Name: 2’,3’-cGAMP-iFluor® 488 conjugate
Brand: AAT Bioquest
SKU: 20320
Price: 1009 USD
Availability: InStock

2’,3’-cGAMP-iFluor® 488 conjugate

2’,3’-cGAMP-iFluor® 488 Conjugate is a green fluorescent probe for detecting cGAMP and studying its activity in innate immune signaling assays.

Fluorescence Detection: Excitation at 491 nm and emission at 516 nm.
High Brightness: Brighter fluorescence than fluorescein conjugates.
Photostability: Greater resistance to photobleaching than fluorescein conjugates.
pH Stability: Maintains fluorescence across pH 4–10.
Applications: Suitable for cGAMP detection and activity monitoring in fluorescence-based assays.

iFluor® 488-labeled cGAMP provides an excellent fluorescent probe for developing fluorescence-based assays and tests for detecting cGAMP or monitoring its activity. iFluor® 488 conjugates are significantly brighter than fluorescein conjugates and are much more photostable.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
20320	100 ug	Price

Overview

iFluor® 488-labeled cGAMP provides an excellent fluorescent probe for developing fluorescence-based assays and tests for detecting cGAMP or monitoring its activity. iFluor® 488 conjugates are significantly brighter than fluorescein conjugates and are much more photostable. Additionally, the fluorescence of iFluor® 488 is not affected by pH (4-10). 2’,3’-cGAMP has gained significant attention in recent years due to its potential as a therapeutic target for diseases such as cancer and viral infections. It has been shown to activate the immune system and enhance the efficacy of immune checkpoint inhibitors, which are a type of cancer immunotherapy. 2’,3’-cGAMP (cyclic GMP-AMP) is a cyclic dinucleotide second messenger molecule that plays a critical role in the innate immune system. It is synthesized by the enzyme cGAS (cyclic GMP-AMP synthase) in response to cytosolic DNA that has been released from damaged or infected cells. Once synthesized, 2’,3’-cGAMP binds to the adaptor protein STING (stimulator of interferon genes) and triggers downstream signaling pathways that result in the production of type I interferons and other cytokines, leading to an immune response against the invading pathogen.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of 2’,3’-cGAMP-iFluor® 488 conjugate to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	54.497 µL	272.486 µL	544.971 µL	2.725 mL	5.45 mL
5 mM	10.899 µL	54.497 µL	108.994 µL	544.971 µL	1.09 mL
10 mM	5.45 µL	27.249 µL	54.497 µL	272.486 µL	544.971 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	1834.96 g/mol	=	mL	x	mM	=	mmol

References

View all 49 references: Citation Explorer

Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity.

Authors:

Zhang, Conggang and Han, Jing and Hu, Shuiqing and Hu, Yawei and Xu, Yifang and Hou, Yanfei and Yang, Yinlong and Su, Huili and Zhang, Zhengyin and Liu, Peng and Sun, Xuxu

Journal:

Cancer immunology research (2023)

Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease.

Authors:

Riederer, Stephanie and Del Canizo, Ana and Navas, Javier and Peter, Marlowe G and Link, Ellen K and Sutter, Gerd and Rojas, Juan J

Journal:

Cancer gene therapy (2023)

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling.

Authors:

Gentili, Matteo and Liu, Bingxu and Papanastasiou, Malvina and Dele-Oni, Deborah and Schwartz, Marc A and Carlson, Rebecca J and Al'Khafaji, Aziz M and Krug, Karsten and Brown, Adam and Doench, John G and Carr, Steven A and Hacohen, Nir

Journal:

Nature communications (2023): 611

Potent Therapeutic Strategies for COVID-19 with Single-Domain Antibody Immunoliposomes Neutralizing SARS-CoV-2 and Lip/cGAMP Enhancing Protective Immunity.

Authors:

Zhou, Yajun and Lu, Xing and Wang, Xiaoqing and Ying, Tianlei and Tan, Xiangshi

Journal:

International journal of molecular sciences (2023)

cGAMP-activated cGAS-STING signaling: its bacterial origins and evolutionary adaptation by metazoans.

Authors:

Patel, Dinshaw J and Yu, You and Xie, Wei

Journal:

Nature structural & molecular biology (2023): 245-260

Physical properties

Molecular weight	1834.96
Solvent	DMSO

Spectral properties

Correction factor (260 nm)	0.21
Correction factor (280 nm)	0.11
Extinction coefficient (cm ^-1 M ^-1)	75000 ¹
Excitation (nm)	491
Emission (nm)	516
Quantum yield	0.9 ¹

Usage and storage

Intended use	Research Use Only (RUO)
Storage	Freeze (< -15 °C); Minimize light exposure

Telephone
Fax
Email	sales@aatbio.com
International	See distributors
Bulk request	Inquire
Custom size	Inquire
Technical support	Contact us
Request quotation	Request
Purchase order	Send to sales@aatbio.com
Shipping	Standard overnight for United States, inquire for international

Page updated on October 25, 2026