2’,3’-cGAMP succinimidyl ester

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Physical properties

Molecular weight	1216.15
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

Alternative formats

Overview SDS Protocol

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of 2’,3’-cGAMP succinimidyl ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	82.227 µL	411.133 µL	822.267 µL	4.111 mL	8.223 mL
5 mM	16.445 µL	82.227 µL	164.453 µL	822.267 µL	1.645 mL
10 mM	8.223 µL	41.113 µL	82.227 µL	411.133 µL	822.267 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
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Images

Figure 1. 2’,3’-cGAMP succinimidyl ester is an excellent reagent to covalently conjugate 2’,3’-cGAMP to biological targets, such as proteins, peptides, and nucleic acids. 2’,3’-cGAMP has gained significant attention in recent years due to its potential as a therapeutic target for diseases such as cancer and viral infections.

References

View all 50 references: Citation Explorer

Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis.
Authors: Luo, Juanjuan and Lu, Chunjiao and Chen, Yang and Wu, Xuewei and Zhu, Chenchen and Cui, Wei and Yu, Shicang and Li, Ningning and Pan, Yihang and Zhao, Weijiang and Yang, Qingkai and Yang, Xiaojun
Journal: Cell reports (2023): 112328

The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus.
Authors: Kong, Lingli and Sui, Chao and Chen, Tian and Zhang, Lei and Zhao, Wei and Zheng, Yi and Liu, Bingyu and Cheng, Xiaochen and Gao, Chengjiang
Journal: Cell reports (2023): 112306

Atractylenolide III suppresses senescence-associated secretome via inhibiting cGAS/NF-κB pathway in hepatic stellate cells.
Authors: Wu, Hongyan and Wu, Lixia and Xiao, Linxia and Gu, Yaqin and Liu, Hongxia and Zhang, Lihu and Zhang, Mingguang and Qi, Liang
Journal: Clinical and experimental pharmacology & physiology (2023): 316-324

TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Authors: Wang, Jie and Qin, Xiao and Huang, Yulu and Zhang, Qunmei and Pei, Jinyong and Wang, Yi and Goren, Idan and Ma, Shujun and Song, Zhishan and Liu, Yanzi and Xing, Hongxia and Wang, Hui and Yang, Bo
Journal: Autophagy (2023): 1-19

Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses.
Authors: Garcia, Gustavo and Irudayam, Joseph Ignatius and Jeyachandran, Arjit Vijay and Dubey, Swati and Chang, Christina and Cario, Sebastian Castillo and Price, Nate and Arumugam, Sathya and Marquez, Angelica L and Shah, Aayushi and Fanaei, Amir and Chakravarty, Nikhil and Joshi, Shantanu and Sinha, Sanjeev and French, Samuel W and Parcells, Mark and Ramaiah, Arunachalam and Arumugaswami, Vaithilingaraja
Journal: bioRxiv : the preprint server for biology (2023)

Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus.
Authors: Payet, Cloé A and You, Axel and Fayet, Odessa-Maud and Hemery, Edouard and Truffault, Frederique and Bondet, Vincent and Duffy, Darragh and Michel, Frédérique and Fadel, Elie and Guihaire, Julien and Demeret, Sophie and Berrih-Aknin, Sonia and Le Panse, Rozen
Journal: Annals of neurology (2023): 643-654

cGAS-dependent proinflammatory and immune homeostatic effects of the microtubule-targeting agent paclitaxel.
Authors: Serpico, Angela Flavia and Pisauro, Caterina and Grieco, Domenico
Journal: Frontiers in immunology (2023): 1127623

Multifunctional biomimetic nanoplatform based on photodynamic therapy and DNA repair intervention for the synergistic treatment of breast cancer.
Authors: Wu, Hang and Du, Xiyou and Xu, Jiangkang and Kong, Xinru and Li, Yingying and Liu, Dongzhu and Yang, Xiaoye and Ye, Lei and Ji, Jianbo and Xi, Yanwei and Zhai, Guangxi
Journal: Acta biomaterialia (2023): 551-565

Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases.
Authors: Mosallanejad, Kenta and Kennedy, Stephanie N and Bahleda, Kristin M and Slavik, Kailey M and Zhou, Wen and Govande, Apurva A and Hancks, Dustin C and Kranzusch, Philip J and Kagan, Jonathan C
Journal: Science immunology (2023): eabp9765

Biomimetic Nanovaccines Potentiating Dendritic Cell Internalization via CXCR4-Mediated Macropinocytosis.
Authors: Yang, Chao and Zhang, Fan and Chen, Fangman and Chang, Zhimin and Zhao, Yuewu and Shao, Dan and Sun, Wen and Dong, Wen-Fei and Wang, Zheng
Journal: Advanced healthcare materials (2023): e2202064