1,2-Diaminoanthraquinone *CAS 1758-68-5*

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Chemical structure for 1,2-Diaminoanthraquinone *CAS 1758-68-5*
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25 mg 15220 $95


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Overview

MW238.24
CAS #1758-68-5
SolventDMSO
Storage Freeze (<-15 °C)
Minimize light exposure
Category Enzyme Detection
Redox Enzymes
Related Cell Signaling Molecules
Reactive Oxygen Species
The role of nitric oxide (NO) as a putative mediator of neuronal death can be understood best if NO is detected directly. 1,2-Diaminoanthraquinone (DAQ) is a red fluorescent probe that is used to detect nitric oxide (NO) productions in live cell and animals. DAQ has minimal neurotoxic effects and it neither influences normal evoked field potential amplitudes nor does it affect induction of long-term potentiation (LTP) in comparison to controls. DAQ is used to directly capture released NO during neurodegeneration in vivo and at the cellular site of its generation. The non-fluorescent 1,2-diaminoanthraquinone (DAQ) is injected into the eyes of rats whose optic nerve is injured to induce retrograde degeneration of the ganglion cells. The reaction product of DAQ with NO is a triazole with red fluorescence. The DAQ-based methodology of NO assessment is convenient and applicable to numerous living systems both in vivo and in vitro.




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Table 1. Volume of DMSO needed to reconstitute specific mass of 1,2-Diaminoanthraquinone *CAS 1758-68-5* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.



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References

Floral transition and nitric oxide emission during flower development in Arabidopsis thaliana is affected in nitrate reductase-deficient plants
Authors: Seligman K, Saviani EE, Oliveira HC, Pinto-Maglio CA, Salgado I.
Journal: Plant Cell Physiol (2008): 1112

Spectroscopic studies of 1,2-diaminoanthraquinone (DAQ) as a fluorescent probe for the imaging of nitric oxide in living cells
Authors: Galindo F, Kabir N, Gavrilovic J, Russell DA.
Journal: Photochem Photobiol Sci (2008): 126

Microbial transformation of amino- and hydroxyanthraquinones by Beauveria bassiana ATCC 7159
Authors: Zhan J, Gunatilaka AA.
Journal: J Nat Prod (2006): 1525

Neuromuscular contacts induce nitric oxide signals in skeletal myotubes in vitro
Authors: Puttmann B, Gerlach EM, Kruger M, Blottner D.
Journal: Neurosignals (2005): 85

Nitric oxide modulates low-Mg2+-induced epileptiform activity in rat hippocampal-entorhinal cortex slices
Authors: Schuchmann S, Albrecht D, Heinemann U, von Bohlen und Halbach O.
Journal: Neurobiol Dis (2002): 96

Spatial nitric oxide imaging using 1,2-diaminoanthraquinone to investigate the involvement of nitric oxide in long-term potentiation in rat brain slices
Authors: von Bohlen und Halbach O, Albrecht D, Heinemann U, Schuchmann S.
Journal: Neuroimage (2002): 633






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