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Voltage-gated T-type calcium channel alpha-1I subunit Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
MibefradilIC50126.0 [1], 130.0 [2], 1000.0 [3]
(R)-2-(4-Cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamideIC503.7 [1], 98.0 [2]
(R)-2-(4-Cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamideKi1.2 [1]
N,3-Bis(4-fluorophenyl)-5-pyridin-4-yl-3,4-dihydropyrazole-2-carboxamideIC50340.0 [1], 2000.0 [2], 7000.0 [3]
3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-fluoropiperidin-4-yl]methyl}benzamideIC5032.0 [1], 44.0 [2], 62.0 [3]
N-((1-(2-(Tert-Butylamino)-2-oxoethyl)piperidin-4-yl)methyl)-3-chloro-5-fluorobenzamideIC5086.0 [1]
CID 24765479IC501.5 [1]
2-[4-(3-Methylpyrazin-2-yl)phenyl]-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamideIC50264.0 [1], 12000.0 [2]
EthosuximideIC505000000.0 [1]
CID 24893979IC5082.0 [1]
N-(1-Benzyl-1H-pyrazol-3-yl)benzamideIC5010000.0 [1]
N-(1-Benzylpyrazol-3-yl)-2-phenylacetamideIC50390.0 [1]
N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamideIC507.5 [1]
1-(3-Chlorophenyl)-3-((1-(3,3-dimethylbutyl)-4-phenylpiperidin-4-yl)methyl)ureaIC50245.0 [1]
3,5-Dichloro-N-[[1-[(4-methylphenyl)methyl]piperidin-4-yl]methyl]benzamideIC50281.0 [1]
3,5-Dichloro-N-[1-(3,3-dimethyl-butyl)-piperidin-4-ylmethyl]-benzamideIC5061.0 [1]
2-[4-(Dimethylamino)phenyl]-N-[1-[(4-fluorophenyl)methyl]pyrazol-3-yl]acetamideIC502.0 [1]
N-[1-[(4-Cyano-3-fluorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC501.8 [1]
N-[1-[(3,5-Difluoro-4-methoxyphenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC500.92 [1]
2-[4-(Dimethylamino)phenyl]-N-[1-[(4-methylphenyl)methyl]pyrazol-3-yl]acetamideIC501.8 [1]
N-[1-[(4-Cyanophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC503.5 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[6-(dimethylamino)pyridin-3-yl]acetamideIC504.0 [1]
N-[1-[[4-(Difluoromethoxy)phenyl]methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC501.6 [1]
2-[4-(Dimethylamino)phenyl]-N-[1-[[4-(trifluoromethoxy)phenyl]methyl]pyrazol-3-yl]acetamideIC501.0 [1]
N-[1-[(4-Chlorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC501.1 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamideIC500.89 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[6-[(3S)-3-fluoropyrrolidin-1-yl]pyridin-3-yl]acetamideIC505.4 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(3-fluorooxetan-3-yl)phenyl]acetamideIC501.3 [1]
2-(6-Cyclopropylpyridin-3-yl)-N-[1-[(3,4-difluorophenyl)methyl]pyrazol-3-yl]acetamideIC5010.0 [1]
2-[4-(Dimethylamino)phenyl]-N-[1-[(4-methoxyphenyl)methyl]pyrazol-3-yl]acetamideIC503.4 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1H-indol-6-yl)acetamideIC501.9 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(oxetan-3-yloxy)phenyl]acetamideIC503.6 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1-methylpyrrolo[2,3-b]pyridin-5-yl)acetamideIC503.3 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1H-indol-5-yl)acetamideIC502.1 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(4-propan-2-ylphenyl)acetamideIC501.8 [1]
2-[4-(3,3-Difluorocyclobutyl)oxyphenyl]-N-[1-[(3,4-difluorophenyl)methyl]pyrazol-3-yl]acetamideIC506.1 [1]
2-(4-Tert-butylphenyl)-N-[1-[(5-cyanopyridin-2-yl)methyl]pyrazol-3-yl]acetamideIC502.6 [1]
2-[4-(3,3-Difluorocyclobutyl)phenyl]-N-[1-[(3,4-difluorophenyl)methyl]pyrazol-3-yl]acetamideIC501.8 [1]
N-[2-[(3,4-Difluorophenyl)methyl]triazol-4-yl]-2-(1-methylindazol-5-yl)acetamideIC501.5 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yl]acetamideIC502.3 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]acetamideIC5011.0 [1]
