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5-OG488 acid
equivalent to Oregon Green® 488 carboxylic acid, 5-isomer
5-OG488 acid is the same molecule to Oregon Green® 488 carboxylic acid, 5-isomer (Oregon Green® is the Trademark of Invitrogen). This fluorinated analog of fluorescein has higher photostability and a lower pKa ~ 4.7 while 5-FAM has pKa ~6.4. The decreased pKa of 5-OG488 makes its fluorescence essentially pH insensitive in the physiological pH range. This amine-reactive 5-OG488 can be used to make bright green fluorescent bioconjugates with excitation/emission maxima ~496/524 nm. It is an excellent replacement to 5-FITC that has severe pH dependence and low photostability.
Chemical structure for 5-OG488 acid [equivalent to Oregon Green® 488 carboxylic acid, 5-isomer]
Chemical structure for 5-OG488 acid [equivalent to Oregon Green® 488 carboxylic acid, 5-isomer]
CatalogSize
Price
Quantity
70825 mg
Price
 
Physical properties

Molecular weight412.30
SolventDMSO
Spectral properties

Correction factor (260 nm)0.31
Correction factor (280 nm)0.12
Extinction coefficient (cm -1 M -1)
76000
Excitation (nm)498
Emission (nm)526
Storage, safety and handling

Certificate of OriginDownload PDF
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12171501
CAS1027168-06-4
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Page updated on October 8, 2025