-inhibitors-ic50-ki.
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