N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-ethyl-4-(2,2,2-trifluoroethoxy)phenyl]acetamideIC502.9 [1]
N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-methyl-4-(trifluoromethoxy)phenyl]acetamideIC502.0 [1]
N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-methyl-4-(3,3,3-trifluoropropoxy)phenyl]acetamideIC504.1 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1-methylindazol-5-yl)acetamideIC500.76 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(1,3,3-trimethyl-2-oxoindol-5-yl)acetamideIC501.8 [1]
N-[1-[(5-Cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]acetamideIC501.7 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-(3-methyl-2-oxo-1,3-benzoxazol-6-yl)acetamideIC502.8 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(3-methyloxetan-3-yl)phenyl]acetamideIC501.2 [1]
N-[1-[(3,4-Difluorophenyl)methyl]pyrazol-3-yl]-2-[4-[(3-methyloxetan-3-yl)methoxy]phenyl]acetamideIC506.6 [1]
(3R,5S)-N,1-Dibenzyl-3,5-dimethyl-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepine-4-carboxamideIC5011.0 [1]
(5S)-N,1-Dibenzyl-5-methyl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC50164.0 [1]
(3R,5S)-1-Benzyl-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC5014.0 [1]
(3R,5S)-1-Benzyl-9-fluoro-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC5017.0 [1]
(3R,5S)-N-[(4-Methoxyphenyl)methyl]-3,5-dimethyl-1-(3-methylbutyl)-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepine-4-carboxamideIC5025.0 [1]
(3R,5S)-1-Benzyl-6-fluoro-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepine-4-carboxamideIC50133.0 [1]
(3R,5S)-N,1-Dibenzyl-3,5-dimethyl-2-oxo-3,5-dihydro-1,4-benzodiazepine-4-carboxamideIC50259.0 [1]
(3R,5S)-N,1-Dibenzyl-3,5,8-trimethyl-3,5-dihydro-2H-pyrido[2,3-e][1,4]diazepine-4-carboxamideIC5033.0 [1]
(3R,5S)-1-Benzyl-8-fluoro-7-methoxy-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC5073.0 [1]
(3R,5S)-1-[(4-Fluorophenyl)methyl]-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC507.0 [1]
(3R,5S)-1-[(3-Fluorophenyl)methyl]-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC505.0 [1]
(3R,5S)-1-Benzyl-3,5-dimethyl-N-(oxetan-3-yl)-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC5012.0 [1]
(2R,5S)-N,1-Dibenzyl-2,5-dimethyl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC50326.0 [1]
(3R,5S)-N-Benzyl-1-[(2,3-difluorophenyl)methyl]-3,5-dimethyl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC504.0 [1]
(3R,5S)-N,1-Dibenzyl-8-fluoro-3,5-dimethyl-3,5-dihydro-2H-pyrido[2,3-e][1,4]diazepine-4-carboxamideIC504.0 [1]
1-[(3R,5S)-3,5-Dimethyl-1-[[2-(trifluoromethyl)-1,3-thiazol-5-yl]methyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-3-pyridin-3-ylpropan-1-oneIC5013.0 [1]
(3R,5S)-1-Benzyl-3,5,8-trimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC5074.0 [1]
(3R,5S)-1-Benzoyl-N-benzyl-3,5-dimethyl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC5010000.0 [1]
1-[(3R,5S)-6-Fluoro-3,5-dimethyl-1-[[2-(trifluoromethyl)-1,3-thiazol-5-yl]methyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-3-pyridin-3-ylpropan-1-oneIC5020.0 [1]
(3R,5S)-N,1-Dibenzyl-6-fluoro-3,5-dimethyl-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepine-4-carboxamideIC509.0 [1]
(3R,5S)-3,5-Dimethyl-N-pyridin-3-yl-1-[[5-(trifluoromethyl)furan-2-yl]methyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC509.0 [1]
(3R,5S)-1-[Dideuterio(phenyl)methyl]-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepine-4-carboxamideIC50148.0 [1]
(3R,5S)-N-Benzyl-3,5-dimethyl-1-(pyridin-4-ylmethyl)-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC501710.0 [1]
