Name: 3'-Uaq Cap CPG
Brand: AAT Bioquest
SKU: 6232
Price: 148 USD
Availability: InStock

3'-Uaq Cap CPG

3′-Uaq-Cap CPG is a uridine-based solid support that enhances oligonucleotide duplex stability and hybridization specificity through anthraquinone-mediated 3′-end capping.

Enhanced Duplex Stability: Increases melting temperature by 10–18 °C per modification, significantly stabilizing short duplexes.
Improved Hybridization Fidelity: Stabilizes correct base pairs while destabilizing mismatches for greater sequence discrimination.
Reduced Terminal Fraying: Strengthens base stacking at the 3′-terminus to maintain duplex integrity
Efficient Purification: Anthraquinone cap enhances reversed-phase retention, simplifying product isolation.
Seamless Integration: Fully compatible with standard phosphoramidite synthesis and deprotection protocols.

The chemical structure of 3'-Uaq Cap CPG.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
6232	100 mg	Price

Overview

3′-Uaq-Cap CPG is a solid support designed for the synthesis of capped oligonucleotides with improved hybridization performance and thermal stability. It consists of a uridine nucleoside modified at the 2′-position with an anthraquinone (Uaq) group, covalently attached to a controlled pore glass (CPG) matrix for use in automated solid-phase oligonucleotide synthesis. The anthraquinone cap enhances base stacking at the 3′-terminus of oligonucleotides, stabilizing Watson–Crick duplexes and reducing terminal fraying that often occurs in unmodified sequences. Incorporation of a 3′-Uaq cap can raise the melting temperature (Tm) of short DNA:RNA, DNA:DNA, or RNA:RNA duplexes by approximately 10–18 °C per modification, providing greater duplex stability without disrupting standard base pairing. The modification also improves sequence selectivity by stabilizing correctly paired termini while destabilizing mismatched base pairs, resulting in higher hybridization specificity. In addition, the anthraquinone group imparts moderate lipophilicity, which aids in purification by reversed-phase chromatography and may help protect oligonucleotides from exonuclease degradation. 3′-Uaq-Cap CPG is compatible with standard phosphoramidite synthesis and deprotection protocols, allowing easy incorporation into existing oligonucleotide synthesis workflows. It is well-suited for applications requiring highly stable and specific hybridization probes, diagnostic oligonucleotides, and research tools for nucleic acid studies.

References

View all 8 references: Citation Explorer

Atomistic insights into liquid crystals of board-like molecules via molecular dynamics simulation.

Authors:

Díaz-Acosta, Adrián and Adroher-Benítez, Irene and Zerón, Iván M and Patti, Alessandro

Journal:

The Journal of chemical physics (2024)

A Dynamic Tetracationic Macrocycle Exhibiting Photoswitchable Molecular Encapsulation.

Authors:

Wu, Huang and Chen, Yong and Zhang, Long and Anamimoghadam, Ommid and Shen, Dengke and Liu, Zhichang and Cai, Kang and Pezzato, Cristian and Stern, Charlotte L and Liu, Yu and Stoddart, J Fraser

Journal:

Journal of the American Chemical Society (2019): 1280-1289

Redox control of thermopower and figure of merit in phase-coherent molecular wires.

Authors:

García-Suárez, Víctor M and Lambert, Colin J and Manrique, David Zs and Wandlowski, Thomas

Journal:

Nanotechnology (2014): 205402

Cross-conjugation and quantum interference: a general correlation?

Authors:

Valkenier, Hennie and Guédon, Constant M and Markussen, Troels and Thygesen, Kristian S and van der Molen, Sense J and Hummelen, Jan C

Journal:

Physical chemistry chemical physics : PCCP (2014): 653-62

Correlations between molecular structure and single-junction conductance: a case study with oligo(phenylene-ethynylene)-type wires.

Authors:

Kaliginedi, Veerabhadrarao and Moreno-García, Pavel and Valkenier, Hennie and Hong, Wenjing and García-Suárez, Víctor M and Buiter, Petra and Otten, Jelmer L H and Hummelen, Jan C and Lambert, Colin J and Wandlowski, Thomas

Journal:

Journal of the American Chemical Society (2012): 5262-75

Physical properties

Solvent

MeCN

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on May 9, 2026