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1,2-Diaminoanthraquinone *CAS 1758-68-5*

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Physical properties
Molecular weight238.24
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure


Molecular weight
The role of nitric oxide (NO) as a putative mediator of neuronal death can be understood best if NO is detected directly. 1,2-Diaminoanthraquinone (DAQ) is a red fluorescent probe that is used to detect nitric oxide (NO) productions in live cell and animals. DAQ has minimal neurotoxic effects and it neither influences normal evoked field potential amplitudes nor does it affect induction of long-term potentiation (LTP) in comparison to controls. DAQ is used to directly capture released NO during neurodegeneration in vivo and at the cellular site of its generation. The non-fluorescent 1,2-diaminoanthraquinone (DAQ) is injected into the eyes of rats whose optic nerve is injured to induce retrograde degeneration of the ganglion cells. The reaction product of DAQ with NO is a triazole with red fluorescence. The DAQ-based methodology of NO assessment is convenient and applicable to numerous living systems both in vivo and in vitro.


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of 1,2-Diaminoanthraquinone *CAS 1758-68-5* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM419.745 µL2.099 mL4.197 mL20.987 mL41.974 mL
5 mM83.949 µL419.745 µL839.49 µL4.197 mL8.395 mL
10 mM41.974 µL209.872 µL419.745 µL2.099 mL4.197 mL

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View all 6 references: Citation Explorer
Floral transition and nitric oxide emission during flower development in Arabidopsis thaliana is affected in nitrate reductase-deficient plants
Authors: Seligman K, Saviani EE, Oliveira HC, Pinto-Maglio CA, Salgado I.
Journal: Plant Cell Physiol (2008): 1112
Spectroscopic studies of 1,2-diaminoanthraquinone (DAQ) as a fluorescent probe for the imaging of nitric oxide in living cells
Authors: Galindo F, Kabir N, Gavrilovic J, Russell DA.
Journal: Photochem Photobiol Sci (2008): 126
Microbial transformation of amino- and hydroxyanthraquinones by Beauveria bassiana ATCC 7159
Authors: Zhan J, Gunatilaka AA.
Journal: J Nat Prod (2006): 1525
Neuromuscular contacts induce nitric oxide signals in skeletal myotubes in vitro
Authors: Puttmann B, Gerlach EM, Kruger M, Blottner D.
Journal: Neurosignals (2005): 85
Spatial nitric oxide imaging using 1,2-diaminoanthraquinone to investigate the involvement of nitric oxide in long-term potentiation in rat brain slices
Authors: von Bohlen und Halbach O, Albrecht D, Heinemann U, Schuchmann S.
Journal: Neuroimage (2002): 633
Nitric oxide modulates low-Mg2+-induced epileptiform activity in rat hippocampal-entorhinal cortex slices
Authors: Schuchmann S, Albrecht D, Heinemann U, von Bohlen und Halbach O.
Journal: Neurobiol Dis (2002): 96