Name: 6-TAMRA BCN
Brand: AAT Bioquest
SKU: 70513
Price: 112 USD
Availability: InStock

6-TAMRA BCN

6-TAMRA BCN is a bright, photostable orange-red fluorescent dye used for site-specific labeling of oligonucleotides and other biomolecules via copper-free click chemistry

Bioorthogonal: Selective for azides or tetrazines with minimal biological interference.
Fast kinetics: BCN reacts more rapidly than most other click chemistries.
Catalyst-free: The reaction does not require a toxic metal catalyst such as copper.
High biocompatibility: The reaction occurs under physiological pH and room temperature.
Versatility: It can be used for site-specific modification of a wide range of macromolecules.

Protocol

COA

Catalog	Size	Price	Quantity
70513	1 mg	Price

Overview

6-TAMRA BCN is a clickable derivative of 6-Carboxytetramethylrhodamine (6-TAMRA), commonly used for labeling biomolecules such as oligonucleotides. 6-TAMRA is a well-characterized orange-red fluorescent dye known for its high brightness, pH-insensitive fluorescence, and good photostability. To minimize steric hindrance and reduce potential interference with biomolecular interactions after conjugation, the molecule incorporates a polyethylene glycol (PEG) spacer. The bicyclononyne (BCN) moiety enables strain-promoted azide–alkyne cycloaddition (SPAAC) with azido groups, forming stable triazole linkages under catalyst-free conditions. In addition, unlike dibenzocyclooctyne (DBCO), BCN also reacts efficiently with tetrazines through an inverse electron-demand Diels–Alder (IEDDA) reaction. This reaction is rapid, selective, and bioorthogonal, allowing labeling of biomolecules under physiological conditions without the need for metal catalysts or disruption of native biological processes.

Physical properties

Solvent

DMSO

Spectral properties

Correction factor (260 nm)	0.32
Correction factor (280 nm)	0.178
Extinction coefficient (cm ^-1 M ^-1)	90000
Excitation (nm)	552
Emission (nm)	578

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on September 26, 2025