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Voltage-gated T-type calcium channel alpha-1H subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
MibefradilIC50130.0 [1], 181.0 [2], 1000.0 [3]
N,3-Bis(4-fluorophenyl)-5-pyridin-4-yl-3,4-dihydropyrazole-2-carboxamideIC5033.0 [1], 220.0 [2], 1700.0 [3]
N-((1-(2-(Tert-Butylamino)-2-oxoethyl)piperidin-4-yl)methyl)-3-chloro-5-fluorobenzamideIC5073.0 [1]
CID 24765479IC508.2 [1]
N-[[5-(2-Methylpropyl)-1-phenylpyrazol-3-yl]methyl]benzenesulfonamideIC505800.0 [1]
3-Chloro-2,5,5-trimethyl-N-[[2-(propan-2-yloxymethyl)phenyl]methyl]-6,7-dihydro-4H-isoindole-1-carboxamideIC506.6 [1], 130.0 [2]
3-(4-Chlorophenyl)-N-(3,4-difluorophenyl)-2-propan-2-yl-2,7-diazaspiro[3.5]nonane-7-carboxamideIC50174.0 [1], 340.0 [2]
3-(4-Chlorophenyl)-N-(3,5-difluorophenyl)-2-propan-2-yl-2,7-diazaspiro[3.5]nonane-7-carboxamideIC50138.0 [1], 328.0 [2]
7-(6-Chloro-1H-benzimidazol-2-yl)-2-(3-chloro-4-fluorophenyl)-1-pyridin-2-yl-2,7-diazaspiro[3.5]nonan-3-oneIC5071.0 [1], 78.0 [2]
2-(3-Chlorophenyl)-7-[5-fluoro-6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1-pyridin-2-yl-2,7-diazaspiro[3.5]nonan-3-oneIC5044.0 [1], 63.0 [2]
2-(3-Chloro-4-fluorophenyl)-7-[5-fluoro-6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1-pyridin-2-yl-2,7-diazaspiro[3.5]nonan-3-oneIC5029.0 [1], 106.0 [2]
2-(3-Cyanophenyl)-N-(3,5-difluorophenyl)-3-oxo-1-pyridin-2-yl-2,7-diazaspiro[3.5]nonane-7-carboxamideIC502377.0 [1], 19300.0 [2]
Methyl (2S,3S)-2-[[3-(4-chlorophenyl)-2-propan-2-yl-2,7-diazaspiro[3.5]nonane-7-carbonyl]amino]-3-methylpentanoateIC50733.0 [1], 3197.0 [2]
N-(3,5-Difluorophenyl)-3-(4-fluorophenyl)-2-propan-2-yl-2,7-diazaspiro[3.5]nonane-7-carboxamideIC50172.0 [1], 995.0 [2]
Methyl (2S,3S)-2-[[1-(4-chlorophenyl)-2-(3-fluorophenyl)-3-oxo-2,7-diazaspiro[3.5]nonane-7-carbonyl]amino]-3-methylpentanoateIC50109.0 [1], 872.0 [2]
2-(3-Chloro-4-fluorophenyl)-N-(3,5-difluorophenyl)-3-pyridin-2-yl-2,7-diazaspiro[3.5]nonane-7-carboxamideIC5041.0 [1], 291.0 [2]
2-(3-Chloro-4-fluorophenyl)-N-(3,5-difluorophenyl)-3-oxo-1-pyridin-2-yl-2,7-diazaspiro[3.5]nonane-7-carboxamideIC5042.0 [1], 176.0 [2]
2-(3-Chloro-4-fluorophenyl)-N-(3,4-difluorophenyl)-3-oxo-1-pyridin-2-yl-2,7-diazaspiro[3.5]nonane-7-carboxamideIC50402.0 [1], 17700.0 [2]
2-(3,4-Difluorophenyl)-3-oxo-1-pyridin-2-yl-N-[3-(trifluoromethyl)phenyl]-2,7-diazaspiro[3.5]nonane-7-carboxamideIC50176.0 [1], 283.0 [2]
2-(3-Chlorophenyl)-N-(3,4-difluorophenyl)-3-oxo-1-pyridin-2-yl-2,7-diazaspiro[3.5]nonane-7-carboxamideIC50118.0 [1], 652.0 [2]
2-(3-Chlorophenyl)-N-(3,5-difluorophenyl)-3-oxo-1-pyridin-2-yl-2,7-diazaspiro[3.5]nonane-7-carboxamideIC50200.0 [1], 3490.0 [2]
7-(5-Chloro-6-fluoro-1H-benzimidazol-2-yl)-2-(3-chloro-4-fluorophenyl)-1-pyridin-2-yl-2,7-diazaspiro[3.5]nonan-3-oneIC5060.0 [1], 84.0 [2]
Cyano (2S,3S)-2-[[1-(4-chlorophenyl)-2-(3-fluorophenyl)-3-oxo-2,7-diazaspiro[3.5]nonane-7-carbonyl]amino]-3-methylpentanoateIC5035.0 [1], 17000.0 [2]
Methyl (2S,3S)-2-[[3-(4-chlorophenyl)-2-cyclopropyl-2,7-diazaspiro[3.5]nonane-7-carbonyl]amino]-3-methylpentanoateIC50325.0 [1], 713.0 [2]
N-[[1-[2-(Tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)piperidin-4-yl]methyl]-3,5-dichlorobenzamideIC50600.0 [1], 1200.0 [2]
8-PrenylnaringeninIC501000.0 [1]
NNC 55-0396 dihydrochlorideIC502000.0 [1]
Sophoraflavanone GIC501000.0 [1]
(R)-2-(4-Cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamideIC5092.0 [1]
1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanoneIC5045000.0 [1]
(S)-4',5,7-Trihydroxy-6-prenylflavanoneIC501000.0 [1]
AuglurantIC50100000.0 [1]
1-[3-(3,5-Dimethylpiperidine-1-carbonyl)benzenesulfonyl]-2-methyl-2,3-dihydro-1H-indoleIC503000.0 [1]
N-Benzyl-2-[2-[5-(dimethylamino)pentyl-methylamino]-3-(4-phenylphenyl)-4H-quinazolin-4-yl]acetamide;dihydrochlorideIC503600.0 [1]
