Voltage-gated potassium channel subunit Kv1.5 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N-[3-(4-Ethyl-benzenesulfonylamino)-2-hydroxy-indan-5-yl]-3-methoxy-benzamide	IC50	33.0 [1], 50.0 [2], 100.0 [3], 160.0 [4]
	N-[(7R,8R)-8-[(4-Butylphenyl)sulfonylamino]-7-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl]-3-methoxybenzamide	IC50	50.0 [1], 140.0 [2], 2900.0 [3]
	2-(3,4-Dimethylphenyl)-3-(4-methoxyphenethyl)thiazolidin-4-one	IC50	137.0 [1], 200.0 [2], 900.0 [3]
	[[(1S,2S,5R)-5-Methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene	IC50	30.0 [1], 500.0 [2]
	5-(4-Phenoxybutoxy)psoralen	IC50	88.0 [1], 3450.0 [2]
	4-Methoxy-3-[(2-methyl-2-phenylpropyl)amino]-1H-isoindol-1-one	IC50	34.0 [1], 84.0 [2]
	CID 135532473	IC50	170.0 [1]
	CID 135532763	IC50	70.0 [1]
	[7-(3,4-Dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-pyrrolidin-1-ylmethanone	IC50	660.0 [1]
	[7-(3,4-Dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methanone	IC50	200.0 [1]
	4-Methoxy-N-(2-methyl-2-phenylpropyl)-1,2-benzoxazol-3-amine	IC50	43.0 [1]
	4-Methoxy-N-(2-methyl-2-phenylpropyl)-1,2-benzothiazol-3-amine	IC50	24.0 [1], 25.0 [2]
	N-[(3S,4R)-6-[(2S)-2-[(2,6-Dimethylanilino)methyl]pyrrolidine-1-carbonyl]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-4-ethylbenzenesulfonamide	IC50	60.0 [1], 120.0 [2]
	1-[(1R,2R)-1,2-Diphenyl-2-piperidin-1-ylethyl]piperidine	IC50	200.0 [1], 1700.0 [2]
	2-(4-Methoxy-benzenesulfonylamino)-N-((S)-1-phenyl-propyl)-benzamide	IC50	600.0 [1]
	1-(2-(3,4-Dimethylphenyl)thiazolidin-3-yl)-2-(4-methoxyphenyl)ethanone	IC50	537.0 [1]
	(3S,4R)-4-[(4-Ethylphenyl)sulfonylamino]-3-hydroxy-N,2,2-trimethyl-N-phenyl-3,4-dihydrochromene-6-carboxamide	IC50	280.0 [1], 281.0 [2]
	(3S,4R)-N-Ethyl-4-[(4-ethylphenyl)sulfonylamino]-N-[(2-fluorophenyl)methyl]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carboxamide	IC50	170.0 [1], 172.0 [2]
	N-[(7R,8R)-8-[(4-Ethylphenyl)sulfonylamino]-7-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl]-3-methoxybenzamide	IC50	440.0 [1]
	[(1S)-1-Phenylethyl] N-[[2-[2-(2-pyridin-2-ylethylcarbamoyl)phenyl]phenyl]methyl]carbamate	IC50	160.0 [1], 200.0 [2]
	N-[6-[(1S)-1-(4-Fluorophenyl)-2,2-dipyridin-3-ylethyl]pyridin-2-yl]methanesulfonamide	IC50	9.0 [1], 11.0 [2]
	N-(1-Hydroxy-2-methylpropan-2-yl)-3-oxo-2-(1-phenylethyl)-1H-isoindole-1-carboxamide	IC50	10000.0 [1], 32000.0 [2]
	4-[[(4-Methoxy-1,1-dioxo-1,2-benzothiazol-3-ylidene)amino]methyl]-4-phenylcyclohexan-1-ol	IC50	34.0 [1], 300.0 [2]
	(1R)-1-[2-(3,5-Dichlorophenyl)pyridin-3-yl]-2,2-dipyridin-3-ylethanol	IC50	11.0 [1], 29.0 [2]
	N-Tert-butyl-5-hydroxy-4-methyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide	IC50	3200.0 [1], 3400.0 [2]
	N-Benzyl-3-oxo-2-(1-phenylethyl)-1H-isoindole-1-carboxamide	IC50	1500.0 [1], 6000.0 [2]
	N-Tert-butyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide	IC50	3000.0 [1], 3300.0 [2]
	N-Tert-butyl-5-(methanesulfonamido)-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide	IC50	7600.0 [1], 17000.0 [2]
	N-Tert-butyl-5-(methanesulfonamido)-4-methyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide	IC50	4500.0 [1], 31000.0 [2]
