Name: 6-TAMRA BCN
Brand: AAT Bioquest
SKU: 70513
Price: 115 USD
Availability: InStock

6-TAMRA BCN

6-TAMRA BCN is a bright, photostable orange-red fluorescent dye used for site-specific labeling of oligonucleotides and other biomolecules via copper-free click chemistry.

Bioorthogonal: Selective for azides or tetrazines with minimal biological interference.
Fast kinetics: BCN reacts more rapidly than most other click chemistries.
Catalyst-free: The reaction does not require a toxic metal catalyst such as copper.
High biocompatibility: The reaction occurs under physiological pH and room temperature.
Versatility: It can be used for site-specific modification of a wide range of macromolecules.

Datasheet

COA

Catalog	Size	Price	Quantity
70513	1 mg	Price

Overview

6-TAMRA BCN is a clickable derivative of 6-Carboxytetramethylrhodamine (6-TAMRA), commonly used for labeling biomolecules such as oligonucleotides. 6-TAMRA is a well-characterized orange-red fluorescent dye known for its high brightness, pH-insensitive fluorescence, and good photostability. To minimize steric hindrance and reduce potential interference with biomolecular interactions after conjugation, the molecule incorporates a polyethylene glycol (PEG) spacer. The bicyclononyne (BCN) moiety enables strain-promoted azide–alkyne cycloaddition (SPAAC) with azido groups, forming stable triazole linkages under catalyst-free conditions. In addition, unlike dibenzocyclooctyne (DBCO), BCN also reacts efficiently with tetrazines through an inverse electron-demand Diels–Alder (IEDDA) reaction. This reaction is rapid, selective, and bioorthogonal, allowing labeling of biomolecules under physiological conditions without the need for metal catalysts or disruption of native biological processes.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of 6-TAMRA BCN to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	121.217 µL	606.083 µL	1.212 mL	6.061 mL	12.122 mL
5 mM	24.243 µL	121.217 µL	242.433 µL	1.212 mL	2.424 mL
10 mM	12.122 µL	60.608 µL	121.217 µL	606.083 µL	1.212 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	824.97 g/mol	=	mL	x	mM	=	mmol

References

View all 50 references: Citation Explorer

Photo-Accelerated Synthesis of Oligo(triazole amide)s.

Authors:

Petropoulos, Alexandros and Charles, Laurence and Becht, Jean-Michel and Schmitt, Michael and Lalevée, Jacques and Lutz, Jean-François

Journal:

Macromolecular rapid communications (2025): e2400759

Genome-wide profiling of unmodified DNA using methyltransferase-directed tagging and enrichment.

Authors:

Tosti, Luca and Mould, Calum and Gatehouse, Imogen and Smith, Anthony C and Ubych, Krystian and Miano, Valentina and Laird, Peter W and Kennefick, Jack and Neely, Robert K

Journal:

Cell reports methods (2025): 101187

Modular Synthesis of Dendritic Oligo-Glycerol Cationic Surfactants for Enhanced Antibacterial Efficacy.

Authors:

Hanheiser, Natalie and Jiang, Yuhang and Zoister, Christian and Dimde, Mathias and Achazi, Katharina and Nie, Chuanxiong and Li, Yuanyuan and Haag, Rainer and Singh, Abhishek K

Journal:

Angewandte Chemie (International ed. in English) (2025): e202425069

Synthesis and Reactivity of Oligo(ethylene glycol)-Tethered Morita-Baylis-Hillman Dimers in the Formation of Macrocyclic Structures Showing Remarkable Cytotoxicity.

Authors:

Paolino, Marco and Saletti, Mario and Venditti, Jacopo and Zacchei, Arianna and Donati, Alessandro and Bonechi, Claudia and Giuliani, Germano and Lamponi, Stefania and Cappelli, Andrea

Journal:

Pharmaceuticals (Basel, Switzerland) (2025)

Template-Directed Synthesis and Isolation of Unimolecular Oligo[n]catenanes Using a One-Pot CuAAC "Click" Reaction Approach.

Authors:

Tran, Sheila L and Harlan, Gray H and Puckowitz, David E and Wohlstadter, Nathan E and Zhang, Yipei and Colley, Nathan D and Barnes, Jonathan C

Journal:

Chemistry (Weinheim an der Bergstrasse, Germany) (2025): e202501344

Physical properties

Molecular weight	824.97
Solvent	DMSO

Spectral properties

Correction factor (260 nm)	0.32
Correction factor (280 nm)	0.178
Extinction coefficient (cm ^-1 M ^-1)	90000
Excitation (nm)	552
Emission (nm)	578

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on April 4, 2026