(3R,5S)-1-[Dideuterio(phenyl)methyl]-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC504.0 [1]
1-[(3R,5S)-6-Fluoro-3,5-dimethyl-1-(3-methylbutyl)-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-3-pyridin-3-ylpropan-1-oneIC5052.0 [1]
(3R,5S)-1-Benzyl-3,5-dimethyl-4-(1-methylimidazol-4-yl)sulfonyl-3,5-dihydro-2H-1,4-benzodiazepineIC50210.0 [1]
(3R,5S)-1-[(2-Fluorophenyl)methyl]-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC505.0 [1]
(3R,5S)-1-Benzyl-6-fluoro-3,5-dimethyl-N-(oxetan-3-yl)-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC5013.0 [1]
(3R,5S)-N-Benzyl-3,5-dimethyl-1-[[5-(trifluoromethyl)furan-2-yl]methyl]-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepine-4-carboxamideIC5010.0 [1]
(7R,9S)-N,5-Dibenzyl-7,9-dimethyl-7,9-dihydro-6H-pyrimido[5,4-e][1,4]diazepine-8-carboxamideIC501000.0 [1]
(3R,5S)-1-Benzyl-7-methoxy-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC50100.0 [1]
(3R,5S)-N,1-Dibenzyl-7-fluoro-3,5-dimethyl-3,5-dihydro-2H-pyrido[2,3-e][1,4]diazepine-4-carboxamideIC5015.0 [1]
(3R,5S)-1-Benzyl-9-methoxy-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC509000.0 [1]
(3R,5S)-3,5-Dimethyl-1-(3-methylbutyl)-N-pyridin-3-yl-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepine-4-carboxamideIC50251.0 [1]
1-[(3R,5S)-1-Benzyl-6-fluoro-3,5-dimethyl-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-3-pyridin-3-ylpropan-1-oneIC5017.0 [1]
(3R,5S)-1-(Cyclopentylmethyl)-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC5014.0 [1]
(3R,5S)-1-Benzyl-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepine-4-carboxamideIC50306.0 [1]
(3R,5S)-N-Benzyl-3,5-dimethyl-1-[[2-(trifluoromethyl)-1,3-thiazol-5-yl]methyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC506.0 [1]
(3R,5S)-1-Benzyl-6-methoxy-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC50130.0 [1]
1-[(3R,5S)-3,5-Dimethyl-1-(3-methylbutyl)-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-3-pyridin-3-ylpropan-1-oneIC5013.0 [1]
(3R,5S)-1-Benzyl-7-fluoro-3,5-dimethyl-N-pyridin-3-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC508.0 [1]
(3R,5S)-N,1-Dibenzyl-3,5-dimethyl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC502.0 [1]
(3R,5S)-N,1-Dibenzyl-8-chloro-3,5-dimethyl-3,5-dihydro-2H-pyrido[2,3-e][1,4]diazepine-4-carboxamideIC5022.0 [1]
(3R,5S)-N,1-Dibenzyl-3,5-dimethyl-8-(trifluoromethyl)-3,5-dihydro-2H-pyrido[2,3-e][1,4]diazepine-4-carboxamideIC50281.0 [1]
(4S,6R)-N,8-Dibenzyl-1,4,6-trimethyl-6,7-dihydro-4H-pyrazolo[3,4-e][1,4]diazepine-5-carboxamideIC5010000.0 [1]
(3R,5S)-N,1-Dibenzyl-3,5-dimethyl-3,5-dihydro-2H-pyrido[4,3-e][1,4]diazepine-4-carboxamideIC508740.0 [1]
(3R,5S)-1-Benzyl-N-[(4-methoxyphenyl)methyl]-3,5-dimethyl-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepine-4-carboxamideIC5012.0 [1]
(3S,5R)-N,1-Dibenzyl-3,5-dimethyl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamideIC50641.0 [1]
1-[(3R,5S)-1-Benzyl-3,5-dimethyl-3,5-dihydro-2H-pyrido[3,4-e][1,4]diazepin-4-yl]-3-(4-fluorophenyl)propan-1-oneIC5025.0 [1]
(3R,5S)-N,1-Dibenzyl-3,5-dimethyl-3,5-dihydro-2H-pyrido[2,3-e][1,4]diazepine-4-carboxamideIC508.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Voltage-gated T-type calcium channel alpha-1I subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/voltage-gated-t-type-calcium-channel-alpha-1i-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Voltage-gated T-type calcium channel alpha-1I subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-t-type-calcium-channel-alpha-1i-subunit-inhibitors-ic50-ki.
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