5'-Amino-Modifier C6, MMT-protected

5'-Modifiers are used in DNA synthesizers to functionalize the 5'-terminus of the target oligonucleotide. 5'-amino-modifier C6 is a linker designed to be added at the terminus of an oligonucleotide synthesis to introduce a primary amino group into an oligo. This resulted amino group is suitable for immediate conjugation on the synthesis column with molecules containing an activated carboxy group, resulting in a stable amide linkage.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
4300	1 g	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMF needed to reconstitute specific mass of 5'-Amino-Modifier C6, MMT-protected to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	169.56 µL	847.802 µL	1.696 mL	8.478 mL	16.956 mL
5 mM	33.912 µL	169.56 µL	339.121 µL	1.696 mL	3.391 mL
10 mM	16.956 µL	84.78 µL	169.56 µL	847.802 µL	1.696 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	589.76 g/mol	=	mL	x	mM	=	mmol

References

View all 7 references: Citation Explorer

Cellulose/DNA Hybrid Nanomaterials

Authors:

Mangalam AP, Simonsen J, Benight AS.

Journal:

Biomacromolecules. (2009)

Fluorinated alcohol mediated control over cis vs trans opening of benzo[a]pyrene-7,8-diol 9,10-epoxides at C-10 by the exocyclic amino groups of O6-allyl protected deoxyguanosine and of deoxyadenosine

Authors:

Yagi H, Jerina DM.

Journal:

J Org Chem (2007): 6037

Rapid synthesis of DNA-cysteine conjugates for expressed protein ligation

Authors:

Lovrinovic M, Niemeyer CM.

Journal:

Biochem Biophys Res Commun (2005): 943

High throughput purification of amino-modified oligonucleotides and its application to novel detection system of gene expression

Authors:

Kojima N, Sugino M, Mikami A, Nonaka K, Fujinawa Y, Ueda Y, Sato K, Ohtsuka E, Matsubara K, Komatsu Y.

Journal:

Nucleic Acids Symp Ser (Oxf) (2005): 181

Synthesis of covalent DNA-protein conjugates by expressed protein ligation

Authors:

Lovrinovic M, Spengler M, Deutsch C, Niemeyer CM.

Journal:

Mol Biosyst (2005): 64

Physical properties

Molecular weight	589.76
Solvent	DMF

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

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Page updated on July 12, 2023