	N-Tert-butyl-6-cyano-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide	IC50	2400.0 [1], 3300.0 [2]
	N-Tert-butyl-5-(fluoromethoxy)-4-methyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide	IC50	1300.0 [1], 1700.0 [2]
	N-Tert-butyl-7-hydroxy-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide	IC50	2100.0 [1], 3000.0 [2]
	N-Tert-butyl-5-methoxy-4-methyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide	IC50	800.0 [1], 2200.0 [2]
	N-Butyl-2-[2-(4-chlorophenyl)propyl]-3-oxo-1H-isoindole-1-carboxamide	IC50	700.0 [1], 1100.0 [2]
	N-Tert-butyl-5-hydroxy-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide	IC50	6900.0 [1], 8400.0 [2]
	Lidocaine	IC50	2188000.0 [1]
	Nifedipine	IC50	6100.0 [1]
	Quinidine	IC50	7300.0 [1]
	Flecainide	IC50	51000.0 [1]
	Sertindole	IC50	2000.0 [1]
	Acacetin	IC50	3400.0 [1]
	Vernakalant	IC50	3200.0 [1]
	Senicapoc	IC50	1000.0 [1]
	Oroidin	IC50	16000.0 [1]
	4'-Methoxyflavone	IC50	9000.0 [1]
	Clathrodin	IC50	30000.0 [1]
	2'-(Benzyloxycarbonylaminomethyl)biphenyl-2-carboxylic acid 2-(2-pyridyl)ethylamide	IC50	700.0 [1]
	N-[(2,4-Difluorophenyl)methyl]-2-[2-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]phenyl]benzamide	IC50	1200.0 [1]
	Hymenidin	IC50	7600.0 [1]
	Auglurant	IC50	100000.0 [1]
	N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide	IC50	33300.0 [1]
	4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide	IC50	50118.72 [1]
	Zuranolone	IC50	30000.0 [1]
	[(7R)-7-(3,4-Dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[4-(4-fluorophenyl)piperazin-1-yl]methanone	IC50	70.0 [1]
	2-(4-Methoxyphenyl)-6-methyl-4H-chromen-4-one	IC50	13700.0 [1]
	3-((Dimethylamino)methyl)-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one	IC50	190.0 [1]
	2-Phenyl-1,1-di(pyridin-3-yl)-2-(pyrrolidin-1-yl)ethanol	IC50	284.0 [1]
	[(7R)-7-(3,4-Dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[(2S)-2-(4-fluorophenyl)pyrrolidin-1-yl]methanone	IC50	50.0 [1]
	[7-(3,4-Dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]methanone	IC50	1000.0 [1]
	6-[[[1-[2-(7-Methoxy-2-oxoquinoxalin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	IC50	100000.0 [1]
	4-(3-(2-Fluorobenzyl)ureido)-N,N-diisopropyl-3-phenyl-2-(pyridin-3-yl)butanamide	IC50	150.0 [1]
	Dronedarone hydrochloride	IC50	2370.0 [1]
	N-[(4R)-4-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-2-oxoimidazolidin-1-yl]methanesulfonamide	IC50	480.0 [1]
	6-Chloro-2-(4-methoxyphenyl)-4H-chromen-4-one	IC50	23500.0 [1]
	N-[(E)-3-(2-Amino-1H-imidazol-5-yl)prop-2-enyl]-1H-indole-2-carboxamide	IC50	30000.0 [1]
	N-[(E)-3-(2-Amino-1H-imidazol-5-yl)prop-2-enyl]-5-fluoro-1H-indole-2-carboxamide	IC50	30000.0 [1]
	1-[(1S,2S)-2-(2-Naphthalen-1-ylethoxy)cyclohexyl]pyrrolidin-3-one	IC50	7700.0 [1]
	1-[(1R,2R)-2-(2-Naphthalen-1-ylethoxy)cyclohexyl]pyrrolidin-3-one	IC50	4300.0 [1]
	{2-[2-(3-Methyl-butylcarbamoyl)-pyridin-3-yl]-benzyl}-carbamic acid benzyl ester	IC50	2600.0 [1]
	N-Benzyl-N-(1-methyl-1H-imidazol-2-ylmethyl)-2-(toluene-4-sulfonylamino)-benzamide	IC50	700.0 [1]
	N-Benzyl-N-(3-imidazol-1-yl-propyl)-2-(toluene-4-sulfonylamino)-benzamide	IC50	8500.0 [1]
	Dichloroclathrodin	IC50	6100.0 [1]