N-(1-Benzyl-1H-pyrazol-3-yl)benzamideIC5010000.0 [1]
N-(1-Benzylpyrazol-3-yl)-2-phenylacetamideIC5010000.0 [1]
3-Fluoro-N-[[5-(2-methylpropyl)-1-phenylpyrazol-3-yl]methyl]benzenesulfonamideIC502080.0 [1]
N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamideIC5018.0 [1]
N-Benzyl-2-[2-[5-(dimethylamino)pentyl-methylamino]-6,8-difluoro-3-(4-phenylphenyl)-4H-quinazolin-4-yl]acetamideIC505600.0 [1]
N-[(4-Fluorophenyl)methyl]-2-[3-(4-phenylphenyl)-2-[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]-4H-quinazolin-4-yl]acetamideIC505100.0 [1]
6-[[[1-[2-(7-Methoxy-2-oxoquinoxalin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-oneIC50333000.0 [1]
[(1S,2S)-2-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoateIC50149.0 [1]
Propan-2-yl 4-(3-chlorophenyl)-6-methyl-3-[3-[methyl-(4-phenoxybenzoyl)amino]propyl]-2-oxo-1,4-dihydropyrimidine-5-carboxylateIC50180.0 [1]
Benzyl N-[2-[3-[benzyl-(3-chlorophenyl)sulfamoyl]anilino]-2-oxoethyl]-N-methylcarbamateIC50110.0 [1]
Benzyl N-[2-[3-[(3-chlorophenyl)-[2-oxo-2-(propan-2-ylamino)ethyl]sulfamoyl]anilino]-2-oxoethyl]-N-methylcarbamateIC501700.0 [1]
Propan-2-yl 2-(3-chloro-N-[3-[3-(phenylmethoxycarbonylamino)propanoylamino]phenyl]sulfonylanilino)acetateIC50420.0 [1]
Propan-2-yl 2-(3-chloro-N-[3-(3-phenylpropanoylamino)phenyl]sulfonylanilino)acetateIC50540.0 [1]
Propan-2-yl 2-(3-chloro-N-[3-[[2-[methyl(phenylmethoxycarbonyl)amino]acetyl]amino]phenyl]sulfonylanilino)acetateIC50240.0 [1]
N-[[4-Methyl-5-(2-methylpropyl)-1-phenylpyrazol-3-yl]methyl]benzenesulfonamideIC504300.0 [1]
2-[4-(Dimethylamino)phenyl]-N-[1-[(4-fluorophenyl)methyl]pyrazol-3-yl]acetamideIC5012.0 [1]
N-[1-[(4-Cyano-3-fluorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC5014.0 [1]
N-[1-[(3,5-Difluoro-4-methoxyphenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC507.8 [1]
2-[4-(Dimethylamino)phenyl]-N-[1-[(4-methylphenyl)methyl]pyrazol-3-yl]acetamideIC5010.0 [1]
N-[1-[(4-Cyanophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC5020.0 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[6-(dimethylamino)pyridin-3-yl]acetamideIC5046.0 [1]
N-[1-[[4-(Difluoromethoxy)phenyl]methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC5010.0 [1]
2-[4-(Dimethylamino)phenyl]-N-[1-[[4-(trifluoromethoxy)phenyl]methyl]pyrazol-3-yl]acetamideIC505.1 [1]
N-[1-[(4-Chlorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC504.1 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC503.4 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[6-[(3S)-3-fluoropyrrolidin-1-yl]pyridin-3-yl]acetamideIC5021.0 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(3-fluorooxetan-3-yl)phenyl]acetamideIC5013.0 [1]
2-(6-Cyclopropylpyridin-3-yl)-N-[1-[(3,4-difluorophenyl)methyl]pyrazol-3-yl]acetamideIC50220.0 [1]
2-[4-(Dimethylamino)phenyl]-N-[1-[(4-methoxyphenyl)methyl]pyrazol-3-yl]acetamideIC5047.0 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1H-indol-6-yl)acetamideIC505.3 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(oxetan-3-yloxy)phenyl]acetamideIC5032.0 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1-methylpyrrolo[2,3-b]pyridin-5-yl)acetamideIC5035.0 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1H-indol-5-yl)acetamideIC5014.0 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(4-propan-2-ylphenyl)acetamideIC506.0 [1]
2-[4-(3,3-Difluorocyclobutyl)oxyphenyl]-N-[1-[(3,4-difluorophenyl)methyl]pyrazol-3-yl]acetamideIC5011.0 [1]
2-(4-Tert-butylphenyl)-N-[1-[(5-cyanopyridin-2-yl)methyl]pyrazol-3-yl]acetamideIC507.5 [1]
2-[4-(3,3-Difluorocyclobutyl)phenyl]-N-[1-[(3,4-difluorophenyl)methyl]pyrazol-3-yl]acetamideIC506.1 [1]
N-[2-[(3,4-Difluorophenyl)methyl]triazol-4-yl]-2-(1-methylindazol-5-yl)acetamideIC508.6 [1]
ABT-639 hydrochlorideIC502300.0 [1]
