Name: 1,2-Diaminoanthraquinone *CAS 1758-68-5*
Brand: AAT Bioquest
SKU: 15220
Price: 115 USD
Availability: InStock

1,2-Diaminoanthraquinone

CAS 1758-68-5

The role of nitric oxide (NO) as a putative mediator of neuronal death can be understood best if NO is detected directly. 1,2-Diaminoanthraquinone (DAQ) is a red fluorescent probe that is used to detect nitric oxide (NO) productions in live cell and animals. DAQ has minimal neurotoxic effects and it neither influences normal evoked field potential amplitudes nor does it affect induction of long-term potentiation (LTP) in comparison to controls. DAQ is used to directly capture released NO during neurodegeneration in vivo and at the cellular site of its generation. The non-fluorescent 1,2-diaminoanthraquinone (DAQ) is injected into the eyes of rats whose optic nerve is injured to induce retrograde degeneration of the ganglion cells. The reaction product of DAQ with NO is a triazole with red fluorescence. The DAQ-based methodology of NO assessment is convenient and applicable to numerous living systems both in vivo and in vitro.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
15220	25 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of 1,2-Diaminoanthraquinone *CAS 1758-68-5* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	419.745 µL	2.099 mL	4.197 mL	20.987 mL	41.974 mL
5 mM	83.949 µL	419.745 µL	839.49 µL	4.197 mL	8.395 mL
10 mM	41.974 µL	209.872 µL	419.745 µL	2.099 mL	4.197 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	238.24 g/mol	=	mL	x	mM	=	mmol

References

View all 6 references: Citation Explorer

Floral transition and nitric oxide emission during flower development in Arabidopsis thaliana is affected in nitrate reductase-deficient plants

Authors:

Seligman K, Saviani EE, Oliveira HC, Pinto-Maglio CA, Salgado I.

Journal:

Plant Cell Physiol (2008): 1112

Spectroscopic studies of 1,2-diaminoanthraquinone (DAQ) as a fluorescent probe for the imaging of nitric oxide in living cells

Authors:

Galindo F, Kabir N, Gavrilovic J, Russell DA.

Journal:

Photochem Photobiol Sci (2008): 126

Microbial transformation of amino- and hydroxyanthraquinones by Beauveria bassiana ATCC 7159

Authors:

Zhan J, Gunatilaka AA.

Journal:

J Nat Prod (2006): 1525

Neuromuscular contacts induce nitric oxide signals in skeletal myotubes in vitro

Authors:

Puttmann B, Gerlach EM, Kruger M, Blottner D.

Journal:

Neurosignals (2005): 85

Spatial nitric oxide imaging using 1,2-diaminoanthraquinone to investigate the involvement of nitric oxide in long-term potentiation in rat brain slices

Authors:

von Bohlen und Halbach O, Albrecht D, Heinemann U, Schuchmann S.

Journal:

Neuroimage (2002): 633

Physical properties

Molecular weight	238.24
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200
CAS	1758-68-5

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Page updated on October 7, 2025