2’,3’-cGAMP-iFluor 647 conjugate

iFluor® 647-labeled cGAMP provides an excellent fluorescent probe for developing fluorescence-based assays and tests for detecting cGAMP or monitoring its activity. iFluor® 647 conjugates are well excited with a red laser and can be monitored with the common Cy5 filter set. Additionally, the fluorescence of iFluor® 647 is not affected by pH (4-10). 2’,3’-cGAMP has gained significant attention in recent years due to its potential as a therapeutic target for diseases such as cancer and viral infections. It has been shown to activate the immune system and enhance the efficacy of immune checkpoint inhibitors, which are a type of cancer immunotherapy. 2’,3’-cGAMP (cyclic GMP-AMP) is a cyclic dinucleotide second messenger molecule that plays a critical role in the innate immune system. It is synthesized by the enzyme cGAS (cyclic GMP-AMP synthase) in response to cytosolic DNA that has been released from damaged or infected cells. Once synthesized, 2’,3’-cGAMP binds to the adaptor protein STING (stimulator of interferon genes) and triggers downstream signaling pathways that result in the production of type I interferons and other cytokines, leading to an immune response against the invading pathogen.