[(1S,2R,4S)-2-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-methoxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoateIC50318.0 [1]
[(1S,2R,4R)-2-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-phenylmethoxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoateIC50132.0 [1]
[(1S,2R,4S)-2-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-phenylmethoxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoateIC50113.0 [1]
[(1S,2R,4R)-2-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-hydroxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoateIC50107.0 [1]
[(1S,2R,4S)-2-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-hydroxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoateIC5076.0 [1]
[(1S,8S,9S)-9-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-9-tricyclo[6.2.2.02,7]dodeca-2,4,6-trienyl] 2-methoxyacetateIC50361.0 [1]
[(1S,8S,9S)-9-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-9-tricyclo[6.2.2.02,7]dodeca-2,4,6-trienyl] cyclopropanecarboxylateIC50210.0 [1]
[(1S,8S,9S)-9-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-3,6-diazatricyclo[6.2.2.02,7]dodeca-2,4,6-trien-9-yl] 2-methylpropanoateIC502065.0 [1]
[(1S,2S)-2-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4,4-dimethyl-1-propan-2-yl-1,3-dihydronaphthalen-2-yl] 2-methoxyacetateIC50207.0 [1]
[(1S,2S,4R)-2-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-4-butyl-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methoxyacetateIC50193.0 [1]
[(1S,2R,4R)-2-[2-[3-(1H-Benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-methoxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoateIC50557.0 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yl]acetamideIC506.7 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]acetamideIC50140.0 [1]
N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-ethyl-4-(2,2,2-trifluoroethoxy)phenyl]acetamideIC507.8 [1]
N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-methyl-4-(trifluoromethoxy)phenyl]acetamideIC5025.0 [1]
N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-methyl-4-(3,3,3-trifluoropropoxy)phenyl]acetamideIC5018.0 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1-methylindazol-5-yl)acetamideIC508.4 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1,3,3-trimethyl-2-oxoindol-5-yl)acetamideIC503.8 [1]
N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]acetamideIC507.0 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(3-methyl-2-oxo-1,3-benzoxazol-6-yl)acetamideIC5015.0 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(3-methyloxetan-3-yl)phenyl]acetamideIC504.3 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-[(3-methyloxetan-3-yl)methoxy]phenyl]acetamideIC5034.0 [1]
2-[(1-Phenyl-5-propan-2-ylpyrazol-3-yl)methyl]-3H-1,2-benzothiazole 1,1-dioxideIC502520.0 [1]
2-[[1-(4-Fluorophenyl)-5-propan-2-ylpyrazol-3-yl]methyl]-3H-1,2-benzothiazole 1,1-dioxideIC502320.0 [1]
Ethyl 3-[3-[2-(benzhydrylcarbamothioyl)hydrazinyl]-3-oxopropyl]-6-methyl-4-(3-nitrophenyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylateIC50340.0 [1]
(3R,5S)-N,1-Dibenzyl-3,5-dimethyl-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepine-4-carboxamideIC50102.0 [1]
(5S)-N,1-Dibenzyl-5-methyl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC50241.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Voltage-gated T-type calcium channel alpha-1H subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/voltage-gated-t-type-calcium-channel-alpha-1h-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Voltage-gated T-type calcium channel alpha-1H subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-t-type-calcium-channel-alpha-1h-subunit-inhibitors-ic50-ki.
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