Name: 2',3'-cGAMP, sodium salt
Brand: AAT Bioquest
SKU: 20313
Availability: InStock

2',3'-cGAMP, sodium salt

2',3'-cGAMP or cGAMP (Cyclic guanosine monophosphate“adenosine monophosphate) is produced in mammalian cells by cGAS (cGAMP synthase) from ATP and GTP upon cytosolic DNA stimulation. cGAMP produced by cGAS contains mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP. 2',3'-cGAMP is also referred to as "noncanonical" cGAMP due to the presence of the atypical 2'-5' phosphodiester linkage between the guanosine and the adenosine. Similar to the canonical 3',3'-cGAMP, 2'3'-cGAMP serves as a second messenger to activate innate immune responses by binding to STING (stimulator of IFN genes) and subsequently inducing the TBK1-IRF3-dependent production of IFN-β. Structural and functional studies revealed that noncanonical 2'3'-cGAMP is distinct from the canonical 3'3'-cGAMP produced by bacteria. 2'3'-cGAMP binds to STING with a much greater affinity than 3'3'-cGAMP. cGAMP has also been shown to be an effective adjuvant that boosts the production of antigen-specific antibodies and T cell responses in mice. cGAMP demonstrates antiviral functions in the cell where it is produced, it can cross cell membranes by passive diffusion to have some effects on neighboring cells.

Protocol

COA

Catalog	Size	Price	Quantity
20313	100 ug	Price
20314	1 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of Water needed to reconstitute specific mass of 2',3'-cGAMP, sodium salt to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	139.202 µL	696.01 µL	1.392 mL	6.96 mL	13.92 mL
5 mM	27.84 µL	139.202 µL	278.404 µL	1.392 mL	2.784 mL
10 mM	13.92 µL	69.601 µL	139.202 µL	696.01 µL	1.392 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	718.38 g/mol	=	mL	x	mM	=	mmol

Citations

View all 54 citations: Citation Explorer

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism

Authors:

Bai, J., Liu, F.

Journal:

Diabetes (2019): 1099-1108

Efficacy and mechanism of cGAMP to suppress Alzheimer's disease by elevating TREM2

Authors:

Xu, Q., Xu, W., Cheng, H., Yuan, H., Tan, X.

Journal:

Brain Behav Immun (2019): se name="20310.enl" path="C:\Users\aatbi\Drop

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

Authors:

Siu, T., Altman, M. D., Baltus, G. A., Childers, M., Ellis, J. M., Gunaydin, H., Hatch, H., Ho, T., Jewell, J., Lacey, B. M., Lesburg, C. A., Pan, B. S., Sauvagnat, B., Schroeder, G. K., Xu, S.

Journal:

ACS Med Chem Lett (2019): 92-97

Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling

Authors:

Eaglesham, J. B., Pan, Y., Kupper, T. S., Kranzusch, P. J.

Journal:

Nature (2019): E12

The STING ligand cGAMP potentiates the efficacy of vaccine-induced CD8+ T cells

Authors:

Gutjahr, A., Papagno, L., Nicoli, F., Kanuma, T., Kuse, N., Cabral-Piccin, M. P., Rochereau, N., Gostick, E., Lioux, T., Perouzel, E., Price, D. A., Takiguchi, M., Verrier, B., Yamamoto, T., Paul, S., Appay, V.

Journal:

JCI Insight (2019): se name="20310.enl" path="C:\Users\aatbi\Drop

Physical properties

Molecular weight	718.38
Solvent	Water

Storage, safety and handling

Intended use	Research Use Only (RUO)
Storage	Freeze (< -15 °C); Minimize light exposure

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