Voltage-gated T-type calcium channel alpha-1G subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Mibefradil	IC50	1000.0 [1]
	N-Benzyl-2-[2-[5-(dimethylamino)pentyl-methylamino]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]acetamide	IC50	41.0 [1], 41.3 [2], 260.0 [3]
	N-[[4-[(4-Methylphenyl)sulfonylamino]phenyl]methyl]-2-(3-phenyl-2-piperidin-1-yl-4H-quinazolin-4-yl)acetamide	IC50	169.82 [1], 170.0 [2], 250.0 [3]
	Methyl 2-(2-(5-aminopentylamino)-3-(biphenyl-4-yl)-3,4-dihydroquinazolin-4-yl)acetate	IC50	559.76 [1], 560.0 [2]
	N-[[4-[(4-Fluorophenyl)sulfonylamino]phenyl]methyl]-2-(3-phenyl-2-piperidin-1-yl-4H-quinazolin-4-yl)acetamide	IC50	110.0 [1], 200.0 [2]
	N-Benzyl-2-(3-phenyl-2-piperidin-1-yl-4H-quinazolin-4-yl)acetamide	IC50	900.0 [1], 1160.0 [2]
	N-Benzyl-2-[2-[methyl(5-pyrrolidin-1-ylpentyl)amino]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]acetamide	IC50	260.0 [1], 260.02 [2]
	Tert-butyl N-[5-[4-[2-(benzylamino)-2-oxoethyl]-2-(4-phenylanilino)-4H-quinazolin-3-yl]pentyl]carbamate	IC50	169.82 [1], 170.0 [2]
	2-[2-(5-Aminopentylimino)-3-(4-phenylphenyl)-1,4-dihydroquinazolin-4-yl]-N-benzylacetamide	IC50	130.0 [1], 130.02 [2]
	Methyl 2-[2-[5-[(2-methylpropan-2-yl)oxycarbonylamino]pentylimino]-3-(4-phenylphenyl)-1,4-dihydroquinazolin-4-yl]acetate	IC50	679.2 [1], 680.0 [2]
	Tert-butyl N-[5-[[4-[2-(benzylamino)-2-oxoethyl]-3-(4-phenylphenyl)-1,4-dihydroquinazolin-2-ylidene]amino]pentyl]carbamate	IC50	159.96 [1], 160.0 [2]
	Methyl 2-[2-[5-(dimethylamino)pentyl-methylamino]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]acetate	IC50	230.0 [1], 230.14 [2]
	Methyl 2-(3-(5-aminopentyl)-2-(biphenyl-4-ylamino)-3,4-dihydroquinazolin-4-yl)acetate	IC50	299.92 [1], 300.0 [2]
	Methyl 5-((3-(1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)-2-(4-bromophenyl)-2-isopropylpentanoate	IC50	8.17 [1]
	N,3-Bis(4-fluorophenyl)-5-pyridin-4-yl-3,4-dihydropyrazole-2-carboxamide	IC50	29.0 [1], 450.0 [2], 1800.0 [3]
	N-((1-(2-(Tert-Butylamino)-2-oxoethyl)piperidin-4-yl)methyl)-3-chloro-5-fluorobenzamide	IC50	37.0 [1]
	N-Benzyl-2-[2-[5-(dimethylamino)pentyl-methylamino]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]acetamide;dihydrochloride	IC50	41.0 [1], 260.0 [2]
	N-Benzyl-2-[2-(4-methyl-piperazin-1-yl)-3-phenyl-3,4-dihydro-quinazolin-4-yl]-acetamide	IC50	35800.0 [1], 35809.64 [2]
	2-(3-Ethyl-2-piperidin-1-yl-4H-quinazolin-4-yl)-N-[[4-[(4-methylphenyl)sulfonylamino]phenyl]methyl]acetamide	IC50	959.4 [1], 960.0 [2]
	CID 24765479	IC50	1.2 [1]
	N-[(4-Aminophenyl)methyl]-2-(3-phenyl-2-piperidin-1-yl-4H-quinazolin-4-yl)acetamide	IC50	13031.67 [1], 14400.0 [2]
	N-Benzyl-2-[3-(4-nitro-phenyl)-2-piperidin-1-yl-3,4-dihydro-quinazolin-4-yl]-acetamide	IC50	2338.84 [1], 2500.0 [2]
	2,3-Diphenyl-3,4-dihydroquinazoline-4-acetic acid methyl ester	IC50	10690.55 [1], 10700.0 [2]
	N-Benzyl-2-(2-morpholin-4-yl-3-phenyl-3,4-dihydro-quinazolin-4-yl)-acetamide	IC50	21577.44 [1], 21600.0 [2]
	Tert-butyl N-[5-[[4-[2-(benzylamino)-2-oxoethyl]-3-phenyl-1,4-dihydroquinazolin-2-ylidene]amino]pentyl]carbamate	IC50	570.0 [1], 570.16 [2]
	2-Piperidino-3-phenyl-3,4-dihydroquinazoline-4-acetic acid methyl ester	IC50	27669.42 [1], 27700.0 [2]
	3-[(4-Chlorophenyl)methyl]-N-[3-(2-ethylpiperidin-1-yl)propyl]-4-oxo-2-sulfanylidene-1H-quinazoline-7-carboxamide	IC50	100.0 [1]
	Methyl 2-[3-[5-[(2-methylpropan-2-yl)oxycarbonylamino]pentyl]-2-(4-phenylanilino)-4H-quinazolin-4-yl]acetate	IC50	369.83 [1], 370.0 [2]
	Methyl 2-[2-[methyl(5-pyrrolidin-1-ylpentyl)amino]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]acetate	IC50	339.63 [1], 340.0 [2]
	2-[3-(5-Amino-pentyl)-2-(biphenyl-4-ylamino)-3,4-dihydro-quinazolin-4-yl]-N-benzyl-acetamide	IC50	139.96 [1], 140.0 [2]
	Methyl 2-[2-[methyl(5-pyrrolidin-1-ylpentyl)amino]-3-phenyl-4H-quinazolin-4-yl]acetate	IC50	5834.45 [1], 5840.0 [2]
	N-Benzyl-2-[2-[methyl(5-pyrrolidin-1-ylpentyl)amino]-3-phenyl-4H-quinazolin-4-yl]acetamide	IC50	4197.59 [1], 4200.0 [2]
	3-[(3-Fluorophenyl)methyl]-2,4-dioxo-N-(2-piperidin-1-ylethyl)-1H-quinazoline-7-carboxamide	IC50	16870.0 [1]
	3-[(4-Fluorophenyl)methyl]-2,4-dioxo-N-(2-piperidin-1-ylethyl)-1H-quinazoline-7-carboxamide	IC50	9230.0 [1]
	3-[(4-Chlorophenyl)methyl]-2,4-dioxo-N-(2-piperidin-1-ylethyl)-1H-quinazoline-7-carboxamide	IC50	2080.0 [1]
	3-[(4-Chlorophenyl)methyl]-2,4-dioxo-N-(3-piperidin-1-ylpropyl)-1H-quinazoline-7-carboxamide	IC50	1950.0 [1]
	3-[(4-Chlorophenyl)methyl]-N-[2-(2-ethylpiperidin-1-yl)ethyl]-2,4-dioxo-1H-quinazoline-7-carboxamide	IC50	3380.0 [1]
	3-[(4-Chlorophenyl)methyl]-2,4-dioxo-N-(2-pyrrolidin-1-ylethyl)-1H-quinazoline-7-carboxamide	IC50	2460.0 [1]
	2-[2-(Dimethylamino)-3-phenyl-4H-quinazolin-4-yl]-N-[(4-nitrophenyl)methyl]acetamide	IC50	349.95 [1], 350.0 [2]
	2-(3-Ethyl-2-piperidin-1-yl-4H-quinazolin-4-yl)-N-[[4-[(4-fluorophenyl)sulfonylamino]phenyl]methyl]acetamide	IC50	1039.92 [1], 1040.0 [2]
	2-[2-(Dimethylamino)-3-phenyl-4H-quinazolin-4-yl]-N-[[4-[(4-methylphenyl)sulfonylamino]phenyl]methyl]acetamide	IC50	629.51 [1], 630.0 [2]
	Methyl 2-(4-bromophenyl)-2-isopropyl-5-(4-(2-methoxyphenyl)piperazin-1-yl)pentanoate	IC50	95.0 [1], 95040.0 [2]
	1-[4-[(2,4-Dichlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one	IC50	4.0 [1], 33.0 [2]
	3-Chloro-2,5,5-trimethyl-N-[[2-(propan-2-yloxymethyl)phenyl]methyl]-6,7-dihydro-4H-isoindole-1-carboxamide	IC50	200.0 [1], 810.0 [2]
	3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-fluoropiperidin-4-yl]methyl}benzamide	IC50	25.0 [1], 43.0 [2]
	8-Prenylnaringenin	IC50	1000.0 [1]
	Sophoraflavanone G	IC50	1000.0 [1]
	(R)-2-(4-Cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide	IC50	89.0 [1]
	(S)-4',5,7-Trihydroxy-6-prenylflavanone	IC50	1000.0 [1]
	3-(4-Methoxybenzyl)-2,4-dioxo-N-(3-piperidin-1-ylpropyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide	IC50	3110.0 [1]
	3-(4-Chlorobenzyl)-7-(1-methylpiperazine-4-carbonyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one	IC50	11390.0 [1]
	3-[(4-Chlorophenyl)methyl]-N-[2-(dimethylamino)ethyl]-4-oxo-2-sulfanylidene-1H-quinazoline-7-carboxamide	IC50	53500.0 [1]
	3-[(4-Chlorophenyl)methyl]-N-[3-(4-methylpiperidin-1-yl)propyl]-4-oxo-2-sulfanylidene-1H-quinazoline-7-carboxamide	IC50	1100.0 [1]
	N-(1-Benzyl-1H-pyrazol-3-yl)benzamide	IC50	10000.0 [1]
	N-(1-Benzylpyrazol-3-yl)-2-phenylacetamide	IC50	1140.0 [1]
	N-[[5-(2-Methylpropyl)-1-phenylpyrazol-3-yl]methyl]benzenesulfonamide	IC50	5650.0 [1]
	3-Fluoro-N-[[5-(2-methylpropyl)-1-phenylpyrazol-3-yl]methyl]benzenesulfonamide	IC50	3200.0 [1]
	N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide	IC50	6.4 [1]
	3-[(4-Chlorophenyl)methyl]-N-[3-(2-ethylpiperidin-1-yl)propyl]-2,4-dioxo-1H-quinazoline-7-carboxamide	IC50	1520.0 [1]
	3-[(4-Chlorophenyl)methyl]-N-[3-(2-methylpiperidin-1-yl)propyl]-2,4-dioxo-1H-quinazoline-7-carboxamide	IC50	3720.0 [1]
	4-Amino-1-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)butan-1-one	IC50	3710.0 [1]
	2-[2-(Dimethylamino)-3-ethyl-4H-quinazolin-4-yl]-N-[[4-[(4-fluorophenyl)sulfonylamino]phenyl]methyl]acetamide	IC50	4102.04 [1]
	2-[2-(Dimethylamino)-3-ethyl-4H-quinazolin-4-yl]-N-[[4-[(4-methylphenyl)sulfonylamino]phenyl]methyl]acetamide	IC50	1119.44 [1]
	N-Benzyl-2-[2-(dimethylamino)-3-ethyl-4H-quinazolin-4-yl]acetamide	IC50	24154.61 [1]
	N-Benzyl-2-(3-ethyl-2-piperidin-1-yl-4H-quinazolin-4-yl)acetamide	IC50	4581.42 [1]
	N-[2-Ethyl-2-(4-fluorophenyl)butyl]-1-(2-phenylethyl)piperidine-4-carboxamide	IC50	89.0 [1]
	2-[2-[4-[2-(Dimethylamino)ethyl]piperazin-1-yl]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]-N-[(4-fluorophenyl)methyl]acetamide	IC50	320.0 [1]
	2-[2-[4-[2-(Dimethylamino)ethyl]piperazin-1-yl]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]-N-[(4-methoxyphenyl)methyl]acetamide	IC50	310.0 [1]
	1-[4-[(2-Chlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one	IC50	141.0 [1]
	1-[4-[(2,6-Dichlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one	IC50	1000.0 [1]
	1-[4-[(2,4-Dimethylphenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one	IC50	35.0 [1]
	1-[4-[(3-Chlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one	IC50	55.0 [1]
	1-[4-[(3,4-Dichlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one	IC50	1000.0 [1]
	N-[[3-[2-(Trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethanamine	IC50	1020.0 [1]
	(2S)-1-[4-[(4-Chlorophenyl)methyl]piperazin-1-yl]-3-(4-fluorophenoxy)propan-2-ol	IC50	1560.0 [1]
	1-{4-[(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-3,3-diphenyl-propan-1-one	IC50	81.0 [1]
	1-[4-[Bis(4-methoxyphenyl)methyl]piperazin-1-yl]-3,3-diphenylpropan-1-one	IC50	745.0 [1]
	1-[4-[(2,3-Dichlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one	IC50	63.0 [1]
	2-[4-(2,4-Dimethylphenyl)piperazin-1-yl]-N-[[3-[2-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]ethanamine	IC50	1530.0 [1]
	1-[4-[(3,5-Dichlorophenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one	IC50	1000.0 [1]
	2-[4-(Dimethylamino)phenyl]-N-[1-[(4-fluorophenyl)methyl]pyrazol-3-yl]acetamide	IC50	4.2 [1]
	N-[1-[(4-Cyano-3-fluorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamide	IC50	3.1 [1]
	N-[1-[(3,5-Difluoro-4-methoxyphenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamide	IC50	3.2 [1]
	2-[4-(Dimethylamino)phenyl]-N-[1-[(4-methylphenyl)methyl]pyrazol-3-yl]acetamide	IC50	7.0 [1]
	N-[1-[(4-Cyanophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamide	IC50	11.0 [1]
	N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[6-(dimethylamino)pyridin-3-yl]acetamide	IC50	12.0 [1]
	N-[1-[[4-(Difluoromethoxy)phenyl]methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamide	IC50	6.8 [1]
	2-[4-(Dimethylamino)phenyl]-N-[1-[[4-(trifluoromethoxy)phenyl]methyl]pyrazol-3-yl]acetamide	IC50	2.2 [1]
	N-[1-[(4-Chlorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamide	IC50	1.1 [1]
	N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamide	IC50	1.5 [1]
	N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[6-[(3S)-3-fluoropyrrolidin-1-yl]pyridin-3-yl]acetamide	IC50	2.5 [1]
	N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(3-fluorooxetan-3-yl)phenyl]acetamide	IC50	4.3 [1]
	2-(6-Cyclopropylpyridin-3-yl)-N-[1-[(3,4-difluorophenyl)methyl]pyrazol-3-yl]acetamide	IC50	15.0 [1]
	2-[4-(Dimethylamino)phenyl]-N-[1-[(4-methoxyphenyl)methyl]pyrazol-3-yl]acetamide	IC50	23.0 [1]
	N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1H-indol-6-yl)acetamide	IC50	1.9 [1]
	N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(oxetan-3-yloxy)phenyl]acetamide	IC50	4.6 [1]
	N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1-methylpyrrolo[2,3-b]pyridin-5-yl)acetamide	IC50	7.1 [1]
	N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1H-indol-5-yl)acetamide	IC50	2.3 [1]
	N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(4-propan-2-ylphenyl)acetamide	IC50	1.4 [1]
	2-[4-(3,3-Difluorocyclobutyl)oxyphenyl]-N-[1-[(3,4-difluorophenyl)methyl]pyrazol-3-yl]acetamide	IC50	1.4 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Voltage-gated T-type calcium channel alpha-1G subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/voltage-gated-t-type-calcium-channel-alpha-1g-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Voltage-gated T-type calcium channel alpha-1G subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-t-type-calcium-channel-alpha-1g-subunit-inhibitors-ic50-ki.
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