	N-Benzyl-N-ethyl-2-(toluene-4-sulfonylamino)-benzamide	IC50	5000.0 [1]
	{2-[2-(Cyclopropylmethyl-carbamoyl)-pyridin-3-yl]-benzyl}-carbamic acid 1-phenyl-ethyl ester	IC50	400.0 [1]
	(1R,2R)-1-(3,4-Dichlorophenethoxy)-2-(4-morpholinyl)cyclohexane	IC50	3600.0 [1]
	N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-2-[2-[(naphthalen-1-ylsulfonylamino)methyl]phenyl]benzamide	IC50	9100.0 [1]
	2-Morpholin-4-yl-2-phenylethanol	IC50	60000.0 [1]
	Benzyl N-[[4-[2-(3-methylbutylcarbamoyl)phenyl]pyridin-3-yl]methyl]carbamate	IC50	7000.0 [1]
	[(1R)-1-Phenylethyl] N-[[2-[2-(2-pyridin-2-ylethylcarbamoyl)phenyl]phenyl]methyl]carbamate	IC50	2400.0 [1]
	N-[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]-2-[2-[(naphthalen-1-ylsulfonylamino)methyl]phenyl]benzamide	IC50	11200.0 [1]
	2-[2-[[[(3S)-3-Phenylbutanoyl]amino]methyl]phenyl]-N-(2-pyridin-2-ylethyl)benzamide	IC50	1000.0 [1]
	{2-[3-(3-Methyl-butylcarbamoyl)-pyridin-2-yl]-benzyl}-carbamic acid benzyl ester	IC50	7800.0 [1]
	2-[2-[[[(3R)-3-Phenylbutanoyl]amino]methyl]phenyl]-N-(2-pyridin-2-ylethyl)benzamide	IC50	300.0 [1]
	Benzyl N-[[2-[2-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]carbamoyl]phenyl]phenyl]methyl]carbamate	IC50	300.0 [1]
	N-(3-Methylbutyl)-2-[2-[(2-phenylethylamino)methyl]phenyl]benzamide	IC50	4000.0 [1]
	2-[2-[[(4-Acetylphenyl)sulfonylamino]methyl]phenyl]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]benzamide	IC50	7700.0 [1]
	Benzyl N-[[2-[2-[[3-(dimethylamino)-2,2-dimethylpropyl]carbamoyl]phenyl]phenyl]methyl]carbamate	IC50	2200.0 [1]
	N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-2-[2-[[[3-(trifluoromethyl)phenyl]sulfonylamino]methyl]phenyl]benzamide	IC50	4800.0 [1]
	4-(3-Fluorophenyl)-6-methoxy-2-[2-[2-methoxyethyl(methyl)amino]ethyl]-1-oxoisoquinoline-3-carbonitrile	IC50	790.0 [1]
	2-(2,3-Dihydroxypropyl)-4-(3-fluorophenyl)-6-methoxy-1-oxo-1,2-dihydroisoquinoline-3-carbonitrile	IC50	870.0 [1]
	1-{[(2S)-2,3-Dihydroxypropyl]amino}-6-methoxy-4-phenylisoquinoline-3-carbonitrile	IC50	680.0 [1]
	1-{[(2R)-2,3-Dihydroxypropyl]oxy}-6-methoxy-4-phenylisoquinoline-3-carbonitrile	IC50	160.0 [1]
	4-(3-Fluorophenyl)-2-(2-hydroxyethyl)-6-methoxy-1-oxo-1,2-dihydroisoquinoline-3-carbonitrile	IC50	690.0 [1]
	2-Morpholino-1,1-di(pyridin-3-yl)hexan-1-ol	IC50	2869.0 [1]
	2-Phenyl-2-(piperidin-1-yl)-1,1-di(pyridin-3-yl)ethanol	IC50	206.0 [1]
	2-(1,4-Oxazepan-4-yl)-2-phenyl-1,1-di(pyridin-3-yl)ethanol	IC50	517.0 [1]
	2-(Dimethylamino)-2-phenyl-1,1-di(pyridin-3-yl)ethanol	IC50	850.0 [1]
	2-Morpholino-1,1-di(pyridin-3-yl)octan-1-ol	IC50	3357.0 [1]
	2-Morpholino-3-phenyl-1,1-di(pyridin-3-yl)propan-1-ol	IC50	4946.0 [1]
	2-((2-Methoxyethyl)(methyl)amino)-2-phenyl-1,1-di(pyridin-3-yl)ethanol	IC50	583.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Voltage-gated potassium channel subunit Kv1.5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/voltage-gated-potassium-channel-subunit-kv1-5-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Voltage-gated potassium channel subunit Kv1.5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-potassium-channel-subunit-kv1-5-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan